Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩 Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵

(1) Happy to share our latest work: We developed an approach to systematically investigate how glycosylation controls protein function across the proteome—and what goes wrong when it is disrupted. www.biorxiv.org/content/10.6...

Congratulations to my very good friend @jfhevler.bsky.social on this amazing pre-print on how mass-spec and MD simulation can enable functional analysis of protein glycoforms. It was a privilege to play a small part in this project and learn a lot from Johannes! #Glycotime #carbohydrate #Proteomics

For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏 arxiv.org/abs/2508.096...

🕷️ Spiders from our blood 🕷️ Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners. 🔗 www.mcponline.org/article/S153... #MassSpec #StructuralBiology

Faster and more accurate protein modeling with CryFold. By focusing on nearby points (Local Attention) and employing map masking, CryFold excels in generating models from challenging maps regions. It enables a more cost-efficient model building. 🧵 💾 github.com/SBQ-1999/Cry...