Slower focused search beats rushing. Taxi drivers who drive slower pick up more passengers. Attention > speed. Brilliant work! www.pnas.org/doi/10.1073/...

Science in the spotlight! Buildings in Shenzhen lit with research themes, and scientists Xue Qikun and Nieng Yan carrying the torch for the national games. So refreshing to see science celebrated. Congrats to both on the relay!

What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.

Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.

Warm congratulations to the young scientists recipients of the 2025 Nordic Photosynthesis community prizes: Jannis Straube (Copenhagen), Vesa Havurinne (Aveiro), Laura Laihonen & Pablo Ortega Martínez (Turku @utu.fi)👏 Kudos to all participants🎉 See you in Umeå next time!

White beaked dolphins breach beside our boat in the North Atlantic as snowcapped peaks of Arctic fjords rise into clouds.

Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.

In Cambridge celebrating 25 years of ribosome structure studies. Wonderful to reconnect with friends, pioneers of the field, and engage with brilliant young scientists. Proud to be part of this community. Thank you @mrclmb.bsky.social for the amazing event! Great photos by Song, Nenad and Shaoxia

1973: Max Perutz explains the solution of hemoglobin. 53 years later, we’re still waiting for someone to solve the missing pointer

A dramatic blood moon is lighting up the sky above Churchill College as Venki @mrclmb.bsky.social delivers the plenary on ribosome synthesis, a memorable alignment of breakthrough in structural biology and the cosmos tonight.

Speak up before more is lost. UCLA lost $600M in federal research grants, freezing work on cancer, neurodegeneration, pediatrics & more. Entire labs, careers, and patients remain in limbo. A devastating blow to US science. Trainees are hardest hit, the community must speak up before more is lost.

The scent of silence! Cool research in Cell @cellpress.bsky.social to brighten up your day🌹. The mystery of why some roses are fragrant and others aren't has an answer. It's called SCREP: a rose-specific gene that evolved from non-coding DNA 16.8 million years ago 👇

Stunning cryo-ET from Peijun Zhang lab: Direct visualization of HIV-1 nuclear import! Hundreds of viral cores captured entering the nucleus. The NPC dilates to let the capsid through. A masterclass in correlative microscopy that makes it quantitative. A leap for structural virology! @emboreports.org

Mitochondrial transfer is a fascinating phenomenon where cells shuttle mitos. The therapeutic potential is compelling and observational science is solid but the mechanism is a black box. Excellent Viewpoint in @naturemetabolism.bsky.social breaks down one of cell biology’s biggest emerging mysteries

Fantastic studies presented by young scientists today: @noodlyscientist.bsky.social, @aliciakmichael.bsky.social, @sramundo.bsky.social, @florentwaltz.bsky.social. Beautifully orchestrated by @cellarchlab.com What a treat here in Münster @uni-muenster.de!

Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science! Give him a warm welcome 🎉 link: www.cell.com/cell/fulltex...

Delighted to be appointed Honorary Visiting Chair Professor at Wuhan Agricultural University. This recognises our work in bioenergetics and opens exciting opportunities for international cryo-EM collaboration and joint supervision of PhD students.

Dedicated my talk at the opening evening of Biophysical Society proton meeting to Karen Davies. Karen's work shaped the field of bioenergetics from solving the horizontal subunit-a of ATP synthase to the structures of photosynthetic CI and more. She was a brilliant scientist, mentor and communicator

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com www.nature.com/articles/s41...

ACA 2025 Starter Pack for attendees of the 75th Annual Meeting. Tried to include everyone, feel free to tag yourself or others missed. Connecting the community at #ACA2025! @acastructuralsci.bsky.social @rcsbpdb.bsky.social 🔗 go.bsky.app/JAmraSp

Science builds bridges🇮🇷🤝🇮🇱 Join me in welcoming our new postdoc Vida who brings PhD in plant sciences and will contribute to new bioenergetic studies. Vida is from Tabriz where her family's lives were disrupted by war. Thankfully no casualties, but career delays to her siblings and psychological toll

Our new preprint: how photoprotection is spatially coordinated with energy metabolism. Photosystem I is major source of radicals. We report EM structure of PSI in complex with superoxide dismutase SOD: direct link between energy conversion & oxidative stress defence www.biorxiv.org/content/10.1...

Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.

Excited to contribute to the Mitoribosome collaborative study led by @wredenberglab.bsky.social in @natcomms.nature.com🎉 "The mitochondrial methylation potential gates mitoribosome assembly" The assembly starts before the completion of the rRNA gene cluster processing🧵 www.nature.com/articles/s41...

Running Phenix and stuck? Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program. Big thanks to Tom Willinger for making this happen! Try it out: phenix-online.org/version_docs...

The mechanism of hydrolysis of the peptidyl-tRNA at the stop codon published in Science by Polikanov and Gagnon labs. RFs induce structural change in tRNA utilising its unique intrinsic property - the 2'hydroxyl group that attacks the bond. This is a basic conserved step in translation termination.

A mitochondria core jewel: Acanthopleura granulata in all its glory. 🤩 🌊 #mitochondria #ocean

Multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, by Eric Betzig et al.

Cryo-EM meeting wrapped up in Hong Kong with a full house over 130 researchers. Huge congrats to the young scientists & award winners for stellar work 👏 Big thanks to everyone who made it such a great exchange of ideas

The biannual cryoEM symposium at Hong Kong University of Science and Technology has kicked off. With Peijun ZHANG, Yifan CHENG, Yiorgo SKINIOTIS, Masahide KIKKAWA, Yigong SHI, Hong ZHOU, Hongwei WANG @weiss-lab.bsky.social and many more. Early morning runs, late discussions and everything in between

Multimodal large language models, like ChatGPT, can form human-like visual and conceptual representations. This links AI cognition to human brain activity. Strong correlations between model dimensions and human neural patterns. Published in Nature Machine Intelligence @natmachintell.nature.com

Wonderful meeting at @cniostopcancer.bsky.social in Madrid on DNA/RNA machines. Thanks to @rfleiro.bsky.social @oscarllorca.bsky.social @nogaleslab.bsky.social for organisation and bringing everyone together. Special thanks to students and postdocs for sharing new findings and sparking discussions!

Breakthrough in HIV latency reversal. A lipid nanoparticle co-formulated with an ionizable lipid and β-sitosterol delivers mRNA encoding HIV Tat or CRISPRa machinery directly into resting T cells. The approach reactivates latent HIV ex vivo without toxic effects or T cell activation.

What a beautiful study in Nature! 'Structural insights into human Pol III transcription initiation in action' The forward translocation of the RNA-DNA hybrid is absolutely fantastic. Huge congrats Yanhui and Qianmin!

Refreshing to see this spelled out directly. Clear stance from the editor on citations. Peer review is about science not self-promotion.

Hydrolytic endonucleolytic ribozymes are being reprogrammed for sequence-specific DNA cleavage, offering a potential CRISPR alternative with expanded versatility. Gene editing may soon have a new RNA-based tool. Simulation presented by Jun-Jie Gogo Liu.

Special science evening by Katrin Amunts @hhu.de @fz-juelich.de exploring the brain’s inner architecture and the nature of thought. July 10, 18:00 | Kunstsammlung NRW, Trinkhaus Auditorium, Düsseldorf 🎙️ Moderated by philosopher Wolfram Eilenberger 🌐 Livestream by Hector Fellow Academy Register free

Personalized medicine is here. The first tailor-made mRNA-CRISPR therapy has been delivered to the liver of an infant with a deadly metabolic disorder, carbamoyl phosphate synthetase 1 deficiency. A one-patient treatment, designed and made to save a single life.

The structure of human sweetness: Cell Sweet receptor bound to two widely used artificial sweeteners: sucralose and aspartame. A single receptor that mediates all our responses to sweet-tasting compounds.

New era for brain mapping, latest from Johann Danzl lab in @nature.com. Light-microscopy connectomics is at single-synapse resolution. Engineered hydrogel embedding + expansion, deep learning-based segmentation, and molecularly resolved reconstructions: axons, spines, connectivity, all visible.

Shenzhen's night light show is something else, and now it pays tribute to science and scientists. 42 skyscrapers, including the 599m Ping An come alive in a dazzling display of brilliant color, choreographed into a kaleidoscopic celebration of innovation and imagination 🌆✨

Ageing speeds up at high altitudes, unless you’re native Tibetan. Their DNA methylation patterns adapt immune function and oxygen use to extreme conditions. A beautiful example of epigenetic resilience.

Spectacular display of blooming blue-green macroalgae migrating along the coast, such a beautiful adaptation! Recorded at Hau Hoi Wan, a designated Site of Special Scientific Interest in Hong Kong. Captured on my phone, shown at 10x speed. Ready for fieldwork.

Visits to past advisors are always special. Back in the legendary lab of Nathan Nelson, spinning centrifuges, running gels, and enjoying lunch with the legend himself. Chatting about mitos, chloroplasts and evolution. A truly inspiring figure in bioenergetics and still full of positive energy!

Hard to beat fieldwork in the Mediterranean with the amazing team from the Oceanographic & Limnological Research! 🌊 Scuba diving 🤿 to study ecological changes driven by climate change and collecting samples for molecular analysis 🔬

Understanding and Managing Aging: excellent new interdisciplinary review in Cell @cellpress.bsky.social outlines 14 hallmarks of aging, including extracellular matrix changes & psychosocial isolation. A precision geromedicine framework to transform aging from a risk factor into a treatable process.

Happy to give a special lecture on the first evening of the DFG meeting GoPMF at the @uni-muenster.de. Three days of inspiring discussions of unpublished data. Thank you all the organizers for bringing together such an amazing group of people and topics in bioenergetics.

Breakthrough in mitochondrial disorders therapy and structural biology by @mito-at-gu.bsky.social! PZL-A a small molecule activator of mtDNA synthesis, restores mutant POLG. Cryo-EM reveals its binding mode, explaining boosted processivity & mtDNA recovery in cells. Step toward treating mt-disorders

A warm welcome to Sonja Lorenz @sonjalorenzlab.bsky.social! Exciting research on ubiquitination specificity and posttranslational regulation. Great to have you here!