Happy 50th Anniversary of the Stanford SSRL synchrotron radiation and protein crystallography initiative

First Molecule of the Month of 2026: Natural RNA-Only Assemblies

A NYE countdown, rendered in 3D! ➡️ Learn more about cutting-edge protein research at #ASBMB26: www.asbmb.org/annual-meeti.... 🎨 Structures from @rcsbpdb.bsky.social #HappyNewYear #Biochemistry #MolecularBiology #MakeItPossible

Molecular Explorations for 2026 Download our new calendar that highlights the work of Molecule of the Month creator Janet Iwasa

Here's a toast to alcohol dehydrogenase, our primary defense against alcohol, a toxic molecule that compromises the function of our nervous system #HappyNewYear

Visit PDB-101 to watch the 2025 video "Caffeine and Adenosine: Antagonist and Agonist"

RCSB PDB's 2025 in photos--looking forward to meeting with collaborators, data depositors, and users in 2026!

AI model helps boost pandemic preparedness Scripps Research breakthrough reduces antibody discovery time from weeks to hours, potentially revolutionizing pandemic response and therapeutic development. www.scripps.edu/news...

First high-resolution structure of key herpes virus protein opens path to new antivirals phys.org/news/2025-1...

In DNA origami, bioengineers use the exquisite specificity of DNA base-pairing to build nanostructures with custom shapes, such as the little box shown here that includes single-stranded regions for use as functional tethers More at PDB-101: pdb101.rcsb.org/motm...

Thinking about sugarplums and sugar chains... Bacteria use the enzyme glucansucrase to build long, sticky chains of sugars called glucans, using the sugar in our diet #HappyHolidays

Biomedical animator Drew Berry created these amazing visuals for @bjork

Season's greetings from RCSB PDB

Ten rules for a structural bioinformatic analysis PLOS Comp Bio offers a roadmap for users to leverage the Protein Data Bank’s vast collection of protein structural models into reliable and valuable insights.

Come to the DIALS pre-congress workshop to learn how to process crystallographic images--great for new and experienced users Register for hands-on tutorials with example data and one-on-one time with DIALS developers Details at event.fourwaves.com/...

December 21 is #NationalCrosswordDay Try your hand at a Molecule of the Month-related crossword puzzle at PDB-101

Variations in protein glucosylation may contribute to diseases like Marfan syndrome.

Visit PDB-101 to learn how structures of poxvirus proteins are helping researchers find new ways to combat mpox.

Visit PDB-101 for animations that illustrate some of the experimental methods used to study PDB structures: X-ray crystallography, NMR, and 3DEM pdb101.rcsb.org/lear...

Dive into 4D-STEM and electron diffraction with open-source simulation and analysis tools and interactive tutorials on multislice and Bloch-wave methods, strain and orientation mapping, and ptychography at this hands-on #IUCr2026 workshop Details: event.fourwaves.com/...#IUCr2026

Join the Magnetic Structure Determination Workshop at #IUCr2026 Learn how to use symmetry-based modeling, apply representation analysis, and perform hands-on refinements to confidently analyze neutron diffraction data Details about this pre-Congress event: event.fourwaves.com/...

wwPDB has received a record number of depositions this year--more than 20,000! Many thanks to all of our depositors and biocurators more making these important data available to all Details:

Interested in Small Angle Scattering? The IUCr2026 meeting has you covered with 8 sessions, including AI/ML applications; the possibilities of pharmaceutical innovation; open data, standards, and repositories; and more event.fourwaves.com/...

PDB-101 has highlighted the structural biology of athletics and well-being throughout 2024-2025. What topic should we explore in 2026?

Register for hands-on workshops held just before #IUCr2026 Choose from 20 workshops, including Enabling PDB Deposition of Integrative/Hybrid Methods Structures Determined using 3DEM plus Chemical Crosslinking and Other Complementary Approaches Details: event.fourwaves.com/...

It's Christmas time at my institute and I'm happy to see they kept the protein and DNA paper toys I made with the middle school interns two years ago to decorate the tree.

Loss or dysfunction of FOXP3 causes a disease known as IPEX syndrome, a devastating and often fatal disease, manifesting as a constellation of autoimmune disorders affecting organs throughout the body. More at Molecule of the Month: pdb101.rcsb.org/motm...

Join the @ccdc.cam.ac.uk at IUCr2026 for hands-on training and expert tips! Learn how to search, visualise, and analyse crystallographic data with confidence using the Cambridge Structural Database (CSD). 👉Details: event.fourwaves.com/...

Brewing waste: The solution to sustainable fashion? Biodegradable fibers spun from yeast protein avoid the resource use and pollution of cotton, wool, and polyester

PDB-101 hosts a gallery of the watercolor paintings of David S. Goodsell. These images integrate information from structural biology, microscopy and biophysics to simulate detailed views of the molecular structure of living cells

Take a tour of the PDB--The vast range of molecular shapes and sizes in the archive are illustrated by these 96 biomolecular machines.

It's that time of year... for creating virus snowflakes from @CVRinfo Viruses were made at RCSB PDB's holiday lunch Download the kit from cvr-engagement.co.uk...

The #NobelPrize award ceremony will take place on December 10. Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archive, including December's Molecule of the Month on FOXP3

Watch the Webinar: Searching the PDB for high-quality ligand-bound structures Learn how to search the PDB for the best examples of ligands using text, chemical drawing, and APIs

David Baker’s Nobel Prize winning lab has generated antibodies from scratch that target user-specified binding sites, offering a powerful AI tool for rational therapeutic design

Most spiders shut down when temperatures slip below freezing, but Clubiona spiders keep hunting through subzero nights in European orchards, an improbable winter endurance that depends on potent antifreeze proteins flowing through their bodies.

Stay up-to-date with API developments by viewing (or subscribing) to the RCSB PDB API announcements Google group. Key developments related to the transition to extended PDB IDs will be posted to this list.

Interested in Electron Crystallography? #IUCr2026 has you covered with 7 focused sessions including 4D-STEM advances; small molecule determination; nanocrystallography of inorganic compounds; from single crystal to serial diffraction; and more! event.fourwaves.com/...

Looking to decorate a #Chemistree? Visit PDB-101 for downloadable paper templates to create DNA, viruses, red and green fluorescent proteins, and more

International attendees are encouraged to visit the #IUCr2026 website for information about entering Canada for the conference, including visa / travel authorization requirements, documentation, timeline tips, and common pitfalls event.fourwaves.com/...

Throughout 2024 and 2025, PDB-101 has focused on the them of #peakperformance, highlighting the structural biology of athletics and well-being Which PDB-101 category should our focus be for 2026-2027?

December's Molecule of the Month features a master transcriptional regulator of immune tolerance with a Nobel Prize connection

Apply for #IUCr2026 travel grants Funds are available to support students, early-career researchers, and participants from under-resourced institutions and/or developing countries. Details at event.fourwaves.com/...

Register for hands-on workshops held just before the start of #IUCr2026 In the PDB Deposition Workshop, attendees will learn how to leverage various OneDep features and tools; how to complete depositions with minimal manual input; and more Details: event.fourwaves.com/...

Using PDB structures, researchers designed treatments for HIV infection, which are now part of effective drug regimens that halt the growth of the virus. Learn more at PDB-101 pdb101.rcsb.org/brow... #WorldAIDSDay

AI-Designed Antibodies Achieve Atomic Precision to Enhance Drug Discovery

Computational process could condense decades of disease biology research into days

Great discoveries often arise from work that was looking for something completely different

During the holidays, we often place greater demands on our digestive system. It contains tough, stable enzymes designed to find rich treats and break them into pieces. Pepsin is the first in a series of enzymes that digest proteins. #HappyThanksgiving

Congratulations to Emily Schaffter (Clark University) for her wwPDB Foundation Poster Prize awarded at The Protein Society for "Differential Interactions between Calmodulin and the IQ Motifs of the HECT E3 Ubiquitin Ligases UBE3B and UBE3C"