Many thanks to the folks at the San Diego Supercomputer Center for highlighting our project!

Celebrating 60 Years of Research and Education with Small Molecules with the @ccdc.cam.ac.uk

Watch Molecules in Motion Subscribe to the RCSB PDB YouTube channel for webinars, molecular animations, and more

Coming Soon: wwPDB Remediation of Metalloprotein-containing PDB Entries and CCDs Existing polyatomic metal containing PDB entries and CCDs will be updated with more complete chemical description and metal coordination annotation.

November Molecule of the Month: GLP-1 Receptor Agonists Popular and effective drugs for the treatment of obesity and diabetes

AI in Protein Design: Hype vs. Reality Explained by David Baker In this GEN interview, he emphasizes that designing new proteins from scratch is now a reality. Whether AI transforms medicine will require improving our understanding of biology's complexity

New bird flu vaccine could tackle multiple variants with one shot www.erasmusmc.nl/en/...

Mutations in the Halloween genes produce a "ghastly" appearance in the fruit flies.

Explore Green Fluorescent Protein In a new tutorial, use RCSB PDB resources to find and explore the 3D structure of GFP

Celebrate #NationalCatDay with the cats of RCSB PDB!

Register Now for Webinar: Exploring Integrative Structures with RCSB PDB On November 12, learn how to explore PDB structures determined using integrative and hybrid methods with RCSB PDB tools

Happening this week! Register for the Thursday October 30 Virtual Office Hour on Structure Summary Pages Learn how a exploring a single PDB structure at RCSB PDB can lead to visualizations, analyses, and searches across the archive

Study identifies entirely new suite of enzymes that can make psilocybin

A new study offers a powerful step forward in programmable proteins that use Boolean logic to make molecular decisions inside the body.

October 24 is #WorldPolioDay In ~1 in 100 cases, poliovirus spreads to the nerve cells that control muscle motion, causing paralysis--polio myelitis--as the nerve cells are infected More at PDB-101:

Register Now for Webinar: Exploring the Workhorses of Biotechnology On November 6, learn how to use RCSB PDB tools to analyze plastic-degrading enzymes

Welcome to flu season. Influenza Neuraminidase is an important target for influenza drugs More at PDB-101:

It's International #LeadPoisoning Prevention Week. Lead ions poison proteins throughout the body, blocking their normal function. #ILPPW2025 More at Molecule of the Month:

Happy Birthday, PDB! RCSB PDB is celebrating the announcement of the PDB archive #OTD in 1971.

October 20 is World CRISPR Day Cascade and CRISPR help bacteria remember how to fight viral infection

Happy Birthday to Irving Geis 1908-1997)! Geis created amazing molecular illustrations (and inspired the OneDep logo)

Irving Geis, born Oct 18, 1908, was a gifted artist who helped illuminate structural biology with his iconic images of DNA, hemoglobin, and other important macromolecules Explore his digital archive, created with permission from @hhmi.org, at PDB-101

Register for the Nov 24 Virtual Office Hour on Exploring CSMs at RCSB PDB Learn how to use RCSB PDB features to navigate 3D Computed Structure Models from AlphaFold DB and ModelArchive

While binding to GLP-1 causes pancreatic cells to secrete insulin, in the brain, GLP-1 activates neurons in the hypothalamus, resulting in a feeling of satiation, or fullness. More at Molecule of the Month: pdb101.rcsb.org/motm...

Register for the Oct 30 Virtual Office Hour on Structure Summary Pages Learn how a exploring a single PDB structure at RCSB PDB can lead to visualizations, analyses, and searches across the archive

Integrative modeling transforms how scientists understand molecular machines, with Rutgers researchers leading the global effort www.rutgers.edu/news...

October is #BreastCancerAwarenessMonth Read how Trastuzumab monoclonal antibodies targeting HER2 receptors are at the forefront of breast cancer treatment

Designed to attain its binding shape prior to binding, the antibiotic can serve as a powerful model for future antibiotics.

How visual rhodopsin responds to light in one of nature’s fastest reactions.

Visit PDB-101 for more about Nobel Prize-winning Computed Structure Models and their measures of reliability; limitations; and how they can help determine experimental structures

October 9 is #WorldSightDay Watch how Vitamin A activates the molecular pathways essential for vision in this new PDB-101 video

The genome of HIV is packaged inside a distinctive cone-shaped capsid, which protects the RNA and delivers it to the cells that HIV infects. Build a paper model of the HIV capsid by downloading and printing this template PDF.

The genome of ebola virus contains instructions for building seven proteins, which assemble with the genomic RNA to form one of the deadliest viruses.

The bloodstream is filled with molecules and cells that search for invaders and destroy them if they are found. PDB structures have revealed how the immune system recognizes viruses and bacteria while leaving our normal molecules alone. More at PDB-101:

Science History Institute makes public multimillion-dollar collection, including Rosalind Franklin’s famous DNA image, assembled by fake scientist

These findings could open the door to new drugs that target host proteins rather than the virus. This strategy may lead to new treatments effective against SARS-CoV-2 and other coronaviruses, even as the pathogens continue to evolve.

Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archive. Who will win next week?

Register Now for Webinar: Exploring the Workhorses of Biotechnology On November 6, learn how to use RCSB PDB to analyze plastic-degrading enzymes

Within minutes of starting to eat, cells in your gut rev into action and start secreting two peptide hormones--glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones are known as incretins. More at PDB-101:

Explore PDB-themed #Inktober #SciArt images from structural biologist Irina Bezsonova from (2023 and 2022)

Watch the Pairwise Alignment Tool Office Hour and learn how to align one or more protein chains to a reference structure in a pairwise manner

An siRNA screen performed by scientists at Scripps Research has pinpointed dozens of human proteins that SARS-CoV-2 uses to complete its replication cycle. These findings could open the door to new drugs that target host proteins rather than the virus.

In a new study, experts discovered that older people produce a glycosylated protein called apoplipoprotein D (ApoD), which is involved in lipid metabolism and inflammation, at much higher levels than in younger people

wwPDB has introducing the first 3DEM Model-Map percentile slider (based on Q-score) to validation reports

September 25th is International #Ataxia Awareness Day PDB structures help us better understand the disease and treament options

MolViewSpec: describe, share, and reproduce Mol* molecular scenes with a simple extension

Register for the Sept 25 Virtual Office Hour on PDB Policies Learn about PDB policies about deposition and biocuration.

Download this PDB-101 poster highlighting common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme

Amyloid-beta precursor protein (APP) is a complicated protein with many functions. A corrupted form can destroy nerve cells, leading to the loss of thought and memory in Alzheimer's disease. #WorldAlzheimersDay

September 21 is #NationalOpioidAwarenessDay Morphine and other opioid drugs bind to receptors in the nervous system, controlling pain