Sox8 is essential for #vertebrate #gastrulation. -> www.embopress.org/doi/full/10....

First November issue is live! www.embopress.org/toc/14693178... The cover features work by Peijun Zhang @ox.ac.uk @wellcometrust.bsky.social @diamondlightsource.bsky.social and co-workers on an in situ system for high-throughput analysis of HIV-1 nuclear import. www.embopress.org/doi/full/10....

Read Franks new collumn! www.embopress.org/doi/full/10....

Clarisse Berlioz-Torrent @cberlioztorrent.bsky.social @institutcochin.bsky.social @upcite.bsky.social and co-workers @unistra.fr report that GABARAP #autophagy proteins regulate the packaging of #HIV-1 genomic RNA into infectious #virions. #virology -> www.embopress.org/doi/full/10....

Ines Anna Drinnenberg @institutcurie.bsky.social @sorbonne-universite.fr and co-workers @nordicembl.bsky.social show that #insects evolved a conserved monomeric #histone fold domain in the CENP-T #kinetochore protein family. #evolution -> www.embopress.org/doi/full/10....

It is a fantastically well written plea to fund basic sciences. Money quote: "We are currently burning through a stockpile of knowledge accumulated during a more enlightened era of public investment, while allocating insufficient resources for replenishing it."

Elizabeth Apsley @kingscollegelondon.bsky.social won the EMBO reports poster prize at the EMBO organoid conference #EESOrgan for her work “Profiling human choroid plexus organoid maturation and response to acute mechanical injury”. Congratulations!

Second October issue is online! www.embopress.org/toc/14693178... Cover features work by Rajarshi Chakrabarti and co-workers from Thomas Jefferson University showing that peri-mitochondrial #actin inhibits #Parkin assembly by disrupting ER-mitochondria contacts. www.embopress.org/doi/full/10....

Andrea Galmozzi @andreagalmozzi.bsky.social @uw-medicine.bsky.social and co-workers show that white and brown #adipose tissues share a convergent fibro-adipogenic progenitor population. #metabolism www.embopress.org/doi/full/10....

New paper published in @emboreports.org from the lab of Dr. Maddika Subba Reddy discussing a non-catalytic role of a phosphatase connected to several autoimmune disorders. Read more: embopress.org/doi/full/10.... #PhosphatasePTPN22 #mTORC2

First October issue is life. www.embopress.org/toc/14693178... Cover features work by Martin Kaltenpoth and co-workers @kaltenpoth-lab.bsky.social @mpi-ce.bsky.social showing that symbionts adjust gene expression according to host life-stage and environment. -> www.embopress.org/doi/full/10....

Yun Zhang and Andrew Samuelson @urochester.bsky.social show that #aging impairs #viral #defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7. -> www.embopress.org/doi/full/10....

Howard Wolinsky, Holger Breithaupt, and Yehu Moran @yehumoran.bsky.social on #scientists targeted by dark PR tactics. Scientists critical of de-extinction projects as targets of anonymous smear articles and weaponized copyright infringement claims. Read more: www.embopress.org/doi/full/10....

For the love of frontier research, or why Elon’s rockets keep blowing up. The current Zeitgeist favouring utilitarian research risks undermining basic research—the very foundation on which innovative technological advances depend. By Nektarios Tavernarakis: www.embopress.org/doi/full/10....

Read the new opinion piece by David Smith. www.embopress.org/doi/full/10....

Frank Uhlmann and Bhavin Khatri @crick.ac.uk and @imperialcollegeldn.bsky.social and co-workers describe progressive #chromosome shape changes during cell divisions, showing that mitotic chromosomes gradually shorten and thicken. -> www.embopress.org/doi/full/10....

One week left – Sign up now! Early registration deadline closes 30 September for the ASCB | EMBO #CellBio2025 Meeting taking place 6–10 December in Philadelphia, US: www.ascb.org/cellbio2025/... 🧪 #LifeSciences #CellBiology #research #conference

The second September issue is online. -> www.embopress.org/toc/14693178... The cover features work by Tomoya Kitajima and co-workers @riken-bdr.bsky.social and @crick.ac.uk showing spatially different requirements for the KIF11 #motor in the #oocyte #spindle. www.embopress.org/doi/full/10....

Jacqueline Beaudry @utoronto.ca and co-workers show that acute exogenous acyl-GIP treatment enhances #lipid handling and fatty acid oxidation by involving brown #fat in rodent models of #obesity. www.embopress.org/doi/full/10....

Kegawa et al show that #Toxoplasma gondii invasion causes a transient increase in conductance within the host cell plasma #membrane explained by creation of multiple pores. #MembraneBiology #apicomplexan -> www.embopress.org/doi/full/10.... See also Male et al -> www.embopress.org/doi/full/10....

Male et al show that early during invasion, #Toxoplasma gondii creates a transient perforation pore in the host cell membrane dependent on rhoptry #exocytosis. #MembraneBiology #apicomplexan -> www.embopress.org/doi/full/10.... See also Kegawa et al -> www.embopress.org/doi/full/10....

Sandra Iden @sandraiden.bsky.social @idenlab.bsky.social @uni-saarland.de @pharmascihub.bsky.social and co-workers show that #melanocyte #differentiation and #mechanosensation are differentially modulated by distinct extracellular matrix proteins. #ECM #MITF www.embopress.org/doi/full/10....

The tyrosine #phosphatase PTPN22 functions as a scaffold protein to maintain mTORC2 complex integrity and function, independent of its phosphatase activity. #cellsignaling -> www.embopress.org/doi/full/10....

The muscle specific MEF2Dα2 isoform is generated by postnatal alternative #splicing. It regulates skeletal muscle ketogenic gene expression, blood ketone levels and exercise capacity. #metabolism -> www.embopress.org/doi/full/10....

A comprehensive molecular atlas of mesenchymal cell types in the adult mouse #liver. -> www.embopress.org/doi/full/10....

CDK1 phosphorylation of lactate dehydrogenase A (LDHA) promotes LADB tetramers directing lactate towards NADH production instead of #glycolysis. NADH fuels oxidative phosphorylation and ATP production sustaining #mitosis of #cancer cells. #metabolism -> www.embopress.org/doi/full/10....

Sunil Kumar Pradhan @sunil-k-pradhan.bsky.social, M Cristina Cardoso and co-workers from the Technical University of Darmstadt show that dynamic association of H3K36me3 with pericentromeric #heterochromatin regulates its #replication time. www.embopress.org/doi/full/10....

Excessive dietary sugar reprograms the metabolic state of #Drosophila larval macrophages. Enhanced glycolysis and lipolysis suppresses organ growth and dominates over growth-supportive lipogenesis. #metabolism #immune -> www.embopress.org/doi/full/10....

Lipoteichoic acid present on extracellular vesicles #EVs from S. pyogenes is sensed by TLR2 and induces activation of an alternative #inflammasome pathway composed of NLRP3 and caspases-4/5 in human monocytes. -> www.embopress.org/doi/full/10....

It is our 25th birthday this year. Read thoughts by our chief editor Bernd Pulverer @berndpulverer.bsky.social, by Howy Jacobs and by Frank Gannon. EMBO reports at 25 - Brief but not bland www.embopress.org/doi/full/10.... www.embopress.org/doi/full/10.... www.embopress.org/doi/full/10....

The first September issue is live. www.embopress.org/toc/14693178... The cover features work by Cassie Clarke @cassiejclarke.bsky.social @cruk-si.bsky.social and co-workers showing that UPP1 supports #metastasis by altering #immune and ECM landscapes. -> www.embopress.org/doi/full/10....

Cargoes move from cis to trans-Golgi compartments and concentrate in the TGN before exiting #Golgi #MembraneTrafficking -> www.embopress.org/doi/full/10....

A new review is online! Lin Luo, Katja Simon and colleagues @mdc-berlin.bsky.social discuss how #aging T cells cope with damaged #mitochondria -> www.embopress.org/doi/full/10....

P300/CBP drives pathogenic enhancer activity and gene expression in Ewing sarcoma #cancer #chromatin -> www.embopress.org/doi/full/10....

lncRNAs SVALKA and SVALNA negatively regulate CBF gene expression in #Arabidopsis during cold stress. #PlantScience -> www.embopress.org/doi/full/10....

Congratulations to Yuta Konishi of Kyoto Sangyo University, Japan on winning the @emboreports.org poster prize #OsakaMito2025, an astonishingly dynamic and exciting conference with full throttle engagement of ECRs

Have #review #articles a future? Or will Large Language Models #LLMs render them obsolete? Read the article by Alexander Sebastian Hauser here: www.embopress.org/doi/full/10....

The second August issue is online! www.embopress.org/toc/14693178... The cover features work by Laura Gámez-Díaz, Bodo Grimbacher and co-workers @uni-freiburg.de showing that LRBA deficiency impairs #autophagy and contributes to #T-cell dysregulation. www.embopress.org/doi/full/10.... ‪

Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors. -> www.embopress.org/doi/full/10....

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10.... @imperiallifesci.bsky.social

A bacterial toxin-antitoxin system involved in an unusual response to genotoxic stress. -> www.embopress.org/doi/full/10....

RagB stimulates the activity of the peptidoglycan polymerase RodA in Bacillus subtilis [RagB = YrrS] @emboreports.org by Frédérique Pompeo et al www.embopress.org/doi/full/10....

Symbionts with eroded genomes adjust gene expression according to #host life-stage and #environment. -> www.embopress.org/doi/full/10....

Don’t miss the article by A. Caplan, F. Pasadyn and N. Mamo published in this issue of @emboreports.org ➡️ "Fool’s-gold science: The ethical and scientific perils of testing most #vaccines using placebo-controlled randomized trials" 🗞️ doi.org/10.1038/s443...

The first August issue is online! www.embopress.org/toc/14693178... The cover features work by Yidan Liu and colleagues at Zhejiang University School of Medicine showing that #BRCA1 preserves #genome #integrity during formation of undifferentiated #spermatogonia. www.embopress.org/doi/full/10....

DNA methylation at #retrotransposons protects the #germline by preventing NRF1-mediated #activation. -> www.embopress.org/doi/full/10....

Student hostages in culture war. The US administration has extended its line of attack on academia to private universities. The abuse of international students is both ethically wrong and ultimately self-defeating. -> www.embopress.org/doi/full/10.... -> www.embopress.org/doi/full/10....

Read the new column by Frank Gannon! www.embopress.org/doi/full/10....

Drshika Mehtani from the lab of Hayley Sharpe ‪ @sharpe-lab.bsky.social @babrahaminst.bsky.social won our poster prize at the EMBO Workshop "Phosphatases: from basic research to translation" for her work on redox mediated substrate interactions with PTPRK. Congratulations!

One week left to register & submit poster abstracts for #FusionAging25! Our @emboreports.org editor Martina Rembold will attend and award a poster prize. Join her and a great line-up of speakers in Malta this October! @fusionconf.bsky.social Register until August 7th => bit.ly/3IWo45X