Very pretty #SciArt 🧪 🎨 render of Asgard chromatin 🧬 (determined by the @dodonova-sveta.bsky.social lab). Nice one Leonora! 👩‍🔬👩‍🎨

Beautiful systematic analysis of membrane thickness inside native cells. This is a great use of both the Chlamy Dataset (bsky.app/profile/cell...) and #MemBrain segmentations (bsky.app/profile/lore...). The open-source workflow is a very helpful resource for #TeamTomo. Thanks and congrats!! 🧪 🔬

Always happy to see the #ChlamyDataset put to good use 😉

Hey #TeamTomo 🧪🔬, ICECREAM is getting tastier! Please give it a try on your tomograms and send us feedback so we can get the recipe just right 🍦😋

Very thorough work that applies cryo-ET to measure bilayer thickness. Surprisingly, the missing wedge is not a big problem!

Check out #DinoSphere 🦖🪩 -- Early Career Researchers sharing their latest insights into dinoflagellate biology. Online and free. Tune in! 👩‍🔬📺 #ProtistsOnSky 🧪🌊 🌍 🔬

Intriguing structures of Asgard hypernucleosomes in open and closed conformations provide a glimpse into the evolution of chromatin from our closest prokaryotic relatives. Bold and eye-opening work by the @dodonova-sveta.bsky.social lab! Also great visualization 🧪👩‍🔬🎨 #CryoEM #ArchaeaSky

REMINDER! One week left to apply for what (in my humble and somewhat biased opinion) is one of the best academic jobs on the planet! Come join our vibrant and collaborative community here at the @biozentrum.unibas.ch @unibas.ch 🧪

Last Friday (17th), we had an amazing first Young Swiss Tomo meeting in Bern, organized with Elda Bauda, Zanetta Kechagia, and @leonieanton.bsky.social! Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬. Huge thanks to the DCI for making the event possible! See you next year! 👋

A class like no other!! From #AI structure hallucination 🤖 to #CryoEM structure reality 🔬 by @biozentrum.unibas.ch @unibas.ch undergraduate students👩‍🔬👩‍🎓 in just a few weeks! One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪

Hey #TeamTomo …would you like to try some 🍦ICECREAM!? Our @unibas.ch colleagues over at the @ivandokmanic.bsky.social lab have developed a stunningly effective tool to de-noise and de-wedge your tomograms. The contrast and details will give you brain freeze! 🍨❄️🤯 Please try, we need feedback 🧪🧶🧬🔬

Icecream 🍨is open source and super easy to instaIll and run. It is already our favorite tool for denoising in the @cellarchlab.com, but it's under active development and we would love to hear your feedback! Please give it a try and let us know: github.com/swing-resear... #TeamTomo

Sounds like fun to deposit 140 subtomogram averages 😳

So, we all know that VIPP1 (the Very Important Protein in Plants) is the "photosynthetic ESCRT-III", required for the biogenesis and maintenance of light-harvesting thylakoids. But what about ESCRT-II, you say? ...Meet VIA1! Congrats @mayankdu.bsky.social on your lab's first paper! #PlantScience 🧪 🌾

Let’s stare into the far red 🏮. A stunning tour-de-force of high-resolution #CryoEM by Gio, Bill, & company reveals how the machinery of photosynthesis redshifts itself so cyanobacteria can live on far red light, deep in the cracks of rocks or under microbial mats. #PlantScience 🧪 🧶🧬 🌾 🔬 🌍

The KEY🔑 to regulating Rubisco phase separation in the Chlamydomonas algal pyrenoid. Beautiful work by Shan He, @mjonikas.bsky.social, and friends. #PhaseSeparation #CO2 #PlantScience 🧪 🧶🧬 🌾 🌍

What happens when the cell's powerhouse gets stressed out? 💪🥵 Great visualization in this #Mitochondria #TeamTomo study! Congrats @denkenny.bsky.social @ruferbus.bsky.social & crew 🧪 🧶🧬 🔬

Hellooooo beautiful!😍 #CryoEM #ArchaeaSky 🧪

#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪

So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!

A place with fantastic colleagues, excellent facilities, a stimulating scientific environment, and a very international and vibrant city - it's got it all!

Biocenter is THE BEST!

Come join us in Basel! @biozentrum.unibas.ch is an amazing place to start your group.

Yay @centriolelab.bsky.social !! 🙌

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬 The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

The former supervisor of @computingcaitie.bsky.social is coming to visit and tell us all about structural proteomics. Looking forward to this #DiscoverySeminar from @edwardmarcotte.bsky.social !! 😃 #ProteinCosmos 🧶🧬

The case for studying proteins inside the cell 😉 #CryoET #TeamTomo

Love it! 🧪🤓 Ya know, thylakoids can also play this paracrystalline lattice game. In plants, they emerge from the prolamellar body during de-etiolation 🟡➡️🟢 Little piece by @wojwie.bsky.social & me: www.nature.com/articles/s41... Lovely review by Andrew Staehelin💚: link.springer.com/article/10.1...

An interesting parallel: Rod outer-segment disk membranes are highly packed with a membrane protein (rhodopsin) 👁️, similar to the stacked domains of thylakoids (PSII-LHCII) 🌱. And isolation of disk membranes may cause rhodopsin to crystallize into 2D arrays 💠 www.nature.com/articles/421... 🧪 🧶🧬🌾🔬

Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on! #TeamTomo #PlantScience 🧪 🧶🧬 🌾 elifesciences.org/articles/105... 1/🧵

This is the team-up I was waiting for 💪💪! Very cool #TeamTomo ❄️🔬 collab from @cellforganized.bsky.social & @shyamalm.bsky.social, showing how to spatially partition organelles in E. coli: from #CO2 -fixing carboxysomes to biomolecular condensates. Big potential for #SyntheticBiology 🧪🧶🧬🌾

Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing @computingcaitie.bsky.social, now at the @biozentrum.unibas.ch 🧪🧶🧬

Huntingtin protein bound to actin filaments. I didn’t know it could do that! Nice one @schurlab.bsky.social and friends! 🧪🧶🧬 #TeamTomo

If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...

Thanks Alister! That Feynman catchphrase is certainly words to live by for #TeamTomo. I actually used to intro my talks with it. But the trick is in the full quote-- these "easy" observations rely on making our microscopes (and tools for analysis) more powerful. Thanks for your help with #MemBrain 🤗

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

The classic Feynman quote from Plenty of Room at the Bottom comes to mind: “It is very easy to answer many of these fundamental biological questions; you just look at the thing!” web.pa.msu.edu/people/yang/...

Great to see a) stunning tomography and b) eLife’s newish publication model working well with big hitters like @cellarchlab.com and @profmattjohnson.bsky.social using it

Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r... Thanks to all interviewees🎤

Nice popular science piece on the Asgard cytoskeleton, revealed using #CryoET by @pilhoferlab.bsky.social & @florianwollweber.bsky.social. Plus, some bonus commentary by @buzzbaum.bsky.social. #TeamTomo #ArchaeaSky 🧪

#TeamTomo 🧪 🧶🧬

Thanks @dodonova-sveta.bsky.social for visiting us at the @biozentrum.unibas.ch and giving a fascinating talk on the structures and mysteries of archaeal chromatin. The room was packed!🤓 #ArchaeaSky #TeamTomo 🧪🧶🧬 Check out their lab’s new study on asgard hypernucleosomes: bsky.app/profile/dodo...

New software from @bronwynalucas.bsky.social Lab for high-resolution 2D template matching of macromolecules inside cells 🔍🔬. #TeamTomo 🧶🧬🧪

Thanks @amunts.bsky.social. This was a fun session at the #Chlamy meeting. The next generation of #TeamTomo is taking off! 🚀🧪

Super cool exotic ciliate cell biology 🧪. I would not want to come face-to-face with one of those supergiants! Congrats @blarson.bsky.social and team! Also great thread🧵 -- thanks for sharing!

BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍

BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍

A great step into a new and exciting research theme. Congrats to @cellarchlab.com and everyone involved.

#TeamTomo 🧪

Super inspiring environmental #cryoET of microbial mats by the @pilhoferlab.bsky.social!! Exploring the native cellular environment 🔬 as it lives out there in our planet's environment 🌍. Such an exciting frontier at the intersection of structural biology & ecology. I love this so much! #TeamTomo 🧪🧶🧬