Not a nudi, but a sacoglossan sap-sucking sea slug, Elysia coodgeensis. 10/10 for alliteration, 12/10 for being tiny & stylish. The R package is just in need of some testing, and in the meantime, more palette-cards coming soon! 🎨 #MarineLife #invertebrates 🦑🐙🧪

New protein complex stoichiometry prediction tool from talent PhD student @daniil-litvinov.bsky.social, check out the thread below!

I'm excited to share *Stoic*, a method for fast and accurate protein complex stoichiometry prediction directly from sequence. Preprint: www.biorxiv.org/content/10.6... 🧵👇(1/10)

Exciting opportunity to work in a lab that’s pushing the boundaries of environmental sampling and work with an amazing scientist!!! 👩‍🔬🔬

I mean Vienna is not a bad place to be, but working and building and expanding and Cryo-ETing with @manondemulder.bsky.social can only make it a billion time better....

Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo

New paper from my team detailing a greatly expanded genomic database of Asgard archaea revealing of high energy metabolism those related to eukaryotes! Led by @katyappler.bsky.social lots of help from @jameslingford.bsky.social @valdeanda.bsky.social @kassipan.bsky.social doi.org/10.1038/s415...

A 🆕 #Ichthyosporea story Led [email protected], in Co. @gautamdey.bsky.social & @hiralshah.bsky.social+🔥team across @embl.org & @sciencesunige.bsky.social We finally have a look at what #microtubules are doing during #cellularization in #Sphaeroforma ▶️ tinyurl.com/MTSARC #ProtistsOnSky

When all the female grad students tell you a candidate seems arrogant & smarmy & they don’t like him, but it’s all vibes, maybe hire one of the other candidates who are just as amazing researchers, but don’t give off bad vibes. Cuz in my experience those vibes have proven right 100% of the time.

There are far more talented candidates than there are tenure-track jobs. Mentoring students is a major component of a faculty position. It is entirely possible to pick talented candidates who aren’t weird assholes, it just requires hiring committees to value interpersonal skills.

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

For #ECR’s: DBG’s Hot Tpoic Workshop on Cryo-Electron Tomography + FIB-milling 13 – 15 April 2026 In @cellarchlab.com 's lab @biozentrum.unibas.ch Organised by @tamb-o.bsky.social, Karen Zinzius, @fannyleblanc.bsky.social Details: www.deutsche-botanische-gesellschaft.de/en/about-us/...

You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint! What a great collaboration this has been!

Excited to share this detailed biophysical study of #PhaseSeparation in the Pyrenoid, an algal microcompartment that fixes a third of the Earth's #CO2 🌏. We combine methods across scales, in vitro 🧪 and in vivo 🦠 Thanks for the very fun collaboration! 🤗 #PlantScience 🌾 #TeamTomo 🔬 #LivingPhysics 🧬🧶

Check out this cool thread on the latest preprint by Gaurav Kumar, @james-r-barrett.bsky.social, @phaips.vd.st from our lab and colleagues, dissecting the physics of Rubisco condensates! You're in for some stunning #cryoET of the pyrenoid - in Chlamy, of course 😉 Congrats to all involved!

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid

🔬🚨New preprint alert! 🚨🔬 We developed quantitative expansion microscopy (qExM) - a method to accurately count proteins in situ by combining expansion microscopy's improved labeling with statistical estimators borrowed from ecology www.biorxiv.org/content/10.6... #SuperResolution #CellBiology

📢 Open faculty position – Origins of Life We have an opening in our section at the University of Geneva! 🧬🚀 SPREAD THE WORD Apply here: jobs.unige.ch/www/wd_porta...

The latest issue is now online www.cell.com/molecular-ce...

Happy to see this out 🥳 authors.elsevier.com/sd/article/S... #TeamTomo #CryoET #CryoEM

If you want to learn how to process cryo-ET data using the Chlamy dataset don't forget to check : tomoguide.github.io @phaips.vd.st

Come join us! Soon I will be advertising a postdoc vacancy in my group as part of my @erc.europa.eu AdG project 'DARK ROOTS'. Focus of the project will be on phylo- and metagenomic mining of novel prokaryotic lineages. I will soon post a link here - stay tuned, and please repost! #asgardarchaea

Starting at 7pm Central I will be streaming from the bottom of the ocean off the coast of Uruguay! Feel free to join and ask questions. www.youtube.com/@SchmidtOcean

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...

We’re back with the next DinoSphere Online Seminar! Join us on Nov 4th, we're hosting: Edmée Royen (ULiège) - Symbiodinium
 Nicolas dos Santos Pacheco (Cambridge) - Perkinsids 📅 Tue, Nov 4 - 4 PM CET/3 PM GMT 
💻 Zoom link: sites.google.com/view/dinosphere
 Please spread the word! #protistonsky

💡🔬 TECHNICAL INNOVATION 💡🔬 Neubauer et al. developed a Nostoc reporter strain enabling high-throughput quantitative monitoring of hormogonia differentiation in cyanobacteria as a response to biotic and abiotic factors. 🔗 doi.org/10.1093/jxb/... #PlantScience 🧪 @peterszovenyi.bsky.social

🥨🔬!

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture. buff.ly/j3TSIkn

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

A new #UExM probe for #Actin! Fun times thinking/developing/testing with @centriolelab.bsky.social & @lreymond.bsky.social ! Congrats to all ! If interested in #UExM, or #HAK-Actin, feel free to reach out ! Soon available at @spirochrome.com #Expansion #Microscopy #ProtistsOnSky

Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc Big group effort with a lot of people involved #archaeasky #archaea www.biorxiv.org/content/10.1...

Please Re-Post. Our global GRUMP microbial ocean database is out in Scientific Data! Unfractionated, single universal PCR, with Archaea, Bacteria, and Eukaryotes all on the same scale with the same denominator. Pole to pole, depths to 6000m. Lots of metadata. www.nature.com/articles/s41...

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳 tinyurl.com/m9s5su7s 1/2

Final PhD paper now reviewed and published in JSB:X. I was happy with some great reviews that improved the paper! Thanks to Sander Roet for his help with the code base, and Remco Veltkamp and @fridof.bsky.social

Are you a recent dinoflagellate convert, or already long dedicated to the craft? Don't you wish you could talk about them more? Join Manon's DinoSphere seminar series! All things phylogeny, imaging, ultrastructure and more :) #protistsonsky

Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n 📄 www.biorxiv.org/content/10.1... 💾 github.com/steineggerla...

Anti-gatekeeping workflows is what keeps #teamtomo growing! Love to see it.

Check out 'the website' by Phil&Flo - a tomo processing pipeline/tutorial from frame to structure. For easy implementation of the Aretomo3 to RELION5 pipeline, or your students first dataset, get processing!

Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪

🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

Join us in Hamburg! May 6: Advancing Correlative Light & cryo-EM: Bridging Molecular Precision & Tissue Architecture Register: indico.desy.de/event/48246/ May 9: Beyond the Barrier: Advanced Microscopy of Pathogens in High-Biosafety-Containment Labs Register: indico.desy.de/event/48139/...

#weekendreading🔬📑 Tissue-like multicellular development triggered by mechanical compression in archaea @science.org #microsky www.science.org/doi/10.1126/...

Very Happy to finally see this story out. I remember the first time @archaeon-alex.bsky.social showed me the videos maybe 3-4y ago on a Zoom call ! Mind blown then and still mind blown today. A must read for all.

#Mitochondria power our cells, but how? Using cryo-electron tomography, @cellarchlab.com and @florentwaltz.bsky.social report in @science.org that energy-producing proteins form supercomplexes, optimizing ATP production.

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

Cryo-ET Analysis Unveils the Minimum Structural Unit and Hierarchical Ultrastructure of Silk Fibers in Silkworm and Spider www.biorxiv.org/content/10.1101/2025.03.12.642793v1 #cryoem

From cytoplasm to lumen-mapping the free pools of protein subunits of three photosynthetic complexes using quantitative mass spectrometry pubmed.ncbi.nlm.nih.gov/40077900/