The In Situ Structure and Distribution of V-ATPase in C. elegans Apical Membrane Stacks www.biorxiv.org/content/10.64898/2025.12.19.695382v1 #cryoem

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

Happy to see this out 🥳 authors.elsevier.com/sd/article/S... #TeamTomo #CryoET #CryoEM

Good morning Basel! @unibas.ch

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

Dear Santa, ... 🥹

Happy to see IsoNet2 performing so well on the #ChlamyDataset EMPIAR-11830. Congrats to the authors really great work. However, I have to say this tomogram looks amazing because the lamella is way too thin (~50 nm) and not vitreous! 🫠 www.biorxiv.org/content/10.6...

🫛 🧪 A network of researchers is helping Planted develop meat substitutes from proteins and microorganisms. Co-founder Lukas Böni tells the success story of how the company became the pioneer in the field of plant-based meat alternatives. 🌍🏆 ➡️ sohub.io/men1

Thrilled to share that my postdoc paper has just been a published in @plosbiology.org ! Thank you to all co-authors, and a special thanks to Paul and Virginie @centriolelab.bsky.social for their support throughout this work. Proud of what we achieved together! journals.plos.org/plosbiology/...

Fresh from bioRxiv our latest work introducing The Embedded Alphabet (TEA), a powerful new representation for protein sequences obtained by discretising ESM2 embeddings into 20 characters. Pre-print: www.biorxiv.org/content/10.1... 🧵👇(1/n)

Icecream for extra crispy tomos 🥶

#Proteomic analysis of the #pyrenoid‐traversing membranes of #Chlamydomonas #reinhardtii reveals novel components 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... by Franklin et al. @mjonikas.bsky.social @ericfranklin.bsky.social @WileyPlantSci

Apply for our Master of Science in Physics of Life – training in cutting-edge research at the interface of physics, mathematics, engineering and life sciences. Scholarships available. Application deadline: 30 November. More: www.biozentrum.unibas.ch/education/de... @biozentrum.unibas.ch @unibas.ch

Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis www.biorxiv.org/content/10.1...

Translation landscape of stress granules | Science Advances www.science.org/doi/10.1126/...

Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

CryoET is a particularly brutal area for combining a spectacular public success with hidden heroic failure!

Authors concluded that this study “demonstrates that following current climate policies will not only overshoot the 1.5-°C limit of the Paris Agreement by a wide margin but also may prohibit returning to it thereafter.” Wishful thinking is not a realistic strategy for future generations. ⬇️ ⬇️ ⬇️

🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages pubmed.ncbi.nlm.nih.gov/40667239/ #cryoem

Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries! www.sciencedirect.com/science/arti...

🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM www.biorxiv.org/content/10.1...

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine. If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.

Almost all Nobel Prizes are awarded for work that is exploratory, or absolutely basic science with no obvious commercial or medical benefit. You cannot predict where advancements come from, so you have to invest in science and scientists. Targeted (corporate) science investment will never do this.

"I invite any Trump administration official who thinks our academic standards have declined to sit for an exam in my class. If you can explain the quantum principles underlying the structure of the Periodic Table (like my 18-year-old freshmen can), then you can lecture me on academic standards".

We’re building a collaborative space for early-career researchers working at the intersection of dinoflagellate taxonomy& molecular biology. 🔗 Learn more: sites.google.com/view/dinosph...
💬 Got questions or input? Please reach out and let us know. Hope to see you there!

We’re kicking off the DinoSphere Online Seminar Series! Join us for our first session with Karel Mockaer (Heidelberg) & Yong Heng Phua (OIST) 📅 1 July 9AM CEST 🔗 tinyurl.com/4mjaverj Spread the word! @protistwtmostest.bsky.social @ehehenberger.bsky.social @chandnibhickta.bsky.social&Norico Yamada

Shameless self-promotion continues...🙃 You might find this #fern book in your local bookstores! mailchi.mp/btiscience/f...

You want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software! Hope it will be useful !

Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪

To all #ChlamyDataset enthusiasts, here is a script that lets you directly import the pre-processed results from EMPIAR-11830 into #RELION v5 for subtomogram averaging: github.com/Chromatin-St... #Chlamydomonas #TeamTomo #CryoET #OpenSoftwareAcceleratesScience

🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

Apply now for our international Master of Science in Physics of Life @biozentrum.unibas.ch @unibasel.ch! Scholarships available. More information: www.biozentrum.unibas.ch/education/de... #Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

In 2004, it took the world a year to add one gigawatt of solar power — now it takes a day.

einstein sent this to curie in 1911 when she was being harassed by tabloids. it contains everything you’d want in such a letter: (1) your haters are trash (2) you’re a baller, a true queen (3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️

To all #TeamTomo #CryoET and #Chlamydomonas aficionados: we have updated EMPIAR-11830 with a bug fix concerning some cryo-CARE denoised tomos as well as additional files and metadata! 🎉👩🏽‍💻 www.ebi.ac.uk/empiar/EMPIA... A little thread about what's new... 🧵 1/n

💡 At a joint press conference, the #SNSF and its ERI partners called on the Federal Council to abandon the planned cuts to #education, #research and #innovation in the "relief package 27", as they would have far-reaching consequences for the #economy and society. ➡️ https://buff.ly/3CTR2AM

We (@cellarchlab.com peeps, @manondemulder.bsky.social @phaips.vd.st @fannyleblanc.bsky.social @computingcaitie.bsky.social and Ricardo) had a blast at the EMBO in situ meeting in Heidelberg! Meeting old friends and making new ones! Lots of cool science and new ideas to try 👨🏻‍🔬🔬

It's a good week for rubisco enthusiasts - very cool preprint from Ron Milo lab www.biorxiv.org/content/10.1... impressive screening of +250 genes spanning available diversity of rubisco, this then used to predict activities of 68,000 known sequences revealing role of phylogeny and habitat

Exciting update on the CryoET Data Portal! A new annotation set from Mart Last & team is now live. They’ve doubled available annotations with >1,800 tomograms of Chlamydomonas reinhardtii which now have almost fully dense labels, and all can be visualized in the browser using Neuroglancer.

In case you missed our first webinar of 2025, it is now available. Lorenz Lamm from MUDS - Munich School for Data Science presented MemBrainv2- an end-to-end tool for the analysis of membranes in cryo-electron tomography. https://buff.ly/4hutFwf #SBGridwebinars #ScienceMatters

Announcing the new bioRxiv dashboard widget - it's now easier to when articles have comments, peer reviews, community discussion, media coverage, videos, and automated analyses 1/2 connect.biorxiv.org/news/2025/01...

WOW!😍 This is exactly the type of development we hoped the Chlamy dataset would help empower! Lots of organelles and cellular features labeled automatically, context-aware particle picking, & area-selective template matching #TeamTomo 🔬 Big props to @mgflast.bsky.social @thomsharp.bsky.social 🧪🧶🧬

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

News flash nerds: hornworts are awesome

More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy! Check out the preprint: www.biorxiv.org/content/10.1... Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com #TeamTomo

We are excited to share 71,700 new #Chlamy mutants from the CLiP2 collection pre-publication! Nearly-saturating genome coverage. Please note: new background strain, mating type, and antibiotic resistance. Read: www.biorxiv.org/content/10.1... Search and order: www.chlamylibrary.org

Entry-level position (80 - 100%) for bioimage analysis specialist at the Imaging Core Facility (IMCF) of the Biozentrum, University of Basel www.biozentrum.unibas.ch/open-positio... @unibas.ch #Biozentrum #Basel #research #science #joboffer #scientific