Stages of biomolecular condensate formation in pro-β-carboxysome assembly doi.org/10.1038/s414...

Interestingly, these chlororibosomes are loosely bound to the thylakoid membranes. High heterogeneity made classification challenging to find clean thylakoid-bound ribosomes! The comparison with cytosolic and mitoribosomes shows how rigidly the latter bind membranes compared to the chlororibosomes.

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

Robust quality assessment of cryo-EM maps, tomograms and micrographs by statistics-based local resolution estimation https://www.biorxiv.org/content/10.64898/2026.02.03.703505v1

We genetically disconnected starch from the matrix in the algal pyrenoid! A saga1;saga2 double mutant lacks a starch sheath! Our model: SAGA1 & SAGA2 locally initiate starch on the pyrenoid surface by enriching starch precursors. 🌞🦠🔬🔌👀 www.biorxiv.org/content/10.6...

You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint! What a great collaboration this has been!

Lastly, if you prefer to see this as a poster, you can find that here: james-r-barrett.github.io/presentation...

This was a great collaboration with bsky-less Gaurav, @cellarchlab.com, @phaips.vd.st, @mariahondele.bsky.social and a product of the York Physics of Pyrenoids Project (YP3) with @bpsiyork.bsky.social, @mjplevin.bsky.social, @alexpaynedwyer.bsky.social and many others!

In summary we used a whole bunch of techniques across in vitro and in vivo contexts to connect valency to condensate formation and fitness. We argue this is a readily tuneable parameter for condensates that determines their properties.

The great thing about working with Rubisco condensates is that we can see individual Rubiscos using cryo-electron tomography #TeamTomo! Using this approach @phaips.vd.st was able to show that higher linker valency increases Rubisco concentration.

You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint! What a great collaboration this has been!

#Fluoride is used worldwide to prevent tooth decay. However, health concerns are raised, particularly in places where fluoride is added to drinking water. An international research team involving the University of Basel has evaluated data from over 11 million births and reached a clear conclusion 👇

Absolute stunning pyrenoid review well worth the read!

How do diatom cells maintain a constant supply of carbon for photosynthesis? Our microelectrode measurements of the phycosphere around individual diatom cells show that diatoms can rapidly switch between distinct carbon acquisition pathways. @thembauk.bsky.social www.science.org/doi/10.1126/...

We've got ISSUES. Literally. We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do? arxiv.org/abs/2601.07563 A 🧵 1/n

Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ https://www.biorxiv.org/content/10.64898/2026.01.07.698105v1

The In Situ Structure and Distribution of V-ATPase in C. elegans Apical Membrane Stacks www.biorxiv.org/content/10.64898/2025.12.19.695382v1 #cryoem

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

Happy to see this out 🥳 authors.elsevier.com/sd/article/S... #TeamTomo #CryoET #CryoEM

Good morning Basel! @unibas.ch

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

Dear Santa, ... 🥹

Happy to see IsoNet2 performing so well on the #ChlamyDataset EMPIAR-11830. Congrats to the authors really great work. However, I have to say this tomogram looks amazing because the lamella is way too thin (~50 nm) and not vitreous! 🫠 www.biorxiv.org/content/10.6...

🫛 🧪 A network of researchers is helping Planted develop meat substitutes from proteins and microorganisms. Co-founder Lukas Böni tells the success story of how the company became the pioneer in the field of plant-based meat alternatives. 🌍🏆 ➡️ sohub.io/men1

Thrilled to share that my postdoc paper has just been a published in @plosbiology.org ! Thank you to all co-authors, and a special thanks to Paul and Virginie @centriolelab.bsky.social for their support throughout this work. Proud of what we achieved together! journals.plos.org/plosbiology/...

Fresh from bioRxiv our latest work introducing The Embedded Alphabet (TEA), a powerful new representation for protein sequences obtained by discretising ESM2 embeddings into 20 characters. Pre-print: www.biorxiv.org/content/10.1... 🧵👇(1/n)

Icecream for extra crispy tomos 🥶

#Proteomic analysis of the #pyrenoid‐traversing membranes of #Chlamydomonas #reinhardtii reveals novel components 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... by Franklin et al. @mjonikas.bsky.social @ericfranklin.bsky.social @WileyPlantSci

Apply for our Master of Science in Physics of Life – training in cutting-edge research at the interface of physics, mathematics, engineering and life sciences. Scholarships available. Application deadline: 30 November. More: www.biozentrum.unibas.ch/education/de... @biozentrum.unibas.ch @unibas.ch

Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis www.biorxiv.org/content/10.1...

Translation landscape of stress granules | Science Advances www.science.org/doi/10.1126/...

Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

CryoET is a particularly brutal area for combining a spectacular public success with hidden heroic failure!

Authors concluded that this study “demonstrates that following current climate policies will not only overshoot the 1.5-°C limit of the Paris Agreement by a wide margin but also may prohibit returning to it thereafter.” Wishful thinking is not a realistic strategy for future generations. ⬇️ ⬇️ ⬇️

🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages pubmed.ncbi.nlm.nih.gov/40667239/ #cryoem

Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries! www.sciencedirect.com/science/arti...

🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM www.biorxiv.org/content/10.1...

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine. If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.

Almost all Nobel Prizes are awarded for work that is exploratory, or absolutely basic science with no obvious commercial or medical benefit. You cannot predict where advancements come from, so you have to invest in science and scientists. Targeted (corporate) science investment will never do this.

"I invite any Trump administration official who thinks our academic standards have declined to sit for an exam in my class. If you can explain the quantum principles underlying the structure of the Periodic Table (like my 18-year-old freshmen can), then you can lecture me on academic standards".

We’re building a collaborative space for early-career researchers working at the intersection of dinoflagellate taxonomy& molecular biology. 🔗 Learn more: sites.google.com/view/dinosph...
💬 Got questions or input? Please reach out and let us know. Hope to see you there!

We’re kicking off the DinoSphere Online Seminar Series! Join us for our first session with Karel Mockaer (Heidelberg) & Yong Heng Phua (OIST) 📅 1 July 9AM CEST 🔗 tinyurl.com/4mjaverj Spread the word! @protistwtmostest.bsky.social @ehehenberger.bsky.social @chandnibhickta.bsky.social&Norico Yamada

Shameless self-promotion continues...🙃 You might find this #fern book in your local bookstores! mailchi.mp/btiscience/f...

You want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software! Hope it will be useful !

Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪

To all #ChlamyDataset enthusiasts, here is a script that lets you directly import the pre-processed results from EMPIAR-11830 into #RELION v5 for subtomogram averaging: github.com/Chromatin-St... #Chlamydomonas #TeamTomo #CryoET #OpenSoftwareAcceleratesScience

🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

Apply now for our international Master of Science in Physics of Life @biozentrum.unibas.ch @unibasel.ch! Scholarships available. More information: www.biozentrum.unibas.ch/education/de... #Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland