For many years, Peer Bork organised Bio-IT retreats to bring together the bioinformaticians across EMBL, in Garmisch-Partenkirchen and later Feldberg. Days out on the mountain followed by forward-looking and meta-science oriented sessions in the hut that fueled many projects and careers.

Sadly Peer Bork passed away. My memory goes back to the junior postdoc from east Berlin arriving to EMBL when bioinformatics was a dream and the future was to be discovered. Happy images in a sad day. My condescends his family and his very large scientific network. www.embl.org/news/embl-an...

This is such hard news to process. Such an amazing scientist and inspiration for so many of us. www.embl.org/news/embl-an...

Apply for the Ascona workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems", 28 Jun-3 Jul 2026 on Monte Verità, Lago Maggiore at the foot of the Swiss Alps. ascona2026.sciencesconf.org

We’re delighted to report a global structural proteome analysis within living cells! doi.org/10.1038/s443... #proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social

Thrilled to share EDEN — a DNA-scale foundation model built with @basecamp-research.bsky.social + NVIDIA partly validated by our lab @upenn.edu . Trained on 1M+ new species, it designs novel antibiotics with 97% success. Biodiversity at scale = models that generalize and design. bit.ly/3NpMR4B

OpenBind is a new open science effort to dramatically increase the number of protein:ligand structures in the PDB, pairing this with high-quality affinity data to enable a new generation of predictive structure and affinity models for drug discovery. Check it out: openbind.ai

Preprints of pandemic potential - new historical piece from me on the history of bioRxiv/medRxiv, their role in the pandemic, and the way forward. 1/n journals.asm.org/doi/10.1128/...

Introducing the official Open Targets Platform Model Context Protocol 🧬🖥️ In partnership with @anthropic.com, we’ve created an MCP server making Open Targets Platform data accessible to AI-powered tools and agents Try it out and watch out for future releases: mcp.platform.opentargets.org/mcp

Group-based Prediction System (GPS) 6.0 gps.biocuckoo.cn Online server for protein Post-Translational Modifications Kinase-specific phosphosite prediction across 185 species! >10 other PTMs #NucAcidRes 2023 academic.oup.com/nar/article/...

PhD position reopened in ProtAIomics DN 🔗 Project details: www.protaiomics.eu/project/dc12... 👩‍🔬 Meet the PI: www.protaiomics.eu/supervisor/v... 👉 Apply here: www.protaiomics.eu/call-for-app... #PhDposition #MSCA #Bioinformatics #Proteomics #ArtificialIntelligence #DoctoralTraining #ResearchCareers

We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci. Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity

Are you in a career transition + want support negotiating independence? Do you face tough negotiations + want a more effective approach to manage difficult conversations? Places available in next @embo.org #Negotiation Skills for Scientists online course: www.embolableadership.org/course/negot...

I have been enjoying the Dwarkesh AI podcasts. The latest was closer to biology but it still felt like a novice AI engineer talking with a novice neuroscientist. Other interviews I have liked were with Richard Sutton, Ilya Sutskever, Andrej Karpathy and Satya Nadella www.youtube.com/watch?v=_9V_...

Happy to share our new preprint from @sashagusevposts.bsky.social and @nmancuso.bsky.social labs! We introduce Mr. PEG, a framework integrating perturbational screens, eQTL, and GWAS data to identify mediating genes for complex traits. (1/n) www.medrxiv.org/content/10.6...

New preprint alert: we use sign errors as a test of how well TWAS works. Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇

A great tenure track position (Assistant Professor) of Sustainable Plant Nutrition @ethz.ch @usyseth.bsky.social @johansix.bsky.social ! Deadline to apply: 28/02/2026. ethz.ch/en/the-eth-z...

I'm honored to have received the 2025 HUPO Distinguished Service Award (hupo.org/HUPO-Awards-...) with @mlaval6.bsky.social for building a dynamic early career researcher (ECR) community within @hupo-org.bsky.social. Empowering and amplifying ECRs has been deeply meaningful to me—thank you, HUPO.

Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾 www.biorxiv.org/content/10.1...

The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from @seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online. 20 targets across an entire cell. Mr. Snouty also joined the fun. www.biorxiv.org/content/10.6...

I love my job but it takes a vacation for me to remember how much it keeps me under a high mental load. After a week I start to think about things I would like to learn and do and then it all inevitably gets buried during work time. Much of my work load is voluntary and I still keep it too high.

So 2025 turned out to be a big year for de novo antibody design! Here are thoughts and predictions on the state of de novo antibody design heading into 2026 🧵

I've been thinking about the "virtual cell" concept and wanted to write up a few thoughts. Specifically on how I think the prior experience in GWAS informs the most likely way these models will be useful. andrewcarroll.github.io/2025/12/23/t...

What about a robot that can assemble IKEA furniture? How long until those.

Japan is joining Horizon Europe, the EU’s flagship research and innovation programme. Openness and international cooperation can shape a bright future for science and technology. Through science, we can build bridges, strengthen competitiveness, and accelerate the green and digital transitions.

Merry Christmas, genetic interaction nerds: www.biorxiv.org/content/10.6...

1/ We’re hiring PIs in AI × Biology The @astar-gis.bsky.social Genome Institute of Singapore (GIS) is expanding its AI & Computation domain and recruiting junior & senior PIs.

here is our first contribution of yeast in microbiomes led by Jason Tsai group[ with contributions from Alberto and Nelly: www.biorxiv.org/content/10.6... more to come

Going full circle! 😊 The University of Padua was home for both my Bachelor’s and Master’s degrees. After 7 amazing years at UCL in the Orengo Group, I’m really happy to share that I’ve won a Tenure-Track Assistant Professorship in Biochemistry at my Alma Mater!

Join the dialogue on the #evolution of cellular processes at the EMBO Workshop "The rules of the game: Biophysical & molecular principles in cellular evolution" in #Oeiras, PT, 2–5 June 2026. Deadline: 1 March https://meetings.embo.org/event/26-cellular-evolution#evolution#Oeiras#EMBORulesOfTheGame #EMBOevents 🧪

📢 Join us in sunny Lisbon 🇵🇹 2-5 June for the @embo.org workshop ☀️ “The rules of the game: biophysical & molecular principles in cellular evolution” Apply by March 1st! Please repost to help spread the word! meetings.embo.org/event/26-cel... #EMBORulesOfTheGame @gimmfoundation.bsky.social

The SNSF is considering restrictions for its Project funding. Goal: to ensure the quality of evaluation & stable success rates despite an increasing number of applications and limited funding. The final decision will be made in January 2026. 👉 buff.ly/iGOCf7R #research #science

Google News is testing an AI generated podcast news summary, reminiscent of those in NotebookLM. This single company can span from chip design and basic CS research to applications with billions of users.Moral judgement aside, seeing a company this big moving this quickly is impressive.

Humbled and honoured to join this club, alongside some of my scientific heroes and colleagues. Grateful to my team, collaborators, and mentors &, just as much, to my wife, family and friends.

See 👇 our new manuscript introducing SpaCEy, an explainable method for predicting clinical outcomes from spatial omics data 🧬 📄 Paper: www.biorxiv.org/content/10.6... 💻 Code repo: github.com/saezlab/SpaCEy

ETH has signed the contract to establish the new campus in Heilbronn focused on AI. Several AI related professorships will be hired across different disciplines across the next few years with the first appointments made already in 2026. ethz.ch/staffnet/en/...

Finetune a codon-level language model with 30k tryptophan synthases, then generate diverse, functional, enzymes with broad substrate scopes. Théophile Lambert @jsunn-y.bsky.social @francesarnold.bsky.social www.biorxiv.org/content/10.1...

The cytosolic PRMT5-CDK4 complex impairs cell cycle kinase signaling https://www.biorxiv.org/content/10.64898/2025.12.11.693714v1

AITHYRA Global Adjunct Principal Investigator Program: Advancing AI-Driven Life Science Through Global Collaborations Learn more about the Program: aithyra.at/fileadmin/do... Application Deadline, 30 January 2026: [email protected] #AITHYRA #GlobalAdjunctPI

Attention scientists from all over the world🙃 The Call for Letters of Intent for #HFSPResearchGrants 2027 is now open! 🧪 Get your international & interdisciplinary team. It's time to put your bold research idea into practice! 🔗https://bit.ly/48VsGCG 📅 15 Dec 2025–26 Mar 2026 #sts #LifeSciences

Cancer pathway connectivity resolved by drug perturbation and RNA sequencing https://www.biorxiv.org/content/10.64898/2025.12.11.692401v1

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I guess it's fitting that it's a reimagined, worse version of someone else's artwork

During my PhD @borklab.bsky.social, we extracted drug side effect data from package inserts and used the dataset to predict new drug targets (doi.org/10.1126/scie...) and pinpoint proteins that mediate the side effects (doi.org/10.1038/msb....). We also published the underlying database... [1/3]

Congratulations, Julia Mahamid! Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology! #LeibnizPreis

The preprint #PeerReview platform Review Commons was launched at the 2019 ASCB | EMBO Meeting to make scientific #publishing more open and effective. Thomas Lemberger, lead of the initiative, tells us more about the platform: https://www.embo.org/features/review-commons-rethinking-peer-review/#PeerReview🧪

We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)! GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging. Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations. 👉 www.unige.ch/genexm/

We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!

🎉 Congrats to Isidro Cortés-Ciriano and Wojciech Galej on receiving ERC Consolidator Grants! 🧬 Cortés-Ciriano (EMBL-EBI) will receive €2M to study genomic rearrangements in cancer. 🧵 Galej (EMBL Grenoble) will receive €2M to explore RNA splicing. Learn more: www.embl.org/news/awards-...

I couldn’t be happier or more flattered to receive an ERC-CoG. I’m grateful for this opportunity and excited to take the next steps in our research! Recruiting early next year! Reach out if you want find out how to use bacterial immunity to tackle infections! @erc.europa.eu @unituebingen.bsky.social