ERC Plus Grants • No career limit, current ERCs are not eligible • Major challenge, transformative research • Up to 7 million euros, up to 7 years • 30 grants per year, 2 years, only once per lifetime • Same application format, plus vision statement • Deadline in September 2026, 2 stage evaluation

Webinar on the new ERC Plus Grants live starting now www.youtube.com/live/Dzkas7f...

Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified. www.biorxiv.org/content/10.1...

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

Instead of simply empowering disadvantaged scientists, advanced AI models are creating an environment of mistrust where we will rely even more on poor proxies of reputation, favoring established scientists, privileged institutions and entrenching us into the system of tiered scientific journals.

There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant. research.pasteur.fr/en/call/mid-...

(1/3) Imagine reconstructing a history over a billion years in the making. New research from EMBL and @Stanford shows how centromeres retain their function despite their rapid rate of change, and the evolutionary constraints that govern this process. www.nature.com/articles/s41...

🧶🧬 We present LMi4Boltz: www.biorxiv.org/content/10.1... Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.

...and if you are interested in doing a PhD with Mafalda and I, we currently have one opening, with deadline this Sunday! www.crg.eu/en/content/t...

i’m not crying you’re crying xkcd: Fifteen Years

Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466

popEVE is out in Nature Genetics! 🎉 We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders. rdcu.be/eRu7K

We are recruiting - deadline approaching!!! Postdoc position available in my lab to develop an exciting project with @alexfsantos2401.bsky.social to advance our understanding of food allergy and oral tolerance in early life. #ILC #organoids #intestine #FoodAllergy www.kcl.ac.uk/jobs/128585-...

I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵

I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.

💫 Thank you to all participants and speakers who joined us at the 2nd @eurocancerdepmap.bsky.social Symposium! Together, we’re advancing #cancer functional genomics across Europe. youtu.be/Qt_ozbzM5js

I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes

The update includes metabolomic, genetic, and imaging data, plus much more, all alongside our existing comprehensive dataset Explore what's new: www.ukbiobank.ac.uk/news/metabol...

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

This looks like a fantastic resource to study human kinase signalling. So much MS instrument time.

New blog post - AI "peer" review - the impact on scientific publishing. Some thoughts on AI manuscript assessments and potential impacts on scientific publishing www.evocellnet.com/2025/11/ai-p...

Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Guess the news is officially out! Extremely excited to announce that I will be starting my own laboratory at Institut Pasteur @pasteur.fr this coming spring! Slight change to my office window view from Tokyo Tower🗼 to the Tour Eiffel. 🇫🇷

Honoured and quite blown-over to receive this award. I have been, and continue to be, very lucky - first with great mentors, and then really prodigious students, postdocs and collaborators. Working with them has been a joy.

Catch our last seminar for the year on Dec 8 at 3pm CET! With Dr. Martin Rennie (@martinrennie.bsky.social), Jamal Fahoum (@hebrewuniversity.bsky.social), and Dr. Boglárka Zámbó (@zbobo2.bsky.social) Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity

Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain: arxiv.org/abs/2511.04820 Strain: direct.mit.edu/qss/article/... Oligopoly: direct.mit.edu/qss/article/...

If you’re at #HUPO2025, be sure to stop by my poster and learn about the latest developments in the BioPlex project!

Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here. www.cam.ac.uk/jobs/faculty...

957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are. erc.europa.eu/news-events/...

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

It has been disappointing to see the general lack of interest and investment into population genetics and genomic medicine in Switzerland. While we can resort to other national cohorts for research the country can only benefit if the know-how can be applied locally www.sfa-phrt.ch/success-stor...

1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!

Open position at the Swiss Institute of Bioinformatics: We are looking for a Director of the Center of Pathogen Bioinformatics apply.refline.ch/499599/0346/... I am in the Center's steering board together with fantastic colleagues (Emma Hodcroft @firefoxx66.bsky.social, Richard Neher @neher.io, and

I am honnestly a bit worried by the latest fuss about qed (the IA driven review). While the results are indeed quite impressive (it is very good at listing the claim and finding potential improvement), I don't quite see how this will eventually reduce the reviewing burden or help us

Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests. We describe a critical concept that we call *specificity*. Led by Jeff Spence and Hakhamanesh Mostafavi:

Very cool! I agree AI scientific review can be useful if it is transparent. It is all progressing very fast and will change everything. @qedScience @bioRxiv is a great first step. We are doing some human-based eval, so more soon from @EMBOPress @ReviewCommons with @qedScience. Watch this space ;-)

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Our revised consensus transcriptional patient map of human heart failure across patient cohorts and single-cell and bulk technologies is now published @natcomms.nature.com www.nature.com/articles/s41...

Let’s talk about rare variant association tests - we have a new method that helps you discover more with the same data! It’s called *FlexRV* to signal our approach: “flexibly modeling rare variant pathogenicity improves gene discovery for complex traits”. www.biorxiv.org/content/10.1...

Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides. Here’s the story of how we discovered the Metis defense system 👇 www.biorxiv.org/content/10.1...

Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️

A functional map of CDK-drug interactions at single amino acid resolution https://www.biorxiv.org/content/10.1101/2025.11.02.685764v1

Just tried q.e.d. by @odedrechavi.bsky.social et al. with a few papers including by myself & others where I knew a claim within was flawed based on a misunderstanding of the signal. 1) it was impressive. I see what the hype is about. 2) it hallucinated. www.qedscience.com Overly long #SciPub🧵 1/n

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...