Bioinformatic process for the identification and characterization of bacterial repeat-in-toxin adhesins https://www.biorxiv.org/content/10.1101/2025.09.30.679566v1

S-Alkyl-Phosphorothioate Modifications Reduce Thermal and Structural Stability of DNA Duplexes https://www.biorxiv.org/content/10.1101/2025.09.30.679560v1

Leaf stage and roasting shape methylxanthine levels, chlorogenic acid, and overall metabolic profile of Ilex vomitoria leaf extracts https://www.biorxiv.org/content/10.1101/2025.09.29.679294v1

Molecular Dynamic Studies on the Interaction of a TatA Oligomer with Tat Translocon Substrates https://www.biorxiv.org/content/10.1101/2025.09.29.679310v1

Understanding the infection mechanism of {Phi}8 using infection method in Pseudomonas syringae pv. Phaseolicola strain: In-situ CryoET analysis https://www.biorxiv.org/content/10.1101/2025.09.29.678632v1

Capturing transient states of heterodimeric ABC transporter TM287/288 by Time-Resolved Small-Angle X-ray Scattering https://www.biorxiv.org/content/10.1101/2025.09.29.679171v1

Development of a genetically encoded and potent PDE6D inhibitor https://www.biorxiv.org/content/10.1101/2025.09.29.679187v1

Targeted Enzymatic Fragmentation of Lipoprotein(a) via Kringle IV Domains: A Novel Therapeutic Approach for Cardiovascular Disease. https://www.biorxiv.org/content/10.1101/2025.09.28.679088v1

Cinematic Simulation of Substrate-to-Product Chemical Reactions with Chemical Accuracy Using QuantaMind MD https://www.biorxiv.org/content/10.1101/2025.09.28.679094v1

PAC/SP3 on-bead carboxyl derivatization allows combined C- and N-terminomics https://www.biorxiv.org/content/10.1101/2025.09.28.679096v1

Helicase-mediated mechanism of SSU processome maturation and disassembly https://www.biorxiv.org/content/10.1101/2025.09.29.679232v1

De Novo Design, Directed Evolution and Computational Study of Heme-Binding Helical Bundle Protein Catalysts for Biocatalytic Enantioselective Ge-H Insertion https://www.biorxiv.org/content/10.1101/2025.09.29.679279v1

Fragment Screening and Structure-Guided Development of Heparanase Inhibitors Reveals Orthosteric and Allosteric Inhibition https://www.biorxiv.org/content/10.1101/2025.09.29.679132v1

Structural Studies of Nedicistrovirus IRES-Driven, Initiation Factor-independent Translation Shed Light on Key Steps of Eukaryotic Translation Elongation https://www.biorxiv.org/content/10.1101/2025.09.29.679340v1

Computational design of pH-sensitive binders https://www.biorxiv.org/content/10.1101/2025.09.29.678932v1

ZnF-UBP domains regulate deubiquitinase activity by relieving ubiquitin product inhibition https://www.biorxiv.org/content/10.1101/2025.09.28.679104v1

Effects of Polyphenolic Extracts from Mediterranean Forage Crops on Cholinesterases and Amyloid Aggregation Relevant to Neurodegenerative Diseases https://www.biorxiv.org/content/10.1101/2025.09.28.677303v1

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle https://www.biorxiv.org/content/10.1101/2025.09.26.678768v1

Neutrophil Extracellular Traps Mediate In Vitro and In Vivo Degradation of α-Synuclein Amyloid Fibrils https://www.biorxiv.org/content/10.1101/2025.09.26.678871v1

Development and validation of a streamlined workflow for proteomic analysis of proteins and post-translational modifications from dried blood https://www.biorxiv.org/content/10.1101/2025.09.26.678912v1

A Universal Method for Quantifying Elemental Sulfur and Selenium in Biological Matrices https://www.biorxiv.org/content/10.1101/2025.09.26.678775v1

In Vivo Mutagenesis of a Ketosynthase Domain Uncovers Productivity and Specificity Control in Modular Polyketide Synthases https://www.biorxiv.org/content/10.1101/2025.09.26.678738v1

CDK11 activates CDK12 to trigger the elongation of RNA Polymerase II https://www.biorxiv.org/content/10.1101/2025.09.27.678947v1

Absolute quantification of TCA cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism https://www.biorxiv.org/content/10.1101/2025.09.25.678562v1

PIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization https://www.biorxiv.org/content/10.1101/2025.09.26.678889v1

Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1 https://www.biorxiv.org/content/10.1101/2025.09.26.678779v1

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

A Daily Cycle of White Collar Complex Dephosphorylation Sustains Circadian Rhythmicity in Neurospora https://www.biorxiv.org/content/10.1101/2025.09.25.678408v1

Microbial lipid shifts in a multi-stage simulated gut https://www.biorxiv.org/content/10.1101/2025.09.25.678496v1

Redox Regulation of Cell Migration via Nischarin S-glutathionylation https://www.biorxiv.org/content/10.1101/2025.09.25.678565v1

Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context https://www.biorxiv.org/content/10.1101/2025.09.25.678608v1

A revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding https://www.biorxiv.org/content/10.1101/2025.09.24.678334v1

Isolation of Extracellular Vesicles from Minimal Volume Ascites Fluid Using Strong Anion Exchange Magnetic Beads https://www.biorxiv.org/content/10.1101/2025.09.24.678291v1

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin. https://www.biorxiv.org/content/10.1101/2025.09.24.678203v1

Neuroblastoma-associated ALK variants have distinct cellular and biochemical activities https://www.biorxiv.org/content/10.1101/2025.09.25.677354v1

Structural basis for regulation of Frizzled-4 signaling by the co-receptor Tetraspanin-12 https://www.biorxiv.org/content/10.1101/2025.09.25.678640v1

MechFind: A computational framework for de novo prediction of enzyme mechanisms https://www.biorxiv.org/content/10.1101/2025.09.25.678649v1

The longer transmembrane helices of class I viral fusion proteins may facilitate viral fusion https://www.biorxiv.org/content/10.1101/2025.09.25.678357v1

EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity https://www.biorxiv.org/content/10.1101/2025.09.25.678634v1

Genetic landscape of DNMT3A R882H reveals mechanism of aberrant oligomerization https://www.biorxiv.org/content/10.1101/2025.09.24.678339v1

Proteome-based investigation of O-GlcNAcylation in a C. elegans model of Ageing and Alzheimer's disease: Functional Support for Earlier Hypothesis-Generating Findings https://www.biorxiv.org/content/10.1101/2025.09.22.677859v1

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics https://www.biorxiv.org/content/10.1101/2025.09.24.678353v1

Structural basis for a filamentous morpheein model of human cystathionine beta-synthase https://www.biorxiv.org/content/10.1101/2025.09.24.678195v1

DNA Content and DNA Damage in Raw and Heat-processed Foods https://www.biorxiv.org/content/10.1101/2025.09.21.677616v1

Single-cell proteomics: a powerful new tool to study kidney cell heterogeneity https://www.biorxiv.org/content/10.1101/2025.09.23.678003v1

RemoteFoldSet: Benchmarking Structural Awareness of Protein Language Models https://www.biorxiv.org/content/10.1101/2025.09.23.678152v1

Novel Binding Partners of the Vacuolar Transporter Chaperone (VTC) complex in Acidocalcisomes of Leishmania tarentolae https://www.biorxiv.org/content/10.1101/2025.09.23.677757v1

Comparative genomic insights into the action of suicide Thi4 thiazole synthases https://www.biorxiv.org/content/10.1101/2025.09.23.678117v1

Structural investigation of QatB and QatC proteins in QatABCD anti-phage defense https://www.biorxiv.org/content/10.1101/2025.09.22.677948v1

Discovery and biosynthesis of biffamycin A, a novel glycotetrapeptide antibiotic https://www.biorxiv.org/content/10.1101/2025.09.22.677794v1