An Unprecedented [Cu 4Fe 4S] Cluster in a Methanotroph Acetol Dehydrogenase https://www.biorxiv.org/content/10.64898/2026.06.11.731722v1

Local and non-local impacts of intra-hexamer interactions on temperature compensation of KaiC https://www.biorxiv.org/content/10.64898/2026.06.12.727564v1

An EpCAM-Targeted Mirror-Image DNA Nanostructure for Precise Drug Delivery in Triple-Negative Breast Cancer https://www.biorxiv.org/content/10.64898/2026.06.11.730265v1

Dehydration/1,6-addition-based Site-specific Bioconjugation Unveils Norepinephrinylation as a Widespread Post-translational Modification in the Cellular Proteome https://www.biorxiv.org/content/10.64898/2026.06.11.731782v1

A low-cost method for collecting and measuring sinking speed of particles in coastal zones https://www.biorxiv.org/content/10.64898/2026.06.11.730824v1

In situ polymerized monolith tips for reproducible, format-flexible proteomic sample preparation applied to biofluids https://www.biorxiv.org/content/10.64898/2026.06.11.731522v1

Infrared light stimulates the mitochondrial large-conductance calcium-activated potassium channel in guinea pig cardiomyocytes. https://www.biorxiv.org/content/10.64898/2026.06.11.731586v1

Full Scan enhanced Dynamic Range MS improves metabolite coverage and cancer cell-line discrimination in untargeted metabolomics https://www.biorxiv.org/content/10.64898/2026.06.11.731534v1

Biochemical Characterization of Fatty Acid Thioesterase Target Site Mutants and their Implication on Herbicide Resistance https://www.biorxiv.org/content/10.64898/2026.06.11.731613v1

Molecular Insights into Solvent-Mediated Stabilization and Aggregate Suppression during Refolding of Recombinant Leucyl Aminopeptidase https://www.biorxiv.org/content/10.64898/2026.06.12.732004v1

Digging deeper into the immunopeptidome with TripleToolWF https://www.biorxiv.org/content/10.64898/2026.06.11.731513v1

Intrinsically disordered N-terminal regions suppress cotranslational protein degradation https://www.biorxiv.org/content/10.64898/2026.06.13.732044v1

Potential for the Terminal SKP1 Glycosyltransferase to Exert Non-Enzymatic Control of SKP1 in Toxoplasma gondii https://www.biorxiv.org/content/10.64898/2026.06.11.731712v1

A ribosomal kinetic checkpoint governs selective mRNA recruitment https://www.biorxiv.org/content/10.64898/2026.06.12.731988v1

Membrane-dependent structural organization of cowpox virus CPXV012 and its recognition of TAP https://www.biorxiv.org/content/10.64898/2026.06.12.731803v1

Optimised haemoglobin depletion improves clinical proteomics from dried blood spots https://www.biorxiv.org/content/10.64898/2026.06.13.731967v1

Unlocking viral evasion: Luminal charge interactions in BoHV-1 UL49.5 allosterically control TAP degradation https://www.biorxiv.org/content/10.64898/2026.06.11.731699v1

Water oxidation-driven histidine dioxidation enables probe-free proximity labeling https://www.biorxiv.org/content/10.64898/2026.06.10.731337v1

Structural and Mechanistic Basis of F227C-Mediated Hypersusceptibility to Islatravir in HIV-1 Reverse Transcriptase https://www.biorxiv.org/content/10.64898/2026.06.08.730881v1

Plant MutS Homolog 1 is a mismatch-directed nuclease required for organelle genome maintenance https://www.biorxiv.org/content/10.64898/2026.06.11.731605v1

Sequence-encoded H2A.Z nucleosome dynamics control DNA unwrapping and SUV420H1 recognition https://www.biorxiv.org/content/10.64898/2026.06.10.731474v1

Controlling metal-carbonate phase, form, and function through de novo protein design https://www.biorxiv.org/content/10.64898/2026.06.10.730916v1

Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists https://www.biorxiv.org/content/10.64898/2026.06.10.731386v1

Preserving Native Cellulose-Xylan Architecture Enables Structure-Property Control in Holocellulose Nanofibrils and High-Performance Sustainable Materials https://www.biorxiv.org/content/10.64898/2026.06.07.730583v1

Statin-Induced Mitochondrial Coenzyme Q Deficiency Alters Mitochondrial Redox Homeostasis and Bioenergetic Function in Astrocytes https://www.biorxiv.org/content/10.64898/2026.06.10.731318v1

Replication protein A prevents unregulated priming and Rad51 loading on single-stranded DNA in nuclear extracts of Xenopus eggs https://www.biorxiv.org/content/10.64898/2026.06.09.731035v1

Deciphering AMP deaminase-2 structure, activators and regulators underpinning cellular function in human fructose and nucleotide metabolism https://www.biorxiv.org/content/10.64898/2026.06.10.731346v1

Na+-translocating oxaloacetate decarboxylase from Vibrio cholerae: the functional tautomeric form of the substrate and the proton pathways in catalysis https://www.biorxiv.org/content/10.64898/2026.06.08.730933v1

From FODMAPs to prebiotic candidates: enzymatic transglycosylation of raffinose oligosaccharides towards new mixed-linkage oligosaccharides https://www.biorxiv.org/content/10.64898/2026.06.09.731070v1

Radiation-induced disruption of cardiac mitochondrial bioenergetics and nucleotide homeostasis in mice https://www.biorxiv.org/content/10.64898/2026.06.08.730816v1

Selenoprotein S plays role in translation and membrane protein biogenesis https://www.biorxiv.org/content/10.64898/2026.06.08.725543v1

The NanoBridge system for targeted post-translational modification of challenging proteins https://www.biorxiv.org/content/10.64898/2026.06.08.730974v1

DNA origami uptake in Y-79 retinoblastoma cells driven by oligolysine coating https://www.biorxiv.org/content/10.64898/2026.06.08.730913v1

A Reaction-Driven Condensate-to-Vesicle Transition Selects, Activates, and Spatially Organizes RNA https://www.biorxiv.org/content/10.64898/2026.06.07.730732v1

SPAFESTWDILK, a plant-derived dodecapeptide from Zingiber officinale, as a predicted inhibitor of the MDM2-p53 interaction: computational discovery and multi-method evaluation https://www.biorxiv.org/content/10.64898/2026.06.06.730565v1

D-Retro-Inverso Peptide Candidates for Inhibiting SAA Cardiac Amyloidosis https://www.biorxiv.org/content/10.64898/2026.06.05.730446v1

Human ASPDH is a 2-aminomuconate reductase that produces L-2-aminohex-3-enedioic acid in tryptophan catabolism https://www.biorxiv.org/content/10.64898/2026.06.05.730449v1

TDP-43 self-assembly is regulated by its disordered NLS-region https://www.biorxiv.org/content/10.64898/2026.06.06.730435v1

Porphyrin driven redox tuning in structurally defined de novo heme proteins https://www.biorxiv.org/content/10.64898/2026.06.09.731085v1

Differentiating 5-thiooxazoles from oxazolone-coupled thioamides in RiPP natural products https://www.biorxiv.org/content/10.64898/2026.06.05.730506v1

The KN domain of KANK proteins contains separable talin-binding and intramolecular interaction modules https://www.biorxiv.org/content/10.64898/2026.06.09.731086v1

Revealing the spatiotemporal dynamics of methionine metabolism with a genetically encoded single-fluorophore biosensor https://www.biorxiv.org/content/10.64898/2026.06.05.730515v1

Early detection of pancreatic ductal adenocarcinoma by single-molecule profiling of pancreatic enzyme activities https://www.biorxiv.org/content/10.64898/2026.06.05.730533v1

Discovery of a novel dehalogenase from Achromobacter mucicolens for PFAS defluorination https://www.biorxiv.org/content/10.64898/2026.06.05.730295v1

Methylmalonic acid: a new target for Hadamard-edited MRS https://www.biorxiv.org/content/10.64898/2026.06.05.730405v1

Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex https://www.biorxiv.org/content/10.64898/2026.06.05.730395v1

Rapid and Cost-Effective Preparation of a RuBisCO-Rich Protein Fraction from Dried Leafy Biomass https://www.biorxiv.org/content/10.64898/2026.06.05.730420v1

Drosophila melanogaster as a platform for the functional expression of engineered PET-degrading enzymes https://www.biorxiv.org/content/10.64898/2026.06.04.729872v1

Fermentation-Induced Molecular Remodeling in African Indigenous Tubers: Cassava and Cocoyam https://www.biorxiv.org/content/10.64898/2026.06.05.730317v1

Regulation of proteasome activation by a ubiquitin-independent feedback mechanism https://www.biorxiv.org/content/10.64898/2026.06.05.730379v1