A bacterial effector blocks SUMOylation by steric occlusion of UBC9 via arginine-GlcNAcylation https://www.biorxiv.org/content/10.64898/2026.03.06.710069v1

Prospective ICH Q2(R2)-aligned total-error validation of label-free untargeted proteomics for host cell protein quantification in biotherapeutics https://www.biorxiv.org/content/10.64898/2026.03.06.710150v1

An improved workflow for rapid, large-scale protein production in HEK293 cells via antibiotic enrichment after lentiviral transduction https://www.biorxiv.org/content/10.64898/2026.03.07.710266v1

A population-scale red blood cell proteome reveals genetically encoded aging clocks predictive of hemolysis and blood donor activity https://www.biorxiv.org/content/10.64898/2026.03.07.710284v1

Development of a photostable pH biosensor based on mStayGold https://www.biorxiv.org/content/10.64898/2026.03.06.710027v1

An Automated HDX-MS Platform for in situ characterisation of Membrane Proteins https://www.biorxiv.org/content/10.64898/2026.03.06.710074v1

Fast and Luminous: CLIP-tag2 https://www.biorxiv.org/content/10.64898/2026.03.05.709795v1

Structural insights into the inactive state of the adhesion GPCR ADGRV1 https://www.biorxiv.org/content/10.64898/2026.03.05.709805v1

Nar1 binds the cytosolic iron sulfur cluster assembly targeting complex via a bipartite interaction interface https://www.biorxiv.org/content/10.64898/2026.03.06.710161v1

Phosphorylation of the C-terminus of PI4KA inhibits lipid kinase activity https://www.biorxiv.org/content/10.64898/2026.03.06.710086v1

Suppression of ITPK1 and IPMK activities impairs mTORC1 signaling in pancreatic β-cells and implicates IP5 in stabilizing activated mTORC1 https://www.biorxiv.org/content/10.64898/2026.03.04.709646v1

Integrated proteomic and phosphoproteomic profiling reveals mechanisms of Bisphenol-A induced placental toxicity https://www.biorxiv.org/content/10.64898/2026.03.04.709712v1

A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric Proteins https://www.biorxiv.org/content/10.64898/2026.03.06.710105v1

An Optimized RNF126-Targeting Covalent Handle for Molecular Glue Degraders https://www.biorxiv.org/content/10.64898/2026.03.06.709959v1

DNA Adenine Methylation Clock in Brain Aging and Alzheimer's Disease Progression https://www.biorxiv.org/content/10.64898/2026.03.05.709867v1

Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs https://www.biorxiv.org/content/10.64898/2026.03.05.709631v1

Systematic assessment of the impact of targeted selection methods and environment-mimicking culture conditions on fungal natural product libraries https://www.biorxiv.org/content/10.64898/2026.03.04.709592v1

UbiB proteins mediate an ATP-dependent decarboxylation step in bacterial ubiquinone biosynthesis https://www.biorxiv.org/content/10.64898/2026.03.05.709815v1

Non-coding RNA RsaE regulates biofilm thickness, viability and dissemination in methicillin-resistant Staphylococcus aureus https://www.biorxiv.org/content/10.64898/2026.03.05.709773v1

Comparison of extracellular vesicles and mechanically induced vesicles for structure determination of membrane proteins https://www.biorxiv.org/content/10.64898/2026.03.04.709473v1

Identification and functional characterization of CXCL17 in cartilaginous fishes reveals an ancient origin of the CXCL17-GPR25 signaling pathway https://www.biorxiv.org/content/10.64898/2026.03.04.709523v1

''Self-gapping'' by a C-terminal domain arginine finger regulates GTP hydrolysis in bacterial zinc metallochaperones https://www.biorxiv.org/content/10.64898/2026.03.03.709369v1

An omega glutathione S-transferase in Apis mellifera contributes to chemical adaptation through pesticide sequestration and antioxidant defense https://www.biorxiv.org/content/10.64898/2026.03.03.709375v1

Functional Locality-Aligned Learning Reveals Structure-Function Causality in Enzyme Kinetics https://www.biorxiv.org/content/10.64898/2026.03.04.709726v1

Miniprotein inhibitors of the Staphylococcus aureus efflux transporter NorA https://www.biorxiv.org/content/10.64898/2026.03.05.709893v1

MauE from Calditrichota and Thermodesulfobacteriota reveal a new pathway for disulfide bond formation in bacteria https://www.biorxiv.org/content/10.64898/2026.03.05.709764v1

Unspecific Molecular Adsorption (UMA) sample preparation method for bottom-up and whole protein analysis. The foundation. https://www.biorxiv.org/content/10.64898/2026.03.02.709073v1

Conformational signatures of native ligand and pharmacochaperone binding in rhodopsin https://www.biorxiv.org/content/10.64898/2026.03.03.709294v1

Development of Carboxymethyl Cellulose (CMC)-Based Bio-composites as a Functional Substitute for Single-Use Plastics for Active Food Packaging Applications https://www.biorxiv.org/content/10.64898/2026.02.22.707343v1

Impact of Sequential Processing (Boiling and Fermentation) on the Nutritional, Anti-nutrient, and Antioxidant Profile of Manihot esculenta Tubers. https://www.biorxiv.org/content/10.64898/2026.03.03.709334v1

Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella https://www.biorxiv.org/content/10.64898/2026.03.03.709364v1

Traceless protein semi-synthesis in cells using the promiscuous ultra-fast split intein NrdJ-1 https://www.biorxiv.org/content/10.64898/2026.03.03.709324v1

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine https://www.biorxiv.org/content/10.64898/2026.03.03.709336v1

Mutagenesis study of a Bacteriophytochrome - insights for the development of labels for optical imaging. https://www.biorxiv.org/content/10.64898/2026.03.03.708993v1

Hierarchical Anchoring Gating Dictates Specific H4K16 Acetylation by the Human MSL Complex https://www.biorxiv.org/content/10.64898/2026.03.03.709310v1

Pan-repository analysis reveals a drug-activating function of microbial bile acid conjugation https://www.biorxiv.org/content/10.64898/2026.03.03.709330v1

Structure basis for single-strand nucleic acid targeting by IscB and variants https://www.biorxiv.org/content/10.64898/2026.03.03.709405v1

Identification and characterization of a poly(ϵ-caprolactone)-degrading enzyme with a unique sequence profile from the marine bacterium Alloalcanivorax gelatiniphagus https://www.biorxiv.org/content/10.64898/2026.03.04.709486v1

Fluorinated RNA origami enables serum-stable nanodevices for sensing and targeting https://www.biorxiv.org/content/10.64898/2026.03.04.709525v1

Temporal regulation of TRP channels during partial sciatic nerve ligation is modulated by PLCγ in male mice https://www.biorxiv.org/content/10.64898/2026.03.02.709140v1

In Cellulo pharmacological profiling and genomic editing reveals paralog-specific targets for PA generation during PLC signaling https://www.biorxiv.org/content/10.64898/2026.03.02.709100v1

MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repair https://www.biorxiv.org/content/10.64898/2026.03.03.709415v1

An Affinity-Based Workflow for Clusterin Purification and Interactome Characterisation in Human Plasma https://www.biorxiv.org/content/10.64898/2026.03.02.708958v1

Structure of the human KEOPS/tRNA complex and characterization of pathogenic variants responsible for the Galloway Mowat syndrome. https://www.biorxiv.org/content/10.64898/2026.03.03.709218v1

Structural basis of MfpD, a versatile pathogeny protein from the mfp conservon of Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.03.03.709265v1

Investigating the versatility of cytochalasan cytochrome P450 monooxygenases using combinatorial biosynthesis reveals stereochemical restrictions https://www.biorxiv.org/content/10.64898/2026.02.28.708751v1

Effects of the Coenzyme Q10 Analog 6-Bromo-ubiquinone (6-Br-Q0C10) on Mammalian Cell Growth https://www.biorxiv.org/content/10.64898/2026.02.28.708723v1

Cancer-Causing Mutations Alter the Interplay Between Loop Dynamics and Catalysis in the Protein Tyrosine Phosphatases SHP-1 and SHP-2 https://www.biorxiv.org/content/10.64898/2026.03.02.708844v1

EnzySeek: Efficient Exploration of Enzyme Reaction Pathways Using AI Agents https://www.biorxiv.org/content/10.64898/2026.03.02.708939v1

Structural Basis for C8 methylation of 23S ribosomal RNA by Cfr https://www.biorxiv.org/content/10.64898/2026.02.27.707579v1