Transition metal activation reframes SAMHD1 regulation https://www.biorxiv.org/content/10.64898/2026.04.23.720456v1

Cryptic starter amidation in antibiotic biosynthesis by trans-acyltransferase polyketide synthases https://www.biorxiv.org/content/10.64898/2026.04.24.720606v1

Structural and biochemical insights reveal substrate-modulated nuclease activity of ComEC during DNA processing https://www.biorxiv.org/content/10.64898/2026.04.23.720307v1

Zero-shot design of a de novo metalloenzyme https://www.biorxiv.org/content/10.64898/2026.04.23.720277v1

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib leads to Potent and Selective Quinoline-based HIPK4 Inhibitor AZ137 https://www.biorxiv.org/content/10.64898/2026.04.22.720179v1

Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes https://www.biorxiv.org/content/10.64898/2026.04.22.719657v1

Dolichol biosynthesis in yeast traces the expanded reaction pathway of higher eukaryotes https://www.biorxiv.org/content/10.64898/2026.04.22.720056v1

The NMR Exchange Format (NEF): Specification and Applications https://www.biorxiv.org/content/10.64898/2026.04.22.715536v1

Fluorescent non-canonical amino acid as a site-specific conformational probe of prion formation https://www.biorxiv.org/content/10.64898/2026.04.21.719968v1

Structural basis of the two-photon photoactivation mechanism of orange carotenoid protein https://www.biorxiv.org/content/10.64898/2026.04.21.718960v1

The structural mechanism of eukaryotic fluoride channel activation and inhibition by monovalent cations https://www.biorxiv.org/content/10.64898/2026.04.21.719972v1

Integrating AI and molecular modeling for structural prediction of a closed state of the hERG channel https://www.biorxiv.org/content/10.64898/2026.04.20.719540v1

Structural divergence in N-terminal domains of AAA proteases paraplegin (SPG7) and FtsH indicates a key structural function in complex formation https://www.biorxiv.org/content/10.64898/2026.04.22.720153v1

Functional interplay between H2B ubiquitylation and H2A.Z deposition https://www.biorxiv.org/content/10.64898/2026.04.22.720199v1

The endogenous metabolite hypochlorite activates indoleamine 2,3-dioxygenase-1 for catalysis: Functional and mechanistic implications https://www.biorxiv.org/content/10.64898/2026.04.21.719948v1

Cryo-EM structure of MutL-activated MutH https://www.biorxiv.org/content/10.64898/2026.04.21.719898v1

Structural basis of substrate recognition and conformational gating in the bacteriophage M15 metalloendopeptidase LysPH https://www.biorxiv.org/content/10.64898/2026.04.21.719881v1

Rate limiting release of product underlies concave Arrhenius break point of thermolysin with a Phe-Leu-Ala substrate https://www.biorxiv.org/content/10.64898/2026.04.22.720203v1

Iron-mediated assembly of lactoferrin-alginate composites for iron encapsulation and structural stabilization https://www.biorxiv.org/content/10.64898/2026.04.21.719905v1

Interleaved multi-magnification cryo-electron tomography bridges cellular and structural biology https://www.biorxiv.org/content/10.64898/2026.04.21.719848v1

An auxiliary protein tunes reductase activity in alkaloid biosynthesis https://www.biorxiv.org/content/10.64898/2026.04.21.719811v1

Mutational Scanning of α-Synuclein using a Clickable Protein Tag Reveals Determinants of Membrane-Induced Aggregation https://www.biorxiv.org/content/10.64898/2026.04.20.719647v1

Longitudinal serum proteomics analyses reveal biomarkers for porcine influenza and coronavirus infections https://www.biorxiv.org/content/10.64898/2026.04.21.719833v1

Molecular basis of Salla Disease: R39C Mutation Effects on the Lysosomal Transporter Sialin https://www.biorxiv.org/content/10.64898/2026.04.20.719580v1

ZDHHC13 is a likely pseudoenzyme protein S-acyltransferase that functions via a non-canonical mechanism https://www.biorxiv.org/content/10.64898/2026.04.20.719575v1

Bioprospecting Novel Luciferase Genes from Museum Coleoptera https://www.biorxiv.org/content/10.64898/2026.04.21.719859v1

S-Adenosyl-D-methionine as a Non-Physiological Substrate for a Wide Range of SAM-Dependent Enzymes https://www.biorxiv.org/content/10.64898/2026.04.20.719600v1

Ant abaecin-2 is a context-dependent copper-binding effector that can be either inhibitory or protective https://www.biorxiv.org/content/10.64898/2026.04.18.719391v1

Neuronal calcium sensors emerge as novel adenylyl cyclase 8 regulators https://www.biorxiv.org/content/10.64898/2026.04.19.719435v1

Redox-dependent lipophilicity of phenazine metabolites is modulated by intramolecular hydrogen bonds and controls their biological distribution https://www.biorxiv.org/content/10.64898/2026.04.18.719255v1

TomoSwin3D: a Swin3D Transformer for the Identification and Classification of Macromolecules in 3D Cryo-ET Tomograms https://www.biorxiv.org/content/10.64898/2026.04.17.719219v1

Molecular determinants of cotranslational chaperone recruitment to nascent p53 https://www.biorxiv.org/content/10.64898/2026.04.17.719227v1

SIMO - Single Section Integrative Multi-Omics - spatial mapping of metabolites and lipids combined with region-specific proteomics in a single tissue slice https://www.biorxiv.org/content/10.64898/2026.04.17.719206v1

PARP1 regulates the genomic ribonucleotide processing activity of TOP1 to prevent the formation of toxic TOP1-DNA adducts and the associated mutations. https://www.biorxiv.org/content/10.64898/2026.04.16.719024v1

Self-Interaction Nanoparticle Spectroscopy Predicts High-Concentration Viscosity of Therapeutic IgG1 Antibodies https://www.biorxiv.org/content/10.64898/2026.04.16.719068v1

A TRANSLATIONAL LC-MS/MS FRAMEWORK FOR LIPID BIOMARKER IDENTIFICATION AND QUANTIFICATION IN HUMAN PLASMA https://www.biorxiv.org/content/10.64898/2026.04.16.718601v1

Full-Atom MPNN Based Redesign of Plant Dehydrogenase Enables Thermostability Enhancement Without Loss of Stereoselectivity https://www.biorxiv.org/content/10.64898/2026.04.20.719482v1

MitoSAM-dependent lipoylation controls postnatal heart development via metabolic remodeling https://www.biorxiv.org/content/10.64898/2026.04.20.719537v1

Machine learning uncovers circulating biomarkers and molecular heterogeneity in obesity and type 2 diabetes https://www.biorxiv.org/content/10.64898/2026.04.16.718836v1

Adenylyl cyclase 9 as a molecular scaffold to dissect the regulatory mechanisms of membrane adenylyl cyclases https://www.biorxiv.org/content/10.64898/2026.04.18.719376v1

Structural Mechanism of Electron Shuttling in Inducible Nitric Oxide Synthase https://www.biorxiv.org/content/10.64898/2026.04.17.719136v1

Defining the DNA Binding Specificity of GRHL2 https://www.biorxiv.org/content/10.64898/2026.04.16.719077v1

Activity-based profiling of bacterial RNA-modifying enzymes reveals species-specific 5-methyluridine modification in Bacillus subtilis 23S rRNA https://www.biorxiv.org/content/10.64898/2026.04.17.719261v1

ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KB https://www.biorxiv.org/content/10.64898/2026.04.15.718671v1

Native entanglement misfolding contributes to age-associated structural changes across the Saccharomyces cerevisiae proteome https://www.biorxiv.org/content/10.64898/2026.04.15.717356v1

The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1 https://www.biorxiv.org/content/10.64898/2026.04.16.718858v1

Integrated bioinformatics and single-cell analysis identifies vascular aging-related hub genes and immune drivers in atherosclerosis. https://www.biorxiv.org/content/10.64898/2026.04.14.718580v1

A new stress-response pathway in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.04.15.718621v1

Acyl-enzyme dynamics, tautomerisation and hydration regulate turnover of carbapenem antibiotics by the OXA-48 β-lactamase https://www.biorxiv.org/content/10.64898/2026.04.15.718664v1

Cephalopod Genome Expansion Drives Broader Reflectin Domain Boundaries https://www.biorxiv.org/content/10.64898/2026.04.14.718489v1