bioRxiv Biochemistry
@biorxiv-biochem.bsky.social
📤 1772
📥 0
📝 5535
Transition metal activation reframes SAMHD1 regulation
https://www.biorxiv.org/content/10.64898/2026.04.23.720456v1
about 22 hours ago
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Cryptic starter amidation in antibiotic biosynthesis by trans-acyltransferase polyketide synthases
https://www.biorxiv.org/content/10.64898/2026.04.24.720606v1
about 22 hours ago
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Structural and biochemical insights reveal substrate-modulated nuclease activity of ComEC during DNA processing
https://www.biorxiv.org/content/10.64898/2026.04.23.720307v1
about 23 hours ago
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Zero-shot design of a de novo metalloenzyme
https://www.biorxiv.org/content/10.64898/2026.04.23.720277v1
about 23 hours ago
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Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib leads to Potent and Selective Quinoline-based HIPK4 Inhibitor AZ137
https://www.biorxiv.org/content/10.64898/2026.04.22.720179v1
1 day ago
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Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes
https://www.biorxiv.org/content/10.64898/2026.04.22.719657v1
1 day ago
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Dolichol biosynthesis in yeast traces the expanded reaction pathway of higher eukaryotes
https://www.biorxiv.org/content/10.64898/2026.04.22.720056v1
1 day ago
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The NMR Exchange Format (NEF): Specification and Applications
https://www.biorxiv.org/content/10.64898/2026.04.22.715536v1
1 day ago
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2
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Fluorescent non-canonical amino acid as a site-specific conformational probe of prion formation
https://www.biorxiv.org/content/10.64898/2026.04.21.719968v1
1 day ago
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Structural basis of the two-photon photoactivation mechanism of orange carotenoid protein
https://www.biorxiv.org/content/10.64898/2026.04.21.718960v1
1 day ago
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The structural mechanism of eukaryotic fluoride channel activation and inhibition by monovalent cations
https://www.biorxiv.org/content/10.64898/2026.04.21.719972v1
1 day ago
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Integrating AI and molecular modeling for structural prediction of a closed state of the hERG channel
https://www.biorxiv.org/content/10.64898/2026.04.20.719540v1
1 day ago
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Structural divergence in N-terminal domains of AAA proteases paraplegin (SPG7) and FtsH indicates a key structural function in complex formation
https://www.biorxiv.org/content/10.64898/2026.04.22.720153v1
1 day ago
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1
1
Functional interplay between H2B ubiquitylation and H2A.Z deposition
https://www.biorxiv.org/content/10.64898/2026.04.22.720199v1
2 days ago
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The endogenous metabolite hypochlorite activates indoleamine 2,3-dioxygenase-1 for catalysis: Functional and mechanistic implications
https://www.biorxiv.org/content/10.64898/2026.04.21.719948v1
2 days ago
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Cryo-EM structure of MutL-activated MutH
https://www.biorxiv.org/content/10.64898/2026.04.21.719898v1
2 days ago
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1
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Structural basis of substrate recognition and conformational gating in the bacteriophage M15 metalloendopeptidase LysPH
https://www.biorxiv.org/content/10.64898/2026.04.21.719881v1
2 days ago
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Rate limiting release of product underlies concave Arrhenius break point of thermolysin with a Phe-Leu-Ala substrate
https://www.biorxiv.org/content/10.64898/2026.04.22.720203v1
2 days ago
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Iron-mediated assembly of lactoferrin-alginate composites for iron encapsulation and structural stabilization
https://www.biorxiv.org/content/10.64898/2026.04.21.719905v1
2 days ago
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Interleaved multi-magnification cryo-electron tomography bridges cellular and structural biology
https://www.biorxiv.org/content/10.64898/2026.04.21.719848v1
2 days ago
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An auxiliary protein tunes reductase activity in alkaloid biosynthesis
https://www.biorxiv.org/content/10.64898/2026.04.21.719811v1
2 days ago
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5
Mutational Scanning of α-Synuclein using a Clickable Protein Tag Reveals Determinants of Membrane-Induced Aggregation
https://www.biorxiv.org/content/10.64898/2026.04.20.719647v1
2 days ago
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Longitudinal serum proteomics analyses reveal biomarkers for porcine influenza and coronavirus infections
https://www.biorxiv.org/content/10.64898/2026.04.21.719833v1
3 days ago
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Molecular basis of Salla Disease: R39C Mutation Effects on the Lysosomal Transporter Sialin
https://www.biorxiv.org/content/10.64898/2026.04.20.719580v1
3 days ago
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1
1
ZDHHC13 is a likely pseudoenzyme protein S-acyltransferase that functions via a non-canonical mechanism
https://www.biorxiv.org/content/10.64898/2026.04.20.719575v1
3 days ago
0
2
1
Bioprospecting Novel Luciferase Genes from Museum Coleoptera
https://www.biorxiv.org/content/10.64898/2026.04.21.719859v1
3 days ago
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S-Adenosyl-D-methionine as a Non-Physiological Substrate for a Wide Range of SAM-Dependent Enzymes
https://www.biorxiv.org/content/10.64898/2026.04.20.719600v1
4 days ago
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1
Ant abaecin-2 is a context-dependent copper-binding effector that can be either inhibitory or protective
https://www.biorxiv.org/content/10.64898/2026.04.18.719391v1
4 days ago
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1
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Neuronal calcium sensors emerge as novel adenylyl cyclase 8 regulators
https://www.biorxiv.org/content/10.64898/2026.04.19.719435v1
4 days ago
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Redox-dependent lipophilicity of phenazine metabolites is modulated by intramolecular hydrogen bonds and controls their biological distribution
https://www.biorxiv.org/content/10.64898/2026.04.18.719255v1
4 days ago
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TomoSwin3D: a Swin3D Transformer for the Identification and Classification of Macromolecules in 3D Cryo-ET Tomograms
https://www.biorxiv.org/content/10.64898/2026.04.17.719219v1
4 days ago
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1
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Molecular determinants of cotranslational chaperone recruitment to nascent p53
https://www.biorxiv.org/content/10.64898/2026.04.17.719227v1
4 days ago
0
2
2
SIMO - Single Section Integrative Multi-Omics - spatial mapping of metabolites and lipids combined with region-specific proteomics in a single tissue slice
https://www.biorxiv.org/content/10.64898/2026.04.17.719206v1
4 days ago
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PARP1 regulates the genomic ribonucleotide processing activity of TOP1 to prevent the formation of toxic TOP1-DNA adducts and the associated mutations.
https://www.biorxiv.org/content/10.64898/2026.04.16.719024v1
4 days ago
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Self-Interaction Nanoparticle Spectroscopy Predicts High-Concentration Viscosity of Therapeutic IgG1 Antibodies
https://www.biorxiv.org/content/10.64898/2026.04.16.719068v1
4 days ago
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A TRANSLATIONAL LC-MS/MS FRAMEWORK FOR LIPID BIOMARKER IDENTIFICATION AND QUANTIFICATION IN HUMAN PLASMA
https://www.biorxiv.org/content/10.64898/2026.04.16.718601v1
4 days ago
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Full-Atom MPNN Based Redesign of Plant Dehydrogenase Enables Thermostability Enhancement Without Loss of Stereoselectivity
https://www.biorxiv.org/content/10.64898/2026.04.20.719482v1
5 days ago
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2
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MitoSAM-dependent lipoylation controls postnatal heart development via metabolic remodeling
https://www.biorxiv.org/content/10.64898/2026.04.20.719537v1
5 days ago
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1
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Machine learning uncovers circulating biomarkers and molecular heterogeneity in obesity and type 2 diabetes
https://www.biorxiv.org/content/10.64898/2026.04.16.718836v1
5 days ago
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2
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Adenylyl cyclase 9 as a molecular scaffold to dissect the regulatory mechanisms of membrane adenylyl cyclases
https://www.biorxiv.org/content/10.64898/2026.04.18.719376v1
6 days ago
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Structural Mechanism of Electron Shuttling in Inducible Nitric Oxide Synthase
https://www.biorxiv.org/content/10.64898/2026.04.17.719136v1
6 days ago
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Defining the DNA Binding Specificity of GRHL2
https://www.biorxiv.org/content/10.64898/2026.04.16.719077v1
7 days ago
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Activity-based profiling of bacterial RNA-modifying enzymes reveals species-specific 5-methyluridine modification in Bacillus subtilis 23S rRNA
https://www.biorxiv.org/content/10.64898/2026.04.17.719261v1
7 days ago
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2
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ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KB
https://www.biorxiv.org/content/10.64898/2026.04.15.718671v1
8 days ago
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1
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Native entanglement misfolding contributes to age-associated structural changes across the Saccharomyces cerevisiae proteome
https://www.biorxiv.org/content/10.64898/2026.04.15.717356v1
8 days ago
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The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1
https://www.biorxiv.org/content/10.64898/2026.04.16.718858v1
8 days ago
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1
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Integrated bioinformatics and single-cell analysis identifies vascular aging-related hub genes and immune drivers in atherosclerosis.
https://www.biorxiv.org/content/10.64898/2026.04.14.718580v1
8 days ago
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A new stress-response pathway in Mycobacterium tuberculosis
https://www.biorxiv.org/content/10.64898/2026.04.15.718621v1
9 days ago
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1
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Acyl-enzyme dynamics, tautomerisation and hydration regulate turnover of carbapenem antibiotics by the OXA-48 β-lactamase
https://www.biorxiv.org/content/10.64898/2026.04.15.718664v1
9 days ago
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Cephalopod Genome Expansion Drives Broader Reflectin Domain Boundaries
https://www.biorxiv.org/content/10.64898/2026.04.14.718489v1
9 days ago
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