The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence https://www.biorxiv.org/content/10.64898/2026.01.21.700848v1

Structural basis for dimerization, catalytic regulation, and substrate selectivity in S9D proteases https://www.biorxiv.org/content/10.64898/2026.01.21.700880v1

Structural, dynamic, and evolutionary determinants of substrate binding in the tetrameric 6-phosphogluconate dehydrogenase from Gluconobacter oxydans https://www.biorxiv.org/content/10.64898/2026.01.21.700892v1

Bifunctional Lipid-Protein Crosslinking Efficiency and Reaction Products https://www.biorxiv.org/content/10.64898/2026.01.18.700185v1

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds anFe-S Cluster https://www.biorxiv.org/content/10.64898/2026.01.20.700672v1

Identification and Functional Characterization of CXCL17 Orthologs in Amphibians https://www.biorxiv.org/content/10.64898/2026.01.18.700233v1

Differential Acceptance Specificity of Human Fucosyltransferases toward GDP-azidofucose and GDP-alkynylfucose as Glycosylation Probes https://www.biorxiv.org/content/10.64898/2026.01.20.700681v1

Selective identification of the herb Picrorhiza kurroa and probiotic Lactobacillus fermentum as a synbiotic with fermentation-enhanced physicochemical, biological, and metabolomic properties https://www.biorxiv.org/content/10.64898/2026.01.17.700043v1

Catalytic and Structural Insights into Neil3-Dependent Unhooking of Endogenous Abasic DNA Crosslink https://www.biorxiv.org/content/10.64898/2026.01.19.700286v1

Establishing the molecular basis for MDA5 mutation-linked autoimmunity https://www.biorxiv.org/content/10.64898/2026.01.20.700587v1

Two components of the early ASH1 mRNA transport machinery undergo PUN motif-dependent liquid-liquid-phase separation https://www.biorxiv.org/content/10.64898/2026.01.20.700544v1

Structural and Spectroscopic Basis for Catalysis by a Class C Radical S-adenosylmethionine Methylase Involved in Nosiheptide/Nocathiacin Biosynthesis https://www.biorxiv.org/content/10.64898/2026.01.19.700444v1

Revisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels https://www.biorxiv.org/content/10.64898/2026.01.19.700258v1

SF3B1 Phosphorylation Prompts U2AF2 Dissociation for Widespread Control of pre-mRNA Splicing https://www.biorxiv.org/content/10.64898/2026.01.19.700466v1

Phosphorylation of serines 287/288 in DEK regulates cell-type-specific chromatin occupancy and compaction https://www.biorxiv.org/content/10.64898/2026.01.19.700267v1

Direct binding of chromosome axis and cohesin complexes underlies meiotic chromosome architecture in fungi and plants https://www.biorxiv.org/content/10.64898/2026.01.19.700424v1

Heparan sulfate promotes autoactivation of pro-Cathepsin K by destabilizing the propeptide-catalytic domain interaction https://www.biorxiv.org/content/10.64898/2026.01.18.700217v1

Ribosomal Protein bL27 Protects Translating Ribosomes from tmRNA-SmpB https://www.biorxiv.org/content/10.64898/2026.01.19.700400v1

From SCUBA to spectra: Broadly applicable methods for coral metabolomics research https://www.biorxiv.org/content/10.64898/2026.01.19.700417v1

5'Untranslated regions provide a versatile toolkit for tunable exogenous protein expression https://www.biorxiv.org/content/10.64898/2026.01.19.700389v1

Exploring differential interactional preferences of enzyme-bearing dockarins for cohesin domains in the Clostridium thermocellum cellulosome https://www.biorxiv.org/content/10.64898/2026.01.19.700288v1

Fibrin Selective Alteplase with Improved Thrombolysis and Inhibition Resistance Engineered by Rational Design https://www.biorxiv.org/content/10.64898/2026.01.19.700241v1

A dual-factor complex governs archaeal ribosome hibernation by sensing energy status https://www.biorxiv.org/content/10.64898/2026.01.19.700304v1

Amino acid variants at the P94 position in Staphylococcus aureus class A sortase modulate substrate binding and enzyme activity https://www.biorxiv.org/content/10.64898/2026.01.18.700168v1

Structural characterization of a minimal KLC2/Nup358/BicD2 complex https://www.biorxiv.org/content/10.64898/2026.01.17.700114v1

Characterization of novel cytoplasmic roles for the N-terminal methyltransferase NRMT1 https://www.biorxiv.org/content/10.64898/2026.01.17.700099v1

MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease https://www.biorxiv.org/content/10.64898/2026.01.16.699229v1

Covalent Leader Peptide Probes Enable Proteome-Level Mapping of RiPP Enzymes beyond Biosynthetic Gene Clusters https://www.biorxiv.org/content/10.64898/2026.01.17.700038v1

The E. coli clamp loader sharply bends DNA to load β-clamp onto small gaps https://www.biorxiv.org/content/10.64898/2026.01.17.700081v1

Localisation of corticosteroids in male mouse kidney by mass spectrometry imaging https://www.biorxiv.org/content/10.64898/2026.01.16.699839v1

Drying parameters and aging modulate protective properties of vitrified trehalose https://www.biorxiv.org/content/10.64898/2026.01.16.700019v1

An Integrated Method for Profiling Lipid-Protein Interactions Using Multifunctional Lipid Probes https://www.biorxiv.org/content/10.64898/2026.01.17.700062v1

Iterative Bump-and-hole engineering creates a bioorthogonal reporter for N-acetylglucosaminyltransferase I https://www.biorxiv.org/content/10.64898/2026.01.16.699845v1

Organic Components Modulate the Morphology of Respirable Aerovirology Relevant Aerosols https://www.biorxiv.org/content/10.64898/2026.01.16.699978v1

Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B https://www.biorxiv.org/content/10.64898/2026.01.16.700024v1

Discovery of a Human Metabolite that Mimics the Bacterial Quorum-Sensing Autoinducer AI-2 https://www.biorxiv.org/content/10.64898/2026.01.16.699917v1

A Sustainable Approach to Natural Food Coloring: Alginate-Based Encapsulation and Stabilization of Beetroot Betalain https://www.biorxiv.org/content/10.64898/2026.01.15.699826v1

Discovery of the Phosphonate Flavophos Produced by Burkholderia https://www.biorxiv.org/content/10.64898/2026.01.15.699783v1

Illuminating spatial dynamics of glutamine metabolism with a sensitive genetically encoded biosensor https://www.biorxiv.org/content/10.64898/2026.01.15.699810v1

Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent RNA Modulation https://www.biorxiv.org/content/10.64898/2026.01.15.699758v1

Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context https://www.biorxiv.org/content/10.64898/2026.01.15.699503v1

A comparative investigation of the mannose binding interface in DC-SIGN and MRC1 carbohydrate recognition domains with all-atom molecular dynamics simulations https://www.biorxiv.org/content/10.64898/2026.01.16.699853v1

Emergence of diverse ligase reactivities from a single RNA evolution experiment https://www.biorxiv.org/content/10.64898/2026.01.15.699813v1

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation https://www.biorxiv.org/content/10.64898/2026.01.14.699417v1

Structural Basis of Glycolytic Control in Trypanosoma cruzi: Insights from Enolase and PGI https://www.biorxiv.org/content/10.64898/2026.01.15.699324v1

Substrate specificity in a designed RAS-targeting protease is coupled to active site and distal motions https://www.biorxiv.org/content/10.64898/2026.01.15.699477v1

Mapping the GCK-GKRP interaction landscape using deep mutational scanning by reverse two-hybrid screening https://www.biorxiv.org/content/10.64898/2026.01.15.699699v1

Novel Protoporphyrinogen oxidase 1 mutations endow resistance to PPO-inhibiting herbicides in Bassia scoparia https://www.biorxiv.org/content/10.64898/2026.01.15.699694v1

Identification and inhibition of the Cyclin D Rb-docking interface that drives cell division https://www.biorxiv.org/content/10.64898/2026.01.14.699544v1

Ancestors of Arylmalonate Decarboxylase show increased Activity, Stability and Stereoselectivity https://www.biorxiv.org/content/10.64898/2026.01.14.699310v1