DUCs are C2 domain containing plant-specific deubiquitinases stabilizing endocytic cargo at the plasma membrane https://www.biorxiv.org/content/10.64898/2025.12.04.692294v1

Toward Site-Specific Characterization of Structural Perturbations on Glycosylated Fc Using NMR at Natural Abundance https://www.biorxiv.org/content/10.64898/2025.12.03.692071v1

Hypofucosylation promotes pertussis toxin binding to cell surface glycococonjugates and pertussis toxin-induced intracellular ERK signaling https://www.biorxiv.org/content/10.64898/2025.12.03.692184v1

Artemisinin-Conjugated Phototheranostic Probe for Golgi-Targeted H2O2 Detection and Side Effect Attenuation https://www.biorxiv.org/content/10.64898/2025.12.02.691769v1

G-quadruplex sequence dictates tau oligomerization and fibril morphology https://www.biorxiv.org/content/10.64898/2025.12.02.691785v1

Beyond SOx: Mining Sulfur Bacteria Produce Less Acid due to Unidentified Enzyme Pathways https://www.biorxiv.org/content/10.64898/2025.12.01.691697v1

Structures of tRNA-bound CRISPR-Cas13 reveal universal HEPN RNase mechanisms https://www.biorxiv.org/content/10.64898/2025.12.03.690598v1

Mapping the Glycogen Synthase 1 Interactome in Brown Adipocytes https://www.biorxiv.org/content/10.64898/2025.12.01.691470v1

From Flux to Function: Extracting Mechanistic Insights from Ion Channels via I-V and I-μ Analyses https://www.biorxiv.org/content/10.64898/2025.12.01.691660v1

PDK1: one abbreviation, two kinases, relentless confusion https://www.biorxiv.org/content/10.64898/2025.12.01.691077v1

Decoding isozyme-specific substrate recognition in protein arginine deiminases by proteome-wide citrullination mapping https://www.biorxiv.org/content/10.64898/2025.12.01.691579v1

MALDI-TOF mass spectrometry and proteomics as phenotypic screening tools for anti-inflammatory drugs https://www.biorxiv.org/content/10.64898/2025.12.01.691706v1

Structural mechanisms of drebrin-mediated F-actin network modulation https://www.biorxiv.org/content/10.64898/2025.12.01.691618v1

Targeted Nanoparticles: an Innovative Modality in the Treatment of Cancer https://www.biorxiv.org/content/10.64898/2025.12.01.691687v1

Targeting Pleiotrophin to mitigate high fat diet-induced liver metabolic disease: Insights into sex-specific metabolic protection. https://www.biorxiv.org/content/10.64898/2025.12.02.691898v1

A guide RNA repeat checkpoint steers CRISPR-Cas9 catalysis https://www.biorxiv.org/content/10.64898/2025.12.02.691602v1

Mosquito Ferritin: A Haem-Binding Iron Store Required for Egg Development and Targetable for Malaria Control https://www.biorxiv.org/content/10.64898/2025.12.01.691523v1

Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-β signaling https://www.biorxiv.org/content/10.64898/2025.12.01.691266v1

Splitting Hairs: Optimized Sample Preparation Strategy for Mass Spectrometry Imaging of Nematode Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.12.01.691628v1

Engineering an Anaerobic Microenvironment to Empower Hydrogenase-Catalyzed Hydrogen Therapy for Diabetic Wound Healing https://www.biorxiv.org/content/10.1101/2025.12.01.691506v1

Covalent Reprogramming of Kinase Binders to Modulate Protein Homeostasis https://www.biorxiv.org/content/10.1101/2025.11.30.691461v1

RNA interactions drive structural and functional diversification of alpha-synuclein fibrils https://www.biorxiv.org/content/10.1101/2025.11.30.691421v1

Splice Isoform Induced Selective Inhibition of Vesicular Monoamine Transporter Assembly Revealed by Multi-level Combinatorial Analysis https://www.biorxiv.org/content/10.1101/2025.11.29.691296v1

ClpK as a Chaperone Hub: Computational Exploration of its Protein Interaction Landscape. https://www.biorxiv.org/content/10.1101/2025.11.28.691151v1

Computational Repurposing and Phytochemical Screening of Inhibitors Against ClpK from Klebsiella pneumoniae. https://www.biorxiv.org/content/10.1101/2025.11.28.691150v1

A dynamical-nonequilibrium molecular dynamics (D-NEMD) alanine scanning approach for identifying allosteric positions in proteins https://www.biorxiv.org/content/10.1101/2025.11.29.691197v1

Butyrate Rescues Cardiac Metabolic Dysfunction in Hypertensive Heart Failure with Preserved Ejection Fraction https://www.biorxiv.org/content/10.1101/2025.11.28.690152v1

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent S-Nitroso Transfer https://www.biorxiv.org/content/10.1101/2025.11.29.691178v1

Loss of STARD7 Impairs Mitochondrial Phospholipid Homeostasis and Contributes to Mitochondrial Myopathy https://www.biorxiv.org/content/10.1101/2025.11.27.691062v1

Development of a New Approach Method to Monitor and Modify Caffeine Metabolism Correlated to CYP1A2 Expression https://www.biorxiv.org/content/10.1101/2025.11.27.691042v1

Biochemical characterization of ABHD14A, an outlying member of the metabolic serine hydrolase family https://www.biorxiv.org/content/10.1101/2025.11.28.691245v1

Characterization of the Mitomycin C Resistance Protein McrA https://www.biorxiv.org/content/10.1101/2025.11.28.691146v1

Process optimization for enhanced enzymatic nylon deconstruction https://www.biorxiv.org/content/10.1101/2025.11.26.690883v1

Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter https://www.biorxiv.org/content/10.1101/2025.11.27.690960v1

Unconventional DNA architecture in a dopamine-bound aptamer complex https://www.biorxiv.org/content/10.1101/2025.11.27.690961v1

Interaction and co-phase separation of SARS-CoV-2 nucleocapsid protein and human hnRNPA1 and its implications for viral life cycle https://www.biorxiv.org/content/10.1101/2025.11.28.691101v1

Structure, function and dynamics of mCoral, a pH responsive engineered variant of the mCherry fluorescent protein with improved hydrogen peroxide tolerance. https://www.biorxiv.org/content/10.1101/2025.11.26.690718v1

POLQ variants with aberrant DNA polymerase activity protect against UV-induced cell death. https://www.biorxiv.org/content/10.1101/2025.11.26.690880v1

A composition-matching algorithm, MatchIDR, identifies prion-like domains that localize to stress granules https://www.biorxiv.org/content/10.1101/2025.11.24.690216v1

Topological adaptation of heliorhodopsins enables exogenous second-antenna acquisition in monoderm phototrophs https://www.biorxiv.org/content/10.1101/2025.11.27.691015v1

Effects of cell growth and temperature on mitochondrial physiology of Drosophila melanogaster embryonic cell line https://www.biorxiv.org/content/10.1101/2025.11.25.690158v1

Multi-stem-loop constrained library enables accelerated SELEX for aptamers with superior kinetics and affinity https://www.biorxiv.org/content/10.1101/2025.11.27.690911v1

Synthesis of stable isotope labeled analogs of phytanic acid for separate and combined tracing of alpha-, beta- and omega-oxidation https://www.biorxiv.org/content/10.1101/2025.11.24.689497v1

Experience from an HTS campaign: Investigation of susceptibility and rescue of SARS-CoV-2 nsp3 protease assay from metal contamination https://www.biorxiv.org/content/10.1101/2025.11.27.690678v1

TDP-43 controls RNA structure through high affinity lattice interactions https://www.biorxiv.org/content/10.1101/2025.11.26.690829v1

Structural basis for ATP regulation of human 5-lipoxygenase https://www.biorxiv.org/content/10.1101/2025.11.26.690380v1

GPR17 structure and agonism with small molecules and oxysterols https://www.biorxiv.org/content/10.1101/2025.11.26.690757v1

Structural insights into autophosphorylation-mediated heat shock response by the protein-arginine kinase McsAB https://www.biorxiv.org/content/10.1101/2025.11.26.690658v1

Structural atlas of Pakpunavirus P7-1 reveals determinants of virion stability and genome ejection https://www.biorxiv.org/content/10.1101/2025.11.26.690771v1

NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells https://www.biorxiv.org/content/10.1101/2025.11.25.689777v1