Caitie McCafferty
@computingcaitie.bsky.social
📤 1048
📥 437
📝 43
Postdoc in the
@cellarchlab.com
at the
@biozentrum.unibas.ch
. Find out more at ciliagirl.com.
pinned post!
Hi! My interests include structure prediction, proteomics, cryo-EM, and citizen science. Many of which are summarized in this review I wrote with
@cellarchlab.com
@svenklumpe.bsky.social
@rommieamaro.bsky.social
Wanda and Lucy earlier this year
tinyurl.com/CellreviewEM
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over 1 year ago
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Caitie McCafferty
Spang Lab
5 days ago
What if you could cut out sub cellular structures and measure the proteome? SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection
www.biorxiv.org/content/10.6...
awesome work by Curdin Franziscus,
@imcf-lex.bsky.social
,
@biehli.bsky.social
, Alexander Schmidt!
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https://www.biorxiv.org/content/10.64898/2026.03.28.714993v1
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New protein complex stoichiometry prediction tool from talent PhD student
@daniil-litvinov.bsky.social
, check out the thread below!
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16 days ago
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Exciting opportunity to work in a lab that’s pushing the boundaries of environmental sampling and work with an amazing scientist!!! 👩🔬🔬
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24 days ago
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Caitie McCafferty
Thibaut Brunet
about 1 month ago
Final version
@nature.com
of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first
@biorxivpreprint.bsky.social
preprint (which we've kept updating). A brief 🧵 (carried over from the old place)
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Nice collab w my neighbor in Basel
@abimoye.bsky.social
on SAXO6 mol bio and genetics!!
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about 1 month ago
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Abigail Moye
about 1 month ago
Thrilled to share that our paper on a novel IRD gene has been published in The American Journal of Human Genetics (AJHG)! 🎉 This wouldn’t have been possible without the incredible group of colleagues and collaborators. Special thanks to
@computingcaitie.bsky.social
, Ditta Zobor, and ERDC members!
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Caitie McCafferty
IOB - Institute of Molecular and Clinical Ophthalmology Basel
about 1 month ago
📏🔬In collaboration with
@computingcaitie.bsky.social
and
@cellarchlab.com
, SAXO6 localization was mapped along ciliary microtubules with direct links to α-tubulin, linking this structural protein class to human retinal disease for the first time. 👉
@ajhgnews.bsky.social
#Ophthalmology
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Caitie McCafferty
Florent Waltz
about 2 months ago
Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖:
shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected! 1/n 🧵
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Helen Foster
about 2 months ago
Very happy to say that our work on how axonemes are generated is now available on bioRxiv:
www.biorxiv.org/content/10.6...
- if you’ve ever wondered how the incredibly beautiful, complex structures within motile
#cilia
are constructed then this is for you!
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https://www.biorxiv.org/content/10.64898/2026.01.30.702858v1
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Caitie McCafferty
German Society for Plant Sciences (DBG)
2 months ago
For
#ECR’s
: DBG’s Hot Tpoic Workshop on Cryo-Electron Tomography + FIB-milling 13 – 15 April 2026 In
@cellarchlab.com
's lab
@biozentrum.unibas.ch
Organised by
@tamb-o.bsky.social
, Karen Zinzius,
@fannyleblanc.bsky.social
Details:
www.deutsche-botanische-gesellschaft.de/en/about-us/...
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Hot Topic Conference
Support for an "Eduard Strasburger Hot Topic Conference" for DBG's members
https://www.deutsche-botanische-gesellschaft.de/en/about-us/foerderung/hot-topic-conference
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Caitie McCafferty
Philippe Van der Stappen
2 months ago
You like
#LLPS
?
#TeamTomo
?
#Rubisco
? Check out our latest preprint! What a great collaboration this has been!
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Caitie McCafferty
John Wallingford
2 months ago
Cilia alert! Stoked to have the new paper from Juyeon Hong about a new domain at the extreme distal tip of motile cilia! (The EDT, y'all!) It's out now
@natcomms.nature.com
. Check it out!
#cilia
www.nature.com/articles/s41...
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A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function - Nature Communications
Here they combine in vivo imaging with proteomics to characterize a protein complex comprised of Ccdc78 and Ccdc33 that acts at the extreme distal tip of 9 + 2 motile cilia to control tip architecture...
https://www.nature.com/articles/s41467-025-67086-9
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Caitie McCafferty
Matt Lycas
2 months ago
🔬🚨New preprint alert! 🚨🔬 We developed quantitative expansion microscopy (qExM) - a method to accurately count proteins in situ by combining expansion microscopy's improved labeling with statistical estimators borrowed from ecology
www.biorxiv.org/content/10.6..
.
#SuperResolution
#CellBiology
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https://www.biorxiv.org/content/10.6..
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Thibaut Brunet
3 months ago
Our research scientist Núria Ros-Rocher won the 1st prize
@zeiss-microscopy.bsky.social
microscopy contest with this beautiful choano colony
www.zeiss.fr/microscopie/...
🥳 C. flexa might not yet be a genetic model, but it is now at least a calendar model, which counts for something. I think.
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Ricardo D. Righetto
3 months ago
This one was quite the journey! The paper describing the
#ChlamyDataset
is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author
@jessheebner.bsky.social
and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]
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Florent Waltz
4 months ago
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in
@cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here:
shorturl.at/z4i4c
#CryoEM
#CryoET
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Ben Engel
4 months ago
Happy to share our fun team-up with
@centriolelab.bsky.social
&
@stearnslab.bsky.social
to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of
#UExM
📏🔬with
#CryoET
❄️🔬. Congrats to
@ebertiaux.bsky.social
&
@computingcaitie.bsky.social
#TeamTomo
🧪
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Caitie McCafferty
Ben Engel
4 months ago
Great talk (and work 🧪 ) by
@computingcaitie.bsky.social
from
@biozentrum.unibas.ch
about exploring multiciliated cells with a complementary trio of structural techniques! Looking forward to sharing the preprint. Thanks for the fab collab
@centriolelab.bsky.social
@stearnslab.bsky.social
#TeamTomo
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Tomorrow!!
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4 months ago
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Caitie McCafferty
FocalPlane
5 months ago
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight
#JCSciliaSI
, guest edited by
@cilialab.bsky.social
&
@lottepedersen.bsky.social
. And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
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JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News
https://focalplane.biologists.com/2025/11/10/jcs-special-issue-cilia-and-flagella-from-basic-biology-to-disease/
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Abigail Moye
5 months ago
Super happy this work is out and included in the really interesting cilia and flagella focused issue!
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
5 months ago
🚨Our collaboration with
@centriolelab.bsky.social
&
@gautamdey.bsky.social
is out today in
@cp-cell.bsky.social
We show that
#Expansion
#Microscopy
is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky
#SciComm
#SciSky
www.cell.com/cell/fulltex...
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Caitie McCafferty
Journal of Cell Science
5 months ago
Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by
@cilialab.bsky.social
and
@lottepedersen.bsky.social
, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at
#JCSciliaSI
.
journals.biologists.com/jcs/issue/13...
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Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
https://journals.biologists.com/jcs/issue/138/20
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Caitie McCafferty
Ben Engel
5 months ago
A class like no other!! From
#AI
structure hallucination 🤖 to
#CryoEM
structure reality 🔬 by
@biozentrum.unibas.ch
@unibas.ch
undergraduate students👩🔬👩🎓 in just a few weeks! One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the
#ProteinCosmos
🧶🧬 🧪
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That’s a wrap of the 2nd edition of our one of a kind structural biology block course at the
@biozentrum.unibas.ch
! In just 6 short weeks students designed protein oligomers; rotated in cryo-ET, cryo-EM SPA, AFM, and NMR labs; and expressed, purified, and structurally characterized their designs
5 months ago
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Mark your calendars for some cilia science!!!
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5 months ago
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Caitie McCafferty
Florent Waltz
6 months ago
Last Friday (17th), we had an amazing first Young Swiss Tomo meeting in Bern, organized with Elda Bauda, Zanetta Kechagia, and
@leonieanton.bsky.social
! Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬. Huge thanks to the DCI for making the event possible! See you next year! 👋
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Thibaut Brunet
6 months ago
Latest from ours:
www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
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So much fun to host
@edwardmarcotte.bsky.social
at the
@biozentrum.unibas.ch
and introduce him to the
@cellarchlab.com
, thanks for a wonderful Discovery Seminar!!
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6 months ago
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Caitie McCafferty
Biozentrum, University of Basel
6 months ago
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum
#University
#Basel
#Professor
#Structural
#Biology
#Biophysics
#Biological
#Imaging
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You don’t want to miss this one!
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6 months ago
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Ben Engel
6 months ago
Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing
@computingcaitie.bsky.social
, now at the
@biozentrum.unibas.ch
🧪🧶🧬
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I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate
www.biorxiv.org/content/10.1...
#cilia
#protistsonsky
🧬🧪
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6 months ago
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Ben Engel
7 months ago
A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday.
#TeamTomo
#PlantScience
🧪🧶🧬🔬🌾
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John Wallingford
7 months ago
Side hustle level-up! My book, IN THE BEGINNING, will be published by
@harperonebooks.bsky.social
in 2027! It's about the human embryo, how it gets built, and what it means for where we come from and where we're going.
@harpercollins.bsky.social
(1/2)
@socdevbio.bsky.social
#devbiol
#scicomm
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Tanmay Bharat
7 months ago
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with
@kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social
@wellcometrust.bsky.social
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Caitie McCafferty
Paul & Virginie - Centriole Lab
7 months ago
Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal.
www.biorxiv.org/content/10.1...
Soon at
@spirochrome.com
Led by O.Mercey and
@lreymond.bsky.social
, in collab with
@dudinlab.bsky.social
and
@marinelap.bsky.social
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Nature
7 months ago
For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began
go.nature.com/3JyRV4S
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How did life get multicellular? Five simple organisms could have the answer
Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.
https://go.nature.com/3JyRV4S
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Caitie McCafferty
Biozentrum, University of Basel
8 months ago
Apply now for the prestigious and independent
#BiozentrumPhDFellowships
. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025.
bit.ly/4caiqqX
@biozentrum.unibas.ch
@unibas.ch
#fellowship
#PhD#Switzerland
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Biozentrum PhD Fellowships
Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...
https://bit.ly/4caiqqX
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Paul & Virginie - Centriole Lab
8 months ago
📢 Excited to share our new study in Nature Communications! We show that the A-C linker safeguards centriole architecture & controls duplication. A big congratulations to Lorène for this beautiful discovery, which represents 4 years of her thesis work.
www.nature.com/articles/s41...
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Mia Konjikusic, PhD
9 months ago
‼️🚨Preprint alert! 🚨‼️ Excited to have some of my first works as a postdoc, and first corresponding author (!!), on biorxiv! This was a fun side quest of a project marrying a few things I deeply love, development, cilia, and hormones in the pituitary! Happy reading!
www.biorxiv.org/content/10.1...
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Primary cilia and BBS4 are required for postnatal pituitary development
Primary cilia orchestrate several signaling pathways, and their disruption results in pleiotropic disorders called ciliopathies. Bardet Beidl syndrome (BBS), one such ciliopathy, provides insights int...
https://www.biorxiv.org/content/10.1101/2025.07.15.664994v1
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
9 months ago
Such a pleasure to be co-organising the
#Latsis
Symposium this year with Guillermina ! Thanks to all the speakers & sponsors. And all our teams members who helped make this a reality. It just felt right.
#Science
#WildCells
#ProtistsOnSky
#Cell
#Biology
#Biophysics
#Behaviour
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Wow! Really nice collaborative work in this piece on RSG1 in human ciliopathy and transition zone assembly
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9 months ago
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Ben Engel
10 months ago
Woo! Very excited to share our collaborative work on the centriole's Luminal Distal Ring ⭕. This project started 13 years ago with
@hugovdhoek.bsky.social
&
@stearnslab.bsky.social
, and then beautifully came together with
@computingcaitie.bsky.social
&
@centriolelab.bsky.social
.
#TeamTomo
#UExM
🧪🧶🧬🔬
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
10 months ago
90% of you probably don’t need to read this. But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy. It’s about sharing something hard to say out loud; partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO
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Omaya Dudin
Interview with Omaya Dudin, who uses Ichthyosporea as models to study how and why unicellular organisms evolved multicellularity at the University of Geneva.
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00444-0
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Manon Demulder
10 months ago
We’re kicking off the DinoSphere Online Seminar Series! Join us for our first session with Karel Mockaer (Heidelberg) & Yong Heng Phua (OIST) 📅 1 July 9AM CEST 🔗
tinyurl.com/4mjaverj
Spread the word!
@protistwtmostest.bsky.social
@ehehenberger.bsky.social
@chandnibhickta.bsky.social
&Norico Yamada
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
10 months ago
Share with your network, group members, colleagues & friends. We are extending the deadline till the 10th of June. This is your last chance of joining us this summer.
#Science
#ProtistsOnSky
#Cell
#Biology
#Microscopy
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Caitie McCafferty
Kevin Drew
10 months ago
Very excited that our work describing hu.MAP3.0 is published in
@molsystbiol.org
. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes.
www.embopress.org/doi/full/10....
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hu.MAP3.0: atlas of human protein complexes by integration of >25,000 proteomic experiments | Molecular Systems Biology
imageimagehu.MAP3.0 integrates mass spectrometry experiments to identify human protein complexes. Using this resource, this study characterizes covariation of complexes, identifies mutually exclusive ...
https://www.embopress.org/doi/full/10.1038/s44320-025-00121-5
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Ariane Briegel
11 months ago
Great dinner with our cryoET friends from Basel!
@sofie-dot-rec.bsky.social
@computingcaitie.bsky.social
@cellarchlab.com
@jacky and Mohamad Harastani
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Priya Ramakrishna
11 months ago
🌱 Excited to share that I will start my lab at EPFL, CH this June supported by a
@snsf.ch
Starting Grant!
ramakrishna.ch
We are interested in plant mineral nutrition and will deep-dive into the fine-tuned mechanisms employed by plants to adapt to abiotic stresses such as salinity.
#newPI
#plantsci
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Plant Adaptation Lab (PAL) – Situated at Institute of Environmental Engineering, EPFL, Switzerland
https://ramakrishna.ch/
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