An internal compass: #pigeons use magnetically responsive immune cells in their livers to sense Earth’s magnetic field, helping them navigate without visual cues like the sun. www.youtube.com/watch?v=-s8i... @mpi-animalbehav.bsky.social @science.org

Nature research paper: SNOR promotes translation restart after dormancy go.nature.com/3RnxFqG

Absolute stunning Blender video and cryo-ET methods, both by @hvdrosa.bsky.social here 👇🏽🤩

It's out! 🥳 In situ architecture of #plasmodesmata - plant cytoplasmic bridges - by #cryoET. 📝 Paper: www.nature.com/articles/s41... 🧵 Thread: bsky.app/profile/madi... #teamtomo #proteomics #AlphaFold

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

Don’t reach for ChatGPT Images or Nano Banana as your first option when creating scientific images There are multiple free and open-source images, icons, and tools for creating scientific illustrations. #plantscience @stephenturner.us blog.stephenturner.us/p/free-open-...

🥰

This is awesome 👇🏽

MissAlignment is out!!! Our new software that improves reference-free tilt series alignment by mimicking human intuition. Check out Dimitry's beautiful thread for a quick summary! And the preprint for more details: www.biorxiv.org/content/10.6... The program: github.com/warpem/miss-...

📜The final version of our paper on eCIS firing is out: www.nature.com/articles/s41... Congrats to @xujwet.bsky.social @chipericson.bsky.social #cryoEM #CIS

The early release version of our #cryoEM work on CDK11-cyclin L-SAP30BP has now been published at Nature Communications: www.nature.com/articles/s41... We got very helpful comments from the reviewers and added more structural analysis and biochemistry to support our conclusions. Please have a look!

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

I’ve been wondering about conference norms. When I can’t attend an invited talk, I offer to send my postdoc who led the relevant work; but this is basically never accepted by organisers. When I organize meetings, I’m more than happy for postdocs to step in.

Out now in Nature Communications! We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky www.nature.com/articles/s41...

New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

Born OTD, one of the most badass scientists ever born. Neuroscientist and developmental biologist, Rita Levi-Montalcini discovered growth factors and studied how the nervous system develops. The poem she chose for her autobiography "In Praise of Imperfection" is still one of my faves 🧪

A little late to the party (or maybe not 😉) but this is nothing short of amazing:

Our #UExM efforts with @gautamdey.bsky.social & @moorefound.bsky.social featured in @nature.com this month. Beyond the #science, every image is a thing of beauty. I think a world-tour exhibition has to happen at one point. #Expansion #Microscopy

As conference season is coming up keep this in mind ☝🏻

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

It’s absolutely incredible that one of the largest Japanese-run Go servers, which has been running since 1992, is still accessed entirely via Telnet. And while most players use GUI clients that use Telnet under the hood, you can still connect manually and get ASCII graphics streamed to you

I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

Crazy biochemistry is the norm for @schullerjm.bsky.social, but here I wanna say I have witnessed up close the amazing effort from @tomaspascoa.bsky.social and @tamb-o.bsky.social to chase the BCRII complex in situ 🤩 Big congrats to Lena Appel and @rnfr2d2.bsky.social for the cryoEM structure too 👏🏽

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems? Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction. www.biorxiv.org/content/10.6...

Campinas, cidade das andorinhas 😉 📷: Rodrigo Espindola

Beautiful work from @computingcaitie.bsky.social and colleagues, showing the power of combining multiple approaches to studying complex in situ cell biology!

I told you it was final 😉, now we celebrate 🎉

Now THIS one was quite the journey. I'm beyond happy to see this work out in the world 🥹 Huge congrats to @computingcaitie.bsky.social and also to @hugovdhoek.bsky.social and everyone else involved ♥️ with @centriolelab.bsky.social @stearnslab.bsky.social @cellarchlab.com #Cilia #CryoET #TeamTomo

Crazy things have been happening in cilia world, catch up on them in Caitie's new paper! 🪱

It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬

📣 Two weeks left to apply! 📣 I2BC is recruiting new team leaders in molecular and cellular biology, with special attention to multidisciplinary approaches and computational biology. 🧬🧪🔬👩‍🔬🧑‍💻 We provide a great environment with top-notch technological facilities. 🗓️ Apply by April 22, 2026!

One of the problems with people not sharing things with attribution, AI etc is that we (rightly) don’t trust things that are real. This picture is making the rounds today and I’ve seen multiple ppl say it is fake. It isn’t!!!! www.nasa.gov/solar-system...

I am so sad to hear about the passing of the great Andreas Engel. Beyond the many scientific accomplishments of his career, he was an amazingly kind person who helped me a lot when I started my own lab. You will be missed Andreas 💔

RIP Andreas Engel, one of the pioneers of our field.

Sad news on the passing of Prof. Andreas Engel, a pioneer in the field of cryo-EM (shared with the 3DEM community by Henning Stahlberg). Andreas' kindness, warmth, and enthusiasm for science and his colleagues will be missed.

I love the optimism of _FINAL.docx

Why bioRxiv

The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!

Really happy to share my 1st first-author work during my PhD @embl.org co-leading with Maciek! 🥳 A serendipitous project shaped with a lot of curiosity and “coffee” (no hibernation😅) I’m really proud of the story we built together! 😊 Excited to share the final version soon with even cooler results 🤩

Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation. www.biorxiv.org/content/10.6...

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

Carbonic anhydrase catalyses the interconversion of CO2 and HCO3- and helps increasing the net-CO2 concentration inside cells. Why? CO2-reducing enzymes like RuBisCO are notoriously slow and ineffective. However, import of HCO3- is typically coupled to ATP consumption...

Coconuts

Added some of these features (notably copy-paste ligand) to the old coot-trimmings. Also added a menu item to set the proportional editing radius, which changes the "sphere of influence" of refinement to allow easy moving of larger parts of the structure (e.g. domains). github.com/olibclarke/c...

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...

"LLMs...change text in a way that significantly alters its semantic meaning...motivating future work on how widespread AI writing will affect our cultural and scientific institutions" arxiv.org/abs/2603.18161

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...

inverse microscopy