I find it... compelling 😉

and yes I had to look up the alphabet on wikipedia 🫣

I never expected to write this line of code

A protocol to solve ~30 kDA proteins by #cryoEM 🤩 - I love it!

We finally wrote up the paper for LocScale-2.0. edu.nl/pvhxv Please try it out. LocScale is evolving & we are actively building in new features and improvements. Your feedback will help us shape the next steps. Code: cryotud.github.io/locscale/ Work by @alok-bharadwaj.bsky.social and Reinier.

A masterpiece

Life on Mars? The latest results and what to do about them:

“The higher you go, the smaller the proportion of women relative to men,” she said in a 1970 Royal Institution discourse for which the recording has just been released. “This applies to all subjects, but especially to science.” www.ft.com/content/96d5...

Militares sendo condenados por tentativa de golpe num país da América Latina. Não é pouca coisa. E no dia em que lembramos do golpe militar patrocinado pelos EUA no Chile. Simbólico.

Breaking News: Brazil’s Supreme Court convicted former President Jair Bolsonaro of plotting a coup after losing the 2022 election. He could face decades in prison. nyti.ms/4pyzL3Q

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La-Proteina from NVidia to do co-design of fully atomistic protein structures (sequence + side-chains + backbone) for up to 800 residues is now open source with permissive licensing 🖥️ github.com/NVIDIA-Digit... 🗎 arxiv.org/abs/2507.09466

Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own. www.quantamagazine.org/tiny-tubes-r...

Thats not to say there haven’t been growing pains. When a great steak comes out of the microwave I get really excited. But more than half the steaks that come out of the microwave get sent back by the customer. To solve this problem I now run ten microwaves in parallel cooking ten steaks.

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social

Better ML for cryo-ET starts with better benchmarks. We built a phantom cryo-ET dataset (~500 tomograms) + hosted a Kaggle challenge. The result: community models beat expert tools. Read more in the @natmethods.nature.com article that just came out: 🔗 doi.org/10.1038/s415...

BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍

things were better when the computer lived in its own specific room and you only went in there sometimes

I can't help but think that a Dyson sphere must be some sort of very expensive and fancy design vacuum cleaner

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

This ad is an old post that Ben imported from Twitter which somehow got traction now 🤔 My position is not open AFAIK 😅

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.

Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum! www.nature.com/articles/s41...

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland

Brazil's map, by ChatGPT 5 I was born in Keras and I didn't know that

Thanks Japan for using the #ChlamyDataset

Is this a Science or a Tool cover?

1/n Dear friends, in light of the current events in Palestine and to help spread awareness, a large number of filmmakers have made their FILMS about PALESTINE AVAILABLE FOR ONLINE FOR FREE Below, we are sharing links to films that you can watch and share to spread our message to the world:

This is fascinating 🤩🦠🐚🌊

This is GenX's version of "Hedy Lamarr invented frequency-hopping technology that helped the Allies win World War II and made cellular phones possible."

If you want a weird but true fact to talk about: Dexter Holland, lead singer of The Offspring, was instrumental in this. His doctorial thesis in molecular biology was sequencing mRNA in HIV. The paper was also heavily cited in creating the COVID-19 vaccine.

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out: www.sciencedirect.com/science/arti...

Using #cryoET to investigate plant cell-cell communication 🤩🌿

Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...

📢 Excited to share our new study in Nature Communications! We show that the A-C linker safeguards centriole architecture & controls duplication. A big congratulations to Lorène for this beautiful discovery, which represents 4 years of her thesis work. www.nature.com/articles/s41...

🚨 New EMBO Practical Course! Ultrastructure Expansion Microscopy: From Cells to Tissue 🔬 📅 20–24 Apr 2026 | 📍 EMBL Heidelberg Co-organised with @banterlegroup.bsky.social @gautamdey.bsky.social 💡 Register your interest to get notified when registration opens: 🔗 www.embl.org/about/info/c...

When we worked on the thyroglobulin structure we knew it could be a great benchmark sample in a world dominated by β-gal and apoferritin. Especially because it is not as rock solid 😉

This is really important work to make #cryoEM heterogeneity analysis more robust and reproducible ♥️

Such an important feature on TotalEnergies by ITV Cycling and Matt Rendell on the Tour de France rest day programme this evening. In support: a repost of this drawing.

Long live the Supernaut! youtube.com/watch?v=qEjm...

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...

Reading about this story from the Brazilian side brings home how the US now functionally operates as an elected autocracy. Brazilian officials note how they can’t even try to negotiate diplomatically, bc there are no channels and no process. It’s only the King and his whims.

So happy to have contributed to this beautiful study led by PetrPelech! A combined theory–experiment effort based on our in situ cryo-ET data, revealing how stress-mediated growth shapes E. coli division site morphogenesis. #teamtomo 🌐 🦠🔬❄️🐎 👉📄 doi.org/10.1073/pnas...

"Trump desnuda o patriotismo antipatriótico bolsonarista para quem ainda não tinha entendido" Thiago Amparo, para variar, didático.

'Notice that Trump barely even pretends that there’s an economic justification for this action. This is all about punishing Brazil for putting Jair Bolsonaro on trial.' @pkrugman.bsky.social paulkrugman.substack.com/p/trumps-dic...

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco

Excelente episódio!