Online Now: Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii Online now:

Surely someone can make a better Martini X-mas tree?

so cheese is made of thylakoids

very unusual - a tRNA regulated anion channel

New Title Alert: CryoLithe- a supervised machine learning method to directly reconstruct the tomogram from aligned cryo-ET tilt series. The methods is trained on real measurements using FBP+cryo-CARE+IsoNet reconstructions as the reference. Learn more here: buff.ly/3jxoax3 #SBGrid #Software

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

I wonder who would put such data online 🫣

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪

Note: this bug only affects v0.3, results from v0.2 should be fine 😉

We just released version v0.3.1 of 🍦Icecream! Importantly, this fixes a bug in missing wedge correction. Please update, and let us know how it works for you! #CryoET #TeamTomo github.com/swing-resear...

not a coincidence 😉🦑

Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET! 🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...

CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

Hi #teamtomo! Want to use OME-Zarr for your tilt series but can't integrate it with your existing sub-tomogram averaging pipelines? Try zarr-particle-tools - RELION-style extraction & reconstruction built for OME-Zarr-based workflows! 📦 pip install zarr-particle-tools 🔗 github.com/czimagingins...

Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁‍♀️💎✨VIP section💅🪩🥂 Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics. s/o to #teamtomo #cryoET co-authors @hamid13r.bsky.social @attychang.bsky.social @baradlab.com

I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...

Last week, the Dodonova lab published a fascinating paper on chromatin structures in Asgard archaea, microbes thought to be the closest relatives of complex life. Asgard histones can wrap DNA into a “closed” form shared across archaea, and an “open” form similar to eukaryotic cells #sciart #blender

Many Stentors were harmed in this study (and it's great)

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

This is pretty cool! Undergrads @biozentrum.unibas.ch are learning RFdiffusion at our Structural Biology Block Course organized by @computingcaitie.bsky.social, Basile Wicky et al. 😉 www.nature.com/articles/s41...

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...

Always happy to see the #ChlamyDataset put to good use 😉

I'm pleased to announce 🍦 Icecream 🍨 v0.3! New features include: * Training on multiple tomograms (same training time, with linear increase in RAM) 🚀 * Logging and plotting of the loss function 📉 * The --scale option is now called --eq-weight for clarity 😉 We'd love to hear your feedback! 🙏🏽

imigração é um direito. fronteiras são inventadas. bichos migram, os seres humanos sempre mudaram de lugar.

Remember when Aaron Swartz downloaded JSTOR archives that he had full legal rights to download and the FBI hounded him literally to death for it? Anyway,

Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action pubmed.ncbi.nlm.nih.gov/41184282/ #cryoem

CryoWriter: A Robotic Solution for Improved Cryo-EM Grid Preparation https://www.biorxiv.org/content/10.1101/2025.11.01.686008v1

Malaria https://botfrens.com/collections/69/contents/19180

And it’s a double feature, as shown by @gautamdey.bsky.social ial & @floravincent.bsky.social for the sturdy #Diatoms! Also out today in @currentbiology.bsky.social 🌊 www.cell.com/current-biol...

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

This will be a long thread on yesterday police massacre in Rio. In nothern Rio de Janeiro city, there is a couple of hills called Complexo da Penha. It's Comando Vermelho("Red Command", a drug gang), or CV, territory. CV is the greatest gang in Rio, second in the whole Brazil. +

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

Congratulations to Yann Quilcaille, postdoc for #Climate Extremes at ETH Zurich, named to the #TIME 100 Climate 2025 list for exposing top carbon emitters driving extreme heat worldwide.

E-mail, Discord, Slack, Zulip, WhatsApp, Signal 🫠 I guess the silver lining is I never, ever, have to use Teams?

Accessible, uniform protein property prediction with a scikit-learn based toolset AIDE Artificial Intelligence Driven protein Estimation (AIDE), enables instantiating, optimizing, and testing many zero-shot and supervised property prediction methods doi.org/10.1093/bioi...

OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇

We’re back with the next DinoSphere Online Seminar! Join us on Nov 4th, we're hosting: Edmée Royen (ULiège) - Symbiodinium
 Nicolas dos Santos Pacheco (Cambridge) - Perkinsids 📅 Tue, Nov 4 - 4 PM CET/3 PM GMT 
💻 Zoom link: sites.google.com/view/dinosphere
 Please spread the word! #protistonsky

💯

Looks like OpenFold3 has been formally released in a public "preview". Not quite on parity with AlphaFold3 on a few benchmarks shown, in particular for antibody interactions. All info on the github link. I am sure we will hear more about this from the developers github.com/aqlaboratory...

📣THREAD: It’s surprising to me that so many people were surprised to learn that Signal runs partly on AWS (something we can do because we use encryption to make sure no one but you–not AWS, not Signal, not anyone–can access your comms). It’s also concerning. 1/

If you tried Icecream🍧and it seemed a little too slow, please make sure you are using torch 2.8.0 and not 2.9.0 for a 2-4x speedup. There is a known bug in mixed-precision GPU computing so please hold back from using the latest torch for now. Check our updated installation instructions:

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

João Fonseca becomes the first Brazilian to win an ATP 500 final. 19 years old. History. 🇧🇷💛

A class like no other!! From #AI structure hallucination 🤖 to #CryoEM structure reality 🔬 by @biozentrum.unibas.ch @unibas.ch undergraduate students👩‍🔬👩‍🎓 in just a few weeks! One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪