Beautiful #phage structure 🤩 Congrats to the colleagues in Brazil! 🍊🦠 www.biorxiv.org/content/10.6... #CryoEM #xanthomonas

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

Open Postdoc position in our lab! #actin #Huntingtin #cryoET #cellbio If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit. ista.ac.at/en/job/postd... Please share and feel free to reach out if there are questions!

Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁 Preprint out now 🦟🦟🦟 www.biorxiv.org/content/10.6...

This is fascinating:

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Perhaps... how life started?! www.science.org/doi/10.1126/...

From one of my favorite books ever 💜

Expectation https://botfrens.com/collections/109/contents/28542

One reason for loving science is how graciously we sometimes deal with errors. www.science.org/doi/full/10....

I'm kind of depressed to see countries like Canada frame this as an opportunity. No one benefits from the collapse of US science. And you certainly don't benefit anyone by poaching a few big names while doing no other meaningful increased investment in your own research ecosystem.

holy shit PR from an ‘agent’ gets closed so it writes a blog post with a personal takedown Some interesting comments from the maintainers too Slop machine go brr, dead internet theory x1000 github.com/matplotlib/m...

🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...

Remote homology and protein design: two sides of the same coin. Instead of finding remote homologs, we used TEA to design completely de novo proteins, folding into desired TEA sequences. I always love working with Jay, and “speed-running” this proof of concept was no exception.

We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ link.springer.com/article/10.1...

Vivian Maier's (1926-2009) photographic self-portraits in mirrors, shadows, reflections, suggest her enigmatic persona, a shadowy presence behind her camera which enabled the capture of candid moments of life #WomensArt

Crystal Gradation https://www.wikiart.org/en/paul-klee/crystal-1921

New level of publishing hell unlocked?

It's crazy hat party time! 🤠🥳 #Chlamy #CryoET #TeamTomo

This is absolutely gorgeous work from @helenfoster.bsky.social, @margotriggi.bsky.social, @gaiapigino.bsky.social and colleagues 🤩 #Chlamy cilia never cease to amaze!

"Meus textos usam IA meu pensamento, não." As colunas de jornal viraram um cemitério do estilo. O pensamento encontra seu rumo e sua forma durante o processo da escrita. Um texto bom nunca nasce pronto, ele é menos q uma intuição antes das palavras serem amassadas feito barro. Escrever *é* pensar.

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

Unsurprisingly among #CryoEM #CryoET peers 🤓🦠❄️🔬

Trapozoid cryo-FIB milling allows to prepare a lamella for dual-axis cryo-ET and assessment of different deep-learning missing-wedge restoration algorithms. rdcu.be/e2nXE

Thx for @mollyherring.bsky.social for featuring our recent work with @centriolelab.bsky.social and our quest with @gautamdey.bsky.social & the support of the @moorefound.bsky.social to look for the beauty in every #eukaryote out there using #Expansion #Microscopy #UExM

M​ichael J. O'Brien et al.: CryoJAX: a cryo-electron microscopy image-simulation library in JAX ##CryoEM##ImageSimulation##AutomaticDifferentiation@harvard@unewhaven@Cornell...##IUCrhttps://journals.iucr.org/paper?S2059798326000550

#ProtistsOnSky no 'swimming' by 𝘝𝘢𝘮𝘱𝘺𝘳𝘦𝘭𝘭𝘢, definitively no 'staying still'. just a relaxed walk towards the lunch...

For #MosaicMonday a #Roman mosaic showing the labyrinth of the Minotaur on Crete. The monster’s head is depicted in the centre. The simple depiction is alluding to the myth of Theseus, in which the Greek hero slays the Minotaur in the labyrinth with the help ... 🧵1/2 📷🏺 #Archaeology

A data-driven mosaic of our warming planet - now updated through 2025 🥵 Download graphic at zacklabe.com/climate-chan...

As cryoEM becomes automated people forget Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl JB it's measured DM it's the CTF JB it's a class ave DM it looks like the ptcls JB it comes out of ab initio DM its the structure JB FSC=0.143 DM that's the res'n JB it's modeled DM it fits the map

New Article! Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET

You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint! What a great collaboration this has been!

Excited to share this detailed biophysical study of #PhaseSeparation in the Pyrenoid, an algal microcompartment that fixes a third of the Earth's #CO2 🌏. We combine methods across scales, in vitro 🧪 and in vivo 🦠 Thanks for the very fun collaboration! 🤗 #PlantScience 🌾 #TeamTomo 🔬 #LivingPhysics 🧬🧶

The great thing about working with Rubisco condensates is that we can see individual Rubiscos using cryo-electron tomography #TeamTomo! Using this approach @phaips.vd.st was able to show that higher linker valency increases Rubisco concentration.

Check out this cool thread on the latest preprint by Gaurav Kumar, @james-r-barrett.bsky.social, @phaips.vd.st from our lab and colleagues, dissecting the physics of Rubisco condensates! You're in for some stunning #cryoET of the pyrenoid - in Chlamy, of course 😉 Congrats to all involved!

Am I the only one increasingly annoyed by cryo-EM papers not showing *any* experimental density in figures? Sometimes not even in the supplementary material??

As soon as I saw this (while cringing a bit about the hype) I thought, "ooh I really hope Philip Ball will write a post on it" and there it is 👇🏻 Thank you! 👏🏻👏🏻 😎🔥

Netcasting spiders hurl a stretchy net to capture prey, a net that can double in size during full extension. A study explores how the silk achieves such impressive elasticity without sacrificing strength. In PNAS: https://ow.ly/qRYu50Y5z8x

Love seeing the archaeal work at EMBL highlighted! 🥰 Feels great to be part of a growing community pushing this fascinating biology forward! #teamArchaea #EMBL 🧫🤓🧪🌏

When you forget to turn on high-res interpolation in 3dmod

Serge Katz magistral aqui 👇🏽

Given the weather today, it’s time to repost my favorite phase diagram: Nakaya’s snow crystal morphology. We are towards the bottom right today. 🧪 ⚛️ #cryoEM

O Agente Secreto 😉

Untitled (from Little Image series) https://www.wikiart.org/en/lee-krasner/untitled-from-little-image-series-1949

But can they scratch their backs with them?😂

Forest Witches https://www.wikiart.org/en/paul-klee/forest-witch-1938

This is an awesome thread 🐮🛠️

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET