NEW: In 2025, 43% of young American adults regularly get their news from TikTok. www.pewresearch.org/short-reads/...

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

Be our neighbour !

Rejected for nationality because I make noise after hours. 😭

Long weekend dump. Torn between going to the 🏔️ or my garden. What did I choose?….

Heritage Foundation has released an absolutely insane policy proposal to label all trans people as domestic terrorists. It uses completely made up instances of terrorism and made up statistics but facts don't matter to them. They want us all eradicated.

anyone can find the preprint? I only found : arcinstitute.org/news/hie-kin...

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

Just discovered Outlook Recall. 🥰

Went up to the highest peak Gross Bigerhorn accessible for non-equipped hikers in Europe (3626m) with the first snow should’ve had some crampons! But made it to the top!

Really excited to have been a small part of this work investigating sarbecovirus host range, receptor usage and antigenicity! www.biorxiv.org/content/10.1101/2025.09.03.673949v1

Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...

What a super storm rainbow

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

In new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2. Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion. www.biorxiv.org/content/10.1...

Computational design of allosteric pathways reprograms ligand-selective GPCR signaling [new] Comp. design infers/designs GPCR ligand responses via protein struct./dynamics. Receptor variants affect signaling.

Friends don’t use friend’s plasmids without sequencing them. For some types of plasmids from academic and industrial labs, up to 40% contained mutations academic.oup.com/nar/article/...

Just cleaning out some photos and found this gem

Asking it to think why a fusion protein of a target I was purifying was more stable and active than the cleaved version triggered a warning when I was using ChatGPT5.. So biology use is pretty much nerfed

Eating my first non-cherry tomato. Everett’s Rusty Oxheart! Juicy, sweet, weakly acidic. And those colours! It’s a rare variety but lots of seed vendors

I’m literally in a cell culture incubator. I think the first time in my life.. well other than the days before my birth

When the reviewers' identities are revealed

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

Introducing Latent-X — our all-atom frontier AI model for protein binder design. State-of-the-art lab performance, widely accessible via the Latent Labs Platform. Free tier: platform.latentlabs.com Blog: latentlabs.com/latent-x/ Technical report: tinyurl.com/latent-X

Working with @astbury-bsl.bsky.social, we report cryo-EM structures of CD163 in its apo state and in complex with haptoglobin–hemoglobin (HpHb), and propose a framework of how CD163-mediated endocytosis clears different isoforms of HpHb. Please check it out on @plosbiology.org!

Designed protein pockets recognize intrinsically disordered protein regions @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... www.statnews.com/2025/07/17/n...

The backstory here is that the Squamish people of what is now Vancouver were illegally dispossessed of this land a century ago. They sued, got their land back, and are using their sovereignty to ignore local zoning rules and build 6,000 new homes over the objections of nearby wealthy NIMBYs.

Just cleaning some resin. This batch we started using in April 2025. Cube Biotech can you ship some more over here? ;)

We then fine-tuned the model on a larger scale, to predict forces across 10K solar systems. We used a symbolic regression to compare the recovered force law to Newton's law. It not only recovered a nonsensical law—it recovered different laws for different galaxies.

To demonstrate, we fine-tuned the model to predict force vectors on a small dataset of planets in our solar system. A model that understands Newtonian mechanics should get these. But the transformer struggles.

So so true

Can an AI model predict perfectly and still have a terrible world model? What would that even mean? Our new ICML paper (poster tomorrow!) formalizes these questions. One result tells the story: A transformer trained on 10M solar systems nails planetary orbits. But it botches gravitational laws 🧵

Some science talk then off to destroying knee ligaments 1/2

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

BioEmu 1.1 can emulate equilibrium distributions of millisecond-timescale MD at many orders of magnitude speedup, bringing GPU-years down to GPU-hours.

The 0737 Saturday train out to the mountains is a great way to bump into familiar faces!

I think I’m addicted growing things. At least they’re not as disposable as Ecoli

First time on the mountain this season!

Same dataset, two different software builds, completely different results. Happy last day of work before Vacation!!!

every designed alpha helix i've built recently looks like they can be perfect cell penetrating peptide. just string R, K, and A. If youre feeling wild you can add an L

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

The videos for the recent CCP4 Study Weekend 2025 are now available on YouTube. www.youtube.com/playlist?lis...

Mapping my wifi strength. Don’t forget the most important spot.

THIS IS SO COOL!!!

Its 2025 and two atoms STILL can exist in the same space according to AF3

Here and there over Ascension

I have been logged out of my toothbrush.

High-Throughput Machine Learning-Aided Antibody Discovery for Cell Surface Antigens [new] Yeast display Fab library w/ CDRH3 diversity enables ML-driven Ab discovery against cell surface Ags, yielding diverse Abs.

AI is getting more human by the day techcrunch.com/2025/05/22/a...