Issue 22: Maternal antibody interference with rotavirus vaccination Conserved complex controls developmental & circadian timing Review: Type IV secretion systems Method: T-cell smFISH images transcription, RNA localization & fate Cover: @jomaalab.bsky.social et al www.embopress.org/toc/14602075...

matt yglesias' primary claim about politics is that to win elections, democrats should adopt the strategy which has given starmer a 13% approval rating in the UK

The Founders were so concerned about bribery that the Constitution forbids it three separate times. Two emoluments clauses ban officials—unambiguously including the president—from accepting things of value, plus bribery is the only named impeachable offense besides treason. Unprecedentedly corrupt.

Lots of people telling me they love Dad jokes, but jokes about graph paper are where they draw the line.

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“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”

Imagine trying to convince someone a decade ago that this sentence would be a 100% literally accurate description of the American political situation.

Asgard collaborative expedition begins… Falkor (too) has left Montevideo

I leave the country for a conference, and of course THIS happens. 🙃

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Join us in a highly collaborative environment. At the IMP everything is possible.

I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA! In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.

New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at @imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

‼️ Excited to share our new paper out now in @science.org ‼️ We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments. Link: www.science.org/doi/epdf/10.... Thread ⬇️ (1/8)

Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software. www.nature.com/naturecareer... Apply by 25 NOV #PostdocJobs #ScienceJobs

The human misery and massive death toll that came from ending USAID was entirely predictable. Elon Musk relied on conspiracy nuts rather than employees and development specialists. Rubio, who previously defended the agency knew what would happen. They chose this. open.substack.com/pub/donmoyni...

Trump just continually shooting our country in the face. This unwarranted (and likely illegal) destruction of Goddard is madness. It jeopardizes the next several decades of space exploration.

UK lawyers warn of ‘race to the bottom’ after Tory MP issues deportation threat

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This is terrible. www.bbc.co.uk/news/live/cm...

arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review. This is due to being overwhelmed by a hundreds of AI generated papers a month. Yet another open submission process killed by LLMs.

“Individuals on the ground sent a message that reached us Monday morning that 1,200 were dead,” Nathaniel Raymond, the lab’s executive director, said. “By that evening, they said 10,000. By Tuesday, we couldn’t reach them anymore. We assume our ground contacts are dead.”

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Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...

Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...

New lab preprint! @zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes 🧵 tinyurl.com/ukny4ptz

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

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Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Decisions, decisions…

Can we keep antibiotics working? Yes, but the world needs to follow the EU and the UK | Devi Sridhar

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Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria

The front page of nytimes.com currently features: 0 articles about yesterday's historically large protests against America's fascist government 1 article about otters stealing surfboards

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They don't think they're public servants. They think they're kings, princes, dukes, and barons. They control the government, and that makes them royalty, and that means our money should be used to buy them planes and gold-plated toys and gilded ballrooms

Helicopter view of Chicago #NoKings in Grant Park via @cbschicago.bsky.social

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Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

Our paper showing that acquired resistance to CDK inhibitors can result from simple mutations in the CDK gene is now out - thanks to Chun-Fui Lai, @vcushing.bsky.social @bjgreber.bsky.social with support from @prostatecanceruk.bsky.social @imperialsandc.bsky.social www.embopress.org/doi/full/10....

New and maybe not-so-new users: If in doubt, I suggest looking up the word in the urban dictionary. You will (hopefully) never post a “skeet” or a “skeetorial” again. Or maybe you will, but at least you will know what you are saying. 😳

I wrote a blog post about the future of structural bioinformatics. Where to go after AlphaFold? How do we avoid the field becoming a load of half-baked LLMs? Let me know what you think. jgreener64.github.io/posts/struct...

A foundational truth of this republic is it has no king.

About 120 million years ago, a pterosaur fell from the sky and died in a pond. A layer of sediment washed over it, preserving not only its skeleton, but also its stomach. The resulting fossil is the first pterosaur ever found with a belly full of plants. #NationalFossilDay https://scim.ag/4hbaedc

Oh no! The volume eraser is back! 😳

Skeetorial on our BRAF preprint! tinyurl.com/asymmBRAF The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)