Happy New Year! Check out 👀our new protocol paper on the analysis of transcription factor-nucleosome interactions! Hope you find it useful 🔬🧬Was a pleasure to write up with you @wkobayashi.bsky.social and Kikuë Tachibana!

AOC: "It's not just that Trump is corrupt. It's that everyone participating in this is corrupt — Elon is corrupt. Jeff Bezos is corrupt. Mark Zuckerberg is corrupt"

If only Americans had a recent way to know how crucial immigrants were for the success of the Manhattan Project. A big Hollywood movie where a lot of the nuclear scientist characters speak with accents and talk about fleeing Europe that makes tons of money and wins a bunch of Oscars, perhaps.

Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:

We have an opening for a research support officer. Come and join us! Please share.

it appears your manuscript "in preparation" was not published in 2025 after all, mr. bond

“These men risked their lives to speak with us. We have a moral and professional obligation to the sources who entrusted us with their stories. Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless.”

But the next time an athlete protests racism, war, genocide, or any other atrocity, we will be reminded that “fans do not want politics to be brought into football”. FIFA is such a 💩 organisation, it beggars belief.

If we treated him like a normal president he’d be in prison right now

Closing out my year with a journal editor shocker 🧵 Checking new manuscripts today I reviewed a paper attributing 2 papers to me I did not write. A daft thing for an author to do of course. But intrigued I web searched up one of the titles and that's when it got real weird...

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

For the last few months, I've been working on a story about January's crash near Washington, D.C. What I learned was that it was simply an accident waiting to happen. Special Report: The night everything at DCA finally went wrong (via @theaircurrent.com) theaircurrent.com/aviation-saf...

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An early Christmas present! The ICR’s new Hydra Bio FIB-SEM has been delivered, which will sit at the heart of a consortium between the @icr.ac.uk, Imperial, QMUL and KCL. Currently being stored at Imperial, it’ll be installed in a brand new lab at the ICR next year. Exciting things coming in 2026!🔬

Before the 1990s, plane crashes caused by microbursts used to kill planeloads of people fairly regularly. Dr. Ted Fujita and NCAR scientists figured out how to detect microbursts and warn pilots about them. Since then? Zero airliner crashes from microbursts.

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

Vault shell turducken. 👀

Here is why friends don't let friends calculate FSC on denoised half-maps. I took EMD-17961, denoised the maps using Warp's Noise2Map, and calculated the FSC between various things. With noise gone from the half-maps, their consistency is no longer related to SSNR. Denoised map vs. model still works

King Charles argued on Friday that, thanks to early diagnosis, his treatment will be reduced in the New Year. He urged people to take up cancer screening saying: “Early diagnosis quite simply saves lives.” www.bbc.co.uk/news/a... 1/10

It would be a great start if the individual methods papers could quantify the quality of their own results instead of relying on visual vibes

Great to see Samuraciclib still doing well and importantly showing benefits to cancer patients www.imperial.ac.uk/news/article...

This is sensationalist. Very well done on defusing that incident, but the plane would have kept flying. In 2023, someone managed to open a door on an Asiana Airlines flight at 650 ft altitude; in another case a door plug blew out of an Alaska Airlines 737 MAX. The planes landed safely in both cases.

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so many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution. #standupforscience

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

All travelers from ESTA countries (yes the ones on visa waiver programs) will have to disclose 5 years of social media + huge amounts of personal data to enter the US now. All US academic associations should now meet outside the US if we want to meet our international colleagues.

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

Unprecedented (to me) magnitude of screw-ups in creation of the proofs for our next paper. Extremely disappointing (not to mention stressful). 🤬

We @icr.ac.uk Structural Biology in London are very pleased to be hosting Prof. Brenda Schulman from MPG Martinsreid for her Feldberg Foundation lecture

My teen, who had dreamt of being an astrophysicist, just told me he wants to go to law school because, “Science isn’t going to be a priority in the US in the future…I don’t want a job where I’ll be constantly worried my funding will be taken away.” Gutting. How many future scientists have we lost?

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By “sovreignty” he means “states should be weak enough so that billionaires like me should be able to treat them as feudal vassals” bsky.app/profile/lora...

Considering the Dems’ performance in holding Trump accountable for all his crimes, that would appear to be a very rational assumption.

How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬 Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉 www.biorxiv.org/content/10.6...

You never know where a good idea is going to come from! Inspiration struck Prof Michael Baum on new ways of thinking about #BreastCancer treatment while watching a production of Arcadia by the late Tom Stoppard Thanks to @harrywallop.co.uk for sharing this from the @thetimes.com #CanSky #OncoSky

New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them? www.biorxiv.org/content/10.1...

CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!

This has now been published in print! Check it out: www.science.org/doi/10.1126/...

Very bad (in Sci Rep).

As usual, Gary Kasparov gets the essence of everything that's going on with Witkoff and the Kremlin... about which most of which the Beltway media hasn't got a clue. Read the whole thing. www.thenextmove.org/p/diplomacy-...

What do you think? Real SDS-PAGE gel or AI-generated ?

Exactly. Just copying two research topics from the website will not cut it. Even worse if applicants additionally want to benefit from my "exquisite leadership" at our "eminent institution". It is best to write like a real person with real interests. We are recruiting people, not LLMs, to our labs.

I've taken a deep dive into the DOGE bro's open source software code commits to verify they never wrote (or even oversaw) any code beyond culture war messaging. It's all trivial stuff like this: taking out the "nonbiary" option on some form.

We saw it with big tobacco, we saw it with the fossil fuels industry. When their own internal research showed the harm from their product, the defunded the research and attacked independent researchers coming to the very same conclusions. #ScienceUnderSiege

Imagine if Biden and his DOJ had cared about protecting democracy as much as the Brazilians do. The US, and the world, would be a different place.

Scientific journals: we don’t want you using generative AI because it makes shit up. Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote Same journal: AI cover art which makes no sense? Oooh!

Image screening is going to fail. We need audit trails for data provenance.