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There's a persistent fantasy that maybe some other nice countries will start mass-hiring US scientists. That's not going to happen. A few high-profile, big name researchers will get poached, sure. But most countries, including some very nice ones, are underemploying their own scientists already.

⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

"Optimised for presentation" is what this is? 🤯🫣

Looks like this is snowballing. 👀

"It is difficult to get a man to understand something, when his salary depends upon his not understanding it" -- Upton Sinclair

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Our first ‘Pearl and Pearl’ husband+wife paper out in Bioinformatics - cool toolkit for analysing cancer gene dependency data to find therapeutic targets and biomarkers using complex cancer profiles @gdsc-sussex.bsky.social @icr.ac.uk academic.oup.com/bioinformati...

Political is when a black quarterback silently kneels Not political is when a white quarterback introduces the president’s speech at a campaign rally

I assigned random gender/ethnicity labels to scientific abstracts from the literature and then asked Claude to do a thematic analysis. Claude identified a clinical versus computational split for female/male authors and a DEI focus for Black/URM authors. All in completely random data.

@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...

Lol I finally heard back from the "journal" They said, and I quote: "That's not you". Hmm....

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇

Don't write your manuscript reviews using AI. DEFINITELY do not feed someone else's manuscript into AI and have it write the review for you.

Microtubules at 2.2 Å resolution. 👀

My heart agrees with this, my brain says "not so fast".

The architecture of carriers formed by AP3:ARF1 for lysosomal membrane protein transport: www.science.org/doi/10.1126/.... Work from @jggkaufman.bsky.social, in collaboration with @dgershlick.bsky.social and David Owen. @mpibiochem.bsky.social @thecimr.bsky.social

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

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“Odd”? Considering that two of the issues this government cannot stop talking about - economic growth and immigration - are directly affected by Brexit, explicitly ruling out EU membership is what is odd.

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Amazing stuff. petapixel.com/2026/05/08/p...

First, I would like to discuss Pratik Basnet’s study. Pratik has just defended his thesis and has some very cool stuff to come out in future, but this nice work is the focus today /7 bsky.app/profile/gene...

Over the past 5 years, 50 structures of full-length HECT-type ligase constructs have been deposited in the PDB. What have we learned from these studies, and what key questions remain open? Check out our new review on this exciting and fast-moving field: www.jbc.org/article/S002...

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This is the horror cherry on top of the egregious fraud, waste, and abuse sundae. DOGE fired the people who send NIH money to research labs—which is a complicated process—so now even more labs are going to go under. All while Jay Bhattacharya goes on a podcast and says no NIH funding was cut.

it's the 23 year anniversary of when bill clinton got a haircut

This is the way

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Oh look, it’s us! 😉

Why did Trump pardon drug trafficker and Honduran president Juan Hernández? According to leaked audio tapes, it was an initial payment in part of a agreement between Trump, Bibi, and others to take down Mexican president Claudia Sheinbaum. english.elpais.com/internationa...

Reminder: bioRxiv has Contradictory and Confirmatory Results categories to encourage studies of reproducibility. Yaniv Erlich had the previous record (hours) for demonstrating irreproducibility of a paper. Now apparently we have a negative time interval 😉

Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...

The single most defining thing Elon Musk has ever done is killing untold numbers of people by having DOGE illegally raid and disband USAID. Not rickets, not cars, not even the CSAMbot on X. It’s this, and so many media pundits just choose to unsee it.

Makary has to be out. This is obscene

Painful but true. "May the Fourth Be With You" was originally a Tory campaign slogan, coined for Margaret Thatcher on election day in May 1979...

One of the problems with hayfever (pollen allergy) is that when you yell at plants, people tend to stare and call the police. So I have provided this handy thread of pollen grains under high magnification (electron microscopy) for my fellow-sufferers to channel their rage at.

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Cartoonists were on fire this week! 🔥 #DemVoice1 #ProudBlue #Pinks #TrumpIsACriminal

Sub-2 Å cryo-EM structures of transcribing RNA polymerase II reveal critical roles of water molecules in catalysis #CryoEM www.cell.com/molecular-ce...

We have reached the phase where scientists and public servants are removed from their homes by armed agents and thrown in jail - based on phony charges. Yet, where are the Academies, societies, institutions, and scientific leaders? Deafening silence. Which is a choice. History will not forget.

Amazing! Well done Lori! 👏

Somewhat related: Not too long ago, Peking University in Beijing offered to move my lab there and give us... *many* electron microscopes. I still think about that from time to time...

🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬 www.biorxiv.org/content/10.1...

The early release version of our #cryoEM work on CDK11-cyclin L-SAP30BP has now been published at Nature Communications: www.nature.com/articles/s41... We got very helpful comments from the reviewers and added more structural analysis and biochemistry to support our conclusions. Please have a look!

Except that only one half of this statement is true.

It's a wrap! Thanks to all the organisers (@haicovanattikum.bsky.social, @titiasixma.bsky.social, @sylvie-noordermeer.bsky.social, @luijsterburglab.bsky.social, @thedownslab.bsky.social, and many others) for assembling this fantastic conference. One of the best meetings I have attended so far!

Trump and Elon Musk destroyed most of the global H.I.V. program that saved hundreds of thousands of lives in Zambia. Now the US is threatening to cut remaining support, unless Zambia gives access to the country’s mineral resources. www.nytimes.com/2026/04/25/h...