A beautifully crafted summary of the extraordinary discovery in the lab of my @mrclmb.bsky.social colleague @philholliger.bsky.social of a tiny RNA that can replicate RNA.

Just posted our latest, led by Consuelo Perez and Pierre Murat, showing the intimate relationship between transcription, DNA supercoiling and chromatin architecture during human stem cell differentiation. Thanks to all at @mrclmb.bsky.social doi.org/10.64898/202...

Required reading for everyone interested in the synthetic genomics - @adrianwoolfson.bsky.social's new book 'On the Future of Species' is published today (Charles Darwin's birthday). Here's the man himself at the launch last night at @dauntbooks.bsky.social in Marylebone. (Photo: Wes Robertson)

I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee.. A few points and new information that bioscientists may find interesting... A 🧵

Ever worried that your redesigned genome might not replicate as expected? Well, help is at hand with a genome language model for replication origins from the Boemo lab (with a little bit of help with some new data from us). www.biorxiv.org/content/10.6...

Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry. Read more: www.nature.com/naturecareer... Apply by 11 FEB #PostdocJobs #ScienceJobs

Deeply saddened by the sudden death of David Abulafia at the weekend. A brilliant historian of the Mediterranean and a Fellow of @caiuscollege.bsky.social for over 51 years. We will miss him enormously.

Our beloved and long-serving @mrclmb.bsky.social PNAC Divisional Administrator Michele Hare has retired. We gathered to wish her well and a long, happy and music-filled retirement.

Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social. www.nature.com/articles/s41...

Tree Court @caiuscollege.bsky.social without, err, its trees. Sad but it provides a marvellous architectural vista from 15th - 19th century

Christmas Holiday project - completed the mixing & edits of Margaret Phillips’ recital on the G.P. England organ in St. John’s, Chichester for the Historic Organ Sound Archive. Transport yourself back with the sounds of a wonderful Georgian instrument and the music of the time.

We have an opening for a research support officer. Come and join us! Please share.

Quite … have a just a little mercy on your editors and reviewers! 😊🎄

Our latest offering from the British Institute of Organ Studies Historic Organ Sound Archive in which you can hear Ben Sheen exploring the delights and outer reaches of fifth-comma meantone tuning in pieces by John Bull and Michelangelo Rossi among others. www.youtube.com/watch?v=XfvQ...

Fantastic news! Core funded institutes are often a highly efficient way of doing impactful science. Good to speak with one voice. 🥳

A great explainer from @rogerhighfield.bsky.social on the first step towards building human genomes, published in @science.org today. #SynHG blog.sciencemuseum.org.uk/how-to-build...

A key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...

"Scientific Reports likely to generate >$100M this year...When a journal publishes 45K articles...some bad papers will be published. The big unknown is whether [the now infamous “Factor Fexcetorn” paper] is the visible tip of a research integrity iceberg" newsletter.journalology.com/p/another-on...

Congratulations Dr.Zeller! Thanks to @niakanlab.bsky.social and Prof Doug Higgs for giving him a good grilling.

After deleting the lab Twitter/X account last year, here we are at last on Bluesky. Some exciting things to come, and some occasional bits and pieces that are just generally fun and interesting (to me at least).