Big congratulations to the authors! 🎉🦠 Using RNA-seq, this study uncovers overlooked viral RNA species and supports a premature termination model for astrovirus subgenomic RNA synthesis, resolving a long-standing replication mystery. 🔬✨ #NARMolecularMedicine #Virology @universitypress.cambridge.org

Few cancer driver mutations have been identified in promoters, maybe for technical reasons. New assay targets >3,000 promoters — hits in CDK4, SMAD3, and GATA3 in breast cancer provide promising leads for functional follow-up. academic.oup.com/narcancer/ar... #CancerGenomics #NonCoding #Promoters

📣 Applications are open for the next Editor‑in‑Chief of NAR Cancer! 📣 Lead an open‑access journal at the forefront of nucleic acids and cancer research. We welcome applications until 1st Aug 2026. More details: academic.oup.com/narcancer/pa... #NARCancer #EditorInChief #CancerResearch

⭐ #NARBreakthrough! ⭐ New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding. 📖 Read here: doi.org/10.1093/nar/...

⭐ #NARBreakthrough! ⭐ 🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity. 📖 Read the article: doi.org/10.1093/nar/...

How do memories last a lifetime when proteins turn over in months? A new NAR review by Peter Cook suggests long‑term memory may stem from transcriptional gene clusters and even pyrophosphate shaping calcium signals. 📖 doi.org/10.1093/nar/... #LongTermMemory #Transcription #ReviewArticle

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

⭐ #NARBreakthrough ⭐ New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource

⭐ #NARBreakthrough! ⭐ 🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers. 📖 Read here: doi.org/10.1093/nar/...

📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation

🔬 Modern #bioinformatics workflows are complex and hard to reproduce. #systemPipeR helps researchers design, run, and track analysis #pipelines in one framework, integrating R + bioinformatics tools, HPC support, and automated #reports for #transparency. Read more doi.org/10.1093/narg... #NARGAB

How does c-MYC overexpression drive transcriptional rewiring in cancer? Sundaram et al report a plausible mechanism involving co-option of TRE/AP1 sites, mainly at enhancers, rising with MYC levels and linked to repression. academic.oup.com/narcancer/ar...

HSF1 drives cancer stress resilience but is hard to target—clever screen identifies spliceosome helicase DHX8 as a druggable regulator of HSF1 splicing→HSF1 program gone, cancer loses stress defenses. Editor's Choice in NAR Cancer. #PrecisionOncology #Spliceosome academic.oup.com/narcancer/ar...

✨A new review in #NARMolecularMedicine explores how #mitochondrialDNA inheritance, copy number changes, and coordination with the nuclear genome shape development, and how #AssistedReproductiveTechnologies may disrupt this balance. Read the review here: doi.org/10.1093/narm... #EditorsChoice

⭐ #NARBreakthrough ⭐ 🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...

Huge congratulations to Tomáš Brůna @tomasbruna.bsky.social and John T. Lovell @jotlovell.bsky.social on their new paper in NAR Genomics and Bioinformatics!! 🎉🚀 Absolutely fantastic work—excited to see this contribution making waves in the field! 👏🔥

📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation

📣 NAR Cancer Call for Papers: Seeds of Cancer, Decades of Silence. Submit work on early cancer initiation, ageing, environment, clonal evolution, genome maintenance and more before July 2026. 👉 academic.oup.com/narcancer/pa... #NARCancer #CancerResearch #Genomics #Epigenetics

⭐NAR Breakthrough! ⭐ Back-to-back NAR studies show #Palbociclib binds #HIV TAR RNA with low affinity & striking specificity. Induced-fit RNA refolding creates a #druggable pocket, blocking #SEC recruitment.📖 Read the articles here: doi.org/10.1093/nar/... doi.org/10.1093/nar/... #DrugDiscovery

⭐ #NARBreakthrough! ⭐ 🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨ Read the full article here: doi.org/10.1093/nar/... #AlternativeSplicing

⭐NAR Breakthrough! ⭐ 🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social Read the full article here: doi.org/10.1093/nar/...

#SpinalMuscularAtrophy (SMA) is treated with the ASO Nusinersen (Spinraza™) to restore SMN via SMN2 splicing. 🧬 New work reveals diverse off-target effects linked to its chemistry—and shows how to mitigate them. 🚀 #NARMolecularMedicine #RNATherapeutics #ASO 🔗 Read here: doi.org/10.1093/narm...

Happy to share our paper in collaboration with cancerbits.bsky.social. We used machine learning & ATAC-seq to refine erythroid differentiation protocols. Recipes for lineage differentiation are written on chromatin! @stanna-ccri.bsky.social @cemm.oeaw.ac.at

Thank you @narjournal.bsky.social for highlighting and appreciating our most research, a method to find efficient differentiation protocols that make the great cells in the lab with less resources and more insight. Do you want to apply this to your favourite cells? Let's talk!

⭐ #NARBreakthrough! ⭐ 🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency. @stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...

🧬 #NARGAB New Research Spotlight Direct #RNA #nanopore sequencing reveals the most detailed #m6A map to date across Human immunodeficiency virus 1 transcripts #HIV-1. @cnrs.fr @i2bcparissaclay.bsky.social 👉 Read the full paper: doi.org/10.1093/narg...

🔬 New study highlights a novel siRNA polypeptide #nanoparticle targeting TGF β1 and VEGFR2 to overcome ICI resistance in #melanoma. In mice, it cut tumor growth, improved survival, and reduced #metastasis. Read the full article here: doi.org/10.1093/narc... #NARCAncer #Immunotherapy

🧬 A common ID3 gene variant, rs11574, found in up to 30% of some populations, alters the #ID3protein and disrupts its interaction with E12. ✨ New research shows this change affects gene expression and cell function, offering insight into #diseaserisk. 🔗 Read the paper here: doi.org/10.1093/narm...

⭐ Explore the NARCAN 5th Anniversary Symposium Collection! 🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more! Read here: lnkd.in/ezznFh2f #NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability

⭐ NARGAB Editor’s Choice: DecoDen integrates multiple epigenomic assays to correct chromatin‑related noise, giving cleaner data and clearer insights. 👉 doi.org/10.1093/narg... #NARGAB #Epigenetics #Genomics #Bioinformatics #PrecisionMedicine

⭐NAR Breakthrough! ⭐ #RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪. Read the full article here: doi.org/10.1093/nar/...

⭐NAR Breakthrough ⭐ New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social 🧬Read more: doi.org/10.1093/nar/...

⭐NAR Breakthrough! ⭐ 🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/... #NARBreakthrough

🌟 2026 Nucleic Acids Research Database issue 🧬 182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54... academic.oup.com/nar/article/... @danielrigden.bsky.social

⭐NAR Breakthrough! ⭐ 🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival. 🧬Read more: doi.org/10.1093/nar/...

⭐NAR Breakthrough! ⭐ 🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/... #NARBreaktrhough #RNA #StructuralBiology

🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/... #NARBreakthrough #RibosomeBiogenesis

Congratulations @simrouxvirus.bsky.social @maureenbug.bsky.social @titus.idyll.org @taylorreiter.bsky.social @ucdavis.bsky.social on this fantastic publication, and thank you for this informative thread! #NARGenomics #NARGAB #EditorsChoice #GenomeAssembly #Sequencing

📢 Read this timely review in #NARCancer! 🧬 Gueble and Menon highlight the critical role of #DNAhelicases in linking #DNAdamage recognition with #repair. The review includes a curated table of #clinicaltrials on #helicaseinhibitors. Read it here: doi.org/10.1093/narc... @yalepress.bsky.social

We're excited to release metaTraits.embl.de! 🦠 Interactively explore 140+ 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗽𝗵𝗲𝗻𝗼𝘁𝘆𝗽𝗶𝗰 𝘁𝗿𝗮𝗶𝘁𝘀, harmonized & integrated from culture-derived collections 🔬 & genome-based predictions 🧬 for >2M MAGs & genomes. Publication at NAR: doi.org/10.1093/nar/... @narjournal.bsky.social #microsky 🧵 1/8

From one of the @ebi.embl.org team, published in @narjournal.bsky.social #NARDatabaseIssue | ChEBI: re-engineered for a sustainable future | #Bioinformatics #Database #Chemistry #OpenData #OpenScience #ChemicalEntitiesofBiologicalInterest 🧬 🖥️🧪🔓 ⬇️ academic.oup.com/nar/advance-...

📢Paper spotlight in NAR Cancer 🧬 A new study in #NARCancer introduces #THRESHOLD, a novel framework that measures gene expression “saturation” 📊—how consistently genes are expressed across cancer patients! Read the full article here: doi.org/10.1093/narc... #Transcriptomics #PrecisionOncology

🚨 Out in NAR @narjournal.bsky.social! Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences. 📄 Paper: doi.org/10.1093/nar/... 💻 DB: bcglab.cibio.unitn.it/hapscoredb #Bioinformatics #Genomics #ProteinLanguageModels #CompBio

⭐ NAR Breakthrough! ⭐ 🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back! 🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity. 🧬 Read more: doi.org/10.1093/nar/...

⭐ NAR Breakthrough! ⭐ 🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race. 🧬 Read more: doi.org/10.1093/nar/... #NARBreakthrough #Microbiology #PhageBiology #BacterialDefense

⭐ NAR Breakthrough! ⭐ 🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors. 🧬 Read more: doi.org/10.1093/nar/... @nebiolabs.bsky.social @pasteur.fr #NARBreakthrough

⭐ NAR Breakthrough! ⭐ A community-driven collection uniting 52 phages, 74 Klebsiella isolates, and extensive genomic + phenotypic data — all freely available at klebphacol.org. 🧬 Learn more: doi.org/10.1093/nar/... @fnobrega.bsky.social @danielarothschild.bsky.social #antimicrobialresistance

📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬 🔍Find out more: academic.oup.com/narmolmed/pa... 👉Submit: mc.manuscriptcentral.com/narmme #CallForPapers #Genomics #RareDiseases #NARMME

🧬 New in NARGAB: A fast, scalable CHT method identifies genomic regions with shared effects across traits. Applied to psychiatric pleiotropy and cucumber virus resistance. Read: doi.org/10.1093/narg... #CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics

🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan. Read: doi.org/10.1093/narm... #Alzheimers #RNAsplicing #Neurodegeneration