Davide Seruggia (@dseruggia.bsky.social)

I am pleased to share a new preprint from my postdoc in the @dseruggia.bsky.social lab. We discovered a structural dependency within the CORE module of the transcriptional coactivator SAGA, which regulates the stability of its histone acetyl transferase, KAT2A. www.biorxiv.org/content/10.1... 1/n

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Disruption of the SAGA CORE triggers collateral degradation of KAT2A The SAGA transcriptional co-activator complex regulates gene expression through histone acetylation at promoters, mediated by its histone acetyl transferase, KAT2A. While its structure and function ha... https://www.biorxiv.org/content/10.1101/2025.07.24.666361v1.article-metrics