🧪The lab of @dseruggia.bsky.social's at @stanna-ccri.bsky.social explores gene regulation in pediatric #leukemia. “Most of what we learn in cancer research in adults does not apply to pediatric cancer,” he said at the 𝘞𝘪𝘦𝘯𝘦𝘳 𝘒𝘰𝘯𝘻𝘦𝘳𝘵𝘩𝘢𝘶𝘴. 👉 bit.ly/4dUbn9q

🧬 𝗔 𝗻𝗲𝘄 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝘁𝗼 𝗳𝗶𝗴𝗵𝘁 𝗰𝗵𝗶𝗹𝗱𝗵𝗼𝗼𝗱 #𝗹𝗲𝘂𝗸𝗲𝗺𝗶𝗮 In a @natcomms.nature.com paper, researchers from @dseruggia.bsky.social's group at @stanna-ccri.bsky.social & CeMM show that collapsing the SAGA scaffold destabilizes & degrades KAT2A, stopping #AML cell growth. 🔗 bit.ly/484XvFv 📄 bit.ly/4cPghT5

What are the roles of UFMylation during ribosome-associated quality control? @gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER link.springer.com/article/10.1...

I’m very happy to be part of our FWF “Emerging Fields” consortium! Together with @gekaragoz.bsky.social, @sebastianfalk.bsky.social and CCRI/CeMM/VetMedUni colleagues Eleni Tomazou, @dseruggia.bsky.social and @floriangrebien.bsky.social, we will study the ribosome code in pediatric cancers.

Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing @natcomms.nature.com @dseruggia.bsky.social @lucapinello.bsky.social @danielevanbauer.bsky.social www.nature.com/articles/s41...

Happy to share our paper in collaboration with cancerbits.bsky.social. We used machine learning & ATAC-seq to refine erythroid differentiation protocols. Recipes for lineage differentiation are written on chromatin! @stanna-ccri.bsky.social @cemm.oeaw.ac.at

If you want to become an expert in #zebrafish research, apply for the 2026 Zebrafish Development & Genetics course! You will be working in small groups taught by leaders in the field, which can be a transformative experience! Application deadline: March 2 www.mbl.edu/education/ad...

📣 Join the @viennabiocenter.bsky.social #SummerSchool 2026! Check out the opening in CeMM Adjunct PI @dseruggia.bsky.social's lab & work on targeting chromatin regulators in leukemia. Find out more & apply now ➡️ bit.ly/4plpBmI

Join us for the second iteration of our yearly, St. Anna CCRI Symposium. This year, we will host experts in Cell Fate in Cancer and Development. Don't miss it!

⬇️ Our latest work on the #SAGA complex - see thread from @paulbatty1.bsky.social ⬇️

I am pleased to share a new preprint from my postdoc in the @dseruggia.bsky.social lab. We discovered a structural dependency within the CORE module of the transcriptional coactivator SAGA, which regulates the stability of its histone acetyl transferase, KAT2A. www.biorxiv.org/content/10.1... 1/n

This also reminds us what an emotional rollercoaster science can be! :)

In a couple of days at Van Swieten Saal in Vienna: join us for an immersive afternoon with six fantastic speakers, and learn more about #pediatric #cancer & #epigenetics.

📣Funded #PhDposition! – Pls RT! Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging. Join us @VetmeduniVienna in a vibrant research environment! #CancerResearch #PhD 👉 euraxess.ec.europa.eu/jobs/302158

Let's start with a group picture of the seruggialab.com 🐁🩸🧬 :)