This is a video summarizing our recent paper (www.nature.com/articles/s41...) youtu.be/eNY2CRlYTRo

And the 4th paper in this week contribution from our lab tells about ribosome biogenesis in yeast. A follow-up story from our wonderful collaborators in Graz - the Bergler Lab. Structural work was again done by the amazing @lgrundmann.bsky.social: academic.oup.com/nar/article/...

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

GERMAN PRESIDENT STEINMEIER: “.. the United States has broken with the values that it helped to establish .. “.. we have now moved beyond the stage where we can lament the lack of respect for international law or the erosion of the international order; we are far beyond that, I believe.”

Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner. #piRNA #histone #mRNA #maternal #RNAbiology #RNASky www.biorxiv.org/content/10.6...

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1

Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...

📢 New preprint: Experiment-guided AlphaFold3 resolves accurate protein ensembles. doi.org/10.1101/2025... AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇

As 2025 comes to an end, it’s time for me to say good bye to my postdoc home during the past 6 years – the Pauli lab @pauligroup.bsky.social @impvienna.bsky.social

Come discuss recent breakthroughs in RNA biology, from molecules to organisms, at the EMBO | EMBL Symposium 'The complex life of RNA'! 👉 s.embl.org/ees26-12-bl Submit your abstract by 7 July and present your research at #EESRNA 🥼

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

When transposons jump, genomes diverge - even in cultured cells. I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)

Professorship in plant genetics. The Botanical Institute at Kiel University is advertising a W2 professorship. Great opportunity to do plant research in the north of Germany. See: www.berufungen.uni-kiel.de/de/dateien/o...

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

🎉 Congrats to @kgaurav.bsky.social, Lukas Stelzl & @reneketting.bsky.social (SFB1551) on their new Biophysical Journal paper! #MUT16 #PhaseSeparation #MutatorFoci #SmallRNA #GeneRegulation #Celegans #ProteinAssembly #RNAResearch #MultiscaleSimulations Great teamwork👏👏👏 www.cell.com/biophysj/ful....

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

This guy…..

Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor! www.nature.com/naturecareer...

Congratulations Marco and team. Great to see it published 🎉

🚀 Group leaders Peter Schlögelhofer, Robert Konrat, and @sebastianfalk.bsky.social have secured @fwf-at.bsky.social projects, bringing in nearly €1.5 million. Their projects span mRNA processing, novel NMR methods, and chromosome architecture ➡️ tinyurl.com/3a6j3pw8 @univie.ac.at @meduniwien.ac.at

If only funders saw the bigger picture… The obsession with medical research has come at a cost: plant biology has been sidelined, with countless discoveries stalled. Just look at Barbara McClintock, who discovered mobile genetic elements—only to be dismissed at the time of her groundbreaking work.

Reisen mit Deutschen Bahn; immer wieder ein Erlebnis, leider selten ein schoenes. ICE228 von Wien nach Wue; 5 h Fahrt und nur drei funktionierende Toiletten im ganzen Zug. Der Zug ist voll.. mehr als 20 minuten Anstehen fuer menschliche Beduerfnisse. @deutsche-bahn.bsky.social @bahn.bsky.social

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1 www.cell.com/cell-reports...

www.nature.com/naturecareer... UBC LSI Job!!

🚨 Out now! The Leonard lab reveals in @pnas.org that phosphatases PHLPP1/2, once thought to dephosphorylate Akt and suppress tumors, are actually catalytically inactive. Instead, they have a non-catalytic role, reshaping our understanding of Akt regulation ➡️ tinyurl.com/hf28b3mu @univie.ac.at

This is Yale Professor Timothy Snyder, who studies authoritarians and tyranny, with a warning. He and another Yale professor, Jason Stanley, who studies similar topics at Yale, are moving to Canadian universities, a result of the political and academic climate here.

Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published: www.pnas.org/doi/10.1073/... The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n

📯📯📯 10 days left to apply for the International Master MemBioMed "From Membrane Biology to Neuroscience & Experimental Medicine". Scholarships available for selected students to acquire intensive training in analysing the complex behavior of biomembranes and exploiting their therapeutic potential 👇👇

Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...

Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social

One week left to register and submit abstracts for being considered for talks at our upcoming #EMBO Meeting "RNA Meets Protein Degradation" in Vienna! Check out the program with a fantastic line-up of speakers, including keynotes by Rachel Green and Manu Hedge. meetings.embo.org/event/25-rna...

Microtubules in Asgard archaea @cellpress.bsky.social @pilhoferlab.bsky.social www.cell.com/cell/fulltex...

🎉 Today, we look back on a milestone moment in Perutz history! On this day in 2005, the rectors of the University of Vienna and the Medical University of Vienna, Georg Winckler and Wolfgang Schütz, signed the notarial deed, officially establishing the Max Perutz Labs. 🧬🎊 #MaxPerutzLabs20Years

This is what we’ve come to, and so quickly.

Mit einem offenen Brief fordern Wissenschaftler aus ganz Deutschland die neue Bundesregierung auf, Klimapolitik ernst zu nehmen – und sammelten innerhalb weniger Tage mehr als 12 000 Unterschriften von Kollegen. www.saarbruecker-zeitung.de/sz-spezial/k...

Dass eine der letzten Dinge, die Sahra Wagenknecht als Abgeordnete des Deutschen Bundestags tut, eine Empfehlung an ihre alte Partei, mit der AfD zusammen zu arbeiten, ist, bringt diese politische Laufbahn auch irgendwie sehr auf den Punkt.

A fantastic meeting of early career researchers in Vienna this week. It was great to see old friends and to meet new people. Thank you so much for the opportunity to present my work at SY-Stem 2025! @impvienna.bsky.social @imbavienna.bsky.social @maxperutzlabs.bsky.social

Interesting! #RNADecay #RNAExosome #RNA #ncRNA Defining the roles of the #Integrator, #NEXT, and #nuclear #exosome complexes in #Drosophila #oogenesis Yongjin Lee, Adriano Biasini, Cindy Tipping, Seong Hyeon Hong, Phillip Zamore www.biorxiv.org/content/10.1...

ACTION ITEM I was chatting with a young scientist who expressed concern re the multiplicity of ongoing issues Over the course of our conversation, we arrived at the idea of a DASHBOARD where issues could be tracked If anyone is interested in helping with this (ideally with expertise) please DM me

Join us in Vienna for exciting #RNA biology! The deadline to submit an abstract for a talk is Friday, February 28th. #microsymposium2025 #smallrna #events #vienna

Reminder - still one month to apply to be a tenure track group leader at MRC LMB. Please do reach out for any information.

#theconferencetoendallconferences ... it's coming! Registration should (will!) open on March 1st, we are working on it, the web is being born thanks to ITs from @imgprague.bsky.social working day & night ... I just tested the registration site ... get ready.