Wilfling Lab (@wilflinglab.bsky.social)

Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with ‪@kraftlabfr.bsky.social‬ www.nature.com/articles/s41... Short teaser below 👇👇👇

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Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ... https://www.nature.com/articles/s41556-024-01572-y