What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

10 years after the first FAMSA paper, its successor is now published in Nat Biotech! We believe that FAMSA2 can enable analyses of large protein collections that were previously unattainable. Thank you, Andrzej and Cedric, for great collaboration www.nature.com/articles/s41...

A useful review on the molecular mechanisms of #Parkinsons-associated PINK1/Parkin-mediated mitochondrial quality control - from www.cell.com/trends/bioch...

🚨 Paper Alert! In this new work published in @jcellsci.bsky.social we shift our focus on MTFR1L and the feedback loop linking mitochondrial fission, mitophagy and apoptosis. MTFR1L emerges as a critical coordinator of the fission and autophagy machinery. 🔗Find the paper here: doi.org/10.1242/jcs....

A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery #NBTNV go.nature.com/4s4X7P7 rdcu.be/fdfzQ

The reticulon homology domain of Pex30 generates membrane curvature at ER subdomains for lipid droplet biogenesis www.biorxiv.org/content/10.6...

Awesome!

There are still spots available (get them while they last) for the 2026 Lysosomes and Endocytosis GRC (June 14-19, 2026). APPLY NOW if you are interested. Newcomers to the field or old friends, everyone is welcome! www.grc.org/lysosomes-an...

Interesting report from the Michael J Fox Foundation - the #Parkinsons Biomarkers Pipeline Report (V3) - an amazing resource! zenodo.org/records/1713...

Please check out our recent review on Parkinson's disease. The focus is on how cell-autonomous vulnerability factors and non-cell-autonomous triggers such as infections may interact to lead to neuronal loss. ASAP-supported work. @asapresearch.parkinsonsroadmap.org www.cell.com/trends/neuro...

How do peroxisomal import receptors return to the cytosol while maintaining the membrane's permeability barrier? We solved cryoEM structures that demonstrate: 1) how receptors find and engage the recycling complex 2) engage with a transiently gated pore t.co/KhqWKJh758

Updated preprint 🧵 We mapped how loss of 23 LSD genes reshapes neuronal proteomes in cortical (iN) and dopaminergic (iDA) neurons New in v2: We added a computational PPI pipeline assessing KO-dependent vulnerability at the interaction and complex level.

More on the potential protective effect of LRRK2 variants in GBA1-PD: Researchers demonstrate that in response to IFNγ-induced inflammatory stimulation of #Parkinsons-patient derived microglia, LRRK2 kinase & GCase activities are positively correlated www.nature.com/articles/s41...

Our paper on [Bentopy](doi.org/10.1002/pro....) is out in Protein Science! We developed Bentopy to make assembling large-scale MD models more accessible, building on what we learned from trying to simulate whole-cell models. Here's our updated Martini JCVI-syn3A cell model👇

Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social

That looks like an amazing resource!

No bull: This Austrian cow has learned to use tools. Learn more: https://scim.ag/3LYTXNd

Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions. www.biorxiv.org/content/10.6...

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET