Thanks for highlighting our work on combining AI-based organelle dynamics detection in phase contrast with fluorescence! www.nature.com/ncomms/edito... @natcomms.nature.com and Nelio Rodriguez. Spearheaded by @wl-stepp.bsky.social with collaborators @jclandoni.bsky.social @maweigert.bsky.social

I’m honored to be part of the next GRS Single Molecule Approaches to Biology, thanks Chairs @qmsmith.bsky.social and Alba Gomez Segalas for organizing this great event! The GRS is a wonderful opportunity for young scientists to share their exciting science and build communities. See you there!

@lycasworks.bsky.social developed quantitative expansion (qExM) to estimate endogenous protein quantities in situ. His ExM protocols offer epitope preservation and accessibility so that standard Western Blot antibodies can be used. Also, check out the cristae, supercomplexes, specialized mitos 🤩

Ultra excited to launch an ERC Synergy project with amazing partners Kai Johnsson @mpi-mr.bsky.social & Wanda Kukulski @unibe.ch! MitoContact will reveal how contacts between identical organelle partners can yield a diversity of important functions, via dynamics, structure and physiology.

I’m excited about this unique meeting, which will bring together some of my favorite scientists working on organelle biophysics and mechanics! I hope to see some of you in beautiful Barcelona in February. Deadlines have been extended: Dec. 8 abstracts Dec. 20 registration

Ep. #3 of The Lemma Journal Club! www.patreon.com/posts/mitoch... Paper: "The biophysical mechanism of mitochondrial pearling" by G. Sturm, @kayleyhake.bsky.social, ... @amsikking.bsky.social ... @sulianamanley.bsky.social @jclandoni.bsky.social @wallaceucsf.bsky.social

This was a delightful meeting, thank you @nynkedekkerlab.bsky.social, @achilleskap.bsky.social , & @lumicks.bsky.social . I had a great time meeting UK’s young single molecule enthusiasts, so many exciting posters!

Interesting! Scientists outside of Europe looking to move to the EU or Switzerland can benefit from this funding opportunity, it includes up to an additional €2 million beyond the grant cap for setup costs.

Our latest preprint www.biorxiv.org/content/10.1..., describes Willi Stepp’s project to make smart microscopy even gentler by doing event detection in phase contrast. We developed neural networks to detect mito-LD and mito-lysosome contacts, as well as mitochondrial pre-fission constrictions.

Following the great success of the 2024 event, @ox.ac.uk and LUMICKS proudly present the second UK-Ireland symposium focusing on single-molecule research! The abstract deadline, 7 March, is approaching fast. Secure a talk or poster by registering now > bit.ly/4gYPPpQ

Rockin’ out at EMBO in situ with @lycasworks.bsky.social @jonasries.bsky.social Christian Zimmerli, Mark Bates 🤘🔬

MBL Physiology is totally invigorating, it’s a joyful mixture of: frontier scientific discoveries, kick-a$$ microscopes, and lovely, brilliant, generous ppl. I can’t wait for the summer!

This was an amazing collaboration, we had the luxury of years of great conversations with @wallaceucsf.bsky.social and his team, as well as our other @HFSP partners @anjbadri.bsky.social and Johan Paulsson. Thanks for telling the story here, Wallace!

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

I’m excited to join this session organized by Assaf Zaritsky and Megan Driscoll for the "Beyond Pretty Pictures" subgroup. I’ll share our latest on Smart Microscopy and mitochondria. #cellbio2024 @ascbiology.bsky.social Sat. Dec. 14, 11:15am, Rm 30C plan.core-apps.com/ascbembo2024/e…

We are so excited that @janfunkey.bsky.social has agreed to give the keynote seminar for @qiatcshl.bsky.social 2025 @cshlnews.bsky.social! 🔬🖥️ 🛤️ Applications due 1/31/2025. t.co/x87ngy34UC

Still on my oldies kick. Schwann proposed in his MDCCCXLVII monograph that muscle came from cell coalescence. "filaments are formed, which, in some situations, have an appearance like strings of pearls ... At a subsequent period, all trace of granules or division in the filament vanishes ..."

I’m reading some old mito classics, Margaret Reed and Walter Harmon Lewis with their camera lucida renderings. From various sources I thought the 1914 Science paper was ‘the one’, but on jstor there were no figures. Instead, it’s the 1915 AJA paper that’s a goldmine (Figs 6 & 10). Am I mistaken?

Here is a blue sky — an auspicious sign for the day I joined bluesky? Enjoying lovely Puerto Varas for the Chilean Cell Biology Meeting with my host Veronica Eisner. 💚