Excited to share DeepTRACE! A new AI-driven single-molecule tracking method developed by Oliver Pambos (congrats for outstanding work!) in my lab. Flexible, efficient, robust - great for monitoring diffusion/interactions in live bacteria. Thanks also to Jacob Wright! www.nature.com/articles/s42...

Happy to share our recent review on cutting-edge AI and deep-learning ways to analyse single-molecule FRET data. We also review HMM approaches and compare/contrast. Big thanks to Maryam Beigzadeh who led this effort! authors.elsevier.com/sd/article/S...

Great to see our Science Review on emerging multiplexed single-molecule methods that use libraries to link sequence to dynamics. A fun collaborative writing project! From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science www.science.org/doi/10.1126/...

Great work from the Mazumder lab, pointing out a new role for universal transcription factor NusG. Nice FCS and single-mol work as well! Single-molecule experiments reveal NusG displaces transcription initiation factor σ70 from mature elongation complexes url: academic.oup.com/nar/article/...

New preprint! We share a new *DNA-only* method for single-molecule DNA sequencing, and use this cool tool to link single-molecule reactions/interactions to sequence. Big thanks🙏 to Jagadish Hazra @becs-andrews.bsky.social and all contributors since our 2016 start! www.biorxiv.org/content/10.1...

A new NSMB study captured one of the clearest real-time views of how DNA transcribes to RNA with the LUMICKS C-Trap. 🧬 It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc. Congrats to all the authors! www.nature.com/articles/s41...

Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with @efodor.bsky.social, @nicolerobb.bsky.social academic.oup.com/nar/article/...

What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...

DNA (once more) lights the way! Very excited re the fluorogenic saga manuscript - big congrats to @mirjamku.bsky.social (tremendous effort!) for leading this and to all the team of contributors.

The RNA helicase HrpA rescues collided ribosomes in E. coli: Molecular Cell www.cell.com/molecular-ce...

A wonderful meeting to share the latest developments on single-molecule research, network, and generate new ideas! Great invited speakers @sulianamanley.bsky.social @jungmannlab.bsky.social, David Rueda, Sebastian Diendl! Send us your Abstracts by *March 7th*!

Following the great success of the 2024 event, @ox.ac.uk and LUMICKS proudly present the second UK-Ireland symposium focusing on single-molecule research! The abstract deadline, 7 March, is approaching fast. Secure a talk or poster by registering now > bit.ly/4gYPPpQ

So happy to see this AMR-related story from our 3-way collaboration!! Huge congrats to Alison + team, and thanks to @oxmartinschool.bsky.social for making it possible. Basic idea: deep "learning" ribosome distributions after antibiotic treatment rapidly classifies cells as resistant or not.

Fascinating...so much still to learn about bacterial mechanisms! Base-modified nucleotides mediate immune signaling in bacteria | Science www.science.org/doi/10.1126/...

Waiting for your abstracts by March 7! Join us with your recent stories for a "single-molecule festival" in mid-May... a lovely time to visit Oxford as well!

First BlueSky post + a breath of fresh air! Excited about our preprint on the packaging + structure of viral RNA segments in influenza virions: doi.org/10.1101/2025.... A saga from amazing Christof and Qing, and a great collaboration with @nicolerobb.bsky.social and @efodor.bsky.social.