Achilles Kapanidis
@achilleskap.bsky.social
š¤ 151
š„ 85
š 11
Professor of Biological Physics at Oxford.
Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with
@efodor.bsky.social
,
@nicolerobb.bsky.social
academic.oup.com/nar/article/...
loading . . .
High-throughput single-virion DNA-PAINT reveals structural diversity, cooperativity, and flexibility during selective packaging in influenza
Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in
https://academic.oup.com/nar/article/53/19/gkaf1020/8285782
about 1 month ago
0
9
5
What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited!
academic.oup.com/nar/article/...
loading . . .
The displacement of the Ļ70 finger in initial transcription is highly heterogeneous and promoter-dependent
Abstract. Most bacterial sigma factors (Ļ) contain a highly conserved structural module, the āĻ-fingerā,Ā which forms a loop that protrudes towards the RNA
https://academic.oup.com/nar/article/53/17/gkaf857/8251898
2 months ago
0
15
5
DNA (once more) lights the way! Very excited re the fluorogenic saga manuscript - big congrats to
@mirjamku.bsky.social
(tremendous effort!) for leading this and to all the team of contributors.
add a skeleton here at some point
4 months ago
0
12
3
The RNA helicase HrpA rescues collided ribosomes in E.Ā coli: Molecular Cell
www.cell.com/molecular-ce...
loading . . .
The RNA helicase HrpA rescues collided ribosomes in E.Ā coli
Antibiotics that inhibit ribosomes lead to collisions on mRNAs when upstream ribosomes catch up with stalled ones. Campbell etĀ al. show that the HrpA protein in E.Ā coli senses ribosome collisions and ...
https://www.cell.com/molecular-cell/fulltext/S1097-2765%2825%2900052-8
8 months ago
0
3
2
A wonderful meeting to share the latest developments on single-molecule research, network, and generate new ideas! Great invited speakers
@sulianamanley.bsky.social
@jungmannlab.bsky.social
, David Rueda, Sebastian Diendl! Send us your Abstracts by *March 7th*!
add a skeleton here at some point
9 months ago
0
5
1
reposted by
Achilles Kapanidis
LUMICKS
9 months ago
Following the great success of the 2024 event,
@ox.ac.uk
and LUMICKS proudly present the second UK-Ireland symposium focusing on single-molecule research! The abstract deadline, 7 March, is approaching fast. Secure a talk or poster by registering now >
bit.ly/4gYPPpQ
0
4
4
So happy to see this AMR-related story from our 3-way collaboration!! Huge congrats to Alison + team, and thanks to
@oxmartinschool.bsky.social
for making it possible. Basic idea: deep "learning" ribosome distributions after antibiotic treatment rapidly classifies cells as resistant or not.
add a skeleton here at some point
9 months ago
0
4
0
Fascinating...so much still to learn about bacterial mechanisms! Base-modified nucleotides mediate immune signaling in bacteria | Science
www.science.org/doi/10.1126/...
loading . . .
Base-modified nucleotides mediate immune signaling in bacteria
Signaling from pathogen sensing to effector activation is a fundamental principle of cellular immunity. While cyclic (oligo)nucleotides have emerged as key signaling molecules, the existence of other ...
https://www.science.org/doi/10.1126/science.ads6055?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=1stRelease&et_rid=17150066&et_cid=5536940
9 months ago
0
1
0
Waiting for your abstracts by March 7! Join us with your recent stories for a "single-molecule festival" in mid-May... a lovely time to visit Oxford as well!
add a skeleton here at some point
9 months ago
0
2
1
First BlueSky post + a breath of fresh air! Excited about our preprint on the packaging + structure of viral RNA segments in influenza virions:
doi.org/10.1101/2025...
. A saga from amazing Christof and Qing, and a great collaboration with
@nicolerobb.bsky.social
and
@efodor.bsky.social
.
9 months ago
0
12
3
you reached the end!!
feeds!
log in
