May your science shine bright this time of year, and the next✨. Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.

Published in Cancer Cell🎉 researchers in Upenn finds high Cell Avidity unlocked superior solid tumor killing. Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context. www.cell.com/cancer-cell/...

CAR T therapy saves lives. But some myeloma patients develop serious delayed toxicities months later. At #ASH2025, Penn researchers led by @marcoruella.bsky.social revealed why: 👉 CD4⁺ CAR T cells show much stronger Cell Avidity to BCMA than CD8⁺ cells. See more in the comment ⬇️

How do cells untangle their DNA under the mechanical stress of mitosis? Last week, Dr. Erin Cutts (the University of Sheffield) shared her new discoveries using LUMICKS C-Trap single-molecule visualization. If you missed it, it's now available on demand! www.lumicks.com/webinars/sin...

Christmas came early! New science toy from @lumicks.bsky.social for @thernainstitute.bsky.social - very excited to get this all set up and operational.

A new NSMB study captured one of the clearest real-time views of how DNA transcribes to RNA with the LUMICKS C-Trap. 🧬 It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc. Congrats to all the authors! www.nature.com/articles/s41...

⏳ Last chance to register! Tomorrow, Dr. Erin Cutts will reveal how she used the LUMICKS C-Trap to directly visualize TOP2A resolving DNA entanglements, a first-of-its-kind view of this key cancer drug target. Join her talk: bit.ly/48nOhoc

Introducing: 🎓 LUMICKS University 🎓 Your new gateway to mastering single-molecule experiments: tutorials, up-to-date documentations, scripts, and tips to help you learn faster and work smarter.​ 👉 Check it out (free for LUMICKS customers): lumicks.com/documentatio...

Amazing to see the C-Trap in action! We’re proud that the C-Trap plays a part in supporting cancer research in @freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌

How do our cells untangle their DNA during division? What happens when this process goes wrong? In a new study, Dr Erin Cutts uncovers DNA entanglements during early mitosis in real time at the single-molecule level. Join the upcoming webinar to learn how Erin made these discoveries: bit.ly/48nOhoc

Are you working on cell therapy? Looking for a reliable indicator to predict patient outcomes from preclinical immune assays? 👉 Last chance to register for LIVE webinar by Prof. Peter Chockley on how Cell Avidity measurements predict leukemia patient survival after transplant: bit.ly/3JHMzou

New! The teams of Simon Boulton and Steve West combined cryo-EM, biochemical assays and the C-Trap to "define the structure and function of a previously uncharacterized complex in the context of DNA double-strand break repair, and replication fork stabilization and restart". bit.ly/43RG6xU

Can Cell Avidity help predict stem cell transplant success? Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival. Curious? Register for the webinar: bit.ly/3Lov39i

Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear. Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.

TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ

It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social

Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy. 👉 Join Dr. Markus Barden: bit.ly/464vLyZ

TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level. Join the webinar: bit.ly/3VdxuNs

CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors? Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ

Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.

This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇. Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh). bit.ly/4fPnHXk

Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!

About 2 months ago, our product managers Bas Groen and Adalberto Costessi introduced the latest upgrades for the C-Trap. Catch the intro from LUMICKS product managers on how to make your C-Trap faster, easier, and more reproducible. Watch now: www.lumicks.com/webinars/c-t...

Discuss single-molecule science with world-renowned Prof. 𝗧𝗮𝗲𝗸𝗷𝗶𝗽 𝗛𝗮 (Harvard)! Join the upcoming 𝗡𝗮𝘁𝘂𝗿𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 to learn how dynamic single-molecule tools reveal new mechanisms behind nucleosome mobilization and transcriptional control! Registrations are now open:

𝗪𝗲’𝗿𝗲 𝗽𝗿𝗼𝘂𝗱 𝘁𝗼 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝘁𝗵𝗲 𝗣𝗮𝗿𝗸𝗲𝗿 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲 𝗳𝗼𝗿 𝗖𝗮𝗻𝗰𝗲𝗿 𝗜𝗺𝗺𝘂𝗻𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆 (𝗣𝗜𝗖𝗜) 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗴𝗵𝘁 𝗮𝗴𝗮𝗶𝗻𝘀𝘁 𝗰𝗮𝗻𝗰𝗲𝗿. @parkerici.bsky.social

🛎️ SMBio Nordics abstract deadline postponed to August 8 Allowing for some (well-deserved) offline time of the single-molecule community during the Nordic summer, the organisation of SMBio 2025 Nordics decided to delay the abstract deadline with ~2 weeks until August 8. Submit here: bit.ly/4l3Sxgx

Final day (!) to register for SMBio Nordics symposium, where top researchers of Northern Europe will come together to talk breakthrough single-molecule science: lumicks.com/event/symposium/smbio-nordics-2025

Speed up C-Trap user training, assay troubleshooting or performance verification 👉 try the new C-Trap Reference Kit. The kit provides standardized and validated reagents for a complete DNA-protein binding assay, incl. data analysis with reference values. Find the protocol & more: bit.ly/4mcXuUM

Get up to 50x data throughput for C-Trap experiments. 👇 A new high-throughput method, called DNA repeat assembly, enables researchers to quickly build long DNA constructs (up to 100 kb) made of many repeats of a DNA sequence of interest.

Abstract deadline for the SMBio 2025 Nordics is approaching soon! Register with the link --> lumicks.com/event/symposium/smbio-nordics-2025

🧬 In a new study, researchers from Fernando Moreno ’s group observed KorB sliding to distant sites & stalling via KorA which directly visualizes the process of long-range repression. This is the first time this regulatory mechanism has been visualized at the single-molecule level.

Exciting Single-Molecule Mini Symposium and C-Trap Launch event at @uniregensburg.bsky.social! If you're nearby, don't miss it! 🧬🧑‍🏫🎉 @caliskanlab.bsky.social @curiousdina.bsky.social @beliulab.bsky.social

There's a new double microfluidics module available for C-Trap users. What does it bring you? 👉 Having two independent microfluidics modules maximizes data acquisition time by enabling flow-cell cleaning in parallel with experimental execution. (1/3)

“It’s really a bit of science fiction.” In his latest interview with #SoftBankVisionFund, LUMICKS CEO Hugo de Wit shares how we're equipping researchers to uncover the molecular mechanisms behind cancer and other diseases. www.linkedin.com/posts/softba...

New for C-Trap users: the Accelerator Suite is here! 7 upgrades across hardware, software & kits to make your experiments faster, easier & more reproducible. 🎙️ Join our launch webinar to learn more + ask your questions live! 🔗 Register: www.lumicks.com/event/webina...

New technology app note 👉 bit.ly/44JH0xe Golden Gate technology: seamlessly ligate DNA fragments in any order into one backbone and test multiple target sequences in a single C-Trap experiment. This enables assays like DNA sequence-specific looping and boosts sequence-screening workflow speed 🐇.

🎆 SMBio is coming to Copenhagen! Join us for the 1st Nordics SMBio 2025 on Sept 4-5, focused on single-molecule research and optical manipulation of biological structures. Connect, collaborate, and grow your network. Register by July 25 - spots are limited! Discover all here: bit.ly/4l3Sxgx

Congratulations to C-Trap users @hymanlab.bsky.social and colleagues for their newest publication, showcasing a lot of spectacular data!

Coming Thursday: Dr. Alexander von Appen (MPI-CBG) will share groundbreaking research showing how a protein-DNA hydrogel forms a protective hydrogel at the nuclear envelope, visualized and tested by cryo-ET and optical tweezers. Join us this Thursday, June 26 at 4PM (GMT+2) for a deep dive!

Great profile video of a great and inspiring single-molecule lab, congratulations @rockefelleruniv.bsky.social for featuring science and scientists like Shixin Liu: www.youtube.com/watch?v=CpDe...

A protein-DNA surface hydrogel mechanically protects the cell nucleus https://www.biorxiv.org/content/10.1101/2025.05.21.655270v1

How does the nuclear envelope protect the genome under stress? Dr Alexander von Appen team saw that DNA + proteins form a co-condensate that reinforces the nucleus under force. 🧬 Join Dr Von Appen in the next webinar to learn how this hydrogel protects DNA! 📅 June 26 | 🕓 4PM 🔗 bit.ly/4dAJRLT

See this new study on the thermodynamic metastability of condensates and amyloid fibril formation. Congratulations to @priya-r-banerjee.bsky.social and all associates who contributed to this paper in Molecular Cell: doi.org/10.1016/j.mo...

Better late then never: we hadn't yet send out a thank-you to the UK Bluesky single-molecule community, so here goes: THANKS to all who contributed to the UK SMBio 2025 -- we had a blast! 🙌🏼 Especially to @nynkedekkerlab.bsky.social & @achilleskap.bsky.social for co-organizing 🙏🏼!

New look, new website! You might have noticed already: over the past period we've been rolling out our content in a new style. Here's what our designers say:

Great to see the C-Trap contributing to advances in DNA repair research, helping drive DNA repair research forward! Can’t wait to see what your lab shares next! @freudlab.bsky.social

This weekend, our team, Trey Simpson and Hannah Stephens, are heading to Nashville for the FASEB Machine on Genes Conference (May 18–21)! We’re thrilled to support the single-molecule community and are especially delighted to sponsor a talk by our collaborator from Rockefeller, Yukun Wang.

See this new study on the principles of co-translational chaperones! Congratulations to Sander Tans, team and collaborators ( @amolf-nl.bsky.social a.o.) for their NatCom publication combining multiple techniques incl dynamic single molecule analysis with the C-Trap: www.nature.com/articles/s41...

The scientific community responded with fantastic curiosity to Avidion at AACR, and we couldn’t be more confident about the future of Cell Avidity in cell and antibody therapy. A great success! (Still) curious? 👉 Discover more on the Avidion page: lumicks.com/avidion

Are you a researcher in cancer immunotherapy? A new study highlights potent biparatopic antibodies against FGFR fusion driven cancer. Join the Nature webinar to hear how the William Sellers lab is advancing biparatopic antibody therapies and tackling tumor resistance. Register 👉: bit.ly/4csrfNt