Video guide for advanced features of the bright-field camera: 👉 How to record the bright-field camera images along with the matching timeline data. 👉 How to crop the camera field of view, and increase the camera framerate. www.lumicks.com/university/v...

A new paper in @narjournal.bsky.social from the team of Fernando Moreno Herrero introduces OT-Curtains using the C-Trap, a massive upgrade from traditional DNA curtains: 1️⃣Zero Surface Artifacts 2️⃣Lower Force Regimes 3️⃣Dynamic Control Congrats to the authors! 🎉 👉Read: academic.oup.com/nar/article/...

An amazing experience! It was truly great to participate and co-organize the 3rd UK & Ireland SMBio symposium in Sheffield this week. Thanks to all 🙏 invited speakers: @gwuite.bsky.social,@slfort.bsky.social, @jwelburn.bsky.social, @akellett.bsky.social, @michellepeckham.bsky.social & Aakash Basu

Nuclear Extracts: we recently published an article in LUMICKS University introducing the prep and use of nuclear extracts for DNA-protein interaction experiments on the C-Trap. From extraction to assessment of fraction purity, to labelling and dilution on the C-Trap: www.lumicks.com/university/a...

LUMICKS is a proud sponsor of the BPS Canada Meeting in Winnipeg. Meet Paul and Edwin at the conference between today and Thursday 👋

Joyous that a new Q‑Trap is now live at the University of Leicester, following the successful completion of the training and a well‑attended seminar for the wider scientific community. Hosted by Prof. Andrew Hudson, the installation was made possible through BBSRC funding. Happy Friday! 🧬

We are thrilled to celebrate the recent publication from the Marcela Maus lab, showcasing a breakthrough in overcoming the physical barriers of #solidtumors. By measuring 𝗖𝗲𝗹𝗹 𝗔𝘃𝗶𝗱𝗶𝘁𝘆, their work on "glycobridges" is a game-changer for CAR-T therapy. 🎉 👉 Read: nature.com/articles/s41...

Cool recent paper by Huan-Xiang Zhou (Uni of Illinois, Chicago) in PNAS with many prime examples of the C-Trap applied to the (fascinating) world of protein-DNA condensates: www.pnas.org/doi/abs/10.1...

For this recent Cell publication, Joseph Loparo (Harvard Medical School) and team studied DNA replication in Herpes Simplex Virus type 1, specifically how a helicase-primase and DNA pol coordinate at the replication fork, tracking helicase activity in real-time with the C-Trap: bit.ly/3QoBHyD

👏 Congrats to the team of Maria Kamenetska (Boston University) for their latest publication on RNA aptamers: pubs.acs.org/doi/full/10....

A new #Nature study from the Rueda and @alicepyne.bsky.social labs identifies the molecular mechanism of DNA supercoiling in CRISPR–Cas9 off-target activity. www.nature.com/articles/s41...

Last call to join Dr. Xiaolan Zhao (MSKCC) to witness the frontier of DNA biology. You can’t miss this chance to see how the LUMICKS C-Trap is enabling her team at MSKCC to decode the "how" behind the Smc5/6 complex. Secure your spot before we go live: web.lumicks.com/l/970813/202...

The next frontier of DNA biology isn't just knowing what happens, but how it happens in motion. The C-Trap has enabled Dr. Xiaolan Zhao's team at MSKCC to push the boundaries of discovery, capturing the mechanical nuances of the Smc5/6 complex at ssDNA gaps. Join: web.lumicks.com/l/970813/202...

New in NatComms: Cell Avidity is the "success metric" in T-cell therapy. Traditional "low-avidity" T-cells are often too weak to kill solid tumors. The team of Chiara Bonini knocked out TIGIT to make them 'high-avidity' potent cancer killers. Congrats to the authors! www.nature.com/articles/s41...

How do you move from static DNA models to real-time mechanics? Join our next webinar to see how the team of Dr. Xiaolan Zhao at MSKCC uses the LUMICKS C-Trap to decode the molecular determinants of Smc5/6 association with DNA junctions. 🔗 web.lumicks.com/l/970813/202...

Last call! 🔔 Would you like to be considered for a poster presentation or a short talk during the SMBio 2026 Sheffield? Today's the last day to sign up! Join the biggest UK gathering of this type yet: www.lumicks.com/event/sympos...

Huge congrats to Poul Martin Bendix (University of Copenhagen) for their feature on Biophysics Society TV at #BPS2026! 🎉 We're proud that the C-Trap helped power multiple research projects in the lab: from cell biology & medicine to nanoscience & plant science! www.youtube.com/watch?v=TcZV...

(2/2) At #bps2026, the valuable science isn't just presented on the main stage, it's on the poster boards. If you're walking the poster halls, stop by the boards of these incredible scientists to see C-Trap data in the context of important applications and ask them directly about their experience!

Read: Measuring the strength of catch bonds (performed on m/C-Trap) helped develop this new technique to elucidate the critical interaction sites leading to TCR activation & applicable to other mechanosensory receptors too. 👏 Congrats Bo Sun and Xiang Zhao among others! www.cell.com/cell/abstrac...

🎉 Congratulations to the teams of @arnegennerich.bsky.social and @floberger.bsky.social among others, for publishing their fascinating work on dyneins: www.nature.com/articles/s41...

User Spotlight: Where you can find C-Trap data at #BPS2026? Browse through the thread to see the schedule of C-Trap customer's talks you don't want to miss, and save this post for later to revisit during the conference. And come say hi to LUMICKS at booth 619 from Sunday to Tuesday!

To accommodate for extra spots made available, we're reopening the abstract deadline for the SMBio26 organized together with the University of Sheffield! Organized with the @sheffielduni.bsky.social team: Matt Newton, @alicepyne.bsky.social & Ruby Peters. Program & registration 👉 bit.ly/3NtxZlM

Solid tumors use a "sugar shield" (glycocalyx) to block immune cells. How do we break through? Join our webinar to see how researchers from Harvard Medical School engineered "glyco-bridge" to enhance tumor recognition and killing, and validated by Cell Avidity measurements. bit.ly/4rlQF5C

Please let us remind you it's the last day before the 1st abstract deadline of the single-molecule biology symposium SMBio26 in Sheffield, May 20th-21st. Don't be late! Single molecules. Joint research. www.lumicks.com/event/sympos...

One of the challenges in single-molecule biophysics is keeping your fluorophores stable long enough to capture the full story. That's why we have partnered with Lumidyne to offer their specialized dyes. Use code “LUMICKS” to enjoy 10% discount on all Lumidyne fluorephores. See info: bit.ly/463pZhQ

We are dedicated to making sure every LUMICKS user has the tools they need to succeed. That’s why we created LUMICKS University, your free, all-in-one gateway to mastering single-molecule experiments. Join the 63% of C-Trap users who are already there: www.lumicks.com/documentatio...

We thought we knew how DNA repair worked. We were wrong. See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/... See comment for our digest:

Jan 31 is the abstract deadline for SMBio26 Sheffield. Join us again this year for the 3rd single-molecule research symposium in the UK! Present your research alongside some of the most inspiring scientists in the field. Some spots are still available! Program & registration --> bit.ly/3NtxZlM

May your science shine bright this time of year, and the next✨. Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.

Published in Cancer Cell🎉 researchers in Upenn finds high Cell Avidity unlocked superior solid tumor killing. Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context. www.cell.com/cancer-cell/...

CAR T therapy saves lives. But some myeloma patients develop serious delayed toxicities months later. At #ASH2025, Penn researchers led by @marcoruella.bsky.social revealed why: 👉 CD4⁺ CAR T cells show much stronger Cell Avidity to BCMA than CD8⁺ cells. See more in the comment ⬇️

How do cells untangle their DNA under the mechanical stress of mitosis? Last week, Dr. Erin Cutts (the University of Sheffield) shared her new discoveries using LUMICKS C-Trap single-molecule visualization. If you missed it, it's now available on demand! www.lumicks.com/webinars/sin...

Christmas came early! New science toy from @lumicks.bsky.social for @thernainstitute.bsky.social - very excited to get this all set up and operational.

A new NSMB study captured one of the clearest real-time views of how DNA transcribes to RNA with the LUMICKS C-Trap. 🧬 It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc. Congrats to all the authors! www.nature.com/articles/s41...

⏳ Last chance to register! Tomorrow, Dr. Erin Cutts will reveal how she used the LUMICKS C-Trap to directly visualize TOP2A resolving DNA entanglements, a first-of-its-kind view of this key cancer drug target. Join her talk: bit.ly/48nOhoc

Introducing: 🎓 LUMICKS University 🎓 Your new gateway to mastering single-molecule experiments: tutorials, up-to-date documentations, scripts, and tips to help you learn faster and work smarter.​ 👉 Check it out (free for LUMICKS customers): lumicks.com/documentatio...

Amazing to see the C-Trap in action! We’re proud that the C-Trap plays a part in supporting cancer research in @freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌

How do our cells untangle their DNA during division? What happens when this process goes wrong? In a new study, Dr Erin Cutts uncovers DNA entanglements during early mitosis in real time at the single-molecule level. Join the upcoming webinar to learn how Erin made these discoveries: bit.ly/48nOhoc

Are you working on cell therapy? Looking for a reliable indicator to predict patient outcomes from preclinical immune assays? 👉 Last chance to register for LIVE webinar by Prof. Peter Chockley on how Cell Avidity measurements predict leukemia patient survival after transplant: bit.ly/3JHMzou

New! The teams of Simon Boulton and Steve West combined cryo-EM, biochemical assays and the C-Trap to "define the structure and function of a previously uncharacterized complex in the context of DNA double-strand break repair, and replication fork stabilization and restart". bit.ly/43RG6xU

Can Cell Avidity help predict stem cell transplant success? Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival. Curious? Register for the webinar: bit.ly/3Lov39i

Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear. Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.

TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ

It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social

Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy. 👉 Join Dr. Markus Barden: bit.ly/464vLyZ

TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level. Join the webinar: bit.ly/3VdxuNs

CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors? Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ

Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.

This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇. Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh). bit.ly/4fPnHXk

Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!