TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ

It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social

Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy. 👉 Join Dr. Markus Barden: bit.ly/464vLyZ

TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level. Join the webinar: bit.ly/3VdxuNs

CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors? Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ

Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.

This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇. Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh). bit.ly/4fPnHXk

Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!

About 2 months ago, our product managers Bas Groen and Adalberto Costessi introduced the latest upgrades for the C-Trap. Catch the intro from LUMICKS product managers on how to make your C-Trap faster, easier, and more reproducible. Watch now: www.lumicks.com/webinars/c-t...

Discuss single-molecule science with world-renowned Prof. 𝗧𝗮𝗲𝗸𝗷𝗶𝗽 𝗛𝗮 (Harvard)! Join the upcoming 𝗡𝗮𝘁𝘂𝗿𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 to learn how dynamic single-molecule tools reveal new mechanisms behind nucleosome mobilization and transcriptional control! Registrations are now open:

𝗪𝗲’𝗿𝗲 𝗽𝗿𝗼𝘂𝗱 𝘁𝗼 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝘁𝗵𝗲 𝗣𝗮𝗿𝗸𝗲𝗿 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲 𝗳𝗼𝗿 𝗖𝗮𝗻𝗰𝗲𝗿 𝗜𝗺𝗺𝘂𝗻𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆 (𝗣𝗜𝗖𝗜) 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗴𝗵𝘁 𝗮𝗴𝗮𝗶𝗻𝘀𝘁 𝗰𝗮𝗻𝗰𝗲𝗿. @parkerici.bsky.social

🛎️ SMBio Nordics abstract deadline postponed to August 8 Allowing for some (well-deserved) offline time of the single-molecule community during the Nordic summer, the organisation of SMBio 2025 Nordics decided to delay the abstract deadline with ~2 weeks until August 8. Submit here: bit.ly/4l3Sxgx

Final day (!) to register for SMBio Nordics symposium, where top researchers of Northern Europe will come together to talk breakthrough single-molecule science: lumicks.com/event/symposium/smbio-nordics-2025

Speed up C-Trap user training, assay troubleshooting or performance verification 👉 try the new C-Trap Reference Kit. The kit provides standardized and validated reagents for a complete DNA-protein binding assay, incl. data analysis with reference values. Find the protocol & more: bit.ly/4mcXuUM

Get up to 50x data throughput for C-Trap experiments. 👇 A new high-throughput method, called DNA repeat assembly, enables researchers to quickly build long DNA constructs (up to 100 kb) made of many repeats of a DNA sequence of interest.

Abstract deadline for the SMBio 2025 Nordics is approaching soon! Register with the link --> lumicks.com/event/symposium/smbio-nordics-2025

🧬 In a new study, researchers from Fernando Moreno ’s group observed KorB sliding to distant sites & stalling via KorA which directly visualizes the process of long-range repression. This is the first time this regulatory mechanism has been visualized at the single-molecule level.

Exciting Single-Molecule Mini Symposium and C-Trap Launch event at @uniregensburg.bsky.social! If you're nearby, don't miss it! 🧬🧑‍🏫🎉 @caliskanlab.bsky.social @curiousdina.bsky.social @beliulab.bsky.social

There's a new double microfluidics module available for C-Trap users. What does it bring you? 👉 Having two independent microfluidics modules maximizes data acquisition time by enabling flow-cell cleaning in parallel with experimental execution. (1/3)

“It’s really a bit of science fiction.” In his latest interview with #SoftBankVisionFund, LUMICKS CEO Hugo de Wit shares how we're equipping researchers to uncover the molecular mechanisms behind cancer and other diseases. www.linkedin.com/posts/softba...

New for C-Trap users: the Accelerator Suite is here! 7 upgrades across hardware, software & kits to make your experiments faster, easier & more reproducible. 🎙️ Join our launch webinar to learn more + ask your questions live! 🔗 Register: www.lumicks.com/event/webina...

New technology app note 👉 bit.ly/44JH0xe Golden Gate technology: seamlessly ligate DNA fragments in any order into one backbone and test multiple target sequences in a single C-Trap experiment. This enables assays like DNA sequence-specific looping and boosts sequence-screening workflow speed 🐇.

🎆 SMBio is coming to Copenhagen! Join us for the 1st Nordics SMBio 2025 on Sept 4-5, focused on single-molecule research and optical manipulation of biological structures. Connect, collaborate, and grow your network. Register by July 25 - spots are limited! Discover all here: bit.ly/4l3Sxgx

Congratulations to C-Trap users @hymanlab.bsky.social and colleagues for their newest publication, showcasing a lot of spectacular data!

Coming Thursday: Dr. Alexander von Appen (MPI-CBG) will share groundbreaking research showing how a protein-DNA hydrogel forms a protective hydrogel at the nuclear envelope, visualized and tested by cryo-ET and optical tweezers. Join us this Thursday, June 26 at 4PM (GMT+2) for a deep dive!

Great profile video of a great and inspiring single-molecule lab, congratulations @rockefelleruniv.bsky.social for featuring science and scientists like Shixin Liu: www.youtube.com/watch?v=CpDe...

A protein-DNA surface hydrogel mechanically protects the cell nucleus https://www.biorxiv.org/content/10.1101/2025.05.21.655270v1

How does the nuclear envelope protect the genome under stress? Dr Alexander von Appen team saw that DNA + proteins form a co-condensate that reinforces the nucleus under force. 🧬 Join Dr Von Appen in the next webinar to learn how this hydrogel protects DNA! 📅 June 26 | 🕓 4PM 🔗 bit.ly/4dAJRLT

See this new study on the thermodynamic metastability of condensates and amyloid fibril formation. Congratulations to @priya-r-banerjee.bsky.social and all associates who contributed to this paper in Molecular Cell: doi.org/10.1016/j.mo...

Better late then never: we hadn't yet send out a thank-you to the UK Bluesky single-molecule community, so here goes: THANKS to all who contributed to the UK SMBio 2025 -- we had a blast! 🙌🏼 Especially to @nynkedekkerlab.bsky.social & @achilleskap.bsky.social for co-organizing 🙏🏼!

New look, new website! You might have noticed already: over the past period we've been rolling out our content in a new style. Here's what our designers say:

Great to see the C-Trap contributing to advances in DNA repair research, helping drive DNA repair research forward! Can’t wait to see what your lab shares next! @freudlab.bsky.social

This weekend, our team, Trey Simpson and Hannah Stephens, are heading to Nashville for the FASEB Machine on Genes Conference (May 18–21)! We’re thrilled to support the single-molecule community and are especially delighted to sponsor a talk by our collaborator from Rockefeller, Yukun Wang.

See this new study on the principles of co-translational chaperones! Congratulations to Sander Tans, team and collaborators ( @amolf-nl.bsky.social a.o.) for their NatCom publication combining multiple techniques incl dynamic single molecule analysis with the C-Trap: www.nature.com/articles/s41...

The scientific community responded with fantastic curiosity to Avidion at AACR, and we couldn’t be more confident about the future of Cell Avidity in cell and antibody therapy. A great success! (Still) curious? 👉 Discover more on the Avidion page: lumicks.com/avidion

Are you a researcher in cancer immunotherapy? A new study highlights potent biparatopic antibodies against FGFR fusion driven cancer. Join the Nature webinar to hear how the William Sellers lab is advancing biparatopic antibody therapies and tackling tumor resistance. Register 👉: bit.ly/4csrfNt

Come by and say hi to the newest central member of our booth setup: #Avidion - The next generation Cell Avidity platform! 📍 Join us at AACR booth #633. The LUMICKS team is ready to meet you at the American Association for Cancer Research (AACR) Annual Meeting.

🚀Introducing Avidion The next generation Cell Avidity platform LUMICKS launches Avidion at #AACR Annual Meeting 2025, booth #633 What has been exclusive to the eyes of our closest ambassadors is approaching its official US launch at the AACR Annual Meeting 2025. @theaacr.bsky.social

🚀 Something BIG is coming to #AACR2025! 🚀 Visit booth #633 from April 25-30 to explore what’s possible with next generation Cell Avidity! Chat with our scientists about the breakthrough technology! More news later this week. #CellAvidity #Avidion #Immunotherapy #CancerResearch

Highlight of a recent publication from our customer in TU Dresden! Read our scientific digest of the publication and learn how understanding the recombination efficiency of integrons in bacteria could lead to breakthroughs in antibiotic resistance! lumicks.com/bacterial-in...

🌷🌷🌷 Looking at the flowering tulip fields, we biologists realize the heterogeneity in all things. Averaging data can mask vital details, but C-Trap’s single-molecule measurements reveal every unique interaction. Capture the full spectrum of molecular dynamics! More here: lumicks.com/products/c-t...

Missed our live session on the pivotal roles of SMC complexes in genome organization? 🧬 Watch the full recording of Prof. Luis Aragon’s webinar now! Get insights into chromosome stability and DNA repair processes: bit.ly/42ktHBf

Read our latest blog post about groundbreaking research from the lab of Prof. Michael Schlierf! They use the C-Trap to study how the mechanical stability of bacterial synaptic complexes influences antibiotic resistance. Read it here: lumicks.com/bacterial-in... (@schlierflab.bsky.social)

Back in Sheffield and excited to play with an exciting new bit of kit - our new @lumicks.bsky.social c-trap optical tweezers with @mattdnewton.bsky.social @insigneoinstitute.bsky.social @mcb-sheffield.bsky.social

Have you registered for today's webinar by Prof. Luis Aragon? Don’t miss the chance to learn the latest discoveries on the mechanism of Structural Maintenance of Chromosomes (SMC) complexes! Register: bit.ly/41juIci

👋 Biophysicists of the UK, come visit our table at the Physics of Life conference between today and March 27 for exclusive demos of the C-Trap -- the world's first instrument for real-time manipulation and visualization of single-molecule interactions! 📍@physicsoflifeuk.bsky.social

🎁 The single molecule biology symposium in Dresden is a wrap! We are incredibly grateful to the Max Planck Institute for Cell Biology Dresden and @stephangrill.bsky.social for hosting the Central European single molecule community in beautiful Dresden! 📷 Group photo by Franziska Friedrich, MPI-CBG

Great time at #SMBioDresden — old friends, new friends, and exciting science! #SingleMolecule #ScienceCommunity #AcademicLife #Dresden #MPI-CBG

Thank you to all visitors of the Breakthroughs in Immunotherapies #BIT2025 symposium at Beth Israel Deaconess Medical Center! Special thanks to Dr. Sizun Jiang for hosting with us 🤝.

In 10 days: Mechanistic insights into how cohesin, condensin, and Smc5/6 facilitate chromosome compaction, segregation and DNA repair. LUMICKS is proud to have Prof. Luis Aragon for a live talk on the SMC complexes and their critical roles in genome integrity. Register here: bit.ly/41juIci