🎓 Discover how to use *Q-Trap mode* to expand your possibilities on the C-Trap. Our new guide explains differences with dual-trap mode, how to switch between configs, what to consider for force detection, calibration & complex assays like DNA braiding and multi-tether experiments: bit.ly/3SE17cE

Recent publication with @gwuite.bsky.social, @barisiclab.bsky.social and Ian Hickson a.o., where the big finding is in the titel: Condensin I but not Condensin II is crucial for mitotic chromosome mechanics. Congratulations to the contributors! www.nature.com/articles/s41...

不只是“看见” #染色体 ，你能真正测量它在 #细胞分裂 中的“力”吗？ 本次中文Webinar中，刘朝伟博士（ Gijs Wuite 实验室，阿姆斯特丹自由大学）将讲解他如何使用 C-Trap： ✔ 在皮牛顿尺度直接测量 #单个分子 力 ✔ 用 #光镊 操控单个染色体 ✔ 解码 #有丝分裂 背后的力学机制 👉 从“观察”到“证明机制”的关键一步： www.lumicks.com/event/webina...

Missed our webinar with Dr. Alba Rodríguez Garcia? Now available on-demand 🎥 Learn how Cell Avidity, as a new parameter, drives CAR-T performance, especially when targets are low. Dual CD19/BCMA CAR-T selected is now in phase I clinical trial: lumicks.com/webinars/avi...

New in #Cell (Xiang Zhao group, SIBCB): The C-Trap measured #catchbonds directly, enabling engineered #TCRs to clear tumors in vivo without off-target toxicity. Great example for all mechanosensory systems! Congrats to all the authors! 🎉 Read the publication: www.cell.com/cell/abstrac...

Cell therapy researchers: in 5 days ⏰ Dr. Alba Rodríguez Garcia shares her Phase I CAR-T study in #NHL: highlighting Cell Avidity as a key driver of performance. Stronger interactions → better function, even at low antigen levels 👉 Join live webinar: web.lumicks.com/l/970813/202...

Can we overcome CAR-T resistance without redesigning the CAR? A new study in #Cell proves it comes down to Cell Avidity. Using the #lumicks z-Movi, researchers showed how restoring cell-to-cell binding strength beats antigen escape. If you're in cell therapy, read www.cell.com/cell/abstrac...

What could you uncover if your fluorophore didn’t blink or bleach? Lumidyne fluorophores feature a built-in self-healing design that reduces blinking and photobleaching for stable, bright and extended fluorescence lifetimes. Read more about this promotion: store.lumicks.com/product/lumi...

Excited to have Dr. Alba Rodríguez Garcia share her preclinical study of a now-in-Phase I CAR-T therapy in our upcoming webinar! 🔬 In her work, co-transduced CD19/BCMA CAR-T cells demonstrated superior avidity and functional performance. 👉 Learn more and register: web.lumicks.com/l/970813/202...

How do CAR-T cells keep working when targets weaken? Join our upcoming webinar to hear Dr. Alba Rodríguez Garcia, PhD highlights the role of cell avidity, not just binding, but functional strength under real conditions. 👉 web.lumicks.com/l/970813/202...

Subtle differences in binding location, dynamics, and off-target behavior in DNA-protein interactions are difficult to resolve traditionally. A recent @nature.com publication from David Ruedalab highlights C-Trap to quickly distinguish off-target activity of Cas9 from its high-fidelity variants 👇

LUMICKS is excited to sponsor and attend Machines on Genes in Crete June 8-11. Connect with us to explore real-time, single-molecule insights with the C-Trap! #BiochemEvent @biochemsoc.bsky.social

Demo: many C-Trap users want to do cell mechanobiology experiments on the C-Trap. Our scientists recorded this video showing what a live cell membrane pulling experiment looks like on the C-Trap. Details of the workflow and key highlights are in the video captions: www.lumicks.com/university/v...

Congratulations to all the authors!🎉

Video guide for advanced features of the bright-field camera: 👉 How to record the bright-field camera images along with the matching timeline data. 👉 How to crop the camera field of view, and increase the camera framerate. www.lumicks.com/university/v...

A new paper in @narjournal.bsky.social from the team of Fernando Moreno Herrero introduces OT-Curtains using the C-Trap, a massive upgrade from traditional DNA curtains: 1️⃣Zero Surface Artifacts 2️⃣Lower Force Regimes 3️⃣Dynamic Control Congrats to the authors! 🎉 👉Read: academic.oup.com/nar/article/...

An amazing experience! It was truly great to participate and co-organize the 3rd UK & Ireland SMBio symposium in Sheffield this week. Thanks to all 🙏 invited speakers: @gwuite.bsky.social,@slfort.bsky.social, @jwelburn.bsky.social, @akellett.bsky.social, @michellepeckham.bsky.social & Aakash Basu

Nuclear Extracts: we recently published an article in LUMICKS University introducing the prep and use of nuclear extracts for DNA-protein interaction experiments on the C-Trap. From extraction to assessment of fraction purity, to labelling and dilution on the C-Trap: www.lumicks.com/university/a...

LUMICKS is a proud sponsor of the BPS Canada Meeting in Winnipeg. Meet Paul and Edwin at the conference between today and Thursday 👋

Joyous that a new Q‑Trap is now live at the University of Leicester, following the successful completion of the training and a well‑attended seminar for the wider scientific community. Hosted by Prof. Andrew Hudson, the installation was made possible through BBSRC funding. Happy Friday! 🧬

We are thrilled to celebrate the recent publication from the Marcela Maus lab, showcasing a breakthrough in overcoming the physical barriers of #solidtumors. By measuring 𝗖𝗲𝗹𝗹 𝗔𝘃𝗶𝗱𝗶𝘁𝘆, their work on "glycobridges" is a game-changer for CAR-T therapy. 🎉 👉 Read: nature.com/articles/s41...

Cool recent paper by Huan-Xiang Zhou (Uni of Illinois, Chicago) in PNAS with many prime examples of the C-Trap applied to the (fascinating) world of protein-DNA condensates: www.pnas.org/doi/abs/10.1...

For this recent Cell publication, Joseph Loparo (Harvard Medical School) and team studied DNA replication in Herpes Simplex Virus type 1, specifically how a helicase-primase and DNA pol coordinate at the replication fork, tracking helicase activity in real-time with the C-Trap: bit.ly/3QoBHyD

👏 Congrats to the team of Maria Kamenetska (Boston University) for their latest publication on RNA aptamers: pubs.acs.org/doi/full/10....

A new #Nature study from the Rueda and @alicepyne.bsky.social labs identifies the molecular mechanism of DNA supercoiling in CRISPR–Cas9 off-target activity. www.nature.com/articles/s41...

Last call to join Dr. Xiaolan Zhao (MSKCC) to witness the frontier of DNA biology. You can’t miss this chance to see how the LUMICKS C-Trap is enabling her team at MSKCC to decode the "how" behind the Smc5/6 complex. Secure your spot before we go live: web.lumicks.com/l/970813/202...

The next frontier of DNA biology isn't just knowing what happens, but how it happens in motion. The C-Trap has enabled Dr. Xiaolan Zhao's team at MSKCC to push the boundaries of discovery, capturing the mechanical nuances of the Smc5/6 complex at ssDNA gaps. Join: web.lumicks.com/l/970813/202...

New in NatComms: Cell Avidity is the "success metric" in T-cell therapy. Traditional "low-avidity" T-cells are often too weak to kill solid tumors. The team of Chiara Bonini knocked out TIGIT to make them 'high-avidity' potent cancer killers. Congrats to the authors! www.nature.com/articles/s41...

How do you move from static DNA models to real-time mechanics? Join our next webinar to see how the team of Dr. Xiaolan Zhao at MSKCC uses the LUMICKS C-Trap to decode the molecular determinants of Smc5/6 association with DNA junctions. 🔗 web.lumicks.com/l/970813/202...

Last call! 🔔 Would you like to be considered for a poster presentation or a short talk during the SMBio 2026 Sheffield? Today's the last day to sign up! Join the biggest UK gathering of this type yet: www.lumicks.com/event/sympos...

Huge congrats to Poul Martin Bendix (University of Copenhagen) for their feature on Biophysics Society TV at #BPS2026! 🎉 We're proud that the C-Trap helped power multiple research projects in the lab: from cell biology & medicine to nanoscience & plant science! www.youtube.com/watch?v=TcZV...

(2/2) At #bps2026, the valuable science isn't just presented on the main stage, it's on the poster boards. If you're walking the poster halls, stop by the boards of these incredible scientists to see C-Trap data in the context of important applications and ask them directly about their experience!

Read: Measuring the strength of catch bonds (performed on m/C-Trap) helped develop this new technique to elucidate the critical interaction sites leading to TCR activation & applicable to other mechanosensory receptors too. 👏 Congrats Bo Sun and Xiang Zhao among others! www.cell.com/cell/abstrac...

🎉 Congratulations to the teams of @arnegennerich.bsky.social and @floberger.bsky.social among others, for publishing their fascinating work on dyneins: www.nature.com/articles/s41...

User Spotlight: Where you can find C-Trap data at #BPS2026? Browse through the thread to see the schedule of C-Trap customer's talks you don't want to miss, and save this post for later to revisit during the conference. And come say hi to LUMICKS at booth 619 from Sunday to Tuesday!

To accommodate for extra spots made available, we're reopening the abstract deadline for the SMBio26 organized together with the University of Sheffield! Organized with the @sheffielduni.bsky.social team: Matt Newton, @alicepyne.bsky.social & Ruby Peters. Program & registration 👉 bit.ly/3NtxZlM

Solid tumors use a "sugar shield" (glycocalyx) to block immune cells. How do we break through? Join our webinar to see how researchers from Harvard Medical School engineered "glyco-bridge" to enhance tumor recognition and killing, and validated by Cell Avidity measurements. bit.ly/4rlQF5C

Please let us remind you it's the last day before the 1st abstract deadline of the single-molecule biology symposium SMBio26 in Sheffield, May 20th-21st. Don't be late! Single molecules. Joint research. www.lumicks.com/event/sympos...

One of the challenges in single-molecule biophysics is keeping your fluorophores stable long enough to capture the full story. That's why we have partnered with Lumidyne to offer their specialized dyes. Use code “LUMICKS” to enjoy 10% discount on all Lumidyne fluorephores. See info: bit.ly/463pZhQ

We are dedicated to making sure every LUMICKS user has the tools they need to succeed. That’s why we created LUMICKS University, your free, all-in-one gateway to mastering single-molecule experiments. Join the 63% of C-Trap users who are already there: www.lumicks.com/documentatio...

We thought we knew how DNA repair worked. We were wrong. See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/... See comment for our digest:

Jan 31 is the abstract deadline for SMBio26 Sheffield. Join us again this year for the 3rd single-molecule research symposium in the UK! Present your research alongside some of the most inspiring scientists in the field. Some spots are still available! Program & registration --> bit.ly/3NtxZlM

May your science shine bright this time of year, and the next✨. Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.

Published in Cancer Cell🎉 researchers in Upenn finds high Cell Avidity unlocked superior solid tumor killing. Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context. www.cell.com/cancer-cell/...

CAR T therapy saves lives. But some myeloma patients develop serious delayed toxicities months later. At #ASH2025, Penn researchers led by @marcoruella.bsky.social revealed why: 👉 CD4⁺ CAR T cells show much stronger Cell Avidity to BCMA than CD8⁺ cells. See more in the comment ⬇️

How do cells untangle their DNA under the mechanical stress of mitosis? Last week, Dr. Erin Cutts (the University of Sheffield) shared her new discoveries using LUMICKS C-Trap single-molecule visualization. If you missed it, it's now available on demand! www.lumicks.com/webinars/sin...

Christmas came early! New science toy from @lumicks.bsky.social for @thernainstitute.bsky.social - very excited to get this all set up and operational.

A new NSMB study captured one of the clearest real-time views of how DNA transcribes to RNA with the LUMICKS C-Trap. 🧬 It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc. Congrats to all the authors! www.nature.com/articles/s41...

⏳ Last chance to register! Tomorrow, Dr. Erin Cutts will reveal how she used the LUMICKS C-Trap to directly visualize TOP2A resolving DNA entanglements, a first-of-its-kind view of this key cancer drug target. Join her talk: bit.ly/48nOhoc

Introducing: 🎓 LUMICKS University 🎓 Your new gateway to mastering single-molecule experiments: tutorials, up-to-date documentations, scripts, and tips to help you learn faster and work smarter.​ 👉 Check it out (free for LUMICKS customers): lumicks.com/documentatio...