See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit: NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes Sachin Kotak @spindlebehavior.bsky.social et al www.embopress.org/doi/full/10....

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Microtubules: from atoms to complex systems www.embl.org/about/info/c...

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

The kinetochore corona orchestrates chromosome congression through transient microtubule interactions https://www.biorxiv.org/content/10.1101/2025.09.10.675486v1

Happy to share our work in @embojournal 👉 shorturl.at/zXNyn For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division? Follow this thread to know more 👇

New preprint from the lab! Please check it out. 🚨 Have you ever wondered how cells decide when it’s time to divide? So did we! www.biorxiv.org/content/10.1...

Check out our new manuscript on biorxiv on the role of MOS in mammalian oocyte meiosis: www.biorxiv.org/cgi/content/... With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social

Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels. www.nature.com/articles/s41...

Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!

Narozna et al @gorbskylab.bsky.social uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate rupress.org/jcb/article/...

The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years! Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out. link.springer.com/article/10.1...

Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...

Check out our latest research now out @embojournal.org. Huge shout-out to our postdocs Susana Eibes and Bhagya Lakshmi and the rest of the team for their amazing work! 1/11

If you would like to attend a #microscopy or #bioimageanalysis training course in the next 6 months but don’t have funding, check out our Microscopy Training Grant from @jcellsci.bsky.social and @focalplane.bsky.social. Next deadline: 6 June 2025 www.biologists.com/grants/jcs-f... #Training

I'm happy to share our study “Proximity-based activation of AURORA A by MPS1 potentiates error correction” now published at @currentbiology.bsky.social www.sciencedirect.com/science/arti... It describes a new way kinetochores and centrosomes communicate to ensure accurate chromosome segregation.

I have a 1 year fellowship available (MSc level) for someone interested in studying how nuclear mechanics regulates the timing of mitotic entry. Plus it´s in the beautiful city of Porto! Please spread the word to anyone who might be interested. dozer.i3s.up.pt/applicationm...

Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes. www.nature.com/articles/s41...

Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required. Please Repost 🙏 thanks !

We're on a roll!🚀 Check our latest research @naturecomms.bsky.social: rdcu.be/ecXzr We reveal how mosaic MTs faithfully mimic the GTP cap, highlighting lattice expansion (not pf twist) as the structural cornerstone of MT stability and dynamic instability. Congrats to Juan and everybody involved! 🎉

Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

Happy to share our latest work on phosphoprotein phosphatase (PPP) regulation. We integrate CRISPR knockout and focused base editor screens to uncover the regulatory landscape of PPPs (more below). Great collaboration with the Zhu, Davey, Kettenbach and Ogris labs. www.biorxiv.org/content/10.1...

New paper alert! ‼️‼️ Super happy to share that my postdoc paper is finally out! 1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.

Interested in Base Editing and Genetic Screening? Check out our method chapter: link.springer.com/protocol/10.... Esther Ng did an excellent job developing these methods in our lab. The constructs will soon be available on @addgene.bsky.social Many thanks to OIST for supporting open access!

We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too! 👉 www.godinholab.com RT please 🙏🙏🙏👍👍

🚨 PLEASE REPOST 🚨 We're still looking for an enthusiastic PhD student 😉 Here are some potential projects: - mechanical stability of microtubules probed by computational force spectroscopy - mechanism of microtubule assembly studied by coarse-grained modeling www.mpinat.mpg.de/28-24?c=2501...

What is the difference between a growing and shortening microtubule end? I thought I knew the answer until I started talking to Maxim Igaev and Maksim Kalutskiy. Turns out the key are protofilament clusters - check out our new preprint for details www.biorxiv.org/content/10.1...

Very happy to receive a Wellcome CDA! The award will fund my lab for a whopping 8 years, allowing us to dissect force-sensing at the kinetochore-microtubule interface in depth using structural methods. We are currently looking for a postdoc: qmul-jobs.tal.net/vx/candidate... Please apply or repost

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs

Our latest work shows that a reported #kinase inhibitor causes cytotoxicity by directly inhibiting MTs. We need a much better understanding of how #chemotherapy drugs work if we are to use them effectively to treat #cancer. Work led by fantastic clinical fellow Josh Coats 🧪 doi.org/10.1158/2767...

People working on the causes or consequences of #aneuploidy or #CIN. Reply if I missed you and you want adding to the list go.bsky.app/G8wHoXx

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community: candidate.hr-manager.net/ApplicationI...

Hello Bluesky community! What a better way to introduce myself and my research team than post our lab’s first paper freshly off press 🥳🍾 We reveal how tubulins regulate the stability of their mRNA via reversible sequestration of TTC5. Bravo A. Batiuk and all coauthors 👏🏻🥂 doi.org/10.1038/s414...

Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...

I gladly bring this meeting to your attention so that you can mark dates in your calendar in case your are interest. Additional information will follow. Please circulate if possible.

iBiology is a REMARKABLE and under-utilized resource for learning from some of the pioneers of microscopy--these videos are suitable for undergraduate classes or experts 🧪

We have 15 PhD positions available as part of the DANIO-ReCODE MSCA DN 🇪🇸🇩🇪🇸🇮🇭🇷🇦🇹🇬🇧 Great opportunity for anyone interested in developmental biology, regeneration, genomics, and computational sciences. For project descriptions and how to apply, check: euraxess.ec.europa.eu/jobs/290548

Starter packs are genius, but I was surprised there wasn't a list of them for people to find. So I built it: blueskydirectory.com/starter-pack... The website monitors the packs being shared and adds the ones it finds to the database. Missed your stater pack? Message me and I'll get it added.

I put together a list of profiles in somehow related subjects of chromosome biology go.bsky.app/KqsM3kd

Ever wondered which of the new green fluorescent proteins you should use for live cell microscopy? 🧪 Maybe there is an answer: biorxiv.org/content/10.1...

here's the starter pack for cytoskeleton go.bsky.app/TF83cpi

Our new perspective piece on all the cool things #microtubules do in cell migration authors.elsevier.com/sd/article/S...

We're excited to announce that the applications for the 2024 Advanced Research Training Courses at the MBL are OPEN! Deepen your horizons. Deepen your understanding. Go deep at the MBL. mbl.edu/courses

I am actively recruiting students for my lab at UMass Dartmouth! Are you interested in a project on actin, amoebae, cell migration, and/or pathogenesis? Send me an email & apply to the Integrative Biology PhD program by Jan 15! Please RT More info: katrinavelle.wixsite.com/science

Registration is open for the Dynamic Kinetochore Workshop 2024. Join us in Caux Palace above Lake Geneva for four days filled with centromeres, kinetochores, and microtubules. A fantastic lineup of speakers, and 20 slots for selected talks (prioritised for ECRs) meetings.embo.org/event/24-kin...

The time has finally come! Join us in Porto 6-9 March 2024 for an excellent meeting "Forces across scales". Registration is now OPEN! Great lineup of speakers and plenty of opportunities for talks. Check out the meeting website: www.i3s.up.pt/event.php?v=...