Denis Chrétien
@dchretien.bsky.social
📤 443
📥 1033
📝 60
Microtubule and cryo-ET addict!
Rosalind Franklin and the damage of gender harassment | Science | AAAS
www.science.org/content/arti...
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Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
https://www.science.org/content/article/rosalind-franklin-and-damage-gender-harassment
4 days ago
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Denis Chrétien
Buzz Baum
6 days ago
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
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Periklis Paganos
7 days ago
I am beyond excited to share that my postdoc project
@szndohrn.bsky.social
and the
@arnonelab.bsky.social
is now available in
#ScienceAdvances
@science.org
.
www.science.org/doi/10.1126/...
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Denis Chrétien
EMBL
7 days ago
Diatoms – microscopic algae found almost everywhere there’s water – make up ~25% of Earth’s annual oxygen production.🌎 EMBL researchers have now found a way to easily reveal their inner structures by combining cryo-fixation with ultrastructural expansion microscopy 🔬
www.cell.com/current-biol...
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Journal of Cell Science
7 days ago
In their Review, Olivier Mercey,
@marinebrunet.bsky.social
, Paul Guichard & Virginie Hamel
@centriolelab.bsky.social
highlight advances in microscopy that have significantly deepened our understanding of centriolar & ciliary structure & function.
journals.biologists.com/jcs/article/...
#OpenAccess
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Advances in high-resolution imaging of centrioles and cilia
Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...
https://journals.biologists.com/jcs/article/138/20/jcs264260/369650/Advances-in-high-resolution-imaging-of-centrioles
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Denis Chrétien
BioCytoLab
about 2 months ago
🎉New Paper Drop🎉 We just uploaded our latest findings on bioRxiv! We report the identification of the limits of microtubule self-repair and how microtubule integrity is maintained under mechanical load. Congratulations
@bucklingmt.bsky.social
www.biorxiv.org/content/10.1...
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Denis Chrétien
Iva Tolić
23 days ago
Two back-to-back stories on mitosis led by my incredible postdoc
@krunovuk.bsky.social
at
@institutrb.bsky.social
, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in
@natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
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Indivisible ❌👑
25 days ago
This is what democracy looks like.
#NoKings
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Denis Chrétien
Joachim Frank
25 days ago
I was one of > 100,000 in New York City
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Institut Pasteur Education
29 days ago
Cryo-Flow : when science freezes and flows ❄️ After turning her thesis on tuberculosis into a rap, Yaëlle Wormser aka Lady Pipette, doctoral student at the Institut Pasteur, is back with a new track — Cryo-Flow — a song that turns Cryo-Electron Microscopy (Cryo-EM) into rhythm & rhyme.
@pasteur.fr
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Cryo-Flow : when science freezes and flows ❄️
YouTube video by Institut Pasteur EDUCATION
https://youtube.com/shorts/FnCJe0njYa4?feature=share
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Denis Chrétien
Journal of Cell Biology
28 days ago
Perspective from Richard McIntosh describing the history of research on
#microtubule
polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers.
rupress.org/jcb/article/...
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Manuel Thery
30 days ago
We hire! The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities. More details here:
cytomorpholab.com/index.php/jo...
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Trip to the center of the microtubule 😵💫
#microtubule
about 2 months ago
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Denis Chrétien
about 2 months ago
🚨 Webinar Alert! - Revolutionizing Structural Biology On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps. Register here:
ter.li/66bytl
#structuralbiology
#proteinmicroscopy
#cryoEM
#cryoET
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Microtubules: from atoms to complex systems
www.embl.org/about/info/c...
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Microtubules: from atoms to complex systems
https://www.embl.org/about/info/course-and-conference-office/events/ees26-09/
about 2 months ago
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Denis Chrétien
BioCytoLab
2 months ago
Happy to share that our paper on Tau- Microtubule interaction is now published in Nature Physics!🥳 We show that Tau isn’t just a microtubule stabiliser - it promotes removal of defects in the microtubule lattice. Congratulations
@subhambiswas.bsky.social
!
www.nature.com/articles/s41...
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Denis Chrétien
Pilhofer Lab 🦠❄️🔬
2 months ago
Story on our Asgard microtubule paper by Nikki Greenwood:
www.quantamagazine.org/tiny-tubes-r...
Thanks to all interviewees🎤
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Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine
Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.
https://www.quantamagazine.org/tiny-tubes-reveal-clues-to-the-evolution-of-complex-life-20250908/
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Denis Chrétien
Institut Jacques Monod
2 months ago
📣 Paris Cytoskeleton day 2025 - Registrations are open! 📆 November 14th 📍 Institut Jacques Monod 🔗
pcd2025.sciencesconf.org
Abstract submission closes on 19 October Registration closes on 7 November
@romet-jegou-lab.bsky.social
@upcite.bsky.social
@cnrs-idf-villejuif.bsky.social
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Denis Chrétien
Gautam Dey
3 months ago
Want to acquire
#ExM
images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With
@dudinlab.bsky.social
@embl.org
@biology-unige.bsky.social
@moorefound.bsky.social
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Denis Chrétien
MRC Laboratory of Molecular Biology
3 months ago
The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by
#cryoEM
. Read about the event and find more photos here:
www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews
🧪🔬
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Denis Chrétien
Kat Toropova
4 months ago
Thrilled to see our study on how kinesin-2 motors are switched on and off published in
@natsmb.nature.com
⚛️ ➡️
www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉
@dunnschool.bsky.social
Check out this animation made by talented PhD student
@matthew-batisio.bsky.social
😆
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Josh Dickerson
5 months ago
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM!
www.sciencedirect.com/science/arti...
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To tilt or not to tilt? Strategies for in situ cryo-EM data collection
Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…
https://www.sciencedirect.com/science/article/pii/S0959440X25001186
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Denis Chrétien
Florian Wollweber
5 months ago
After 5 amazing years
@pilhoferlab.bsky.social
I'm starting my lab
@embl.org
Grenoble this November
embl.org/wollweber
We'll image Asgard archaea and many other strange microbes (
#archaeasky
,
#protistsonsky
..) to understand eukaryogenesis First job ad:
#teamtomo
scientist!🔬❄️
tinyurl.com/2rdu2ze6
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Denis Chrétien
Bettina Böttcher
5 months ago
Our paper on Lymphostatin is now out (
rdcu.be/etk2v
). It shows
#cryoEM
structures of this huge virulence factor revealing amazing domain reorganisations. Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de
🧪❄️
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Denis Chrétien
Paul & Virginie - Centriole Lab
5 months ago
🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with
@cellarchlab.com
@chgenoud.bsky.social
@stearnslab.bsky.social
🙌.
#TeamTomo
#UExM
www.biorxiv.org/content/10.1...
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Denis Chrétien
A/Prof Sam Stehbens PhD (She/Her)
about 1 year ago
it never gets old......
#microtubule
dynamics - the fireworks of EB comets
#microscopy
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Beautiful 😍
add a skeleton here at some point
5 months ago
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Dual-axis cryo-ET on cryo-FIB milled lamella 🙂
www.researchsquare.com/article/rs-6...
#CryoEM
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On-lamella dual-axis cryo-electron tomography and modelling of lamella stability
Cryogenic electron tomography (cryo-ET) of cryogenic focused ion beam (cryo-FIB) milled lamellae enables the study of 3D cellular architecture in near-native conditions at nanometer-scale resolution. ...
https://www.researchsquare.com/article/rs-6497420/v1
5 months ago
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Denis Chrétien
European Research Council (ERC)
6 months ago
🎉 Congratulations to Wolfgang Baumeister
@maxplanck.de
, awarded the 2025
#ShawPrize
in Life Science & Medicine for pioneering work in cryo-ET! Learn more 👉
europa.eu/!JBXDBG
#FrontierResearch
#ERCSyG
#CryoET
#StructuralBiology
#shawprize2025
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ERC grantee wins the Shaw Prize in Life Science and Medicine
2025 Shaw Prize honours ERC-funded research in molecular imaging
https://europa.eu/!JBXDBG
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Denis Chrétien
Institut Pasteur | 130 years of biomedical research
6 months ago
Zoom into a human cell infected by Shigella, the bacteria behind dysentery. Using cryo-EM,
@leaswistak.bsky.social
and team revealed how it pierces cells with molecular syringes. Stunning science at the nanoscale.
@enningalab.bsky.social
@jytinevez.bsky.social
@nanoimaging.bsky.social
#CryoEM
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Philippe Van der Stappen
6 months ago
Hey
#TeamTomo
, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why
@florentwaltz.bsky.social
and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET
#CryoEM
🔬🧪
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Welcome to TomoGuide
A step-by-step Cryo-ET guide
https://tomoguide.github.io/
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Denis Chrétien
Marine Biological Laboratory
6 months ago
It's
#MicroscopyMonday
, so let's take a peek into the 🔬 This movie was taken by Shinya Inuoe, who built the polarizing microscope that allowed scientists to see mitotic spindle fibers live for the first time. Dr. Inuoe premiered his research at MBL.
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Alexis Verger 🧬🧫🧪
6 months ago
Choose Europe (France) for Science
#ESR
(credit : Jérôme Sié)
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Denis Chrétien
Romain Gibeaux
7 months ago
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Romain Gibeaux
7 months ago
WOSM-TIRF up running! Awesome
#Tirf
imaging of microtubules and EB comets in
#Xenopus
egg extract. The WOSM-TIRF is the big brother of the eduWOSM (
doi.org/10.7554/eLife.104046.1
). So grateful to
@irobcross.bsky.social
& Nick Carter for this collaboration &
@agencerecherche.bsky.social
for funding.
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Denis Chrétien
JEOL EUROPE
7 months ago
#JEOL
CRYO ARM™ 200
#CryoEM
installed at the Institute Genetics & Development of Rennes. First installation of this type of instrument in France and incorporates the latest technologies in cryo contrast enhancement and dual-axis
#tomography
. We wish IGDR success with their future research projects.
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First images coming soon 🤩
add a skeleton here at some point
7 months ago
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So beautiful 😍
7 months ago
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Jeff Aurand
7 months ago
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NanoImaging Services
7 months ago
The third and final chapter of our webinar series “Cryo-EM: Back to Basics” is on demand. Hear from Giovanna about challenges in
#cryoEM
, how to overcome them. Catch all three chapters: Chapter 1:
youtu.be/e8GyDe4_BAQ
Chapter 2:
youtu.be/2dBnPVkaoFs
Chapter 3:
youtu.be/kUGNSTGc8II
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Cryo-EM: Back to Basics - Chapter 1
Rediscover the fundamentals of cryo-EM with NIS CSO, Giovanna Scapin! Join us for three engaging sessions covering Sample Preparation & Imaging, Data Process...
https://youtu.be/e8GyDe4_BAQ
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Denis Chrétien
Joachim Frank
8 months ago
regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:
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Denis Chrétien
Pilhofer Lab 🦠❄️🔬
8 months ago
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper
www.cell.com/cell/fulltex...
by
@xujwet.bsky.social
&
@florianwollweber.bsky.social
, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules!
#TeamTomo
#ArchaeaSky
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Eric Lagadec
8 months ago
Revivez les dernières secondes de l'alunissage de la sonde Blue Ghost dimanche dernier!
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Joachim Frank
8 months ago
This is just wonderful
add a skeleton here at some point
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Denis Chrétien
Institut de Génétique & Développement de Rennes
8 months ago
📢 Are you planning to do a
#PhD
in
#Biology
? Do not miss our call for
#IGDR
PhD Program Apply before April 21st, 1:00 pm 4 to 8 positions available ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program cc
@cnrs-bretagneloire.bsky.social
@insermgrandouest.bsky.social
@rennesuniv.bsky.social
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Denis Chrétien
Institut de Génétique & Développement de Rennes
8 months ago
IGDR Keynote Lectures | Pr. Gabriel Waksman
#Science
#Biology
#Health
Structural and Molecular Biology of Bacterial Conjugation 📅 Thursday, April 3 🕒 11:00 AM 📍 Amphi A ℹ️
openagenda.com/fr/igdr-inst...
cc
@cnrs-bretagneloire.bsky.social
@insermgrandouest.bsky.social
@rennesuniv.bsky.social
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Scrat (JEOL ARM 200) is now installed in Rennes with a Direct Electron Apollo camera. Don't hesitate to get in touch if you need nice SPA or cryo-electron tomography (single and dual axis) data 😍
biosit.univ-rennes.fr/en/tem2c
#CryoEM
8 months ago
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Denis Chrétien
Joachim Frank
8 months ago
I think it's important to reach out to your own community and explain what the funding cuts mean in practice.
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Manuel Thery
8 months ago
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required. Please Repost 🙏 thanks !
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Denis Chrétien
laydgeur
8 months ago
Je pense qu’ici je prêche des convaincus, mais ce rappel est toujours bon, parce que je ne comprends toujours pas pourquoi nos politiques et officiels utilisent encore cette plate-forme de propagande hostile à la France pour leur communication… ça me dépasse.
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