Big congrats to our SFB alumna @vcmentowski.bsky.social on receiving the Bayer Pharmaceuticals PhD Award! Her work (previously also conducted in @andrea-musacchio.bsky.social's lab) reveals how CENP-E orchestrates kinetochore corona assembly and links it to mitotic checkpoint signaling. 🎉

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

Led by Investigator Scientist @hongmiaohu.bsky.social, @kellythd-nguyen.bsky.social’s group in the LMB’s Structural Studies Division have produced the first ever structure of telomerase from yeast. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch #cryoEM 🧪

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances! He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding. See more details in EMBL post below!

We had a fantastic time meeting so many people at the @cambridgebiocampus.bsky.social Career Fair earlier this month. Couldn’t make it? Visit our website to get a taste of life at the LMB and see our current vacancies: mrclmb.ac.uk/careers-and-...

📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵 www.biorxiv.org/content/10.6...

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

Have a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

TOMORROW – Nenad Ban from ETH Zürich will be joining us to discuss ‘Ribosome Upside Down: Co-translational Protein Biogenesis at the Tunnel Exit’. Don’t miss this fantastic #LMBSeminar, beginning at 11am (BST). More info: www2.mrc-lmb.cam.ac.uk/news-and-eve...

LMB welcomes @sventruckenbrodt.bsky.social as a new Group Leader in our Neurobiology Division! Sven will develop molecular brain mapping, harnessing expansion microscopy & molecular biology methods to better understand the neural basis of behaviour. www2.mrc-lmb.cam.ac.uk/the-lmb-welc... #LMBNews

Excited to share our new paper! 🎉 The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona www.science.org/doi/10.1126/... Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social

Excited to see this work published online at @cp-cell.bsky.social today! www.cell.com/cell/fulltex...

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳 How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look. www.cell.com/structure/fu...

We’re looking for a Research Support Officer to join @matteoall.bsky.social’s group, working with @piotrkolata.bsky.social to investigate nuclear-cytoskeletal coupling in mammalian cells using #cryoEM, #cryoET & other biochemical approaches. www.jobs.ac.uk/job/DOE317/r... Closes 31 AUG #ScienceJobs

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo www.biorxiv.org/content/10.1...

Check out our latest work now out on biorxiv www.biorxiv.org/content/10.1...

Check out this exciting new study from the @rgassmann.bsky.social lab that we are thrilled to be part of — revealing that CDR2 is a dynein adaptor that regulates ER sheet organization!!

Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology! You will be supported by core funding, excellent facilities & enthusiastic colleagues. Apply by 18 MAR www.nature.com/naturecareer...

Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool! www.nature.com/articles/s41...

We are looking for a senior administrator to take care of the Structural Studies Division at @mrclmb.bsky.social. Come and work for the benefit of human health in a fantastic environment. Happy to chat! www.jobs.ac.uk/job/DLY086/s...

The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/... (1/6)🧵

A cryo-electron tomography study of ciliary rootlet organization pubmed.ncbi.nlm.nih.gov/39641991/

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! www.biorxiv.org/content/10.1... 🧵 1/6

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps. www.nature.com/articles/s41...

We have three PhD projects with motor-cytoskeleton theme though collaborations with three new(ish) PIs at Bristol Biochemistry supported by SWBio_DTP with Berni Carroll (lysosome transport), @abidalilab.bsky.social (endocytosis) and Jessica Cross (protein design) see swbio.ac.uk/biomolecular...