Scientists at Cambridge's @loke-ctr.bsky.social have, for the first time, used base editing to study gene function in human embryos. In future, the findings could help to improve IVF success rates and better understand early pregnancy loss. Read more: https://bit.ly/4aQOAZD

New preprint! In collaboration with the Steinmetz Lab at PSI we report cryo-EM structures of microtubules at up to 1.9 Å (!) resolution & in different nucleotide state mimics, suggesting a mechanism for lattice-induced GTP hydrolysis and why it leads to catastrophe: tinyurl.com/7cjrf863

📢 (1/2) Excited to share the first preprint from my PostDoc! We developed UbSeRP to map co-translational ubiquitination in a translatome-wide, revealing thousands of quality control sites, and how they reshape with aging. www.biorxiv.org/content/10.6... #proteostasis #ribosomes #preprint

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...

How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: https://www.nature.com/articles/s41586-026-10650-0

There are lots of exciting opportunities to join the in situ structural biology community at Leeds this Autumn - 2 studentships in the Cheney PhD program (astbury.leeds.ac.uk/cheney-phd/) and I am recruiting a PhD student and research assistant. Please share and send any future tomographers our way!

New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc

Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms out in @plosbiology.org by @abultarafder.bsky.social and team. Exciting collaboration with @geiselbiofilm.bsky.social @pearce-maths.bsky.social and others

Design principles of human membrane protein topology. New study from Haoxi Wu @ox.ac.uk and Ramanujan S Hegde @mrclmb.ac.uk: rupress.org/jcb/article/... #membrane #lipid

🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...

Really happy to share our latest work on the dynactin complex. We were so surprised to find that overexpression of dynactin p50 causes part of the dynactin complex to form clusters that contain our recently discovered dynactin assembly factor VezA/vezatin. www.biorxiv.org/content/10.6...

We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

New preprint alert! Ever wonder if cells can talk to each other? Tunneling nanotubes (TNTs) are tiny bridges between cells used to pass organelles, nucleic acids, proteins & even viruses but we've never seen inside them clearly. Until now! 👇🧵 biorxiv.org/content/10.64898/2026.05.27.728322v1

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

How do mitochondrial ribosomes keep pace with membrane insertion? Now out in NSMB: We show that mitoribosomes slow down at defined positions linked to membrane insertion and protein topology: rdcu.be/fhqIT #Mitochondria #Ribosome #CryoEM

Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...

Our latest preprint list is now up on FocalPlane. This week, bioimage analysis takes centre stage! focalplane.biologists.com/2026/05/01/m... #microscopy #bioimageanalysis #preprints

Really exciting to see our new review published! This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology. Check it out here: doi.org/10.1242/dev....

Check out this new study led by @amicoennio.bsky.social , with important contributions from @sami-c.bsky.social, @abidalilab.bsky.social and @leonmichalski.bsky.social. The work dissects how dynein–dynactin engages distinct adaptors to drive transport of diverse cargoes within cells.

The #ADFLIP approach by @kaiyi94.bsky.social and @kjamali.bsky.social, combined with their approach to backpropagation through #AlphaFold2, is really powerful. Keep tuned for more exciting results! 🥳

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

We're excited to have our first webinar in our new webinar series on quantitative plant imaging happening this Thursday! For more info and to register for the webinar: focalplane.biologists.com/2026/03/30/n...

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

A new paper in which we could contribute structural insights to the great biochemical work from our collaborators from UNC Chapel Hill. Sascha Amann from our lab was yet again able to solve several very challenging structures. This time of a SCF with Protac and target www.nature.com/articles/s41...

Congratulations to Manu Hegde, Group Leader & Joint Head of @cellbiol-mrclmb.bsky.social, who has been elected a member of the American Academy of Arts & Sciences. Congratulations also to the #LMBalumni joining him, Julie Ahringer & Edward Egelman. Read more: mrclmb.ac.uk/news-events/... #LMBNews

Eva Simpson (University of Nottingham) is awarded the 2026 Raff Medal PhD Award at #DynamicCellVI by our PhD Rep @harrietasmith.bsky.social, before her fantastic medal talk about her research using 3D-CLEM to study meiotic chromosome organisation Congratulations Eva 👏👏

Fantastic talk from our 2026 Postdoc ECR Medal Winner @giuliapaci.bsky.social from @lmcb-ucl.bsky.social at #DynamicCellVI explaining her research on the role of 3D epithelial topology in developmental patterning Congratulations Giulia 👏👏

Hooke Medal winner Stephen Tait @mitosrus.bsky.social @cruk-si.bsky.social is presented with his medal by BSCB president Laura Machesky before his fantastic medal talk on 'mitochondria, death and something in between' #DynamicCellVI

Don’t miss next week’s #LMBSeminar from Clemens Plaschka (@plaschkalab.bsky.social), Senior Group Leader at IMP, Vienna. Beginning at 11am (BST) on Monday 27 April, Clemens will join us to discuss ‘Mechanisms of mRNA packaging and export’ Visit our website for more info: mrclmb.ac.uk/news-events/...

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year. Applications are open now! More details: mrclmb.ac.uk/careers-and-... Please share this post with anyone who may be interested!

Dimerisation and twist reversal of the Lewy fold in alpha-synuclein mutants with Parkinson's disease and dementia. Together with Yang Yang (now at @vai.org) and Michel Goedert. 🥳 www.biorxiv.org/content/10.6...

Happy to see our paper describing cryo-EM structures of the budding yeast KMN kinetochore complex published in @jcb.org! Our structure reveals how an important hub mediates and regulates assembly of the machine that segregates chromosomes. #cryo-EM @mrclmb.ac.uk 🔗 rupress.org/jcb/article/...

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint. 'Motile ciliophagy promotes ciliary recycling under stress' www.biorxiv.org/content/10.6...

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...

On 27th April, we’ll be welcoming Clemens Plaschka back to the LMB to present an #LMBSeminar on ‘Mechanisms of mRNA packaging and export’ Clemens, previously an LMB postdoc, is now a Senior Group Leader at IMP, Vienna - @plaschkalab.bsky.social. Talk details: mrclmb.ac.uk/news-events/...

It's a big day for our team. Excited to share the launch of the Thermo Scientific™ Glacios™ 3 Cryo-TEM, our latest 200 kV #cryoEM platform. High-performance imaging with the Thermo Scientific™ READY™ System that can lower installation time and infrastructure costs. Learn more: ter.li/alac5m

Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...

Extended this (map_salami) a bit - added a movie option which will generate a labeled movie (1080p or 4k) transitioning between all scenes, with a short rocking motion at each scene for depth perception:

Big congrats to our SFB alumna @vcmentowski.bsky.social on receiving the Bayer Pharmaceuticals PhD Award! Her work (previously also conducted in @andrea-musacchio.bsky.social's lab) reveals how CENP-E orchestrates kinetochore corona assembly and links it to mitotic checkpoint signaling. 🎉

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

Led by Investigator Scientist @hongmiaohu.bsky.social, @kellythd-nguyen.bsky.social’s group in the LMB’s Structural Studies Division have produced the first ever structure of telomerase from yeast. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch #cryoEM 🧪

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances! He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding. See more details in EMBL post below!

We had a fantastic time meeting so many people at the @cambridgebiocampus.bsky.social Career Fair earlier this month. Couldn’t make it? Visit our website to get a taste of life at the LMB and see our current vacancies: mrclmb.ac.uk/careers-and-...

📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.