Haselbach Lab
@haselbachlab.bsky.social
📤 1023
📥 387
📝 73
cryo EM enthusiasts with interest in molecular machines.
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Haselbach Lab
Kashish Singh
10 days ago
Happy to share my first adventure in
#TeamTomo
in collaboration with the talented
@inaharasimov.bsky.social
. It was a fun experience experience with a lot of learning along the way.
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Carter Lab
10 days ago
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with
@niakanlab.bsky.social
and work led by
@kashishsingh.bsky.social
and
@inaharasimov.bsky.social
. It is now out on BioRxiv:
www.biorxiv.org/content/10.6...
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Haselbach Lab
16 days ago
The
@natsmb.nature.com
March issue is out! Though always interested in proteostasis, in 2026 we have published and will continue to do so relevant content. Our editorial
www.nature.com/articles/s41...
recaps why the processes and mechanisms of proteostasis continue to interest us.
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No stasis in proteostasis - Nature Structural & Molecular Biology
In this issue of Nature Structural & Molecular Biology, we focus on all things protein homeostasis, highlighting a variety of processes, from protein quality control in translation to autophagy.
https://www.nature.com/articles/s41594-026-01783-x
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Haselbach Lab
EMBL-EBI
18 days ago
You asked, we listened. Millions of AI-predicted protein complex structures are now available in the
#AlphaFold
Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list.
www.ebi.ac.uk/about/news/t...
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Vienna BioCenter Scientific Training
21 days ago
Learn more about the collaboration possibilities offered at Vienna BioCenter as Victoria Deneke shares her insights as a Postdoc at the Research Institute of Molecular Pathology. The VIP³ PostDoc Program call is open – apply now!
training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
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Haselbach Lab
Vienna BioCenter Scientific Training
23 days ago
Our Spring call is now open with over 30+ fully funded positions in the life sciences. Want to know more? Join our Info Session on 26 March, 1600 (CET). Register now: www.vbcphd.at
Institute of Molecular Biotechnology
,
Max Perutz Labs Vienna
,
IMP
,
Gregor Mendel Institute of Molecular Plant Biology
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Welcome to the vbc and the wonderful Vienna cryo EM community
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23 days ago
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Haselbach Lab
Kresten Lindorff-Larsen
26 days ago
Review from Fia B. Larsen in
@rhp-lab.bsky.social
with everything you always wanted to know about proteasomal control of transcription factors (but were afraid to ask about) Proteasomal control of transcription factors: mechanisms, regulation and dysregulation.
doi.org/10.1007/s000...
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Haselbach Lab
IMP
25 days ago
A consortium of group leaders from IMP, IMBA (Vienna BioCenter) and ISTA has been awarded an FWF Emerging Fields grant to study how germ cells safeguard and pass on genetic information across generations.
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Haselbach Lab
Max Planck Institute of Biochemistry
about 1 month ago
#pictureofthemonth
: March shows a “Cross-section” of the endoplasmic reticulum, a kind of membrane-labyrinth, using cryo-electron microscopy. More:
www.biochem.mpg.de/plitzko
March – Calendar of
@mpiforbi.bsky.social
and
@mpibiochem.bsky.social
📸 Illustration by Jürgen Plitzko & Sven Klumpe
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Haselbach Lab
MRC Laboratory of Molecular Biology
about 1 month ago
Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR
www.nature.com/naturecareer...
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Haselbach Lab
Vienna BioCenter
about 1 month ago
SAVE THE DATE: Ubiquitin & Friends Symposium 2026 on April 29-30 or even better, sign up now:
lnkd.in/eEQmaCYT
It takes place at Van Swieten Hall, 1090 Vienna & is organized by the SFB Targeted Protein Degradation (incl. numerous research groups at Vienna BioCenter)
@sfb-tpd-vienna.bsky.social
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Haselbach Lab
Kristina Stapornwongkul
about 1 month ago
We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply!
#optogenetics
#metabolism
#devbio
#hESCs
Please RT. Thank you!🙏
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Haselbach Lab
Sjors Scheres
about 2 months ago
Please spread the word: the Structural Studies Division
@mrclmb.bsky.social
is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
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Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
https://mrc.tal.net/vx/mobile-0/appcentre-int/brand-3/spa-1/candidate/so/pm/1/pl/3/opp/2775-Research-Group-Leader-Tenure-Track-Structural-Studies-LMB-2775/en-GB
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reposted by
Haselbach Lab
about 1 month ago
Our paper is out in
@natcomms.nature.com
! APOBEC3s drive mutagenesis in cancer. We uncover a novel pathway keeping them in check. The key is APOBEC3 binding of cellular RNAs, which simultaneously controls their nuclear localization and shields them from degradation. Read it here:
rdcu.be/e4qaa
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This is a video summarizing our recent paper (
www.nature.com/articles/s41...
)
youtu.be/eNY2CRlYTRo
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A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications
Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...
https://www.nature.com/articles/s41467-026-69162-0
about 2 months ago
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And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story:
www.nature.com/articles/s41...
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about 2 months ago
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Haselbach Lab
Kresten Lindorff-Larsen
about 2 months ago
A near-complete map of human cytosolic degrons and their relevance for disease We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence Led by
@vvouts.bsky.social
in
@rhp-lab.bsky.social
doi.org/10.1126/scia...
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Great story from our neighbours at the university of Vienna. We are that we could contribute to this.
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2 months ago
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Haselbach Lab
Juan Carlos De la Concepcion
2 months ago
Please share! My group at
@zmbp-tuebingen.bsky.social
is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th!
uni-tuebingen.de/universitaet...
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Haselbach Lab
Lorenz Grundmann
2 months ago
Check out our new paper in
@natcomms.nature.com
.com where we used
#cryoEM
together with biochemical and mutational analyses investigated the cotranslational protein folding by Ssb in yeast. Publication:
doi.org/10.1038/s41467-025-67685-6
Check below for the cryoEM centric feed. 👇
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Haselbach Lab
Max Planck Institute of Biochemistry
2 months ago
Formation & function of
#MembranelessOrganelles
!
#CryoET
structures of
#proteasome
storage granules inside cells! Read our paper
@cp-cell.bsky.social
! ❕Publication:
doi.org/10.1016/j.ce...
❕Press Release:
www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu
#UPSmeetMet
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Haselbach Lab
IMP
2 months ago
New work from our Haselbach lab with collaborators captures ribosomes 𝘮𝘪𝘥-𝘣𝘶𝘪𝘭𝘥 and reveals a flexible, modular strategy behind their assembly, rather than a strict assembly line. Published in _Nucleic Acids Research _👉
https://doi.org/10.1093/nar/gkag036
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Haselbach Lab
Michael Prattes
2 months ago
🔬 Ribosomes are hands down one of the most intricate molecular machines we know. Huge (for a cellular scale at least) complexes made of long RNAs (rRNAs) and proteins … a lot of different proteins. 1/6 (❗️Sound on!)
@narjournal.bsky.social
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And the 4th paper in this week contribution from our lab tells about ribosome biogenesis in yeast. A follow-up story from our wonderful collaborators in Graz - the Bergler Lab. Structural work was again done by the amazing
@lgrundmann.bsky.social
:
academic.oup.com/nar/article/...
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A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic ribosome formation
Abstract. Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) whil
https://academic.oup.com/nar/article/54/3/gkag036/8437648?searchresult=1
2 months ago
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Haselbach Lab
Maximilian Madern
2 months ago
Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions.
www.biorxiv.org/content/10.6...
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I am very happy that I could advice in this great story. Seeing single proteasomes degrade in cells is opens so many interesting possibilities. Check the preprint.
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2 months ago
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And another paper with contribution from us. Here Sascha Amann solved the structure of the BORC complex. Due to its shape it is extremely challenging for cryo EM analysis but still he cracked it. Read the full story spearheaded by the Huber lab in Innsbruck:
www.pnas.org/doi/10.1073/...
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2 months ago
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Haselbach Lab
Gregor Weiss
2 months ago
🔬 Postdoc position – Infection Biology & Cryo-ET (Zurich) 🇨🇭 We are looking for a motivated Postdoc to join our interdisciplinary team. 📩 Interested? Check out the job advert:
www.imm.uzh.ch/dam/jcr:cb17...
👉 More info on the lab:
www.weiss-laboratory.com
Please share with interested colleagues!
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Have a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the
@uni-freiburg.de
. Structural work has been done by the amazing
@lgrundmann.bsky.social
Stay tuned for the next ribosome paper from him, following very soon.
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2 months ago
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Haselbach Lab
Jakob Farnung
3 months ago
When RNA Degradation 🤝 meets 🤝 Protein Degradation!
tinyurl.com/E3TDMD
In a collaboration of
@bartellab.bsky.social
and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
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My this years Christmas chocolates ended up a little IMP branded ;)
4 months ago
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Haselbach Lab
Kate Beckham
4 months ago
www.nature.com/articles/s41...
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AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
https://www.nature.com/articles/s41592-023-02087-4
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Haselbach Lab
Karolin Luger
4 months ago
so many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution.
#standupforscience
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Haselbach Lab
Yasin Dagdas
4 months ago
Please RT‼️
#TenureTrack
position
@zmbh.uni-heidelberg.de
one of the best
#proteostasis
research centres in the world.
www.nature.com/naturecareer...
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Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
https://www.nature.com/naturecareers/job/12850668/tenure-track-professorship-w1-with-tenure-track-to-w3-in-molecular-biology-f-m-d-/
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Haselbach Lab
Alicia Michael
4 months ago
One month later and still thinking about the great science and conversations from the 8th Austrian Cryo-EM Symposium 🧊🔬 Huge thanks to all who joined - let’s make next year even bigger!
cryoem-symposium.pages.ist.ac.at/invited-spea...
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Haselbach Lab
Rachel O'Dea
4 months ago
SAVE THE DATE! The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026. Exciting line up of talks and an amazing location! Organised by
@kulathu.bsky.social
,
@merbllab.bsky.social
,
@simonapolo.bsky.social
, Claudio Joazeiro. Registration open soon.
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Oh if this isnt a very familiar molecule :)
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4 months ago
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So now its official I will have to spend my christmas for a second time in a row with grant writing - but maybe third time is the charm ...
4 months ago
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Join us in a highly collaborative environment. At the IMP everything is possible.
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5 months ago
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Haselbach Lab
IMP
5 months ago
🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP:
www.imp.ac.at/career/open-...
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Max Perutz Labs Vienna
5 months ago
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️
tinyurl.com/brswbymu
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It was a great pleasure hosting
@lindorfflarsen.bsky.social
at the VBC today. Great talk and engaging discussions! Thanks for your visit!
5 months ago
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Haselbach Lab
Kresten Lindorff-Larsen
5 months ago
Looking forward to visit colleagues in Vienna and Graz 🇦🇹 If you’re in Vienna I’m speaking on: Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA) & Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
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Haselbach Lab
Institute of Science and Technology Austria (ISTA)
6 months ago
Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉
cryoem-symposium.pages.ist.ac.at/registration/
#cryoEM
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Haselbach Lab
Kenneth Ehses
6 months ago
✨Excited that the main project of my PhD is now available as a pre-print on
#bioRxiv
Here, we used
#CryoET
to visualise mitochondrial proteostatic stress and together with SPA
#CryoEM
shed light into the functional cycle of the Hsp60:10 chaperone system.
#TeamTomo
🔗
www.biorxiv.org/content/10.1...
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Haselbach Lab
Julius Brennecke
6 months ago
The Vienna BioCenter PhD Program application deadline is approaching: October 10! Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology. Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD
#LifeSciences
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Haselbach Lab
Josh Hardy
6 months ago
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates
#RFdiffusion
,
#ProteinMPNN
,
#FAMPNN
,
#AlphaFold2
and
#Boltz-2
. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028
#proteindesign
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Finally! This was really missing.
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6 months ago
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Haselbach Lab
David Balchin
7 months ago
Our article on human multidomain protein biogenesis is now published in
@natsmb.nature.com
www.nature.com/articles/s41...
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The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
https://www.nature.com/articles/s41594-025-01676-5
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