Haselbach Lab
@haselbachlab.bsky.social
📤 939
📥 336
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cryo EM enthusiasts with interest in molecular machines.
Join us in a highly collaborative environment. At the IMP everything is possible.
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4 days ago
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Haselbach Lab
IMP
5 days ago
🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP:
www.imp.ac.at/career/open-...
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Max Perutz Labs Vienna
15 days ago
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️
tinyurl.com/brswbymu
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It was a great pleasure hosting
@lindorfflarsen.bsky.social
at the VBC today. Great talk and engaging discussions! Thanks for your visit!
15 days ago
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Kresten Lindorff-Larsen
20 days ago
Looking forward to visit colleagues in Vienna and Graz 🇦🇹 If you’re in Vienna I’m speaking on: Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA) & Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
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Institute of Science and Technology Austria (ISTA)
about 1 month ago
Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉
cryoem-symposium.pages.ist.ac.at/registration/
#cryoEM
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Kenneth Ehses
about 1 month ago
✨Excited that the main project of my PhD is now available as a pre-print on
#bioRxiv
Here, we used
#CryoET
to visualise mitochondrial proteostatic stress and together with SPA
#CryoEM
shed light into the functional cycle of the Hsp60:10 chaperone system.
#TeamTomo
🔗
www.biorxiv.org/content/10.1...
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Julius Brennecke
about 1 month ago
The Vienna BioCenter PhD Program application deadline is approaching: October 10! Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology. Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD
#LifeSciences
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Josh Hardy
about 2 months ago
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates
#RFdiffusion
,
#ProteinMPNN
,
#FAMPNN
,
#AlphaFold2
and
#Boltz-2
. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028
#proteindesign
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Finally! This was really missing.
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about 2 months ago
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David Balchin
about 2 months ago
Our article on human multidomain protein biogenesis is now published in
@natsmb.nature.com
www.nature.com/articles/s41...
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The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
https://www.nature.com/articles/s41594-025-01676-5
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Haselbach Lab
Edouard Hannezo
about 2 months ago
Core achievement unlocked!! Congrats to Fabrizio amd all authors!!
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Jack Bravo
2 months ago
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at
@istaresearch.bsky.social
! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉
cryoem-symposium.pages.ist.ac.at
#cryoEM
#teamtomo
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Laura Lorenzo Orts
2 months ago
I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal
#mRNA
regulation and
#translation
in early vertebrate development, please apply! Deadline: 16 October. More info:
www.imb.de/students-pos...
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Laura Lorenzo Orts
IMB Mainz
https://www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/projects-offered/laura-lorenzo-orts
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Wow this seems to be a major breakthrough can’t wait to test it on all the small stuff we could never solve
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2 months ago
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It was wonderful to be back in Göttingen and see so many friendly and familiar faces. Still a city of vibrant science.
2 months ago
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cryoEM papers
2 months ago
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22
pubmed.ncbi.nlm.nih.gov/40909644/
#cryoem
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Haselbach Lab
Itai Yanai
4 months ago
🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!
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Jack Bravo
4 months ago
Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at
@istaresearch.bsky.social
, with speakers inc.
@grigoriefflab.bsky.social
,
@oliveiramann.bsky.social
,
@bjgreber.bsky.social
@svenklumpe.bsky.social
@sebastianglatt.bsky.social
https://tinyurl.com/cryo2025
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Austrian Cryo-EM Symposium
https://cryoem-symposium.pages.ist.ac.at/
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Span Lab FAU
6 months ago
Great work highlighting how important it is to carry out experimental structure determination instead relying on AlphaFold predictions.
#crystallography
#structure
#biology
#chemistry
www.nature.com/articles/s41...
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AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
https://www.nature.com/articles/s41592-023-02087-4
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Indeed it was a rather eventful meeting with a lot of great science
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6 months ago
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Arjen Jakobi
6 months ago
We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation. Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation.
cryotud.github.io/locscale/
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Lorenz Grundmann
6 months ago
The 'RNA meets Protein Decay'
@embo.org
workshop was really a blast. Thanks to everyone for the lively discussions! I am especially honoured that my poster was awarded with one of the two poster prizes 😇
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Itai Yanai
6 months ago
It was amazing to do a Night Science workshop today at the Karolinska Institute in Stockholm!
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Haselbach Lab
Di Jiang
6 months ago
@science.org
🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science
www.science.org/doi/10.1126/...
@yiweichang.bsky.social
www.yiweichanglab.org
@jiwasa.bsky.social
#virology
#Influenza
#Cryo-EM
#StructuralBiology
#RNA
#polymerase
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Congrats to
@lgrundmann.bsky.social
for winning a poster award at
#EMBORNAmeetsproteindecay
6 months ago
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Haselbach Lab
Max Fürst
7 months ago
If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”? If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein. Think I’ve finally found a way.
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Sergio Cruz-León
7 months ago
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/
@jpkreysing.bsky.social
,
@johannesbetz.bsky.social
,
@marinalusic.bsky.social
, Turoňová lab,
@hummerlab.bsky.social
@becklab.bsky.social
@mpibp.bsky.social
🔗 Preprint here
tinyurl.com/3a74uanv
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Ste Muench
7 months ago
I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.
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Haselbach Lab
Sven Klumpe
7 months ago
Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn
www.biorxiv.org/content/10.1...
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New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains:
www.biorxiv.org/content/10.1...
This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9
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Structural basis for the ubiquitin chain recognition of the human 26S proteasome
Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...
https://www.biorxiv.org/content/10.1101/2025.04.07.647569v1
7 months ago
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Amazing! Congratulations!
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7 months ago
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Georg Winter
7 months ago
🚨 Hiring Alert – Senior Scientist (Biology) 🚨 My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology 🧬 Lead screens 🤝 Collaborate with top-tier AI/chemistry/biology minds Interested? then apply:
cemm.onlyfy.jobs/job/t7lhh1kz
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AITHYRA
https://www.oeaw.ac.at/aithyra
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We are looking for PhD students using time resolved cryoEM or cryoET on topics of the ubiquitin proteasome system, fertility and immunity. However, there is freedom to shape projects in own ways.
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7 months ago
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Okay really nice video, but except that the instrument is now black it does not give any detail on the Krios5.
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8 months ago
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Haselbach Lab
Institute of Molecular Biotechnology
8 months ago
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
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15 years ago I took this course. It was really amazing! So this is highly recommended!
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8 months ago
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Haselbach Lab
eurobioimaging.bsky.social
8 months ago
With
@agroserv.bsky.social
funding,
@delaconcepcionjc.bsky.social
visited
@embl.org
Imaging Centre to use cryo-EM & CLEM to see how fungal pathogens penetrate plants with unprecedented results.🔬🌾 Learn more🔽
eurobioimaging.eu/news/imaging...
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Imaging to combat crop diseases: How Euro-BioImaging transforms agricultural research
Between 20-40% of global food crop production is lost each year due to plant pests and pathogens, highlighting the urgency for scientific research in this area. Disease losses are particularly…
https://eurobioimaging.eu/news/imaging-to-combat-crop-diseases-how-euro-bioimaging-transforms-agricultural-research/
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We are looking for a PhD student working on the ubiquitin proteasome system with time resolved cryo EM or cryoET. Topics in biophysical mechanisms, a well as immunology or reproduction are available.
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8 months ago
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Haselbach Lab
Georg Winter
8 months ago
Something that qualifies as big news from my side: I am very happy and excited to announce that I have been appointed as Life Science Director at AITHYRA, a new Research Institute for Biomedical Artificial Intelligence. Find out more in the link and 🧵 below
lnkd.in/d_HaGuSE
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LinkedIn
This link will take you to a page that’s not on LinkedIn
https://lnkd.in/d_HaGuSE
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Congratulations
@georgwinter.bsky.social
great to have you even closer around :)
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8 months ago
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really sad news. Karen was always extremely helpful and supportive with everything we did at Diamond.
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8 months ago
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Haselbach Lab
IMP
8 months ago
We are seeking to fill a type of position that will be new to the IMP: a Scientific Grant Writer to help with externally funded research projects throughout the process: identify donors, apply, coordinate collaborators, oversee implementation, & report back to donors.
www.imp.ac.at/career/open-...
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Ref2504: Scientific Grant Writer (m/f/d), full-time | Research Institute of Molecular Pathology
https://www.imp.ac.at/career/open-positions/ref2504-scientific-grant-writer
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great work! Good to have you soon on Campus Sven
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8 months ago
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IMP
9 months ago
👩🔬Are you an IMP alumnus? The new Vienna BioCenter Alumni Platform is launching soon. Follow
@vbcscitraining.bsky.social
for updates and check your inbox!
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Haselbach Lab
Pavol Harar
9 months ago
Finally, my postdoc work is published in Cell Structure! 🎉 Grateful for the chance to apply deep learning to cryo-ET and learn from
@haselbachlab.bsky.social
about structural biology🦠. Huge thanks to Lukas Herrmann for coding help and Philipp Grohs for my position and all the GPUs.
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Haselbach Lab
IMP
9 months ago
🔬Our
@haselbachlab.bsky.social
with Pavol Harar have developed ‘FakET’! The new method creates ‘fake’ electron microscopy images to train AI, reducing manual work in particle identification. Read the full story:
www.imp.ac.at/news/article...
@viennabiocenter.bsky.social
#AI
#cryoem
#microscopy
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Haselbach Lab
IMP
9 months ago
At the IMP we’re dedicated to the fun of finding out. Few places in the world let you dive into curiosity-driven science like we do. 📽️Watch what the IMP is all about:
youtu.be/mtl5Vod652Q
@viennabiocenter.bsky.social
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Haselbach Lab
IMP
9 months ago
We will soon welcome
@svenklumpe.bsky.social
to the Vienna BioCenter, where he will use cryo-Electron Tomography to study - among other things - how
#transposons
shape
#germlines
. Sven's lab will be
@imbavienna.bsky.social
*AND* the IMP. Full story:
www.viennabiocenter.org/about/news/s...
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Sven Klumpe to start cryo-Electron Tomography lab at IMP and IMBA
The Vienna BioCenter institutes IMP and IMBA will soon host a joint research group headed by Sven Klumpe. The structural biologist will join the two institutes with an innovative double-affiliation to...
https://www.viennabiocenter.org/about/news/sven-klumpe-to-start-cryo-electron-tomography-lab/
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Haselbach Lab
MRC Laboratory of Molecular Biology
11 months ago
Exciting 3-year postdoc opportunity with
@carter-lab.bsky.social
within a programme aimed at identifying the links between microtubule motors and axonal cargos. Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs
#CambridgeJobs
#PostdocJobs
#GenomeEngineering
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