My this years Christmas chocolates ended up a little IMP branded ;)

so many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution. #standupforscience

Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...

One month later and still thinking about the great science and conversations from the 8th Austrian Cryo-EM Symposium 🧊🔬 Huge thanks to all who joined - let’s make next year even bigger! cryoem-symposium.pages.ist.ac.at/invited-spea...

SAVE THE DATE! The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026. Exciting line up of talks and an amazing location! Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro. Registration open soon.

Oh if this isnt a very familiar molecule :)

So now its official I will have to spend my christmas for a second time in a row with grant writing - but maybe third time is the charm ...

Join us in a highly collaborative environment. At the IMP everything is possible.

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

It was a great pleasure hosting @lindorfflarsen.bsky.social at the VBC today. Great talk and engaging discussions! Thanks for your visit!

Looking forward to visit colleagues in Vienna and Graz 🇦🇹 If you’re in Vienna I’m speaking on: Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA) & Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)

Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at/registration/ #cryoEM

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1...

The Vienna BioCenter PhD Program application deadline is approaching: October 10! Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology. Apply and start your scientific journey in Vienna! training.vbc.ac.at/phd-program/ #PhD #LifeSciences

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

Finally! This was really missing.

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

Core achievement unlocked!! Congrats to Fabrizio amd all authors!!

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Wow this seems to be a major breakthrough can’t wait to test it on all the small stuff we could never solve

It was wonderful to be back in Göttingen and see so many friendly and familiar faces. Still a city of vibrant science.

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 pubmed.ncbi.nlm.nih.gov/40909644/ #cryoem

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

Great work highlighting how important it is to carry out experimental structure determination instead relying on AlphaFold predictions. #crystallography #structure #biology #chemistry www.nature.com/articles/s41...

Indeed it was a rather eventful meeting with a lot of great science

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation. Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation. cryotud.github.io/locscale/

The 'RNA meets Protein Decay' @embo.org workshop was really a blast. Thanks to everyone for the lively discussions! I am especially honoured that my poster was awarded with one of the two poster prizes 😇

It was amazing to do a Night Science workshop today at the Karolinska Institute in Stockholm!

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/... @yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

Congrats to @lgrundmann.bsky.social for winning a poster award at #EMBORNAmeetsproteindecay

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”? If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein. Think I’ve finally found a way.

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

Amazing! Congratulations!

🚨 Hiring Alert – Senior Scientist (Biology) 🚨 My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology 🧬 Lead screens 🤝 Collaborate with top-tier AI/chemistry/biology minds Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz

We are looking for PhD students using time resolved cryoEM or cryoET on topics of the ubiquitin proteasome system, fertility and immunity. However, there is freedom to shape projects in own ways.

Okay really nice video, but except that the instrument is now black it does not give any detail on the Krios5.

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

15 years ago I took this course. It was really amazing! So this is highly recommended!

With @agroserv.bsky.social funding, @delaconcepcionjc.bsky.social visited @embl.org Imaging Centre to use cryo-EM & CLEM to see how fungal pathogens penetrate plants with unprecedented results.🔬🌾 Learn more🔽 eurobioimaging.eu/news/imaging...

We are looking for a PhD student working on the ubiquitin proteasome system with time resolved cryo EM or cryoET. Topics in biophysical mechanisms, a well as immunology or reproduction are available.

Something that qualifies as big news from my side: I am very happy and excited to announce that I have been appointed as Life Science Director at AITHYRA, a new Research Institute for Biomedical Artificial Intelligence. Find out more in the link and 🧵 below lnkd.in/d_HaGuSE

Congratulations @georgwinter.bsky.social great to have you even closer around :)

really sad news. Karen was always extremely helpful and supportive with everything we did at Diamond.