Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

Core achievement unlocked!! Congrats to Fabrizio amd all authors!!

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Wow this seems to be a major breakthrough can’t wait to test it on all the small stuff we could never solve

It was wonderful to be back in Göttingen and see so many friendly and familiar faces. Still a city of vibrant science.

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 pubmed.ncbi.nlm.nih.gov/40909644/ #cryoem

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

Great work highlighting how important it is to carry out experimental structure determination instead relying on AlphaFold predictions. #crystallography #structure #biology #chemistry www.nature.com/articles/s41...

Indeed it was a rather eventful meeting with a lot of great science

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation. Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation. cryotud.github.io/locscale/

The 'RNA meets Protein Decay' @embo.org workshop was really a blast. Thanks to everyone for the lively discussions! I am especially honoured that my poster was awarded with one of the two poster prizes 😇

It was amazing to do a Night Science workshop today at the Karolinska Institute in Stockholm!

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/... @yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

Congrats to @lgrundmann.bsky.social for winning a poster award at #EMBORNAmeetsproteindecay

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”? If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein. Think I’ve finally found a way.

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

Amazing! Congratulations!

🚨 Hiring Alert – Senior Scientist (Biology) 🚨 My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology 🧬 Lead screens 🤝 Collaborate with top-tier AI/chemistry/biology minds Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz

We are looking for PhD students using time resolved cryoEM or cryoET on topics of the ubiquitin proteasome system, fertility and immunity. However, there is freedom to shape projects in own ways.

Okay really nice video, but except that the instrument is now black it does not give any detail on the Krios5.

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

15 years ago I took this course. It was really amazing! So this is highly recommended!

With @agroserv.bsky.social funding, @delaconcepcionjc.bsky.social visited @embl.org Imaging Centre to use cryo-EM & CLEM to see how fungal pathogens penetrate plants with unprecedented results.🔬🌾 Learn more🔽 eurobioimaging.eu/news/imaging...

We are looking for a PhD student working on the ubiquitin proteasome system with time resolved cryo EM or cryoET. Topics in biophysical mechanisms, a well as immunology or reproduction are available.

Something that qualifies as big news from my side: I am very happy and excited to announce that I have been appointed as Life Science Director at AITHYRA, a new Research Institute for Biomedical Artificial Intelligence. Find out more in the link and 🧵 below lnkd.in/d_HaGuSE

Congratulations @georgwinter.bsky.social great to have you even closer around :)

really sad news. Karen was always extremely helpful and supportive with everything we did at Diamond.

We are seeking to fill a type of position that will be new to the IMP: a Scientific Grant Writer to help with externally funded research projects throughout the process: identify donors, apply, coordinate collaborators, oversee implementation, & report back to donors. www.imp.ac.at/career/open-...

great work! Good to have you soon on Campus Sven

👩‍🔬Are you an IMP alumnus? The new Vienna BioCenter Alumni Platform is launching soon. Follow @vbcscitraining.bsky.social for updates and check your inbox!

Finally, my postdoc work is published in Cell Structure! 🎉 Grateful for the chance to apply deep learning to cryo-ET and learn from @haselbachlab.bsky.social about structural biology🦠. Huge thanks to Lukas Herrmann for coding help and Philipp Grohs for my position and all the GPUs.

🔬Our @haselbachlab.bsky.social with Pavol Harar have developed ‘FakET’! The new method creates ‘fake’ electron microscopy images to train AI, reducing manual work in particle identification. Read the full story: www.imp.ac.at/news/article... @viennabiocenter.bsky.social #AI #cryoem #microscopy

At the IMP we’re dedicated to the fun of finding out. Few places in the world let you dive into curiosity-driven science like we do. 📽️Watch what the IMP is all about: youtu.be/mtl5Vod652Q @viennabiocenter.bsky.social

We will soon welcome @svenklumpe.bsky.social to the Vienna BioCenter, where he will use cryo-Electron Tomography to study - among other things - how #transposons shape #germlines. Sven's lab will be @imbavienna.bsky.social *AND* the IMP. Full story: www.viennabiocenter.org/about/news/s...

Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos. Read more about the role here: www.nature.com/naturecareer... Apply by 30 DEC #ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering

For those interested in ubiquitinating their own sugars: our plasmid for bacterial expression of the constitutive HOIL-1 variant is now available via Addgene: www.addgene.org/229539/

🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...

More details in the #preprint biorxiv.org/content/10.1... As always please let us know what you think! #plantscience #autophagy #preprint

Looking for a primer on why the contrast transfer function matters in #cryoEM? Have a look at our updated #CryoSPARC Guide pages on CTF estimation! We cover intuition, theory, job types and practical considerations: guide.cryosparc.com/processing-d...

🔊Registration OPEN NOW: Ubiquitin & Friends Symposium, 8-9 May 2025, in Vienna, Austria. Fantastic guest speakers👇PLUS open slots for talks from abstracts. Great opportunity for #ECRs! 🗓️Deadline for abstracts & registrations: 7 April 2025 ➡️ www.protein-degradation.org/symposium/ #ubfriends2025

How is protein degradation inhibited in dormant cells? The @haselbachlab.bsky.social discovered that proteasomes are blocked by PITHD1, e.g. in dormant zebrafish eggs. Very happy that we (josefroe.bsky.social @pauligroup.bsky.social) could contribute to this very interesting mechanistic work!

🚀 New publication 🚀 I am excited that the preprint on the nuclear import mechanism of the proteasome is published. It was a major team effort from the two labs @haselbachlab.bsky.social @johanneszuber.bsky.social. The project was spearheaded by the amazing first author @hannabrunner.bsky.social.

Since I read about AKIRIN2 in 2021 in their earlier paper in Nature, I have always been fascinated by this protein. This follow-up preprint is aimed at unraveling the mechanistic aspects of its functions! Just excited at the fact that we have so much more to learn about the world of #proteostasis!

The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/... (1/6)🧵

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! www.biorxiv.org/content/10.1... 🧵 1/6