David Bartel's Lab
@bartellab.bsky.social
📤 468
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David Bartel's lab @WhiteheadInst @MIT @HHMI | microRNAs, mRNAs, and other RNAs
Check out the latest work from Jordan Ray (
@jordanray.bsky.social
), a collaboration between our lab and David Sabatini’s lab.
www.biorxiv.org/content/10.1...
(1/2)
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Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
https://www.biorxiv.org/content/10.1101/2025.09.09.674968v1
14 days ago
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reposted by
David Bartel's Lab
Eugene Valkov
about 1 month ago
Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by
@filippekovic.bsky.social
, in collaboration with Perry Blackshear.
www.nature.com/articles/s41...
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Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin - Nature Communications
Deadenylation leads to mRNA decay, with PABPC1 protecting the poly(A) tail, while tristetraprolin and CCR4–NOT promote deadenylation. Here, the authors describe how these three proteins interact to re...
https://www.nature.com/articles/s41467-025-62741-7
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Check out the latest study from our lab, led by Coffee Xiang (
@coffeebond007.bsky.social
)
www.nature.com/articles/s41...
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PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility - Nature Communications
Gene regulation in oocytes relies heavily on poly(A) tail-length changes. Here, the authors develop PAL-AI, a neural network model that predicts tail-length changes, identifies regulatory motifs, and ...
https://www.nature.com/articles/s41467-025-62171-5
about 2 months ago
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reposted by
David Bartel's Lab
Iain Cheeseman
2 months ago
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
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Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
https://www.biorxiv.org/content/10.1101/2025.07.22.666109v1
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Don’t miss this Q&A with Dr. Michelle Frank (
@michelle-frank.bsky.social
), an awesome postdoc in our lab!
add a skeleton here at some point
6 months ago
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Check out the latest study from our lab, led by
@mhall98.bsky.social
:
www.biorxiv.org/content/10.1...
(1/2)
6 months ago
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18
reposted by
David Bartel's Lab
Peter Wang
9 months ago
Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between
@voslab.org
and
@bartellab.bsky.social
with
@amohamed98.bsky.social
add a skeleton here at some point
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Check out our latest paper in collaboration with
@voslab.org
on the cryo-EM structure of slicing by human AGO2:
tinyurl.com/AGO2-slicing
add a skeleton here at some point
9 months ago
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Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!
9 months ago
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