David Bartel's Lab
@bartellab.bsky.social
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David Bartel's lab @WhiteheadInst @MIT @HHMI | microRNAs, mRNAs, and other RNAs
reposted by
David Bartel's Lab
Iain Cheeseman
3 days ago
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
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Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
https://wi.mit.edu/news/alternate-proteins-same-gene-contribute-differently-health-and-rare-disease
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Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage:
www.biorxiv.org/content/10.1...
(1/3)
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mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
https://www.biorxiv.org/content/10.1101/2025.11.06.686990v1
3 days ago
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Check out the latest work from our lab, led by Arash Latifkar
@ara-latifkar.bsky.social
,
www.biorxiv.org/content/10.1...
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mRNA poly(A)-tail length is a battleground for coronavirus–host competition
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...
https://www.biorxiv.org/content/10.1101/2025.10.09.680815v1
28 days ago
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Check out the latest work from Jordan Ray (
@jordanray.bsky.social
), a collaboration between our lab and David Sabatini’s lab.
www.biorxiv.org/content/10.1...
(1/2)
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Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
https://www.biorxiv.org/content/10.1101/2025.09.09.674968v1
about 2 months ago
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reposted by
David Bartel's Lab
Eugene Valkov
3 months ago
Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by
@filippekovic.bsky.social
, in collaboration with Perry Blackshear.
www.nature.com/articles/s41...
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Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin - Nature Communications
Deadenylation leads to mRNA decay, with PABPC1 protecting the poly(A) tail, while tristetraprolin and CCR4–NOT promote deadenylation. Here, the authors describe how these three proteins interact to re...
https://www.nature.com/articles/s41467-025-62741-7
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Check out the latest study from our lab, led by Coffee Xiang (
@coffeebond007.bsky.social
)
www.nature.com/articles/s41...
(1/2)
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PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility - Nature Communications
Gene regulation in oocytes relies heavily on poly(A) tail-length changes. Here, the authors develop PAL-AI, a neural network model that predicts tail-length changes, identifies regulatory motifs, and ...
https://www.nature.com/articles/s41467-025-62171-5
3 months ago
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reposted by
David Bartel's Lab
Iain Cheeseman
4 months ago
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
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Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
https://www.biorxiv.org/content/10.1101/2025.07.22.666109v1
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Don’t miss this Q&A with Dr. Michelle Frank (
@michelle-frank.bsky.social
), an awesome postdoc in our lab!
add a skeleton here at some point
7 months ago
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Check out the latest study from our lab, led by
@mhall98.bsky.social
:
www.biorxiv.org/content/10.1...
(1/2)
8 months ago
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reposted by
David Bartel's Lab
Peter Wang
10 months ago
Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between
@voslab.org
and
@bartellab.bsky.social
with
@amohamed98.bsky.social
add a skeleton here at some point
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Check out our latest paper in collaboration with
@voslab.org
on the cryo-EM structure of slicing by human AGO2:
tinyurl.com/AGO2-slicing
add a skeleton here at some point
10 months ago
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Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!
11 months ago
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