✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇

Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)

My first first-author paper is out!🎉 Here we propose a model where a silencing complex, PIWI*, assembles on target RNAs to recruit effectors and shut down transposon activity. Huge thanks to the Brennecke and Plaschka labs, especially Julius and Clemens, and all co-authors!

Check out the latest work from Jordan Ray (@jordanray.bsky.social), a collaboration between our lab and David Sabatini’s lab. www.biorxiv.org/content/10.1... (1/2)

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

Argonautes are coming :-) ... soon at @imgprague.bsky.social ... finishing preparations. Still missing a few things like drums, guitar, badges, beer ... but it's under control. I think. I hope. :-)) #argonautes2025

"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "? One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...

Check out the latest study from our lab, led by Coffee Xiang (@coffeebond007.bsky.social) www.nature.com/articles/s41... (1/2)

Beautiful work by Katya Khalizeva from @iaincheeseman.bsky.social lab, uncovering a surprising feedback loop to globally suppress mRNA decay during mitosis! This helps explain how cells maintain their transcriptome during a mitotic arrest without new transcription! www.biorxiv.org/content/10.1...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

Nucleic acid structural biologists expose that many CASP16 predictions, even ones obtaining high scores by CASP metrics, are inaccurate in the most functionally relevant regions! Read more insights on functionally relevant features by the expert structure determiners (doi.org/10.1101/2025...).

AlphaFold is amazing but gives you static structures 🧊 In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃 Code: github.com/KULL-Centre/... Colab: github.com/matteo-cagia...

Don’t miss this Q&A with Dr. Michelle Frank (@michelle-frank.bsky.social), an awesome postdoc in our lab!

What was that you said? You are looking for new #RNA research to read in the weekend? You are in luck! 📣 📣 Check out the new preprint from our lab!!!! 📣 📣 www.biorxiv.org/content/10.1...

Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides. Check it out:

Congrats Jimmy and team! Excited to see this work out

Congrats Leo and all!

Check out the latest study from our lab, led by @mhall98.bsky.social : www.biorxiv.org/content/10.1... (1/2)

Check out the latest work led by @mhall98.bsky.social in the Bartel lab! Matt solved a long-standing mystery about miRNA targeting, and drove the story to impressive mechanistic detail. More information below:

ARGONAUTES 2025 The grassroot meeting of Argonaute afficionados is looking for afficionados! Full coverage of Argonautes from prokaryotes to #RNAi, #piRNA and #microRNA Join us in Prague at @imgprague.bsky.social during 27-30/8, 2025. Registration, program and more info here: argonautes.img.cas.cz

Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!

After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service. @jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases Details: cdn.rcsb.org/rcsb-pd...

Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between @voslab.org and @bartellab.bsky.social with @amohamed98.bsky.social

Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!