Thanks for highlighting - thread to follow. Mini-summary: beyond assigning oscillatory genes expression by scRNA-seq to individual cell types, we also show that chromatin opens rhythmically and that we can predict this (and gene expression) with a small set of TFs in a mathematical model.

New preprint! How are developmental cycles coordinated across cell types? It turns out that, like Geppetto's cuckoo clocks in the GIF below, individual cell types are each performing their own little crazy routine, but all in sync with each other.

David Baltimore, giant of molecular biology, has died.

Go Mei!

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

The Argonautes 2025 - we made a special gift for participants - a card set with 32 different Argonautes + an extension pack with four Nobel prize winners from the small RNA field. Mello, Fire, Ambros & Ruvkun as jokers :-) #argonautes2025

Huge thanks to Cathy Savage-Dunn @cswormlab.bsky.social and Baris Tursun @baristursun.bsky.social for an amazing #worm25 !! I want to call out the OUTSTANDING meeting they created! Talks and posters were A+++. Most of all they brought us together in one of the most challenging times we've had.

Special thanks to Ahna Skop, Morris Maduro, and Curtis Loer for bringing so much joy to the meeting! Also, big thanks to GSA and Anne Marie Mahoney for making #worm25 happen despite the challenging times. Thank you also to USDavis for hosting us and the delicious food.

We are looking forward to the Worm Meeting 2027 and thank Suhong Xu(Zhejiang University School of Medicine, Hangzhou, China), Kavita Babu (Indian Institute of Science, Bangalore, India), and Erik Andersen (Johns Hopkins University Baltimore, USA) for organising. #worm25

Congrats to all, including Lo-Yu Chang from our lab 😁

New paper out in @natcomms.nature.com! A surprising story of a "non-conserved" protein that's vital for human cell fitness! Fantastic work by Alexandra Shulkina in collaboration with the @lcochella.bsky.social & @clausenlab.bsky.social labs.

Our dean is taking the message to where it needs to hit. www.foxnews.com/opinion/cutt...

"Funding from the NIH was contributed to 354 of 356 drugs (99.4%) approved from 2010 to 2019 totaling $187 billion" Reference: jamanetwork.com/journals/jam...

Much will be written about how 4 PhD students and a PhD –Colette Delawalla, Sam Goldstein, Emma Courtney, Leslie Berntsen & JP Flores – organized @standupforscience.bsky.social to unite scientists in the US and worldwide. Now let's keep the momentum going to defend science! bsky.app/starter-pack...

Of course times are tough, but is anyone (or does anyone know) of anyone in the DC-VA-MD area with openings for a masters-level researcher with experience in molecular biology, RNA and DNA work, transcriptomics, and specific experience with both plant and nematode genomics?

Bluetorial: The rationale for the “NIH” indirect cost “plan” is based on misunderstood (unintentional or intentional) accounting and math The value of real government transparency

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

You've waited for it, now it's finally here ... On-Demand is now available for our joint meeting on RNA Mediated Regulation of Immunity / Non-Coding RNA Biology! Purchase at keysym.us/KSRNAImmune2... or keysym.us/KSNCRNA25OD. #KSRNAImmune25 #KSNCRNA25 @skadener.bsky.social @lcochella.bsky.social

Booster RNAs from the Coller lab!

While I realize this is not relevant to many of the present day discussions, the remarkable similarity of organisms at the biochemical, genetic, cellular, and physiological levels is not understood by many people. 1/n

💯 We need people trained in evidence-based critical and logical thinking in all kinds of fields. Politics included - see current disaster in the US. PhDs/PDs from my lab are pursuing careers in diverse areas - policy, education, writing, law, as well as industry & academia. And that's a win for all.

Every week, I check the CDC's Mortality and Morbidity Weekly Report. This week for the first time in its 60 years it was not published on schedule. American healthcare workers all over the country are less informed about health crises that affect their patients. CDC led reports matter a 🧵

The rapid actions of the Trump Administration to shut down all communication by NIH, thus putting both study sections and councils on hold, is challenging for all of us. We can make our voices known. Below is an example email I sent to both NC Senators (text in alt text) 1/2 🧪

Apply to our Pathway to Independence programme by 31 January The programme aims to support postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. https://journals.biologists.com/dev/pages/pi-programme-2025 #DevBio #StemCells🧪

Fellow worm breeders: instead of fretting alone at home about the current state of the NIH, I encourage you to write to your Senators and Congressmen and the President touting why basic research fuels our economy and that the constraints placed on the NIH this week will stifle scientific progress.

Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions. They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).

Buenos Aires is beautiful and I keep posting about how I'm having a great time, but don't forget the tragic situation for science in Argentina at the moment. Argentinian scientists are working despite this and they deserve our full support! www.nature.com/articles/d41...

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...

Science is big enough (especially biomedical) that you have the opportunity to shape your project to match as many of your innate talents, passions, and proclivities as possible. Highly encourage leaning into those strengths when you choose a project: rajlaboratory.blogspot.com/2024/06/proj...

MirGeneDB 3.0 is published. Great teamwork and substantial improvement of database, Taxon sampling and we took over nomenclature of novel genes and families, too academic.oup.com/nar/advance-...

Which one are you? Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics. –Peter Medawar

If you had a mentor in school, college or grad school who (positively) changed your outlook or the course of your career, why not consider thanking them this Thanksgiving? Send them a letter or email. If you feel comfortable, post on here to share the positive vibes.

Join us in San Diego. A great meeting and also featuring the RNA Journal

The Company of Biologists @biologists.bsky.social have been such great supporters of the biology community in the UK and around the world. Celebrating 100yrs at a meeting/party in Liverpool next year. Some great speakers (and me too).

Hi worm world! We are looking for promoters that label hyp 4-6 (in any combination/subset). Do you have any leads? Have not gotten clean promoter bashed version from alr-1, so would love any help. Thank you in advance! #celegans #worm

WormBook has Worm Breeder's Gazettes from 1975 - 2014! So much history. Here's a cover from 1986 (posted by Dave Pilgrim on C. elegans FB group) wbg.wormbook.org/about/archiv...

🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook. C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more! #neuroscience journals.plos.org/plosbiology/...

The ribosome comes to life www.cell.com/cell/fulltex...

Brilliant perspective from Herve Seitz on miRNA targeting expressing in a super-clear way how miRNAs may have many biochemical targets, but only a few 'biological' ones. Cf great recent work from @lcochella.bsky.social , @labgrosshans.bsky.social & Katherine McJunkin academic.oup.com/nar/article/...

“The product of your education is not your thesis, it’s yourself“ @annarogers.bsky.social on why not to rely on LLM AI to write for you in graduate school. hackingsemantics.xyz/2024/writing/

Terrific piece summarizing a recent report: Every dollar of NIH research funding doubles in economic returns www.fiercebiotech.com/research/rep...

Here is the conclusion of the tribute: "Joe was admired and trusted by all who knew him. His instinct for important biological problems was phenomenal. He was a role model, an amazing mentor & a giant in the field of cell biology. He was kind, deeply thoughtful & modest." We need more like him 13/n

A fantastic write up of one of the greats. The last line really got me: “The authors are proud to have been his trainees.” An incredible legacy.

It's officially GRFP season. Join the NSF GRFP team on Sept. 20 at 11:15 a.m. EDT to learn more about the #NSFGRFP application process & eligibility requirements. To register for the GRFP 2024 Applicant Info Webinar #4 visit bit.ly/3RiL4hK.

Two groundbreaking women neuroscientists. Eve has been an incredible mentor and friend and support system over my time at Brandeis. Congrats to Eve and Lily! www.rockefeller.edu/news/34584-l...