The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from @seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online. 20 targets across an entire cell. Mr. Snouty also joined the fun. www.biorxiv.org/content/10.6...

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

Where am I? Don’t say Heaven… 😁

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

no idea if this will be a good movie or not, I’m just ecstatic to see a poster like this for an upcoming movie — peak of the artform, IMO

We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...

Wollen wir Hightech importieren, oder selbst entwickeln? Meine Rede von der Prelude-Veranstaltung ist jetzt als Video verfügbar: www.youtube.com/watch?v=iyM-...

Wow. CERN has secured a promise of $1 billion (!) towards its planned Future Circular Collider from private donors (such as the Breakthrough Prize Foundation & Eric & Wendy Schmidt Fund) - the first such donation for CERN, which has until now been taxpayer funded home.cern/news/press-r... 🧪⚛️

Our🥶COOLNESS paper to date is finally published! Ice cold and lithium dramatically delay forgetting (extend memory) in C. elegans. Why? read all about it! 👇 rdcu.be/eVhn2

📣 #Job alert! Looking to establish your own independent research in cell biology, development or evo-devo? The @cnrs.fr is recruiting 7 scientists in that area of research. Here are updated unofficial guidelines. Reach out to members of the committee if you have questions c3n-cn.fr/section-24-w...

Stoked that this paper, summarizing a vast series of experiments from past and present members of the team is out. A great way to end this year. www.nature.com/articles/s41...

@merihuchlab.bsky.social & @labshevchenko.bsky.social put the icing on the cake. Congratulations to Meri & team! It has been an amazing year for @mpi-cbg.de. Time to take a short break, but stay tuned next year. There are some big things to come 😉

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

This might well become your best summer experience

“A process which led from the amoeba to man appeared to the philosophers to be obviously a progress - though whether the amoeba would agree with this opinion is not known" - Bertrand Russell, 1976. Time-lapse video of Vampyrella lateritia eating Spirogyra algae from Science Source/Oliver Skibbe. 🦠

@mpi-cbg.de ends the year with a bang. Congratulations @merihuchlab.bsky.social and team.

Researchers from @merihuchlab.bsky.social, together with colleagues from @labshevchenko.bsky.social and clinicians from Dresden and Leipzig developed a patient-specific human periportal liver assembloid. Publication in @nature.com. Full news: www.mpi-cbg.de/news-outreac...

Congratulations to Prof. Omaya Dudin for receiving the Friedrich Miescher Award 2026! Find out more: www.ls2.ch/awards/fried... Prof. Dudin will present his award lecture at the LS2 Annual Meeting 2026 in Zurich: annual-meeting.ls2.ch/2026 @dudinlab.bsky.social @fmiscience.bsky.social

Great quote Waddington Seen @DBT_inStem #Embryo #CellsRUs #NotInTheGenes

Apples xkcd.com/3180/

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Talin didn’t evolve for integrins... integrins evolved for talin 🤯 pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later. Read this amazing paper here 👇🏽 www.nature.com/articles/s41...

Our dispatch: https://www.sciencedirect.com/science/article/pii/S0960982225014691 on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues: #connectomics, without synapses https://www.sciencedirect.com/science/article/pii/S0960982225013090 #neuroscience

Thrilled to share the preprint from my PhD! 🥳 Where I characterised epithelial cell extrusion in a sea anemone 🔗 www.biorxiv.org/content/10.6... Big thanks to my supervisor @prhsteinmetz.bsky.social and coauthors @noahbruderer.bsky.social @lionlchristiaen.bsky.social at🇳🇴 @msarscentre.bsky.social ⬇️🧵

New paper out in Sci Rep 🎉 Xenopus + azoles + developmental biology 🐸 A great collaboration with Veterinary University Brno. Read it here: pubmed.ncbi.nlm.nih.gov/41350377/

The best research funding scheme on the planet. #stuffthatmatters

Since November, @mpi-cbg.de has a new research group for “Mechanisms of translational control during embryogenesis,” led by cell and molecular biologist @madalenamrp.bsky.social. Madalena will focus on RNA biology in the context of development. Welcome! 🎉 www.mpi-cbg.de/news-outreac...

I was invited by @focalplane.bsky.social to write a short description about it: focalplane.biologists.com/2025/12/12/a...

I have lost focus in recent weeks of what is important in #life. Silly me. Not anymore. 🤠🚴‍♀️💕 Thanks James for this #winter #ride punctuated by a power #eierpunch

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

#Mastodon, the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets, is finally heading for publication (well, let's see). To #cite or not to cite shall no longer be the question 🙃, because the #preprint. Software is available in every #Fiji near you. www.biorxiv.org/content/10.6...

Thank you @InamdarManeesha for hosting my visit to CREATE, an initiative within @DBT_inStem devoted to advancing knowledge and empowering innovation on #Human#Development instem.res.in/research/maj... an amazing project #Fertility #Blastoids #Gastruloids

Something a bit different for the weekend 🎥 🎤 An interview from French BFMTV (EN) featuring our PI Víťa, this time as a founder of CasInvent - a company developing selective Casein Kinase 1 inhibitors 🔬 Worth a watch 👇 www.bfmtv.com/pratique/ent...

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

Wait, Mastodon wasn't published yet???????? @jytinevez.bsky.social @paveltomancak.bsky.social

If you want to learn more about Appose, check out the hands-on Appose workshop from "Halfway to I2K" 2025: fiji.github.io/i2k-2025-app... – along with the reference implementation of the demo project at github.com/ctrueden/uns.... New releases of python and java flavors coming before year's end.

Good company on the 🚂 train back to #Dresden with @paveltomancak.bsky.social

New release of #BigVolumeBrowser. Many things were added: UI improvement (thanks to @kwolbachia.bsky.social feedback), pyramidization for BioFormats dataset, bug fixes. Now there is an isosurface rendering mode (1/4)

The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource

👏

Now #published @physrevlett.bsky.social: the answer to the question that Euler did not solve three hundred years ago*. @zhaoshh.bsky.social doi.org/10.1103/63py-ph5s * Possible reasons include not having access to Mathematica and predating Riemann (in the non-ecological sense).

How does an elastic line buckle within a curved surface? The answer, by @zhaoshh.bsky.social and @lepuslapis.bsky.social @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social, has now been #published @physrevlett.bsky.social: doi.org/10.1103/63py-ph5s

New research group leader @matthiasmuhar.bsky.social joins @mpi-cbg.de! 🥳 With his group "Functional genomics of proteome remodeling,” Matthias wants to pursue high-throughput genetic studies to understand how protein turnover is regulated. Welcome, Matthias! www.mpi-cbg.de/news-outreac...

The new version of TrackMate, the v8.1 has just been released. It builds upon the recent v8, linked below, and offers two main improvements 👇

Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...

How hydrogen atoms feel when oxygen is too close

Latest in “The Unerased Whiteboards of UCL” series… now this is a classic example of insufficient erasure leading to multiple sedimentary layers of thought – my personal favourite sort of whiteboard residue. Also resembles something you might see in the Tate Modern.

Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄 Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...

Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches May 18-22, 2026 Roscoff, France Abstract deadline: January 31, 2026 Apply here: cjm.sb-roscoff.fr/en