@paveltomancak.bsky.social
📤 1231
📥 381
📝 476
pinned post!
We are all super happy and proud to see our work on the function and evolution of the
#cephalic
#furrow
published in
@nature.com
. Let me say a few things about the background and history of this work on the
#Evolution_of_Morphogenesis
(1/12)
4 months ago
16
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126
reposted by
Reto Fiolka
about 19 hours ago
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from
@seweryn-galecki.bsky.social
,
@kevin-dean.bsky.social
et al is online. 20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
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35
13
reposted by
Alex Stark
10 days ago
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv:
www.biorxiv.org/content/10.6...
. Amazing collaboration by
@shenzhichen1999.bsky.social
, Vincent Loubiere (
@impvienna.bsky.social
,@viennabiocenter.bsky.social),... (1/2)
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Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
https://www.biorxiv.org/content/10.64898/2025.12.22.695948v1
2
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48
Where am I? Don’t say Heaven… 😁
14 days ago
1
16
0
reposted by
Florent Waltz
15 days ago
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in
@cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here:
shorturl.at/z4i4c
#CryoEM
#CryoET
3
130
47
reposted by
paul khruangbin (Dan Lehner)
15 days ago
no idea if this will be a good movie or not, I’m just ecstatic to see a poster like this for an upcoming movie — peak of the artform, IMO
26
1558
177
reposted by
Denis Wirtz
16 days ago
We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1:
nature.com/articles/s41...
Review 2:
nature.com/articles/s41...
1
73
38
reposted by
Patrick Cramer
16 days ago
Wollen wir Hightech importieren, oder selbst entwickeln? Meine Rede von der Prelude-Veranstaltung ist jetzt als Video verfügbar:
www.youtube.com/watch?v=iyM-...
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Warum Europa jetzt in Spitzenforschung investieren muss | Rede Patrick Cramer
YouTube video by Max Planck Community
https://www.youtube.com/watch?v=iyM-Tnv6P7E
0
13
3
reposted by
Elizabeth Gibney
16 days ago
Wow. CERN has secured a promise of $1 billion (!) towards its planned Future Circular Collider from private donors (such as the Breakthrough Prize Foundation & Eric & Wendy Schmidt Fund) - the first such donation for CERN, which has until now been taxpayer funded
home.cern/news/press-r...
🧪⚛️
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Private donors pledge 860 million euros for CERN’s Future Circular Collider
For the first time in CERN’s history, private donors (individuals and philanthropic foundations) have agreed to support a CERN flagship research project. Recently, a group of friends of CERN, includin...
https://home.cern/news/press-release/cern/private-donors-pledge-860-million-euros-cerns-future-circular-collider
2
50
18
reposted by
Oded Rechavi
16 days ago
Our🥶COOLNESS paper to date is finally published! Ice cold and lithium dramatically delay forgetting (extend memory) in C. elegans. Why? read all about it! 👇
rdcu.be/eVhn2
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Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans
Nature Neuroscience - In this study, we identify an actively regulated process that governs the rate of forgetting in Caenorhabditis elegans, modulated by both temperature and the mood-stabilizing...
https://rdcu.be/eVhn2
4
80
17
reposted by
Jean Léon Maître
16 days ago
📣
#Job
alert! Looking to establish your own independent research in cell biology, development or evo-devo? The
@cnrs.fr
is recruiting 7 scientists in that area of research. Here are updated unofficial guidelines. Reach out to members of the committee if you have questions
c3n-cn.fr/section-24-w...
add a skeleton here at some point
0
42
37
reposted by
Rottinger Lab
17 days ago
Stoked that this paper, summarizing a vast series of experiments from past and present members of the team is out. A great way to end this year.
www.nature.com/articles/s41...
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Whole body regeneration deploys a rewired embryonic gene regulatory network logic - Nature Communications
To what extent regeneration recapitulates embryonic development is a longstanding question. Here, they show that embryonic gene modules are re-used, rewired, and interconnected to specific injury-indu...
https://www.nature.com/articles/s41467-025-67196-4
1
22
11
reposted by
André Nadler
17 days ago
@merihuchlab.bsky.social
&
@labshevchenko.bsky.social
put the icing on the cake. Congratulations to Meri & team! It has been an amazing year for
@mpi-cbg.de
. Time to take a short break, but stay tuned next year. There are some big things to come 😉
add a skeleton here at some point
1
13
3
reposted by
Job Dekker
17 days ago
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
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An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
https://www.nature.com/articles/s41586-025-09890-3
2
105
59
reposted by
Freddy Frischknecht
17 days ago
This might well become your best summer experience
add a skeleton here at some point
0
6
1
reposted by
c0nc0rdance
17 days ago
“A process which led from the amoeba to man appeared to the philosophers to be obviously a progress - though whether the amoeba would agree with this opinion is not known" - Bertrand Russell, 1976. Time-lapse video of Vampyrella lateritia eating Spirogyra algae from Science Source/Oliver Skibbe. 🦠
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19
506
188
@mpi-cbg.de
ends the year with a bang. Congratulations
@merihuchlab.bsky.social
and team.
add a skeleton here at some point
17 days ago
0
10
3
reposted by
Max Planck Institute of Molecular Cell Biology and Genetics
17 days ago
Researchers from
@merihuchlab.bsky.social
, together with colleagues from
@labshevchenko.bsky.social
and clinicians from Dresden and Leipzig developed a patient-specific human periportal liver assembloid. Publication in
@nature.com
. Full news:
www.mpi-cbg.de/news-outreac...
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Patient-specific human liver model to understand disease mechanisms
Dresden research team develops human modular “LEGO-like” model that lays foundation for a new era in liver research.
https://www.mpi-cbg.de/news-outreach/news-media/article/patient-specific-human-liver-model-to-understand-disease-mechanisms
3
36
13
reposted by
Life Sciences Switzerland (LS2)
17 days ago
Congratulations to Prof. Omaya Dudin for receiving the Friedrich Miescher Award 2026! Find out more:
www.ls2.ch/awards/fried...
Prof. Dudin will present his award lecture at the LS2 Annual Meeting 2026 in Zurich:
annual-meeting.ls2.ch/2026
@dudinlab.bsky.social
@fmiscience.bsky.social
3
30
13
reposted by
Alfonso Martinez Arias
17 days ago
Great quote Waddington Seen @DBT_inStem
#Embryo
#CellsRUs
#NotInTheGenes
0
28
7
reposted by
Randall Munroe
18 days ago
Apples
xkcd.com/3180/
42
3348
415
reposted by
Yamuna Krishnan
18 days ago
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
add a skeleton here at some point
27
468
233
reposted by
Raimon Sunyer
18 days ago
Talin didn’t evolve for integrins... integrins evolved for talin 🤯 pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later. Read this amazing paper here 👇🏽
www.nature.com/articles/s41...
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Talin force coupling underlies eukaryotic cell-substrate adhesion - Nature Communications
Talin is a well-known regulator of cell adhesion and intracellular force transmission in animals. Here, the authors demonstrate that talin’s mechanical function is evolutionarily conserved and already established in unicellular eukaryotes.
https://www.nature.com/articles/s41467-025-67354-8
0
33
14
reposted by
Gaspar Jekely
18 days ago
Our dispatch: https://www.sciencedirect.com/science/article/pii/S0960982225014691 on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics
, without synapses https://www.sciencedirect.com/science/article/pii/S0960982225013090
#neuroscience
1
52
25
reposted by
Inés Fournon Berodia
18 days ago
Thrilled to share the preprint from my PhD! 🥳 Where I characterised epithelial cell extrusion in a sea anemone 🔗
www.biorxiv.org/content/10.6...
Big thanks to my supervisor
@prhsteinmetz.bsky.social
and coauthors
@noahbruderer.bsky.social
@lionlchristiaen.bsky.social
at🇳🇴
@msarscentre.bsky.social
⬇️🧵
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6
72
33
reposted by
Jakub Harnos lab
18 days ago
New paper out in Sci Rep 🎉 Xenopus + azoles + developmental biology 🐸 A great collaboration with Veterinary University Brno. Read it here:
pubmed.ncbi.nlm.nih.gov/41350377/
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Developmental toxicity of fluconazole and 1,2,4-triazole in Xenopus laevis - PubMed
Fluconazole (FLU) is a widely used antifungal agent frequently detected in surface waters because of its extensive use in medicine, agriculture, and personal care products.Despite concerns about its persistence and developmental toxicity in aquatic species, its effects on amphibians remain poorly un …
https://pubmed.ncbi.nlm.nih.gov/41350377/
1
6
2
reposted by
Kate Beckham
20 days ago
www.nature.com/articles/s41...
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AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
https://www.nature.com/articles/s41592-023-02087-4
0
24
15
The best research funding scheme on the planet.
#stuffthatmatters
add a skeleton here at some point
19 days ago
1
14
5
reposted by
Max Planck Institute of Molecular Cell Biology and Genetics
19 days ago
Since November,
@mpi-cbg.de
has a new research group for “Mechanisms of translational control during embryogenesis,” led by cell and molecular biologist
@madalenamrp.bsky.social
. Madalena will focus on RNA biology in the context of development. Welcome! 🎉
www.mpi-cbg.de/news-outreac...
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Madalena Reimão Pinto is new research group leader at MPI-CBG
New research group for “Mechanisms of translational control during embryogenesis” established.
https://www.mpi-cbg.de/news-outreach/news-media/article/madalena-reimao-pinto-is-new-research-group-leader-at-mpi-cbg
0
36
9
reposted by
Jean-Yves Tinevez
19 days ago
I was invited by
@focalplane.bsky.social
to write a short description about it:
focalplane.biologists.com/2025/12/12/a...
add a skeleton here at some point
1
58
26
I have lost focus in recent weeks of what is important in
#life
. Silly me. Not anymore. 🤠🚴♀️💕 Thanks James for this
#winter
#ride
punctuated by a power
#eierpunch
20 days ago
1
30
3
reposted by
Jacob Schreiber
24 days ago
After a huge amount of work w/
@alex-stark.bsky.social
's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
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Programmatic design and editing of cis-regulatory elements
The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...
https://www.biorxiv.org/content/10.1101/2025.04.22.650035v2
2
59
26
#Mastodon
, the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets, is finally heading for publication (well, let's see). To
#cite
or not to cite shall no longer be the question 🙃, because the
#preprint
. Software is available in every
#Fiji
near you.
www.biorxiv.org/content/10.6...
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21 days ago
1
112
47
reposted by
Alfonso Martinez Arias
22 days ago
Thank you @InamdarManeesha for hosting my visit to CREATE, an initiative within @DBT_inStem devoted to advancing knowledge and empowering innovation on
#Human#Development
instem.res.in/research/maj...
an amazing project
#Fertility
#Blastoids
#Gastruloids
0
11
1
reposted by
Bryjalab
21 days ago
Something a bit different for the weekend 🎥 🎤 An interview from French BFMTV (EN) featuring our PI Víťa, this time as a founder of CasInvent - a company developing selective Casein Kinase 1 inhibitors 🔬 Worth a watch 👇
www.bfmtv.com/pratique/ent...
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CasInvent : la biotech tchèque qui ouvre une nouvelle voie contre les cancers résistants
Depuis Brno, en République tchèque, CasInvent se distingue par une approche inédite dans la lutte contre les cancers les plus agressifs. Issue de l’Université Masaryk, la jeune biotech développe une n...
https://www.bfmtv.com/pratique/entreprises-d-avenir/cas-invent-la-biotech-tcheque-qui-ouvre-une-nouvelle-voie-contre-les-cancers-resistants_AB-202511260111.html
0
3
1
reposted by
Ben Barad
22 days ago
Holy cow the Zhou lab at UCLA is cooking with Isonet 2 -
www.biorxiv.org/content/10.6...
Averaging-free direct visualization of ribosome translational state!
#teamtomo
#cryoet
2
101
34
reposted by
MadScientist
21 days ago
Wait, Mastodon wasn't published yet????????
@jytinevez.bsky.social
@paveltomancak.bsky.social
add a skeleton here at some point
2
18
5
reposted by
𝙲𝚞𝚛𝚝𝚒𝚜 𝚁𝚞𝚎𝚍𝚎𝚗 (@
[email protected]
)
22 days ago
If you want to learn more about Appose, check out the hands-on Appose workshop from "Halfway to I2K" 2025:
fiji.github.io/i2k-2025-app...
– along with the reference implementation of the demo project at
github.com/ctrueden/uns...
. New releases of python and java flavors coming before year's end.
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Appose Workshop - Slidev
"## Appose: Interprocess Cooperation with Shared Memory\nI2K 2025 Workshop\n\nTeaching participants how to use Appose with Fiji for Python integration\n"
https://fiji.github.io/i2k-2025-appose/
0
9
5
reposted by
James Saenz
22 days ago
Good company on the 🚂 train back to
#Dresden
with
@paveltomancak.bsky.social
0
39
1
reposted by
Eugene Katrukha 🇺🇦
22 days ago
New release of
#BigVolumeBrowser
. Many things were added: UI improvement (thanks to
@kwolbachia.bsky.social
feedback), pyramidization for BioFormats dataset, bug fixes. Now there is an isosurface rendering mode (1/4)
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1
24
7
reposted by
Qiyun Zhu
23 days ago
The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you.
www.nature.com/articles/s41...
#Bioinformatics
#OpenSource
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Scikit-bio: a fundamental Python library for biological omic data analysis - Nature Methods
Nature Methods - Scikit-bio: a fundamental Python library for biological omic data analysis
https://www.nature.com/articles/s41592-025-02981-z
3
88
46
👏
add a skeleton here at some point
23 days ago
0
4
0
reposted by
Pierre Haas
23 days ago
Now
#published
@physrevlett.bsky.social
: the answer to the question that Euler did not solve three hundred years ago*.
@zhaoshh.bsky.social
doi.org/10.1103/63py-ph5s
* Possible reasons include not having access to Mathematica and predating Riemann (in the non-ecological sense).
add a skeleton here at some point
3
23
7
reposted by
Max Planck Institute for the Physics of Complex Systems
23 days ago
How does an elastic line buckle within a curved surface? The answer, by
@zhaoshh.bsky.social
and
@lepuslapis.bsky.social
@mpipks.bsky.social
@mpi-cbg.de
@csbdresden.bsky.social
, has now been
#published
@physrevlett.bsky.social
:
doi.org/10.1103/63py-ph5s
1
14
8
reposted by
Max Planck Institute of Molecular Cell Biology and Genetics
23 days ago
New research group leader
@matthiasmuhar.bsky.social
joins
@mpi-cbg.de
! 🥳 With his group "Functional genomics of proteome remodeling,” Matthias wants to pursue high-throughput genetic studies to understand how protein turnover is regulated. Welcome, Matthias!
www.mpi-cbg.de/news-outreac...
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New research group leader for functional genomics
Molecular biologist Matthias Muhar becomes part of the MPI-CBG faculty
https://www.mpi-cbg.de/news-outreach/news-media/article/new-research-group-leader-for-functional-genomics
0
42
16
reposted by
Jean-Yves Tinevez
24 days ago
The new version of TrackMate, the v8.1 has just been released. It builds upon the recent v8, linked below, and offers two main improvements 👇
add a skeleton here at some point
1
45
18
reposted by
Nature Methods
26 days ago
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
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Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
https://www.nature.com/articles/s41592-025-02988-6
1
47
21
reposted by
Peter Fabian
27 days ago
How hydrogen atoms feel when oxygen is too close
add a skeleton here at some point
1
13
1
reposted by
Prof Jenny Rohn
29 days ago
Latest in “The Unerased Whiteboards of UCL” series… now this is a classic example of insufficient erasure leading to multiple sedimentary layers of thought – my personal favourite sort of whiteboard residue. Also resembles something you might see in the Tate Modern.
1
11
1
reposted by
Anna Czarkwiani
29 days ago
Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄 Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology
www.science.org/doi/10.1126/...
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Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl
The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.
https://www.science.org/doi/10.1126/sciimmunol.adw9903
4
55
23
reposted by
Bardin Lab
about 1 month ago
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches May 18-22, 2026 Roscoff, France Abstract deadline: January 31, 2026 Apply here:
cjm.sb-roscoff.fr/en
0
31
25
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