#lipidtime!

Is part of fentanyl’s high activity as an opioid agonist because it slides through cell membranes even more quickly than morphine?

📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...

Lipid-trap mass spectrometry identifies lipid–protein interactions in cells @natcellbio.nature.com @kingscollegelondon.bsky.social www.nature.com/articles/s41...

Exploiting internal symmetry can be a powerful approach to analyse convergence in MD simulations. If two conformational states are symmetry related, their kinetic and thermodynamic properties should be the same. If one doesn't enforce this during analysis this provides a useful test. 1/n

Median survival went from 6 months to 13 months. It may not sound like much, but for metastatic pancreatic cancer, this is big, IMO. We finally have something solid to build on in this field.

🍰Read also the News & Views article written by Aubrey Weigel: 👉https://rdcu.be/fdcf4 bit.ly/4tNdLn9

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains. bit.ly/4moYLJH

This week’s Essential Read in #chembio - my vote: what actually happens to diazirine photolabels? @nadlerlab.bsky.social strikes again. Enjoy #photopharma and caveat N2or! pubs.acs.org/doi/10.1021/...

Now out in its final form in @jacs.acspublications.org: Reaction pathways & photoreaction yields of bifunctional lipid probes. The numbers that explain why we spend so much time optimizing protocols for cellular assays. 😉 pubs.acs.org/doi/10.1021/...

THE MOST BEAUTIFUL RACE IN THE WORLD

Early spring flow trail ride.

Congratulations to Institute Scholar @abu-remaileh.bsky.social on receiving the ASBMB Walter A. Shaw Young Investigator Award in Lipid Research! His journey from East Jerusalem to Stanford highlights resilience and passion for science and mentorship:

Excited to share our new paper out today in @science.org 🎉 We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩 Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/ #microsky #phagesky www.science.org/doi/10.1126/...

📣 New Perspective out in @natcellbio.nature.com! With an interdisciplinary team of scientists, ethicists & lawyer we propose embedded ethics as a framework for navigating the complex ethics of human stem cell–based embryo models. www.nature.com/articles/s41... Free full text link: rdcu.be/fckmY 🧵

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

Mirror mirror on the wall who is the brightest of them all? Brightness is a key parameter for choosing fluorescent reporters in bioimaging. As tricky to assess, we present a pipeline to compare chemigenetic labels and FPs in tissue culture and #zebrafish embryos. www.biorxiv.org/content/10.6...

🥳 Excited to share our #diatom work out in @pnas.org. In a great collaboration with @nic-poulsen.bsky.social and @ulrichschwarz.bsky.social we show that diatoms modulate the curvature of their paths by dynamic switching of their cell–substrate contact sites. doi.org/10.1073/pnas.2506122123

Postdoctoral researcher @isaacsiuwong.bsky.social in the @hymanlab.bsky.social @mpi-cbg.de is 2026 Grass Fellow @grassfoundation.bsky.social @mblscience.bsky.social. 🎉 He will pursue his project “Dancing diatoms as a proto-neural model” at MBL for 14 weeks. www.mpi-cbg.de/news-outreac...

New paper out 💥 3D cell-cell contact reconstitution with synthetic vesicles and (primary) immune cells to study how different proteins and carbohydrates influence the immune synapse dynamics. advanced.onlinelibrary.wiley.com/doi/10.1002/...

ICYMI: A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites @natcomms.nature.com

Applications are open for our Next Generation Leaders program! Our NGL program recognizes emerging scientific leaders and invites them into a supportive network. 🔗 Apply by March 31: https://alleninstitute.org/about/people/next-generation-leaders/

A high-affinity split-HaloTag for live-cell protein labeling. And much more. www.nature.com/articles/s41...

Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101

The 2026 Otto Warburg Medal winner Maya Schuldiner received the medal from @volkerhaucke-lab.bsky.social after a moving laudatio by Christian Ungermann Thanks to @elsevierconnect.bsky.social for the continuous support!

Closing remarks by @nadlerlab.bsky.social A huge thank you goes to the sponsors and partners of the 77. Mosbacher Kolloquium!

Great images of where lipids are in cells – sharing for the images mostly!

Busy lipids in nano hotspots: a team with @mathilda95.bsky.social, @nadlerlab.bsky.social & Ori Avinoam @weizmanninstitute.bsky.social developed Lipid-CLEM - an imaging technique to make lipids in cellular membranes visible & show how they are organized at nanoscale. www.mpi-cbg.de/news-outreac...

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...

📣 To celebrate Biophysics Week, the Membrane Structure and Function Subgroup (MSAF) of @biophysicalsoc.bsky.social will host a webinar on March 24 at 11am EDT. Our speakers are @mejohnson81.bsky.social, @ibudin.bsky.social, and Cecília Leal (not on 🦋). 🧪 👀 More info in the alt text! Please share! 🔄

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Holy smoke. What ultimately happened???

This recently happened to us, with similar tells… infuriating.. you can see how it unfolded in the public peer review file: static-content.springer.com/esm/art%3A10...

<sigh> One reviewer used AI to review our manuscript. How do we know? Suggested papers to cite that do not exist. Some titles correct, but everything else is wrong or just fabricated out of whole cloth. Requested citations for things I’ve said in review papers that were citing other papers.

#czechcellence on tap

🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4

Diese Uni-Standorte werden weitergefördert. Gratulation! 👋✨

The application deadline for the 20th FEBS/EMBO Spetses meeting is extended to the 15th March! Please sign up at the link below, or encourage your PhDs and postdocs to come along for what is certain to be a wonderful week!

call for PI position at our department, we're nice :) www.linkedin.com/posts/depart...

Exciting new work on inter-organelle lipid transfer, from our always-friends and sometimes-collaborators in the Conibear lab at UBC:

You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!

I believe that I can guarantee that you will *not* have guessed this potential antiviral mechanism or even thought about it before:

Looking forward! I am, in fact, preparing a new talk with tons of unpublished data, you're not getting the same old from me 😉

By altering the growth environment, the group of @merihuchlab.bsky.social @mpi-cbg.de with first authors Javier Bregante & Flaminia Kaluthantrige has developed a liver model that extensively mimics the heterogeneity of the real organ. @cp-cellreports.bsky.social. www.mpi-cbg.de/news-outreac...

🤩to see this behemoth of a story out ! Pushed by @nikobiota.bsky.social & the Amazing @embl.org AML Team (Tina, Michael, Paulina) and in Co. with the Best #science #family you can dream of! This truck was #home, for weeks in a row & in my heart for a lifetime. www.biorxiv.org/content/10.6...

Ever wondered how to quantify the spatial relationship between different species (eg cell co/trilocalisation)? Lovely working with this interdisciplinary team — math @nerdarajan.bsky.social @tomchaplin.xyz @majirouses.bsky.social meets oncology @leedham-simon.bsky.social @joshuabull.bsky.social

This is a fantastic #biophysics job opportunity to join us in Dresden @mpipks.bsky.social! Apply by the 3rd of April!

We are very excited to share a new resource from our team: spatial subcellular proteome maps in plants! We developed an MS-based method that registers localizations of about 8000 proteins in Arabidopsis roots in a single experiment. (1/9) www.biorxiv.org/cgi/content/...

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.