Congrats folks! Another fabulous approach! 🤩

Mechanoresilience of #lysosomes conferred by TMEM63A. New study from Angelina S. Kim, Jing Ze Wu, Ruiqi Cai, and Spencer A. Freeman @sickkidsto.bsky.social: rupress.org/jcb/article/... #Membrane #lipid #Organelles #Immunology #Metabolism

These Bridge-like lipid transfer proteins are so amazing. Backward lipid flow from autophagosomes to ER through Atg2!

💡💡💡 I can testify, CIMR is an awesome place to start your lab. We are currently advertising Fellowship sponsorship for new group leaders...feel free to check out the link below and get in touch if you have any questions! Please RT!! www.nature.com/naturecareer...

A reminder to those interested to book a place! 🎉🎉

Save the date for #NeuroBioUK26 Do you like neurons? Maybe glia? Molecules? Cell biology? - The venue is booked and we are excited to see you and your incredible science there on the 11th of September! Please do join our email list to stay up to date. neurobiouk.sites.sheffield.ac.uk

Hoi1 targets BLTP2 to ER–PM contact sites to regulate #lipid homeostasis. New study from Samantha K. Dziurdzik, Vaishnavi Sridhar, Elizabeth Conibear @lizconibear.bsky.social and colleagues (University of British Columbia): rupress.org/jcb/article/... #Genetics #MembraneContactSites #ER_literature

Last week, our team joined the @embo.org Workshop “Intracellular Mechanics & Organelle Mechanobiology” at @icfo.eu 🔬 Great talks, inspiring conversations, and fresh ideas for our projects! 💪 #Biology #Barcelona #EMBO @adelaljord.bsky.social @pierre-bercier.bsky.social @crg.eu @prbb.org

Join us for a great session @asbmb.bsky.social annual meeting tomorrow. Our session starts at 9:30 am!

This is happening tomorrow! Looking forward to seeing all the #membranes enthusiasts on zoom!

Dziurdzik, Sridhar, Conibear et al. identify a conserved adaptor that recruits BLTP2-like proteins to ER–plasma membrane contacts by binding helical projections on their lipid transfer channel to maintain #lipid homeostasis. rupress.org/jcb/article/... #MembraneContactSites #ER_literature

SF and Bay Area friends…at #bps2026 for the next five days…if you’re around and have time to catch up let me know 🙏😘

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris

Congrats Pierre and Edward!

‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩 www.biorxiv.org/content/10.1...

😍😍😍. Congrats folks.!!

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Finally out in Nature Chem Bio: SNAP-tag2 for faster and brighter protein labeling www.nature.com/articles/s41... Thank you Steffi and Veselin.

The german research foundation DFG will fund the new graduate school for "Biomolecular Condensates: from physics to biological function" here in Dresden This new graduate school is part of 18 new graduate schools funded by the DFG in germany!

Hugely significant finding for contact site research - can’t wait to read properly! www.nature.com/articles/s41...

Do you see any underlying driver/correlator for these numbers? Number of canceled NIH grants by institution: 1 Columbia U 163 2 Johns Hopkins 12 3 Emory 6 4 U. Michigan 5 5 U. Minnesota 5 6 U Miami Med Sch. 4 7 UCSF 4 8 U Chicago 3 Source: taggs.hhs.gov/Content/Data...

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes! Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner. @abelljonny.bsky.social, @michael-e-ward.bsky.social, et al. www.nature.com/articles/s41...

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with @knowleslab.bsky.social, Vendruscolo lab, @michael-e-ward.bsky.social lab, @deriverylab.bsky.social lab, @profmarciniak.bsky.social lab 🎉🎉🎉

Great interview with the always inspiring JLS - absolutely shaped so much about mine and so many others careers…

*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...

I have to say…unlike the Twitter heyday (and even still X now), I just don’t get good science content on Bluesky. In particular, I can’t find people posting new cell biology/microscopy/neurobiology papers at anywhere near the same frequency. My feed on Twitter used to be 90%+ of this content…

Such a cool story! Congrats guys…

We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country. This Friday, where will you be? standupforscience2025.org

This is such a great programme and a big thanks to Venkat Pisupati who has done all the heavy listing from our group to make this possible.

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. www.nature.com/articles/s41...

So much happening in the segmentation space for bioimage analysis. These two papers that were published online today really stood out to me as noteworthy (a thread).

Hello! Although we are still in the other place, this will become our main social media feed. We're part of the University of Cambridge Clinical School Cell biology, molecular mechanisms of human disease

Our first preprint list for 2025 is focussed on research using microscopy tools to answer questions in biology. As always, please let us know if there are other preprints that you’d like to see on our list. focalplane.biologists.com/2025/01/10/m...

Fantastic work by my Biohub colleague Manu Leonetti and his amazing team published in #Cell! 🧪 Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP. Paper here www.cell.com/cell/fulltex... Explore the date organelles.czbiohub.org Congratulations to the team

😮‍💨😮‍💨😮‍💨 nothing beats isotropy 🤷

🎉 If you’re at #cellbio24 then make sure to join us tomorrow for a bloody great lineup of talks on the ER! Anddddd if you’re heading to the MBL party tonight then come and find me for some painkillers 😅…

🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉 We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods. I am beginning the search for two postdocs now - stay tuned for more details! ewaldlab.org

Very cool!

Yo yo yo….. #Cellbio2024 friends. Landing today in San Diego and leave evening of 18th. Shoot me a WhatsApp or email if you want to catch up 😊😊. Looking forward to seeing you!!

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...

Hands down one of the best experiences you can have. Working with incredible scientists and having an amazing time! I could not recommend anything more!!! Please help circulate!

Love #lipids and #membranes??? Then you cannot miss these seminars tomorrow with two amazing rising ⭐️ ⭐️ @abelljonny.bsky.social @ibudin.bsky.social

Reminder that if disordered proteins are your thing, this starter pack exists (and I try to update it as best I can as new folks reach out/I see them!) 🍝 go.bsky.app/J23B51L

Should be fun and hope to see some of you there 😬!

My turn to create a starter pack for scientists using live imaging in their research! Of course, I’ve likely missed many—please let me know who else I should include. Thanks! go.bsky.app/KYYr7xc #liveimaging #livevellimaging #microscopy

I meant to do this last week but hi everyone, I'm Alex. I love all things neuronal and spend most of my time trying to image motor proteins and organelle movement in the axon.

detection of membrane contact dynamics and Ca2+ signals w/ nice acronym- PRINCESS (PRobe for INterorganelle Ca2+-Exchange Sites based on SplitFAST), a class of reporters to simultaneously detect MCSs and measure the associated Ca2+ dynamics using a single biosensor www.nature.com/articles/s41...

Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳

go.bsky.app/HU7e761 @mattoolab.bsky.social done !!!!