If you’ve built DNA-barcoded antibody panels, you know the pain: every barcode means another conjugation. In our new preprint we introduce UnO, which transforms antibody conjugation problem into a universal barcode conversion workflow, enabling rapid panel generation. www.biorxiv.org/content/10.6...

Cells are not just bags of molecules. Function depends on spatial interactions: RNAs and/or proteins come together with interaction partners to drive regulation and function. In our new preprint, we introduce ProPER, a novel method for in situ proximity detection. Preprint: tinyurl.com/muju86s6

Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling www.biorxiv.org/content/10.6...

I am delighted to co-organize the 2nd #ESSB meeting as an #EMBL Conference, with incredible support of @events.embl.org. Abstract submission deadline is July 15! #ESSB members submitting an abstract are eligible for one of 100 registration subsidy awards (up to 50%). #ESSB2025 #EMBLSpatialBiology

We had a lovely week in Heidelberg teaching ins and outs of #spatialbiology, and providing hands-on training for custom protocols like #immuno-saber, #ibex, #hybRISS. Massive thanks to my co-organizers, our dedicated trainers and excellent speakers, and #EMBO, #EMBL & sponsors. #EMBOSpatialOmics

We are happy to participate in the ARISE program and have a range of collaborative opportunities for various backgrounds including biochemistry, imaging, omics or lab automation. Get in touch if interested!

We are repeating our EMBO Practical course for imaging-based spatial omics this June in Heidelberg. We will cover sample preparation, multiplexed IF (IBEX and Immuno-SABER), antibody-DNA conjugation, in situ sequencing, data analysis and visualization. Lots of fun and in-depth discussions!

The beautiful DNA-microart created by the wonderful Jennifer Heck and Kristina Jevdokimenko in our group to celebrate the festive season: Using Light-Seq, pixels of a DNA canvas was "painted" on a microscope by photocrosslinking DNA barcodes with 3 different fluorophores @embl.org's PhD course '24

The 1st European Society for Spatial Biology (#ESSB) meeting has been a blast! Great talks, exciting posters, new tech platforms and a budding vibrant community - made this a joy beyond our expectations. See you all again next year's edition at @embl.org Heidelberg on 14-17 Oct 2025!

Come be our colleague at @embl.org! New EMBL Group Leader applications are open until the end of the year: 1. www.embl.org/jobs/positio... 2. www.embl.org/jobs/positio... @futurepislack.bsky.social #genome #FuturePI