Kai Johnsson
@kjohnsson.bsky.social
๐ค 502
๐ฅ 117
๐ 6
Chemical biologist @ Max Planck Institut for Medical Research in Heidelberg
Molecular recording of cellular protein kinase activity with chemical labeling:
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
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Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology
Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.
https://www.nature.com/articles/s41589-025-01949-6
4 months ago
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Teaching an old bacterial protein new tricks: Fast, bright and reversible rhodamine tags for live-cell imaging:
www.biorxiv.org/content/10.1...
Congratulations to Julian Kompa and the entire team.
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Fast, Bright and Reversible Rhodamine Tags for Live-Cell Imaging
We present Rho-tag and SiR-tag, engineered protein tags derived from bacterial multidrug-resistance proteins that bind unsubstituted (silicon-) rhodamines with nanomolar affinity, enabling fast, rever...
https://www.biorxiv.org/content/10.1101/2025.07.06.663254v1
4 months ago
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Finally out in Nature Chem Bio: SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
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SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kรผhn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
https://www.nature.com/articles/s41589-025-01942-z
4 months ago
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Please check out our new high-affinity split-HaloTag for live-cell protein labeling
www.biorxiv.org/content/10.1...
Congratulations to Yin-Hsi Lin!
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https://www.biorxiv.org/content/10.1101/2025.06.15.659771v1
5 months ago
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Improving split-HaloTag through computational protein engineering:
onlinelibrary.wiley.com/doi/10.1002/...
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Improving splitโHaloTag through computational protein engineering
Split-HaloTag can be used to transform transient molecular interactions into permanent marks through chemical labeling, thereby enabling the recording of transient physiological events in individual ....
https://onlinelibrary.wiley.com/doi/10.1002/pro.70123
7 months ago
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Check out our new fluorescent probe for imaging f-actin dynamics: ๐ฆ๐ถ๐ฅ-๐ซ๐๐ฐ๐๐ถ๐ป: ๐ ๐ณ๐น๐๐ผ๐ฟ๐ฒ๐๐ฐ๐ฒ๐ป๐ ๐ฝ๐ฟ๐ผ๐ฏ๐ฒ ๐ณ๐ผ๐ฟ ๐ถ๐บ๐ฎ๐ด๐ถ๐ป๐ด ๐ฎ๐ฐ๐๐ถ๐ป ๐ฑ๐๐ป๐ฎ๐บ๐ถ๐ฐ๐ ๐ถ๐ป ๐น๐ถ๐๐ฒ ๐ฐ๐ฒ๐น๐น๐
www.biorxiv.org/content/10.1...
Thank you
@veselin-nasufovic.bsky.social
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SiR-XActin: A fluorescent probe for imaging actin dynamics in live cells
Imaging actin-dependent processes in live cells is important for understanding numerous biological processes. However, currently used natural-product based fluorescent probes for actin filaments affec...
https://www.biorxiv.org/content/10.1101/2025.02.04.636537v1
9 months ago
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