☕Zhao et al. develop a microwell cell-chip-based culture platform enabling high-throughput generation of micro-tumorspheres and enrichment of functional #CancerStemCells from biopsies from patients with #BreastCancer, facilitating personalized drug testing. 👉https://rdcu.be/flpvR bit.ly/3Rx7AWt

☕The authors provide a spatial transcriptomic atlas of cynomolgus monkey #embryos at Carnegie stages 9 and 10 and further do comparative analyses using public human and mouse data to dissect conserved and species-specific transcriptional programs. 👉https://rdcu.be/flpt3 bit.ly/4efr21J

☕Li, Huo, Zhang, Liu et al. report that the transcripts of genes involved in hematopoietic stem cell function share a protective mechanism against RNA decay through a non-canonical function of NAT10, independent of its N4-acetylcytidine catalytic activity. 👉https://rdcu.be/flpsV bit.ly/4uDZHgv

☕Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and interferes with the cytoprotective roles of PABPC1 and MKRN1. bit.ly/49kgpZN

☕Yu, Li et al. explore the #metabolome of neurons, microglia and astrocytes under normal, ageing and #Alzheimers disease conditions. They find enrichment of glutathione and polyamine metabolism in microglia, which decreased with #aging and in Alzheimer’s disease. bit.ly/4tV7XaQ

☕Song et al. report that ATM maintains replication fork speed by counteracting chromatin-bound cGAS-induced fork slowing. They show that ATM and ATR phosphorylate MRE11 to release cGAS from chromatin in a process dependent on MRE11 nuclease activity. 👉https://rdcu.be/fkC8i bit.ly/4x6ZtjN

En route to @events.embl.org #EESPhaseSeparation! Representing @natcellbio.nature.com as Senior Editor + npj Biological Physics&Mechanics as Advisory Editor. Let's chat at talks, coffee, food, & #MeetTheEditor sessions to discuss your interesting work, publishing, and anything else you'd like!

👋Our May issue is out! Cover: #Trogocytosis - inspired delivery 👉Perspective: #lipids #endocytosis 👉Review: #organelles in #aging #longevity 🔬 #gastruloids #LeukemiaStemCells #ferroptosis #ribosome #chromatin #cGAS #immunotherapy #glioblastoma #alzheimers & more! www.nature.com/ncb/volumes/...

☕Tang, Dai, Qing, Zhang et al describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K9me3 heterochromatin and genome stability. 👉https://rdcu.be/fjqd3 bit.ly/4wyVSdO

☕ @tarumur.bsky.social , @nina-kozlova.bsky.social & co report a functional role for NDRG1 in regulating R-loops & DNA repair, thus linking cancer-associated fibroblast-derived extracellular matrix to chemotherapy responses in pancreatic cancer. #PDAC @bidmc-cancercenter.bsky.social bit.ly/4dwcz0W

☕ @shainlab.bsky.social , @bishaltandukar.bsky.social & co dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution. bit.ly/4wzMyX0

☕ @riddhiman.bsky.social et al. use experimentally matched mass-spec and RNA-seq to quantify proteins, phosphosites & transcripts across 4 stages of human & mouse gastruloid development. @jshendure.bsky.social @leastarita.bsky.social @nobuhamazaki.bsky.social @dschweppe.bsky.social bit.ly/4dAYyA1

☕D’Ambrosio et al. screen 10,480 electrophilic compounds for senolytic effects and show that senolytic chloroacetamides or GPX4 inhibitors selectively kill senescent cells by ferroptosis. bit.ly/4uMnZVj

☕Wang et al. find that #LeukemicStemCells preferentially localize to the metaphysis bone marrow niche and lose stemness when mobilized to the central marrow. Targeting DPP4–CXCL12–GPC3 disrupts this niche and enhances #leukemia treatment. bit.ly/3P6gUiW

☕Sun et al. present a stem cell-derived embryo model recapitulating certain aspects of human peri-gastrulation, including the formation of trilaminar disc-, amnion- and yolk sac-like structures. 👉https://rdcu.be/fgNz2 bit.ly/4t93yAv

☕Liu, @markgad.com et al. develop an approach to purify the #EndoplasmicReticulum (ER) and integrate genetic, structural, molecular and #CellBiology analyses to identify SLC33A1 as an ER oxidized glutathione (GSSG) exporter in mammalian cells. #metabolism 👉https://rdcu.be/fgNqg bit.ly/4uuGJIM

☕Paquola et al. present a technique named lipid-trap mass spectrometry (LTMS) to study lipid–protein interactions directly captured from mammalian cells. bit.ly/4tEPW10

☕Xiang, Wang, Tian et al. report that during nutrient insufficiency, inflammatory cytokines promote a ZBTB5-mediated mechanism to activate mTORC1 signaling, thereby enhancing amino acid uptake in tumor cells and restricting antitumor immune response. 👉https://rdcu.be/fgu85 bit.ly/4cKrKV5

☕ @joshifrenster.bsky.social @amartinezarias.bsky.social & co utilize mosaic mouse #gastruloids as a model of cell fitness & competition, identifying a temporal window between primed pluripotency and early gastrulation during which #CellCompetition occurs in mammalian #embryogenesis. bit.ly/4cBmfGK

☕Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via direct cell–cell contact. 👉https://rdcu.be/fem8Q bit.ly/4dYkDJA

In @natcellbio.nature.com: Rockefeller's Birsoy lab has discovered that the antioxidant glutathione plays a vital role in maintaining smooth operations of a protein-producing hub in the cell called the endoplasmic reticulum by acting as a protein “proofreader.” 🔗: https://bit.ly/3Ow8lxM

👋Our April issue is out! Cover: Visualizing #lipids 👉2 Perspectives: #embryo models 👉Comment on #mitochondria DNA 🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more! www.nature.com/ncb/volumes/...

☕You, Hu et al. discover a population of COTL1high NK cells regulated by GITRL+ #macrophages and demonstrate their functional importance in mediating anti-tumor #immunity in #cancer with impaired tumor-specific MHC-I expression. bit.ly/3Oh0unH

☕Yu et al. identify HELDR as a #lncRNA co-amplified with EGFR in #glioblastoma to promote a KAT7-activated malignancy program, which can be potentially targeted with anti-EGFR therapy for improved therapeutic outcomes. 👉https://rdcu.be/fdBOX bit.ly/4tnYyZN

☕Markiewicz-Potoczny et al. report that the nonsense-mediated #mRNA decay pathway protects #telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at telomeres. bit.ly/4tBHzD4

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains. bit.ly/4moYLJH

☕Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection. bit.ly/3QBQmXa

📰Our editor Zhe Wang will be attending the AACR Annual Meeting in San Diego. Please feel free to reach out to him ([email protected]) if you would like to meet in person to discuss your work and ask questions about Nature Cell Biology.

☕He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO2-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain pyrenoid size and number through the cell cycle. bit.ly/4tFSlIB

☕Hoffmann et al. show that the glycolytic intermediate fructose-1,6-bisphosphate, which accumulates in the absence of aldolase, regulates focal adhesions by relieving RCC2-mediated Rac1 inhibition. bit.ly/3NLbU2T

☕Aird et al. report that promyelocytic #leukemia (PML)-localized speckled protein 110 (SP110) controls SP100 oligomerization, which then regulates the mitotic dissolution of nuclear PML bodies. 👉https://rdcu.be/fbTnQ bit.ly/4sf9nMc

☕Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of #autophagy and uncovers new regulatory pathways. bit.ly/4sfZa2g

☕After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and #ferroptosis sensitivity in #cancer cells. bit.ly/4t91gm1

☕Liu et al. report DHHC20-mediated palmitoylation as a key mechanism for regulating KAT2A expression, which plays an essential role in breast cancer lung metastasis. @fendtlab.bsky.social 👉https://rdcu.be/fbeZe bit.ly/4bUOgJ6

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

☕Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoral #adipose tissue is hijacked by #cancer cells to mediate #ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumor growth. bit.ly/4uWc73X

☕Xu, Li, Deng et al identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and #autophagy. They show this modulates #pyroptosis, antitumor immunity and #chemotherapy response in mouse models. 👉https://rdcu.be/faqWC bit.ly/4c9WBtJ

☕Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in interferonopathy and herpes simplex virus-1 protection. bit.ly/4uRjZnc

☕Tao, Feng, Yang, Liu et al. identify a lncRNA-dependent mechanism that controls ALKBH5-mediated demethylation and expression of ATF4, which confers an adaptive metabolic response under nutrient stress in cancer cells. 👉https://rdcu.be/e90NV bit.ly/40T1X6s

☕Lee et al. report a mechanism regulating mRNP export mediated by N6-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases. 👉https://rdcu.be/e90KO bit.ly/4sulAh5

☕New Review article discussing the mechanisms underlying both cavitation and folding #amniogenesis, as well as various recent stem cell-based human #embryo models developed to elucidate amniotic formation and function. 👉https://rdcu.be/e9wos bit.ly/4uGeh7v

👋Our March issue is out! Cover: #Adipose – #tumor in #immune escape 👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids 🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more! www.nature.com/ncb/volumes/...

☕New Review discusses #brain #lipid #metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implications for brain health and disease. 👉Read here: rdcu.be/e8rlJ bit.ly/4rxWpJm

☕Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed with increased condensate size and RNA valency. bit.ly/4dfwrqq

☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production. bit.ly/40US4Vy

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 👉https://rdcu.be/e7dRa bit.ly/4baJZAO

☕Wang et al. show that promyelocytic leukemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases. 👉https://rdcu.be/e7dOe bit.ly/4ucFCy1

☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination. bit.ly/4aPkNBc

☕Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoral visceral #adipose tissue and colorectal #tumor microenvironment and report an immune escape mechanism, which may be potentially targeted for improved #immunotherapy. bit.ly/4rMX2iV

☕Dynein–dynactin–cargo adaptor complexes typically function with two dynein motors. Rao et al. show that, under mechanical load, these complexes can recruit a third dynein via a second adaptor, increasing force generation. bit.ly/405sjBD