👋Our April issue is out! Cover: Visualizing #lipids 👉2 Perspectives: #embryo models 👉Comment on #mitochondria DNA 🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more! www.nature.com/ncb/volumes/...

☕You, Hu et al. discover a population of COTL1high NK cells regulated by GITRL+ #macrophages and demonstrate their functional importance in mediating anti-tumor #immunity in #cancer with impaired tumor-specific MHC-I expression. bit.ly/3Oh0unH

☕Yu et al. identify HELDR as a #lncRNA co-amplified with EGFR in #glioblastoma to promote a KAT7-activated malignancy program, which can be potentially targeted with anti-EGFR therapy for improved therapeutic outcomes. 👉https://rdcu.be/fdBOX bit.ly/4tnYyZN

☕Markiewicz-Potoczny et al. report that the nonsense-mediated #mRNA decay pathway protects #telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at telomeres. bit.ly/4tBHzD4

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains. bit.ly/4moYLJH

☕Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection. bit.ly/3QBQmXa

📰Our editor Zhe Wang will be attending the AACR Annual Meeting in San Diego. Please feel free to reach out to him ([email protected]) if you would like to meet in person to discuss your work and ask questions about Nature Cell Biology.

☕He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO2-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain pyrenoid size and number through the cell cycle. bit.ly/4tFSlIB

☕Hoffmann et al. show that the glycolytic intermediate fructose-1,6-bisphosphate, which accumulates in the absence of aldolase, regulates focal adhesions by relieving RCC2-mediated Rac1 inhibition. bit.ly/3NLbU2T

☕Aird et al. report that promyelocytic #leukemia (PML)-localized speckled protein 110 (SP110) controls SP100 oligomerization, which then regulates the mitotic dissolution of nuclear PML bodies. 👉https://rdcu.be/fbTnQ bit.ly/4sf9nMc

☕Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of #autophagy and uncovers new regulatory pathways. bit.ly/4sfZa2g

☕After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and #ferroptosis sensitivity in #cancer cells. bit.ly/4t91gm1

☕Liu et al. report DHHC20-mediated palmitoylation as a key mechanism for regulating KAT2A expression, which plays an essential role in breast cancer lung metastasis. @fendtlab.bsky.social 👉https://rdcu.be/fbeZe bit.ly/4bUOgJ6

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

☕Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoral #adipose tissue is hijacked by #cancer cells to mediate #ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumor growth. bit.ly/4uWc73X

☕Xu, Li, Deng et al identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and #autophagy. They show this modulates #pyroptosis, antitumor immunity and #chemotherapy response in mouse models. 👉https://rdcu.be/faqWC bit.ly/4c9WBtJ

☕Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in interferonopathy and herpes simplex virus-1 protection. bit.ly/4uRjZnc

☕Tao, Feng, Yang, Liu et al. identify a lncRNA-dependent mechanism that controls ALKBH5-mediated demethylation and expression of ATF4, which confers an adaptive metabolic response under nutrient stress in cancer cells. 👉https://rdcu.be/e90NV bit.ly/40T1X6s

☕Lee et al. report a mechanism regulating mRNP export mediated by N6-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases. 👉https://rdcu.be/e90KO bit.ly/4sulAh5

☕New Review article discussing the mechanisms underlying both cavitation and folding #amniogenesis, as well as various recent stem cell-based human #embryo models developed to elucidate amniotic formation and function. 👉https://rdcu.be/e9wos bit.ly/4uGeh7v

👋Our March issue is out! Cover: #Adipose – #tumor in #immune escape 👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids 🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more! www.nature.com/ncb/volumes/...

☕New Review discusses #brain #lipid #metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implications for brain health and disease. 👉Read here: rdcu.be/e8rlJ bit.ly/4rxWpJm

☕Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed with increased condensate size and RNA valency. bit.ly/4dfwrqq

☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production. bit.ly/40US4Vy

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 👉https://rdcu.be/e7dRa bit.ly/4baJZAO

☕Wang et al. show that promyelocytic leukemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases. 👉https://rdcu.be/e7dOe bit.ly/4ucFCy1

☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination. bit.ly/4aPkNBc

☕Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoral visceral #adipose tissue and colorectal #tumor microenvironment and report an immune escape mechanism, which may be potentially targeted for improved #immunotherapy. bit.ly/4rMX2iV

☕Dynein–dynactin–cargo adaptor complexes typically function with two dynein motors. Rao et al. show that, under mechanical load, these complexes can recruit a third dynein via a second adaptor, increasing force generation. bit.ly/405sjBD

☕Morales-Sanfrutos, Etxeberria-Ugartemendia, Barroso-Gomila et al map the elution profiles of small #ExtracellularVesicles along density gradients from human biofluids and cell lines, distinguishing extracellular vesicle content from co-isolation components. bit.ly/3ZWmeHJ

☕Wan, Li, Cao et al report a feedback crosstalk between THY1+ #cancer #StemCells and neutrophils via #migrasome - mediated release of #mitochondria, which induces a pseudohypoxic state and promotes metastasis. 👉https://rdcu.be/e51HE bit.ly/3ZZRw0q

Our Opening Doors Internship Programme is open for applications! #BePartOfProgress and join one of our teams to gain hands-on experience working on impactful projects and benefit from the expertise of our talented colleagues. spklr.io/63327DL797#BePartOfProgress #Publishing #WorkInPublishing

☕Jacquemyn et al. identify key #lipid determinants controlling ectosome shedding from #neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein, with relevance to #Parkinsons disease pathology. 👉https://rdcu.be/e5k6a bit.ly/46QhSpi

☕Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics such as charge and hydrophobicity. @alexholehouse.bsky.social bit.ly/46iObx3

👋Our February issue is out! Cover: spatial #transcriptomics 👉Review: telomeric #chromatin 🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more! www.nature.com/ncb/volumes/...

☕Bång-Rudenstam et al. report that the acidic #tumor microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent #ferroptosis, thereby providing an adaptive mechanism upon tumor acidosis. bit.ly/3Mvuvz1

☕Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia. bit.ly/46MZ3Di

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity bit.ly/40dNHEE

☕ @zyt0329.bsky.social et al develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in juxta-lysosomal pH. 👉https://rdcu.be/e3TPL bit.ly/4auh4aD

☕Thendral et al. describe a mitophagic programme that removes deleterious mtDNA during the oocyte-to-zygote transition in C. elegans, promoting #mitochondria health and offspring survival. Loss of this #mitophagy leads to mutant mtDNA accumulation. 👉https://rdcu.be/e3tpJ bit.ly/4aqi7Zk

☕Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumulation at stalled forks followed by replication protein A exhaustion and cell death. bit.ly/4rBKhYe

☕Wang, Chu, Chen, Wei et al discover a subset of tumour-associated #macrophages expressing SLC2A1 whose spatial proximity to CD8+ T cells drives resistance to anti-PD-L1 treatment in non-small-cell #LungCancer. bit.ly/4tCcNLd

☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social bit.ly/4asbwO3

Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social rdcu.be/e3smG

☕Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages #histology images and enhances the resolution of spatial #transcriptomics, thus enabling the dissection of complex tissue structures. bit.ly/4chkfoD

☕Li, Cui, Yang, Lu, Jiang, Zhang et al identify a lactate transport mechanism from tumor-associated #macrophages that regulates DNA repair and immune cell infiltration, which could be targeted to enhance #immunotherapy efficacy in #glioblastoma models. 👉https://rdcu.be/e2WxT bit.ly/3MwtOph

☕Scourzic et al. showed that germinal centre #Bcells display an enhanced ability to #reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher #plasticity level and is T follicular helper cell-dependent. 👉https://rdcu.be/e2Wxm bit.ly/4aDyDWY

☕ @karsten-rippe.bsky.social & co analyse #chromatin accessibility to identify sites that open simultaneously in response to TNF. They discover 2 distinct types of co-accessible regulatory module for controlling the induction of #proinflammatory gene expression. 👉https://rdcu.be/e2WwS bit.ly/3MiB4oH

☕ @allanaschooley.bsky.social @jobdekker.bsky.social & co find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm. bit.ly/4r6uO2D

☕Smith and Bartel show that #mRNA recruitment to #StressGranules imparts resistance to the integrated stress response translational shutdown. bit.ly/45WSNbP