In the 26-year history of our journal @natcellbio.nature.com this has never happened before, but the time has come: Nature Cell Biology is now open to considering #ClinicalTrials . I’m curious to hear what people in the field are up to - please reach out to me! #CellTherapy #stemcells #genetherapy

💫NEW: Dehingia, Milewska-Puchała et al find a pervasive #lncRNA -mediated increase in interactions between CTCF and RNA-binding proteins during embryonic #StemCell differentiation. These interactions reinforce #chromatin architecture in #neural cells. bit.ly/46mc4UR

💫NEW: Djeghloul, Cheriyamkunnel et al. apply chromosome sorting to isolate active and inactive X chromosomes and report a role for Hbo1 and Msl histone acetyltransferase complexes in preserving active X #chromosomes in female cells during #mitosis. bit.ly/4pIA0ta

💫NEW: Yin, Lin, Cai, Nie et al report #PhaseSeparation of ERCC6L2 as a mechanism that regulates RNF138-mediated ubiquitination and degradation of CtIP, thereby modulating DNA end resection and treatment response to ATM inhibitors in #cancer. bit.ly/46H9p75

💫NEW: Yang, Li, Huang, Ji, Luo, Jiang et al report that chemotherapy induces MLKL PARylation and #necroptosis in tumor endothelial cells, which in turn affects tumor-associated #macrophages and CD8⁺ T cells, promoting #immunosuppression and tumorigenesis. 👉https://rdcu.be/eHUob bit.ly/4njRM4p

👋Our September issue's out! Cover: Oncofusion condensates 👉🏼Review on #hematopoietic #aging 🔬 #StemCells #trophectoderm #immunotherapy #fibrosis #cancer #necroptosis #chromatin #mitosis #mitophagy #ProteinFolding #BiomolecularCondensates #organelles & more! www.nature.com/ncb/volumes/...

Looking forward to several days of interesting research work at the GBM Compact Meeting – Focus on Condensate Biology @gbmev.bsky.social + the Satellite meeting @spp2191.bsky.social If you’re attending, do reach out to chat w/me as your friendly neighbourhood @natcellbio.nature.com senior editor!

💫NEW: Gasnier et al. identify NOX1 and NPY1R as markers of colon #StemCells within the mouse caecum and the middle and distal colorectum, respectively. These stem cells contribute to the initiation of invasive colon #tumors in mice. bit.ly/4m2ZSwC

💫NEW: @studerl.bsky.social , Ciceri & co present a whole-genome CRISPR-Cas9 knockout screen using directed differentiation systems. They find that MEN1 and SUZ12 modulate human developmental timing by epigenetically controlling bivalent promoters of developmental genes. bit.ly/4m4YKsx

💫NEW: Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective #autophagy receptors to initiate phagophore formation. bit.ly/3JJeJPp

💫NEW: Arabzade, Shirnekhi, Varadharajan, Ippagunta et al show that the zinc finger translocation-associated (ZFTA) fusion oncoproteins gain intrinsically disordered regions, inducing nuclear condensate formation and oncogenic activation. bit.ly/4g0EqqI

🍹This Perspective discusses recent insights into #vimentin filament structure and function, as well as emerging findings that point to a role in #tumor invasion in #mesenchymal cells analogous to embryonic development and wound healing. 👉https://rdcu.be/eCOQp bit.ly/423dC3c

🍹Interested in #DevBio and #metabolism ? This Review discusses the relationship between metabolism and embryogenesis! 👉https://rdcu.be/eCHvJ bit.ly/4oVnB4t

💫NEW: Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent lysotoxicity via microautophagy. #lysosomes #autophagy 👉https://rdcu.be/eCG8I bit.ly/4lKvlna

💫NEW: Bi, Mo, Liu et al. carry out high-throughput screening and analysis to profile genome-wide pro-tumor enhancers and uncover enhancer connectomes in #glioma. In particular, they identify specific single-nucleotide polymorphisms associated with glioma risk and progression. bit.ly/41Snwom

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration. bit.ly/3HFAQ8S

💫NEW: Gao, Li et al derive #trophectoderm #StemCells from 32-cell mouse embryos. These cells represent an early trophectoderm state, develop into #placenta cells, form placental organoids and contribute to blastoid generation. #DevBio 👉https://rdcu.be/eB9i2 bit.ly/3UFGb2S

💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social bit.ly/47b3Mjk

💫NEW: @brianstrahl.bsky.social & co report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity. 👉https://rdcu.be/eBW3D bit.ly/3Vff6DO

💫NEW: X. Du, W. Li, G. Li, C. Guo et al. report that dietary galactose regulates the cellular crosstalk between #hepatocytes and CD8+ #Tcells via IGFBP-1 production and IGF-1 signaling, thereby modulating T cell exhaustion and #antitumor immunity. 👉https://rdcu.be/eBW1z bit.ly/4mU4qpX

💫NEW: Akincilar, Fidan et al. report a conserved role for #telomerase reverse transcriptase in regulating #inflammation via the cGAS–STING nucleic acid-sensing pathway in myeloid cells, independent of its telomerase activity. 👉https://rdcu.be/eBB96 bit.ly/45sOTYv

Feeding mice galactose rewires hepatocyte metabolism to boost CD8+ T cell function via IGFBP-1, relieving exhaustion, thus suppressing tumors. Neat diet-immunity link with an interesting mechanism @natcellbio.nature.com: doi.org/10.1038/s415... 🧪

💫NEW: @buszczaklab.bsky.social @jun-wu-lab.bsky.social & co use human #brain #organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired #ribosome production and protein synthesis, and delayed radial glial cell specification. bit.ly/4lvVBBP

💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation. bit.ly/4fLWe99

Do you want to meet our stem cell editor @slefkopoulos.bsky.social and chat about your work for our journal? He will be attending in person! Register now for the FEBS Workshop on #Aging in #Hematopoiesis that will take place in Crete on October 20-24. aginginhematopoiesis2025.febsevents.org

🍹 @walterwchen.bsky.social et al show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins. bit.ly/4lmjv2l

🍹@martenslab.bsky.social @elias-adriaenssens.bsky.social & co show that, unlike soluble, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective #autophagy machinery. bit.ly/4lpGh9P

🍹 @abbybuch.bsky.social & co report the role of #lamin proteins and the lamin B receptor (LBR) in #chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse ESCs leads to heterochromatin detachment and derepression of gene and transposon expression. bit.ly/4mPf5Cx

🍹Zhang, Chang et al. identify the protein TMEM65 as the #mitochondria Na+/Ca2+ exchanger, showing that it dimerizes to mediate ion transport and contains a binding site for a well-known inhibitor of mitochondrial Na+/Ca2+ exchange. 👉https://rdcu.be/eAN3r bit.ly/3UtNlag

🍹Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating #ferroptosis sensitivity, #tumor development and chemoradiotherapy efficacy. 👉https://rdcu.be/eAN1I bit.ly/3JasCWN

Anyone here interested in #metabolism in #devbio ? We recently published a Review article by Jin Zhang & co discussing the relationship between metabolism and #embryogenesis. Enjoy the read! :D 👉https://rdcu.be/eADIT www.nature.com/articles/s41...

🍹 @ninacabezas.bsky.social & co combine #metabolomics, #lipidomics and transcriptomics of #hematopoietic stem and progenitor cells during differentiation, #aging and #leukemia, finding a role for choline and showing that supplementation enhances stemness. bit.ly/3H98V0U

🍹 @zernickagoetz.bsky.social & co use single-cell RNA sequencing to explore the transcriptional profile of human #amnion samples spanning the developmental window from Carnegie stage (CS)16 to CS23. bit.ly/45sNobu

🍹 @grahamlab-vandy.bsky.social @jainbhawik.bsky.social & co report that the Neo1 P4-ATPase flips the #lipid PI4P across the #Golgi membrane to the cytosolic leaflet, preventing PI4P exposure and thereby conferring neomycin resistance. bit.ly/45tauP7

🍹Kefalopoulou, Rullens et al. develop Dam&ChIC to assay #chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division and X chromosome inactivation. bit.ly/4fGJFMi

🍹Mondal et al. report that #autophagy inhibition promotes p63 activation and metastasis in #BreastCancer. This process depends on NBR1, which forms cytoplasmic p62/SQSTM1 condensates that sequester the ITCH ubiquitin ligase and prevents p63 degradation. 👉https://rdcu.be/eADAA bit.ly/3HxkL4Y

🍹Banerjee et al. report that the Vps13-like #lipid transport protein BLTP2 regulates plasma membrane fluidity by maintaining phosphatidylethanolamine homeostasis. BLTP2 also facilitates #BreastCancer cell growth, suggesting a separate role in tumorigenesis. bit.ly/45ieyD9

🍹 @jacobsenucla.bsky.social & co demonstrated that REM #TranscriptionFactors and GDE1 guide RNA polymerase IV to specific #genomic loci, establishing a DNA sequence-dependent mechanism for siRNA biogenesis and DNA methylation patterning. bit.ly/3Upx1Yf

🏖️Our August issue's out! Cover: Flexibility of #autophagy initiation 👉🏼Review on #metabolism in #embryogenesis #devbio 👉🏼Review on #DNArepair 🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more! www.nature.com/ncb/volumes/...

🍹Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional program that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending #healthspan. #lysosome bit.ly/46G38dx

🍹Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and #PhaseSeparation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from individuals with #AmyotrophicLateralSclerosis 👉https://rdcu.be/ezd0q bit.ly/4lYo1oO

🍹Zhang et al. provide evidence that, during #meiosis, recombination proteins assemble into active droplets, the coarsening of which partially explains the phenomenon of crossover interference. #PhaseSeparation 👉https://rdcu.be/ezdVj bit.ly/3IXNj8a

🍹 @thomasclarke.bsky.social, Mostoslavsky & co identify chromatin factor ZNF280A, which is recruited to damaged chromatin to promote long-range DNA-end resection. Loss of ZNF280A is linked to genome instability in patients with 22q11.2 distal deletion syndrome. 👉https://rdcu.be/ezdPR bit.ly/46Cpr3L

🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social bit.ly/4l93AUW

🍹Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in #organelle size control. bit.ly/4mhMvsU

🍹Sharma, Jiao et al. report glycosylation of small RNAs within #exosomes and propose a glycosylation-dependent mechanism for #RNA targeting into exosomes, which may influence intercellular communication and RNA stability in the extracellular environment. 👉https://rdcu.be/eykKY bit.ly/455vyuP

🍹Wan, J. Shi, M. Shi, Huang et al. report a role for lactate dehydrogenase B in regulating CD8+ T cell #disulfidptosis and exhaustion through the activity of glucose-6-phosphate dehydrogenase, thereby impacting the efficacy of #antitumor immunity. 👉https://rdcu.be/eykHG bit.ly/3IQKS7d

🗞️Do you want to meet and chat with our stem cell editor @slefkopoulos.bsky.social about your work for our journal? He will be there! Register now for the FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24. aginginhematopoiesis2025.febsevents.org

🏳️‍🌈It was a great pleasure to interview @jzylicz.bsky.social and hear about his views on the importance of celebrating #Pride, representation in science, and more! Don’t be afraid to be you, young friends and colleagues - you are not alone. Join us! #PrideInSTEM‍ 👉https://rdcu.be/ewRh8 bit.ly/3U8857v

🏖️Our July issue's out! Cover: Droplets in meiotic crossovers 👉🏼Comment on #Alzheimers 👉🏼Reviews on #aging and #EndoplasmicReticulum -associated degradation 🔬 #BreastCancer #autophagy #neurodegeneration #amnion #chromatin #meiosis #PhaseSeparation #healthspan & more! www.nature.com/ncb/volumes/...