Can Nicotinamide Lessen the Risk of Skin Cancer Development? ascopost.com/news/septemb...

I felt it #moderate

Earthquake! Bay Area

RFK said he would determine the cause of autism by "September" and Trump has pre-announced a major announcement on autism to come on Monday. 🍿

STmut is now working on Visium HD data! Infer copy number from spatial transcriptomics data at unparalleled accuracy and resolution

Does anyone else have dogs that ruin their sleep score? I was all good till 7am, but then an intermittent Mastiff with a HrV of 300 took over

After clearly saving changes to an NIH RPPR form, the system inevitably gives this warning.

Serious question for the crowd: has a K-awardee ever actually done the coursework/mentor meetings they promised in the training plan? Or is it just a rite of passage?

1,333 Notices issued by the NIH in the past week. Including 116 new R01 projects. reporter.nih.gov/search/6lVq4...

Politicized research comes and goes, but it always leave behind a legacy of permanent paperwork.

Very happy to share our work on signature SBS5. See Molly's thread for a short summary

I HAVE BEEN SILENCED and CENSORED BY OUR GOVERNMENT!!!! My latest… sciencebasedmedicine.org/vinayprasadl...

Top FDA official demands removal of YouTube videos of himself that criticized Covid vaccines www.theguardian.com/us-news/2025...

BREAKING: per email sent to agency staff NIH will _NOT_ reterminate the ~900 grants which were reinstated. "[W]e would strongly recommend against re-terminating such grants, because it will likely be viewed as a reapplication of the now-vacated Challenged Directives."

Microcolony-Seq. This paper is in the setting of bacteria, but it very accurately describes our experience in sequencing microcolonies of skin cells. www.cell.com/cell/fulltex...

Shutting down the NIH guide for grants was a bad idea. Sure, the grant postings were redundant with grants.gov, but grants.gov posts ALL grant opportunities across the government. My inbox is now flooded with irrelevant calls from the Department of Labor

I feel the most sympathy for scientists with grants scored within the historical payline, but they will not be funded. But what about all the reviewers, too? They just wasted their time critiquing grants for, essentially, no reason.

I have NIGMS R35, impact score 12 NIHGRI R21, 4th percentile NHGRI R01, 7th percentile (co-I) and it seems like none will be funded. 0/3. PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25." 😭

Here is my hot take of the day. Most pre-tax accounts are upper middle class tax breaks that can be done away with. Even the people who benefit could be doing something more productive with their time rather than navigating bureacracy.

This sums up the MAHA movement well. "Unfortunately, from my standpoint, what’s happened is the worst of both worlds: The changes on the food side are minor, performative and irrelevant, while the changes on the vaccine side are enormous and terrible. " www.nytimes.com/2025/08/13/o...

Is there a way to simplify progress reports while still being respectful to the fact that funders deserve to see the outcomes of their projects? The current NIH movement towards multi-year awards would suggest that they do not care much about interim progress reports.

One thing I wish that Blue Sky had was a breakdown of interactions on your posts. E.g. how many views does your post get?

How awesome is it that we are less than one month away from finding the cause of autism!

After all these years in science, I remain bewildered by the concept of a "retreat" held on the campus or in the city in which one works.

Funding is back?

Wow. Vinay Prasad only lasts 3 months in his new post. www.statnews.com/2025/07/29/v...

Are you interested in following scientists in the Human Tumor Atlas Network (HTAN)? If so, this starter pack is for you! go.bsky.app/AXaDeng

Breaking News: The EPA said it would eliminate its scientific research arm and begin firing hundreds of scientists, after denying that it intended to do so.

Jennifer Ficko was diagnosed with stage IV melanoma in 2010. Thanks to a clinical trial of a novel immunotherapy, she has been cancer free for the last 8 years. Please ask Congress to support future advances and restore NIH funding to the FY26 budget: buff.ly/n4oul0s

I think the new rule that one can only submit 6 NIH apps per year is great. In fact, I would support an even stricter cap. I support a cap of 6 apps per year for investigators with less than 1.5 million per year in direct funds (essentially someone with 0-1 R01), but ...

I honestly do not know how Matthew Memmoli looks himself in the mirror...

Anyone heard about the NIH forward funding model? "NIH forward funding proposal: The NIH has announced its intention to “forward fund” its multi-year extramural awards through a Type 4 multi-year (MYF) award, meaning it would allocate the entire multi-year award into the NIH’s current year budget."

The Nature brand is strong. Just came across yet another variant, though I don't think this one is affiliated with Springer

After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech. I've cleaned up my notes — here are his remarks in full. 🧵

Meanwhile Marco Rubio is celebrating National Russia Day. www.state.gov/releases/202...

Politico leaked the draft DOD budget being debated in the House subcommittee, and apparently research funding is going to be cut severely, including the entire melanoma research program for 2026

I pasted one of my papers into an AI detector, and it predicted that 78% of the text was written by AI. It was 0%. I am not convinced that we will be able to distinguish between AI and human written text moving forward. Maybe it is a moot point as long as the content is true

After the unprecedented retiring of the entire CDC vaccine advisory committee, RFK Jr has announced his new slate, some of whom are avowed anti-vaxxers and will attend the 6/25 meeting Robert Malone Martin Kulldorff Joseph Hibbeln Retsef Levi Cody Meissner James Pagano Vicky Pebsworth Michael Ross

I have been listening to the Hubermann-JB podcast. It is 4 hours, so it will take some time to finish, but here are some thoughts...

What I am currently reading. pubmed.ncbi.nlm.nih.gov/40473950/

a great opportunity to join Nature Metabolism as an Associate or Senior editor springernature.wd3.myworkdayjobs.com/SpringerNatu...

A new theory on the end of the universe www.theatlantic.com/science/arch...

Explains a lot of the chaos. www.statnews.com/2025/06/02/b...

Any recommendations on the best studies to perform exome sequencing of melanomas that acquire resistance to immune checkpoint inhibitors?

Congressman DeSaulnier and I just solved all of America's problems. Stay tuned for the biggest most beautifulest Bill!

Cancer doc’s $50B ask to Trump www.politico.com/newsletters/...

t acquire resistance to immune checkpoint inhibitors?

A solid winning percentage (29.2%) for panelist with 100+ appearances! The null hypothesis would be a 25% win rate. Nice work!

I cannot seem to find anything about NIH funding in the "Big beautiful bill". Shouldn't this be stipulated somewhere for an omnibus spending bill? Or will it be covered by separate legislation?