Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

Happening tomorrow! Join our upcoming webinar, organised by the @helloeacr.bsky.social, on 09 April (14:00–15:30 CET) to explore the new CGI platform, virtual Molecular Tumour Boards, and a real clinical use case from Lyon. Save your spot: us02web.zoom.us/webinar/regi...

📢 This Week at #IRBBarcelona: Join us for a plenary #seminar this Friday, with Dr. @isidrolauscher.bsky.social from @ebi.embl.org @sangerinstitute.bsky.social @cancerresearchuk.org  🤝 Hosted by @nlbigas.bsky.social and @milanlab.bsky.social  Register here ➡️ https://shorturl.at/imwHx 🧪

Today is the #InternationalDayofWomenandGirlsinScience - celebrating women across our @helloeacr.bsky.social community 🙌 From Board members across Europe to the #EACR HQ team and the scientists we serve worldwide, women play a central role in advancing cancer research every day #WomeninScience 👩🏻‍🔬🧪

This week, Loic Verlingue (CLB) & Santi Demajo (@irbbarcelona.org) represented CGI-Clinics at the EUnetCCC seminar 'Advancing Precision Oncology through Molecular Tumour Boards' - a fantastic opportunity to bring the CGI tool to the forefront of the European precision cancer diagnostics community 🌍

Huge congratulations to Fran on being awarded the ERC Consolidator Grant! 🎉 Such a well-deserved recognition of an outstanding trajectory and a truly creative, exciting proposal on T-cell clonal hematopoiesis. Can’t wait to see the discoveries that come out of this project. So proud of you! 👏✨

Today, Nuria López-Bigas @nlbigas.bsky.social and Mònica Sánchez-Guixé @guixe-m.bsky.social are at the #BarcelonaBiomed Conference, organised by #IRBBarcelona. A great occasion to share our projects related to childhood cancers.

Delighted and honored to have hosted the 3rd PROMINENT Retreat in Barcelona. The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!

Don't miss our extraordinary #seminar to be held next week, with @jdegregori.bsky.social, from the University of Colorado Anschutz (@cuanschutz.bsky.social). Host: Dr. @nlbigas.bsky.social (@bbglab.bsky.social#seminar #IRBBarcelona) Register here 👉 https://shorturl.at/n74Th #CancerResearch 🧪

Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.

Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature. A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey! ⬇️More info⬇️

Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey! 🧵Summary following ⬇️

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

New paper from our lab - ‪@bbglab.bsky.social‬. Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection academic.oup.com/nar/article/... Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

@ewaszczurek.bsky.social explains how evolution is the generative process of cancer at #AACR25.

Jeffrey Townsend (that's me!) presents on dismantling the coarse approximation of drivers and passengers in cancer at #AACR25. Thank you @nlbigas.bsky.social for the photo!

@nlbigas.bsky.social explains how they assemble a compenduim of driver genes 🧬 in cancer at #AACR25.

We're at #CCG2025 in Amsterdam! Project Coordinator @nlbigas.bsky.social is delivering a keynote lecture on the CGI-Clinics project today, 'Data-driven cancer genome interpretation for clinical decision making': www.ccg2025.eu/speaker/nuri...

European Association of Cancer Reasearch statement on threats to cancer reasearch @helloeacr.bsky.social eacr.org/statement-on...

#standupforscience Boston

Tackling Cancer through Global Team Science aacrjournals.org/cancerdiscov...

Seven New Cancer Grand Challenges Announced www.cancergrandchallenges.org/new-challenges With awards of up to £20m ($25m). Expressions of Interest are now open. @cancergrand.bsky.social #CancerGrandChallenges

🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]

Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing #ccg2025

Molt trista per aquesta notícia. Gran professor, comunicador i científic. Una persona propera que ha deixat empremta a tots els que hem tingut la sort d'interaccionar amb ell. Deixa un llegat immens a l'IRB i a la ciència al nostre país.

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social doi.org/10.1093/bioi...

**Clinical Cancer Genomics Conference** First of an annual recurring series. It will be a very important meeting for the advance of clinical implementation of cancer genomics. Proud to be part of it. March 20th-21st 2025 in Amsterdam. Registration open: www.ccg2025.eu #CCG2025

**Mutations in Time and Space** Looking forward to it. Abstract submission is now open broadinstitute.swoogo.com/mits2025/

This Friday 12/6 at 4pm, Núria López-Bigas, PhD @nlbigas.bsky.social @irbbarcelona.bsky.social presents "Somatic mutations in tumors and normal tissues" at our Friday Seminar Series in Basic and Translational Research cancer.ucsf.edu/seminars

Today at IRB Barcelona (@irbbarcelona.bsky.social) #NodeSeminar Stefano Pellegrini presented: "Detection of cancer driver genes with clusters of somatic mutations in protein three-dimensional structure" Very good presentation and nice discussion within the IRB Barcelona community

Only a subset of patients respond to immunotherapy Why? Which ones? We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response. www.nature.com/articles/s41...

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

Children who develop two independent tumors during childhood are extremely rare We wanted to see if our genomic technologies could shed light into those exceptional cases. Read about it in this recent paper: tinyurl.com/yt9m584d

We recently announced a dual new release of intOGen and boostDM Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations ➡️ Compendium of Cancer Driver Genes - www.intogen.org ➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm

We recently announced a dual new release of intOGen and boostDM Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations ➡️ Compendium of Cancer Driver Genes - www.intogen.org ➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm

Hi everyone! Glad to see that science bluesky is growing so rapidly :) My research focuses on pediatric cancer, genomics, and tumor evolution. Follow me if interested! 🧪🧬

CGI-Clinics project just joined Bluesky. Follow it to stay tuned on exciting updates coming soon about the project 👉 @cgiclinics.bsky.social cgiclinics.eu

Hi all 👋 My first post here. I'm very happy to see that many scientists I admire and whose work I enjoy following are now here on Bluesky. See you around!