Somatic evolution following cancer treatment in normal tissue @nature.com @nickymcgranahan.bsky.social @ucl.ac.uk @crick.ac.uk @charlesswanton.bsky.social www.nature.com/articles/s41...

Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction @cellcellpress.bsky.social www.cell.com/cell/fulltex... @charlesswanton.bsky.social @ucl.ac.uk

I am very excited that Imrans and @magnushaughey.bsky.social article in @aacrjournals.bsky.social is now online. This was a great collaboration with @charlesswanton.bsky.social and Paul Mischel amongst many others. A small thread will follow below. aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: ecDNA–Driven Oncogene Spatial Heterogeneity & Evolution in Glioblastoma - by Imran Noorani, @magnushaughey.bsky.social, Paul Mischel, @charlesswanton.bsky.social, @benjaminwerner.bsky.social, and colleagues doi.org/10.1158/2159...

This research was led by Imran and co-first author Magnus Haughey, with senior authors Paul Mischel at @stanforddeptmed.bsky.social, @benjaminwerner.bsky.social at @qmucu.bsky.social, and @charlesswanton.bsky.social at the Crick.

Research from the Cancer Grand Challenges eDNyamiC team found that rogue rings of DNA appear early in glioblastoma, a very aggressive form of brain cancer. Co-first author Imran Noorani explains how this work makes the case for early detection of these tumours. www.crick.ac.uk/news/2025-09...

New in @cp-cancercell.bsky.social: Drs. Krijn Dijkstra, Sergio Quezada, Emile Voest, and @charlesswanton.bsky.social established patient-derived #organoids to study immune invasion in #LungCancer. 🫁 Article: bit.ly/4ltQPp2 Discussion: bit.ly/3GP9NaK

Subclonal immune evasion in non-small cell lung cancer www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @charlesswanton.bsky.social

New evidence that age-related clonal hematopoiesis (CHIP) drives solid cancer progression by remodelling the tumour immune microenvironment. Out in @nejm.org Congrats @oriolpich.bsky.social, @elsabernard.bsky.social, Maria Zagorulya, @charlesswanton.bsky.social et al. www.nejm.org/doi/full/10.... 🧪

This research was led by @oriolpich.bsky.social, Elsa Bernard and Maria Zagorulya, with corresponding authors Elli Papaemmanuil, Elsa Bernard and @charlesswanton.bsky.social. The project was supported by @cancerresearchuk.org and @uclhresearch.bsky.social.

Researchers from the Crick, @ucl.ac.uk, @gr-research.bsky.social and @mskcancercenter.bsky.social have discovered that certain age-related genetic changes in the blood are associated with worse outcomes for cancer patients. www.crick.ac.uk/news/2025-04...

Super to work with Oriol Pich, Elsa Bernard Maria Zagorulya, @PapaemmanuilLab exploring how the age related process CHIP might impact tumour biology; incredible team. Thank you to all our funders, CRUK, Crick, BCRF, Rosetrees Trust, Mark Foundation+ Royal Society www.nejm.org/doi/full/10....

Wow!!! 🤯 Amazing, @oriolpich.bsky.social, @charlesswanton.bsky.social, and team! www.nejm.org/doi/full/10....

Are you a clinician looking for a fully-funded postdoctoral research opportunity? 🩺 Take a look at our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community of clinician scientists. Apply by 30 April ➡️ www.crick.ac.uk/careers-and-...

@charlesswanton.bsky.social kicks off the @cancergrand.bsky.social Summit and mentions the commentaries on the impact of the original #CancerGrandChallenges teams published in the January issue of Cancer Discovery - you can read them here: aacrjournals.org/cancerdiscov...

Please share! @charlesswanton.bsky.social @isidrolauscher.bsky.social @peterlylab.bsky.social @maitehuartelab.bsky.social @florentmouliere.bsky.social @andreaventura.bsky.social @anton-henssen.bsky.social

A huge thanks to my co-authors, especially my PI Prof. Nicholas McGranahan for guiding all of this and @charlesswanton.bsky.social who gave his support throughout. Thanks also to @genomicsengland.bsky.social , @cruk-cityoflondon.bsky.social , UCL Cancer Institute, and @crick.ac.uk

Phenomenal data and unique insights from @charlesswanton.bsky.social and colleagues. Bravo!

And a final thanks to our funders without which none of this work would have been possible: @cancerresearchuk.org, @wellcometrust.bsky.social and Rosetrees as well as most importantly all the patients & participants.

🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells. Out today in @naturegenet.bsky.social : doi.org/10.1038/s41588-025-02086-5 🧵👇

💫New Article Dhruva Biswas, Nicolai J. Birkbak & @charlesswanton.bsky.social and team present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma. www.nature.com/articles/s43...

A new test, developed by a team led by @charlesswanton.bsky.social from UCL Cancer Institute & @crick.ac.uk, can better predict lung cancer survival at the point of diagnosis and could help to inform treatment decisions www.ucl.ac.uk/news/2025/ja...

Scientists at the Crick, @ucl.ac.uk , @uclh.bsky.social and Personalis have found that a test to detect circulating tumour DNA can help predict the outcome of lung cancer treatments 🧪 First authors: James Black, Gabor Bartha Senior author: @charlesswanton.bsky.social www.crick.ac.uk/news-and-rep...

Scientists led by James Black, Gabor Bartha and @charlesswanton.bsky.social from 🇬🇧 @crick.ac.uk, 🇬🇧 @ucl.ac.uk, 🇬🇧 @uclh.bsky.social and 🇬🇧 Personalis have tested a method which detects circulating tumour DNA (ctDNA), to predict the risk of #lungcancer relapse before surgery.

Good to be involved in the @cancerresearchuk.org #ClinicalReseachers meeting at @rcn.org.uk Cavendish Sq. Great opportunity to meet other #ClinicianScientists, network & discuss high quality science. @thineskrishna.bsky.social @charlesswanton.bsky.social @clareturnbull.bsky.social

Thrilled our review was selected as a #science #highlight in this #Cell timeline of the last decade 🧪 "Embracing #cancer complexity: Hallmarks of systemic disease" Swanton et al, 2024 www.sciencedirect.com/science/arti... @charlesswanton.bsky.social @cancerresearchuk.org @cp-cell.bsky.social