This week: A group led by Drs. Masayuki Amagai, Hayato Takahashi, and Miho Mukai converted conventional effector T cells into functional and stable Tregs. Read the paper: https://bit.ly/4qKYimH Catch the discussion on our latest episode: https://bit.ly/43M7r4x

📢 Laine Goudy, Dr. Luke Gilbert's lab, and their collaborators recently developed a new #epigenetic editing platform that safely reprograms multiple genes in human T cells. 📃 https://go.nature.com/3JQdKNL 🗨️ https://bit.ly/43M7r4x

Our next episode features Dr. Camila Coelho ( @camilahcoelho.bsky.social ) from Icahn School of Medicine at Mount Sinai! Tune in tomorrow to learn about her work on emerging viruses. 🦠

📢 New in @nature.com! Work led by Dr. Zihai Li at the Pelotonia Institute for Immuno-Oncology have shown that #ProteotoxicStress, induced by protein aggregation, is not merely a consequence, but a driver, of the exhausted T cell state. 📄: https://go.nature.com/47zVDog 🎧: https://bit.ly/3LlRCeo

New work from the lab of Dr. Wan-Lin Lo at @utah.edu demonstrates that age-dependent Zap70 expression regulates negative selection and thymic #Treg cell development. Study🗒️: https://go.nature.com/4o9oqWn Episode 🔊: https://bit.ly/3LlRCeo

Congrats to Drs. Mary Brunkow and Fred Ramsdell on receiving the #NobelPrize in Physiology or Medicine! 🏆 We discuss their early work identifying #FOXP3 as a master regulator of regulatory T cells. 🎧 https://bit.ly/3LlRCeo

In this week's episode, we review the seminal study from Dr. Sakaguchi that led to his recent #NobelPrize! It shows that a population of T cells expressing the IL-2 receptor α chain acts to maintain self-tolerance by suppressing other T cells. 📃: https://bit.ly/49f551F 🎧: https://bit.ly/3LlRCeo

🎤 Our next episode it out! We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection. 🎧 Listen now: https://bit.ly/4o2W8xa

Dr. Heather Parsons has been awarded the Maudslien Endowed Chair in Breast Cancer Precision Oncology Research. Dr. Parsons’ research at @fredhutch.org focuses on a type of cancer marker called circulating tumor DNA (#ctDNA) that can be detected in human blood. 🎈 Congrats! https://bit.ly/3LlEpST

Online now: ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding journals.plos.org/plospathogen...

Deletion of the X-escapee gene Kdm6a in microglia reverses the disease-associated microglial translatome and has protective effects in female mice www.science.org/doi/10.1126/...

Quantification of timelapse 3D tumor spheroid killing activity of NK cells using a live-cell imaging system @plosone.org journals.plos.org/plosone/arti...

What is the relationship between food allergies and #AtopicDermatitis? We cover a @cp-immunity.bsky.social#AtopicDermatitispaper from Boston Children's Hospital that explores how S. aureus skin colonization can lead to exaggerated #anaphylaxis. Check it out on our latest episode: https://bit.ly/4mXBKMr

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation www.science.org/doi/10.1126/...

🔔 New episode alert! Dr. Robin Orozco ( @robsorozco.bsky.social ) from the @universityofkansas.bsky.social joins us to chat about her work on allelic variation and immune responses. Stream it here or on any podcast app: https://bit.ly/46Jf7GI

Want to see immune cells in 3D? We’ve published a protocol for 5-plex 3D imaging of whole lymph nodes, revealing germinal centers at single-cell resolution. So many possibilities ahead! Congratulations Victoire Boulat! tinyurl.com/y9ekha8c #Microscopy #Immunology #SpatialBiology

Our next guest is Dr. Robin Orozco ( @robsorozco.bsky.social ) from @universityofkansas.bsky.social Her research focuses on the role of allelic variations in immunity.🧬 🔔 Tune in to the episode on Tuesday!

Happy #InternationalPodcastDay! 🥳 We're celebrating by counting down our top three episodes of the year below. 👇

Dr. Dayana Rivadeneira and a team in Dr. Greg Delgoffe's lab showed that dysfunctional T cells in cancer harbor damaged #telomeres, which arise from oxidative stress. 📄 - https://bit.ly/42MrvmK 🗨️ - https://bit.ly/4mybUyr

This week: Dr. Upasana Das Adhikari and a team in Dr. Douglas Kwon's lab at the Ragon Institute of Mass General Brigham, MIT, and Harvard studied how immunometabolic defects disrupt the intestinal barrier in people with #HIV. Paper: https://bit.ly/46wC5zp Discussion: https://bit.ly/4mybUyr

🔪 "On a knife’s edge between #pathogen control and #autoimmunity!" Learn about Dr. Harikesh Wong's research on how #Tregs prevent autoimmunity during infection. @hswonglab.bsky.social#pathogen#autoimmunity#Tregs📍 https://bit.ly/4mybUyr

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

Join us next week for a conversation with Dr. Harikesh Wong ( @hswonglab.bsky.social ) from the @ragoninstitute.bsky.social ! Check out his team's work on how #Tregs prevent #autoimmunity: https://bit.ly/3IuYdlL

📢 New in #Nature! Researchers led by Dr. Chris at Stanford have leveraged synthetic #CytokineReceptor engineering to successfully rewire #TCell fate decisions and amplify anti-cancer immunity. 📗: https://go.nature.com/4n6F6gQ 🔊: https://bit.ly/4mYJIWy

Researchers led by Dr. Manolis Pasparakis at the University of Cologne have shown that XBP1 and caspase-8 synergize to prevent #ColonInflammation. 📄: https://bit.ly/46bdosb 🎧: https://bit.ly/4mYJIWy

A new #Nature study from the lab of Dr. Nicolas Gaudenzio shows that offspring of stressed pregnant dams have dysregulated mast cells and skin-projecting neurons & quickly develop #eczema in response to harmless mechanical friction. 📄: https://go.nature.com/42dFCRW 🎧: https://bit.ly/4mYJIWy

Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV: Cell www.cell.com/cell/fulltex...

Scientists led by Dr. Katayoun Rezvani at @mdanderson.bsky.social have found that #NKCells become better at killing #cancer cells after removal of key gene targets identified by genome-wide CRISPR screening. 📄: https://bit.ly/4m8mV9y 🎧: https://bit.ly/4mYJIWy

We've got a new episode out for you now! We chat with Dr. Eric Vivier from Aix-Marseille Université about the importance of investing in science, the responsibility of governments and other organizations in funding research, and the role science plays in society. 🎧: https://bit.ly/4mYJIWy

Check out this special episode from #IUIS2025! We chat with delegates about their favorite research presented and their experiences in Austria. 🇦🇹 Listen now: https://bit.ly/4p3vmWh @iuis-online.bsky.social#IUIS2025

We have a special episode for you coming straight from #IUIS2025 in Vienna! Dr. Zwi Berneman joined us for a live show where he discussed his work on mRNA-based #DendriticCell cancer vaccines. Listen now: bit.ly/4lR60bl

So long, Vienna! I'm back home in Amsterdam after a great week of #immunology at #IUIS2025! I had an amazing time! Check out @immunologypodcast.com for daily episodes covering our favorite talks & recording of the live episode! Thanks @iuis-online.bsky.social! See you all in Toronto #IUIS2028

Thank you all for an incredible #IUIS2025! We're already looking forward to #IUIS2028 in Toronto, hope to see you there!🍁

Looking for something to listen to on the way home from #IUIS2025? 🚅 Our final daily episode is out now! Catch up on the research presented on the last day of the meeting: https://bit.ly/4fQOGlt

From 🎶 harmonica at last night’s party to 🎤 the stage today — Nobel Laureate James P. Allison is now delivering the closing talk at #IUIS2025. A fitting finale to an unforgettable congress! ✨ #ImmunologyWithoutBorders

We have a new episode out! Brenda and Jason summarize the research presented yesterday at #IUIS2025, including sessions on cancer immunotherapy and #neuroimmunology. Listen now: https://bit.ly/41Sb1sQ

Gotta catch 'em all! 😎 Congratulations Dr. Jefferson Leite on collecting all four #ImmuneCell pins at #IUIS2025!

A huge thank-you to Dr. Zwi Berneman for joining us for this special show at #IUIS2025, and thanks to everyone who came to listen! If you missed it, the episode will be published on podcast platforms next week!

@iuis-online.bsky.social #IUIS2025 Day 4! reporting for the @immunologypodcast.com Started the day w/ neuro immunology session - cool story from Ulrich von Andrian @harvardmed.bsky.social -> close interaction of dermal DCs and nociceptive neurons in dermatitis & myeloid suppressor cells in cancer

🤯 What a day! Catch up on all the excitement from yesterday's sessions at #IUIS2025, including talks on brain-eating amoebas and the effects of antibiotics on #immunotherapy: https://bit.ly/3JoW23u

Today is a jam-packed day at #IUIS2025, including our live show on mRNA-based dendritic cell cancer vaccines! Dr. Zwi Berneman is joining us at 4 p.m. in Hall M. See you there!

Thank you to everyone who joined our #IUIS2025 workshop today! To learn more about STEMprep™, visit us at booth #5.

Thank you to everyone who joined us for our "On the Ground" #IUIS2025 episode! Hear what they had to say when the episode airs on September 2nd!

Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.

You can see how happy we were to see Dr. James Allison in person at #IUIS2025! 😁 We had the pleasure of speaking with Dr. Allison in 2024. Listen to the conversation here: https://bit.ly/47EUFYm

Drs. José Carlos Alves Filho, Luciana Berod (@luberod.bsky.social), and Thomas Weichhart (@weichhartlab.bsky.social) are presenting their work on the metabolic regulation of immune responses at #IUIS2025! Check out the session at 1:45 pm in Hall E1.

Day 3 #IUIS2025 @immunologypodcast.com Lost a pair of pants and was late to the 1st session of today 🥲 - but enjoyed a masterclass on immune suppression after severe illness from Laura Cook @Peter Doherty Institute - finished strong w/cute organoid-derived pineapple shaped cilliated cells

📣 Happening now! We're recording in Room 0.44 until 12:30. Drop by for a ten-minute Q&A with Jason and Brenda and you could appear on an episode of the Immunology Podcast! #IUIS2025

Our Day 2 #IUIS2025 episode is out now — or as we call it, #DendriticCell Day! Listen now to catch up on the latest research presented: https://bit.ly/4oKwspH