After >10 years of our lab studying bacterial cGAS-like enzymes, @hobbslabutah.bsky.social finally reconstitutes viral sensing in vitro and discovers how these ancient receptors sense phage protease enzymes to detect virion assembly and activate antiviral immunity www.biorxiv.org/content/10.6...

@nitzantal.bsky.social @romihadary.bsky.social @soreklab.bsky.social use structure prediction and in silico binding site analysis to discover viral immune evasion proteins! Exciting for our lab @reneechang.bsky.social @riveralopz.bsky.social to help with this project. www.science.org/doi/10.1126/...

What actually shapes a career in science? In Season 3 of the Lab Coats & Life™ Podcast, launching March 11, we zoom out from the bench to examine the systems surrounding researchers. 🔍 Listen wherever you get your podcasts, starting next week! Or catch up on our previous two seasons now. 🎧

Deficiency in the leukocyte integrin LFA1 increases susceptibility to commensal human papillomaviruses (HPVs) by impairing T cell homing and surveillance in the skin. Learn more in #ScienceImmunology: https://scim.ag/3Mzi05P

Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!

In this week's episode, we discuss a study from Dr. Stephen Jameson at the University of Minnesota, showing that #IL4 can dial down how strongly memory CD8+ T cells respond to infection without direct antigen stimulation. 📘: https://go.nature.com/3OqIhnk 🎙️: https://bit.ly/40muGA2

Researchers led by Drs. Michael Gantier, Toshiyuki Shimizu, and Ben Corry show that modified #RNA from our own cells naturally blocks TLR7 and TLR8, preventing harmful immune activation. 📖: https://go.nature.com/4azVWjp 🔊: https://bit.ly/40muGA2

📢 New in Cell! Researchers led by Dr. Kai Wucherpfennig at Dana-Farber Cancer Institute found that a single viral treatment enabled the immune system to attack tumors in patients with #glioblastoma. 🗒️ Study: https://bit.ly/406V8Oh 🎧 Discussion: https://bit.ly/40muGA2

Immunity in Alzheimer’s disease: From mechanisms to therapies @cp-immunity.bsky.social www.cell.com/immunity/ful...

Pinpointing the exact noncoding variants driving locus-disease associations is an enduring challenge. Using MPRA, a @jacksonlab.bsky.social, Broad & @yaleschoolofmed.bsky.social team tested >220,000 variants in 5 cell types, resolving >13,000 and revealing mechanisms behind several disease traits.

Register early and save on IMMUNOLOGY2026™ attendance! Join us from Wednesday, April 15 to Sunday, April 19 in Boston for the leading annual all-immunology event worldwide. Don't miss out on these discounts, especially as an AAI member! Learn more: https://bit.ly/4ovupVf

In our latest episode, we discuss a study from Dr. Nicholas Collins at Weill Cornell. They show that when #food is scarce, #StressHormones rebalance the immune system to fight infection while conserving glucose and preserving immune memory. 🗒️: https://bit.ly/4kJmval 🎧: https://bit.ly/40muGA2

📢 We have a new episode out! We chat with Dr. Ido Amit at the Weizmann Institute of Science about his research applying cutting edge single-cell #genomics technologies to uncover immune regulatory mechanisms and pathways. 🎧 Listen now: https://bit.ly/40muGA2

I REALLY hope this can be replicated in humans. A trial in mice showed that a nasal vaccine targeting multiple respiratory pathogens including COVID-19 worked really well - enabling development of protective Immunity in the lung for 3 months (the duration of testing) 🧪

Congratulations to Ben Morehouse @benmorehouse.bsky.social and the other 2026 Michelson Prize Awardees. All five newly funded projects are incredibly exciting areas of immunology! www.michelsonmedicalresearch.org/news/michels...

Highly dynamic dural sinuses support meningeal immunity @nature.com @niaidnews.bsky.social www.nature.com/articles/s41...

Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps: www.cell.com/cell/fulltex...

This Science Immunology article talks about the #aging immune system! The Winer lab at @utoronto.ca#agingshowed how #Bcells affect #Tcell aging. 📃 https://bit.ly/4aDfEuK 🎤 https://bit.ly/4kEDz1s

CD56bright NK cells are negatively associated with antibody response to vaccination in people with multiple sclerosis on B-cell-depleting therapy onlinelibrary.wiley.com/doi/10.1002/...

This week: A team at Westlake University identified a neuro-#epithelial axis in the skin that can tune regional immunosurveillance against #melanoma. Article: https://bit.ly/4arswnF Episode: https://bit.ly/4kEDz1s

🔔 This is your reminder to register for #IMMUNOLOGY2026™, happening April 15-19 in Boston! Register by March 13th to enjoy early discounted registration rates. 📝 https://bit.ly/4qCSjiL @aai.org#IMMUNOLOGY2026

We have a new episode out now! Dr. Sharon Lewin from the Doherty Institute talks about targeting latent #HIV. Listen now: https://bit.ly/4auGDbD

A new @cp-cell.bsky.social paper outlines how #EpsteinBarrVirus and HLA-DR15 may jointly contribute to #MultipleSclerosis. 📃 https://bit.ly/3NKn0EP 🎤 https://bit.ly/3NSNcNu

Check out our latest episode! Dr. Rafi Ahmed from Emory University talks about his research on #ImmuneMemory. Listen now: https://bit.ly/4bjqWpO

Sharing our latest by Filio Karakousi online today in @cp-cancercell.bsky.social ! authors.elsevier.com/a/1mUU45TA51... We demonstrate that cytotoxic immune responses metabolically program the lymphatic vasculature to restrain regional metastasis and promote immunity!

New from Dr. Kory Lavine's lab! Ruijun He and the team demonstrated that DNA-damaging chemotherapy can reshape cardiac #macrophage ontogeny and tissue injury responses. 🫀 Paper: https://bit.ly/4qnSz5B Discussion: https://bit.ly/3ZgtkGo

This is your last chance to submit a late-breaking #immunology abstract for #IMMUNOLOGY2026™! Don't miss this final opportunity to connect, collaborate, advance your career, and access the cutting-edge research showcased in Boston, MA, from April 15-19, 2026. https://bit.ly/4pHUEZB @aai.org#immunology

Drs. Hashem Mohammadian, Andreas Ramming, Maria Raimondo, and Simon Rauber led a team at @fau.de to study how #psoriasis spreads from the skin to the joints. 🖇️ @natimmunol.nature.com#psoriasis- https://go.nature.com/4sDFZke 🗨️ - https://bit.ly/3ZgtkGo

What goes into planning the world's largest all-immunology event? Join AAI President Dr. Uli von Andrian and Program Chair Dr. Shekhar Pasare for a preview of #IMMUNOLOGY2026™! 🧬 Presidential Symposium 🔬 Special Sessions 🎓 Trainee Programs 🔗 immunology2026.aai.org

Organoids models and CAR T cell therapy was used to research diffuse midline glioma (DMG) in the brainstem. 🧠 Researchers from @themaximacenter.bsky.social tested GD2-specific CAR T cells on DMG #organoids and found reduced effectiveness when microglia were present: https://bit.ly/4jBD2fY

🎉 We're back with our first episode of 2026! Drs. Ulrich von Andrian and Shekhar Pasare from @aai.org discuss what to expect at #IMMUNOLOGY2026™! Listen now: https://bit.ly/3ZgtkGo

We're kicking off 2026 with Drs. Uli von Andrian and Shekhar Pasare from @aai.org! Join us next week for a discussion on what to expect at #IMMUNOLOGY2026, including program highlights, opportunities for trainees, and what to see in Boston. 🍵 Learn more: https://bit.ly/49JR37X

Register early and save on #IMMUNOLOGY2026™ attendance! Join us from Wednesday, April 15 to Sunday, April 19 in Boston for the leading annual all-immunology event worldwide. Don't miss out on these discounts, especially as an @aai.org#IMMUNOLOGY2026member. https://bit.ly/4ovupVf

Drs. Christian Gaebler, Samad Kor, Olaf Penack, and a team in Berlin found that after receiving a stem cell transplant, a patient discontinued antiretroviral therapy and sustained HIV remission for 6 years to date. 🖇️ https://go.nature.com/4j9OfnI 🎧 https://bit.ly/44Ay1OG

Congratulations to Drs. Jose Villadangos and Hamish McWilliam's (@hay-mish.bsky.social) labs on their @science.org paper! Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity. 🗒️ https://bit.ly/49W1GW1 🎤 https://bit.ly/44Ay1OG

Happy Holidays from the Immunology Podcast team! ☃️ ❄️ We're taking a short break and will be back with a new episode on January 13th. Until then, we're dreaming of white blood cells and elf-ector T cells. 🎅 See you in 2026!

💉✨ Building a better flu vaccine — A joint study by the University of Michigan and the Institut Pasteur reveals that antibodies targeting the flu’s NA protein can help block not only infection but also transmission. Read more 👉 www.pasteur.fr/en/press-are...

Marjon Wouters, Isabelle Meyts @isabellemeyts.bsky.social and colleagues show that dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti... #InbornErrorsOfImmunity

This week: Maternal dust allergy and neonatal #RSV infection! Drs. Hamida Hammad and Bart Lambrecht's teams at @viblifesciences.bsky.social#RSVstudied how maternal factors influence RSV-associated allergic #asthma. Paper - https://bit.ly/3N7Mrj7 Discussion - https://bit.ly/44Ay1OG

An experimental vaccine against IgE protects against #anaphylaxis in humanized mice! Read the @science.org paper from a team at @pasteur.fr#anaphylaxis https://bit.ly/4s35z1L Listen to the discussion on our latest episode: https://bit.ly/44Ay1OG

Our immune system declines with age. Now the lab of @zhangf.bsky.social has found a way to overcome this decline by temporarily programming liver cells to improve T cells’ ability to fight infection.

Tune in to today's episode to learn about the role of the #microbiome in #Type1Diabetes! 🦠 Dr. Jayne Danska from @sickkidsvs.bsky.social#microbiome#Type1Diabetesoined us for a great conversation. Listen here: https://bit.ly/44Ay1OG

We can't wait to chat with Dr. Jayne Danska from @sickkidsvs.bsky.social next week! Her research focuses on #Type1Diabetes and the #microbiome. Stay tuned!

Shoutout to our listeners for proving you can love #Tcells, Taylor Swift, and #tuberculosis epidemiology all at once. Long live The Tortured Immunologists Department. 🤍 #SpotifyWrapped

The latest issue of #Science #Immunology is out now! This week: • evaluating large language models ( #LLMs ) / #AI as potential #systems #vaccinology tools • de novo #thymus #regeneration in the #axolotl! New content every week!!!

My latest 'pinch yourself' moment from the Lab. We previewed two really really exciting papers from the Eisenbarth and Pabst Labs for @cp-immunity.bsky.social Read our summary here> www.cell.com/immunity/ful... A big well done to Gaby Berman in my group and authors of both excellent manuscripts!

Present your #immunology research among the world's leading immunologists! Submit your abstracts today for #IMMUNOLOGY2026™. Upon submission, apply for an AAI Travel Award to assist with travel expenses to Boston, MA. ✈️ https://bit.ly/48cjOtl @aai.org#immunology

Recent work in @jci.org shows that subcutaneous white adipose tissue dysfunction triggers aging-like intestinal dysfunction in mouse models. Read the article: https://bit.ly/4rBatTB Listen to the discussion: https://bit.ly/4pJvw4u

A purr-fect place to record! 😻 @brendaraud.bsky.social is not the only one enjoying her soundproof setup. 😉

Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193...