Happy Holidays from the CISR! May all your days and fluorophores be BRIGHT. #MicroscopyMonday

Happy Holidays from our team!

❄️ Happy Holidays! Our team will be away next week, so there will be a pause in our regular content. 📯 We'll be back the week of January 5th to deliver newsletters and daily posts.

Check out this new study from Dr. Tanya Stoyanova's lab! 🥼 Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊 🔗 https://go.nature.com/3KTvwQQ

Some fiery prefrontal cortical neurons projecting to the locus coeruleus that are labeled in the mouse brain #FluorescenceFriday 🧠🔬🔥 Image credit to @rehg-j.bsky.social and the @lieberinstitute.bsky.social Circuits Team

Dr. Masoud Manjili and collaborators identify Bcl-xL as a central survival factor in chemotherapy-induced dormancy. They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC 🔗 https://go.nature.com/4p5bUau

Love the #bacteriophage cheese board! 😂

Very pleased to share our new review "The Evolving Landscape of Brain Metastasis" in @cp-trendscancer.bsky.social 🧠🔬🧪 Grateful to an outstanding team of co-authors, all pioneers in the #brain #metastasis field and to @valientelab.bsky.social for co-leading this 🙏🏻 Link: www.cell.com/trends/cance...

#Integrin α3 is implicated in #ADHD and other neurodevelopmental disorders. A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes. https://go.nature.com/4aiBN2P

A group of scientists from Sun Yat-sen University show that as #BladderCancer progresses, matrix stiffness and tumor #stemness increase. High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size. 💡 https://go.nature.com/4pEqerl

Led by Drs. Jocelynn Pearl and Annette Marleau, scientists review clinical advancements in the understanding of the therapeutic properties of MSCs and their subpopulations, assessing the evidence supporting their use in #RegenerativeMedicine. 💡Read it here! bit.ly/48N2kmg

🧪 Dr. Justus Duyster and team found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce oncostatin M, which triggers disease progression and immunosuppression. @sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4

Hot off the press in @natcomms.nature.com 🔥 Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊 https://go.nature.com/48SQ0RE

From the Abrams & Brentjens labs, scientists reported that IL-36γ armored CAR T cells eradicate primary solid tumors and enable rejection of rechallenged antigen-negative tumors. 📙 Learn more: https://bit.ly/4qf3o9S

This @pnas.org study found that prostaglandin E2(PGE2) produced in TME confers the tumor-infiltrating Tregs signature to #Tregs via its receptors, EP2 and EP4. ➡️ Read the full article here: bit.ly/4q2xahV

Drs. Michael Keller and Navid Djassemi examine advancements in virus-specific T cell manufacturing that broaden their accessibility to a wider range of viral infections and immunocompromised populations. 👉 Read their review in @bloodjournals.hematology.org bit.ly/4oJ1Qnd

In this study, scientists utilized androgenetic, parthenogenetic, and biparental hESCs and their neural derivatives to identify novel imprinted genes by analyzing their methylome and transcriptome profiles. 📖 Read more: https://bit.ly/452mvvr

🧠 This study suggests that targeting the CCL2/CCR2/ERK1/2 pathway may help overcome chemoresistance in #glioblastomas caused by cancer-associated fibroblasts! 👉 https://go.nature.com/3XI0cHu

🔬 Researchers investigated the involvement of cyclin B2 in pancreatic ductal adenocarcinoma growth and progression using glycolysis inhibitors in vivo and in vitro. 🔗 https://bit.ly/44gwTzD

💓 Scientists with Dr. Nobuaki Fukuma at @columbiauniversity.bsky.social investigated whether and how #cardiomyocyte NO-sensitive soluble guanylyl cyclase mediates female-specific, adaptive right ventricular pressure-overload remodeling. 👉 https://bit.ly/3WYQdx2

Researchers found that isoflurane facilitates hemispheric lateralization in BBB permeability, leading to different responses between the left and right hemispheres. 🧠 📖 https://bit.ly/3Yho4lq

Astrocytes make up a quarter of all brain cells and are emerging as key players in #neuroskyence research. Take a look at how scientists have discovered astrocytes' role in memory, learning, and other brain functions. 🧠

#fluorescencefriday OPCs hanging out near blood vessels in the brainstem 🟡 Pdgfra 🟣 Olig2 🔵 DAPI

It’s #FluorescenceFriday ! Expression of synapsin-EGFP in neurons in one of our organoid models 🧠

📊 In this study, an integrative analysis of public datasets and immunohistochemistry revealed that ACTC1 is upregulated in prostate cancer, identifying ACTC1 as an oncogenic regulator of prostate cancer progression. 🔗 https://bit.ly/4osaoPm

Teach neuroscience to undergrads? Learn how to incorporate our connectomics data into your courses! 🗓️ July 23-24 🛫 Travel funds available ⏳ Apply by Feb. 2. https://alleninstitute.org/events/incorporating-open-connectomics-data-into-teaching-neuroscience/

🥊 Researchers with Giovanni Papa and Jiazhuo He perform in vivo CRISPR knockout screening for gastric tumor suppressors using gastric murine organoids in a subcutaneous as well as a surgical model of orthotopic tumor growth. 🔗 https://bit.ly/3Ks8AI7

Drs. Wolfdieter Springer, Xu Hou, and @mayoclinic.org co-authors revealed complex interactions between #LewyBody pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body #Dementia brains. 🧠 📝 Check out the paper: https://bit.ly/3MfHUuU

🩸 Acute #leukemia is the most common type of cancer in children; however, the etiology is poorly understood. This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia. 👉 https://bit.ly/4rxHsbc

Among the five types of stem cells that have been experimentally applied to #LiverDisease, #MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide. 📖 Read the review: https://bit.ly/48tNMYN

💊 Researchers uncover a heme rheostat that is connected to gene expression and drug sensitivity in #AML and implicates heme biosynthesis enzyme inhibition as a trigger of cuproptosis. 🔗 https://bit.ly/4p6Wsvf

🧫 By leveraging lipid nanoparticles designed to selectively transfect tumor-associated #macrophages, scientists circumvent extensive ex vivo manipulation and achieve robust CAR expression directly within the tumor microenvironment. 👉 https://bit.ly/3KqyagG

A team of scientists from Air Force Medical University clarify how N-trans-feruloyloctopamine, as an FGF2 inhibitor, mitigates UVB-induced #SkinDamage and #hyperpigmentation by regulating this pathway. 💡Check it out: bit.ly/3KB67Lx

Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtain University-led research project. 📰 Check out the article: bit.ly/4ootZzU

A research team from Fudan University identify a subset of antibodies with broad-spectrum receptor-binding domain binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3. 🦠 🔗 https://go.nature.com/3MoQQxO

Researchers, including Drs. Sören Müller & Shannon Turley, show that Gremlin1-expressing lymph node fibroblastic reticular cells support #DendriticCell homeostasis via provision of Fms-like tyrosine kinase 3 ligand. https://go.nature.com/3LZSV38

Happy #MicroscopyMonday everyone!🔬 Today's image comes from Alice and it's a great fluorescent image of inner hair cells (stained with Phalloidin, magenta) from a 2-months old mutant.🐁 In this photo the expression of Baiap2l2 (green) was successfully restored with AAV-gene therapy.💉🧪 #NeuroSkyence

🧪 Scientists from Fudan University identified ADK fusion genes as novel and recurrent drivers in hormone receptor-positive/human epidermal growth factor receptor 2-negative #BreastCancer. https://go.nature.com/4pn42Bt

This review article delineates the mechanistic landscape by which resveratrol attenuates #glioblastoma (GBM) progression, with emphasis on #apoptosis induction, the promotion of differentiation, and the modulation of GBM stem-like cell phenotypes. 🧠 🔗 https://bit.ly/3XpWq5D

New release from @natcellbio.nature.com! Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion. ✅ go.nature.com/4ib4Ln6

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🥼 Two researchers from @uazcancercenter.bsky.social received $917,000 as part of a two-phase grant to investigate novel #immune-based approaches to prevent #keratinocytic skin cancers. Congratulations! 👏 📰 Learn more: https://bit.ly/4o4IXL3

Just in! 🔥 Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus. https://go.nature.com/4pgiD1I

Researchers with Drs. Feng Qian and Lei Sun demonstrate the critical role of LMO7 in orchestrating tumor-associated macrophage (TAM) phagocytosis. 🥼 The expression of LMO7 in TAMs is associated with poor patient survival. 🔗 https://bit.ly/3LG4XOZ

⚗️ Researchers uncover the novel mechanistic insights in HCC recurrence after insufficient radiofrequency ablation, demonstrating the important role of heat stress-mediated tumor metabolism adaption by mRNA translation in HCC development. 👉 https://bit.ly/47SqX0A

🫁 Investigators presented preclinical evidence of a safe and effective respiratory-delivered vaccine platform for inducing T cell-mediated sterilizing immunity against a respiratory pathogen. @natmicrobiol.nature.com | go.nature.com/4p5zJiF

🔎 Dr. Frank Grosveld and team investigated the role of three relatively poorly studied transcription factors in early embryonic hematopoietic development at single-cell resolution: Atf3, Zfp711 and Bcl6b. bit.ly/49NHaqf

Scientists with Dr. Emeric Limagne uncover the role of the tumor-associated macrophage axis in inhibiting PD-L1 efficacy in microsatellite stable #ColorectalCancer. 📚 https://bit.ly/43q99Zn

This image shows a mass of human stem cells, collectively known as an ‘organoid’. We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma. Image credit: @carmenmorenogon.bsky.social