Immune imbalance contributes to #MetabolicSyndrome progression. This study shows that sodium nitrate restores #macrophage balance through sialin, improving metabolic homeostasis and therapeutic potential. #STTT #OpenAccess: doi.org/10.1038/s413... #MetabolicSyndrome #Immunometabolism

Targeting latent HIV remains a key challenge. This study identifies RBP4 as a latency-reversing factor that reactivates HIV-1 via NF-κB, JAK/STAT5, and JNK signalling, highlighting a potential #TherapeuticTarget. #STTT #OpenAccess: doi.org/10.1038/s413... #InfectiousDiseases #Immunotherapy

Can #TACE combined with #Immunotherapy improve intermediate-stage #HepatocellularCarcinoma treatment? This phase 2 trial reports that atezolizumab plus bevacizumab shows promising efficacy and manageable safety. #STTT #OpenAccess: doi.org/10.1038/s413...

#CytokineStorm underlies life-threatening #Inflammation in multiple diseases. This review examines its #Pathogenesis, immune signaling pathways, and therapeutic strategies to improve clinical management. #STTT #OpenAccess: doi.org/10.1038/s413...

Severe #COVID19 remains a major clinical concern. This phase 3 trial shows that meplazumab, a CD147 antibody, demonstrated a favorable safety profile and improved clinical outcomes, supporting its therapeutic potential. #STTT #OpenAccess: doi.org/10.1038/s413... #InfectiousDiseases #Immunotherapy

#GeneFusions are key drivers of many #Cancers and important #TherapeuticTargets. This review summarizes their biology, detection methods, approved targeted therapies, and future directions for #PrecisionOncology. @gumedcenter.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...

This study evaluates the PTK7-targeting ApDC Sgc8c-M across rodent and non-human primate models, confirming its potent antitumor efficacy and favorable safety, thereby supporting its clinical translation. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerResearch #TargetedTherapy #DrugDelivery

A new blood-based #GeneExpression #DiagnosticTest may enable early #PancreaticCancer screening and improve long-term survival.  #BloodTest #EarlyDetection #CancerScreening

👉 ESMO Asia 2026: Your Research, Your Region, Your Impact. 🌍 Only a few days left to submit your abstract for the congress in Singapore (4–6 Dec). Turn your innovation into impact! ⏰ Deadline: Tues 21 July, 18:00 SGT / 12:00 CEST. 🔗 https://ow.ly/KACm50ZlTan #ESMOAsia26 #esmomeetings

The #ESMOGUAsia27 programme is live! 📍Hong Kong SAR, China 📅 15–17 Jan 2027 ✅ Registration open ⏳ Early deadline: 11 Nov 👉 Secure your place: https://ow.ly/eMnn50ZlY2c 🔎 View programme: https://ow.ly/Cb9V50ZlY2e#ESMOGUAsia27 #ESMOMeetings #MedOnc #RadOnc #UroSoMe

Can metabolic reprogramming strengthen #Cancer #Immunotherapy? This study shows a photoresponsive Nano-PROTAC enhances pyroptosis-mediated antitumor immunity and suppresses triple-negative #BreastCancer progression. #STTT #OpenAccess: doi.org/10.1038/s413...

Which maintenance therapy offers greater benefit after first-line #Chemotherapy? The phase 3 FAMILY trial compares fulvestrant with capecitabine in hormone receptor-positive, HER2-negative metastatic #BreastCancer. #STTT #OpenAccess: doi.org/10.1038/s413...

This study identifies GSK-3 as a key regulator of CD4⁺–CD8⁺ cooperation that generates super-armed CD8⁺ cytolytic T cells with enhanced #Antitumor activity, revealing a mechanistic strategy to strengthen immune responses against tumors. #STTT #OpenAccess: doi.org/10.1038/s413...

A myeloid Mas–PKM2–Spi1 signaling axis promotes inflammatory #Senescence in #MASLD through PKM2-mediated Spi1 #Lactylation, revealing a mechanistic pathway and potential therapeutic targets for metabolic #LiverDisease. #STTT #OpenAccess: doi.org/10.1038/s413...

Discover how #TumorHeterogeneity influences #Cancer progression and therapy resistance. This review explores its underlying mechanisms and emerging precision strategies to improve therapeutic outcomes. #STTT #OpenAccess: doi.org/10.1038/s413...

How do targeted therapies reshape the #TumorMicroenvironment? Using a multiplex implantable microdevice assay, this study reveals dynamic spatial architectures that inform treatment response and #PrecisionOncology. #STTT #OpenAccess: doi.org/10.1038/s413...

Engineered NK cells combining PD-L1 and HLA-E targeting with endogenous IL15 production overcome multiple #Immunosuppressive pathways, strengthening persistence and antitumor activity across diverse tumor models. #STTT #OpenAccess: doi.org/10.1038/s413... #TumorImmunology #Oncology #CancerResearch

What drives #DiabeticCardiomyopathy beyond metabolic dysfunction? VCPIP1 regulates AMPKγ1 that disrupts AMPK assembly to promote disease progression, highlighting it as a potential #TherapeuticTarget for diabetic heart disease. #STTT #OpenAccess: doi.org/10.1038/s413... #MolecularBiology

5-Fluorouracil resistance limits #ColorectalCancer therapy. This study shows EHMT2 inhibition restores drug sensitivity by regulating cell cycle and #Apoptosis, supporting a potential strategy to overcome resistance. #STTT #OpenAccess: doi.org/10.1038/s413...

📣 Applications are open for Translational Medicine Explored – #TMex 2026! Watch the video below and hear what last year's participants have to say about their experience! 👉 Learn more and apply while spaces last here: https://eatris.eu/events/translational-medicine-explored-tmex-2026

WATCH: Frederick Howard, MD, discusses the importance of the appropriate use of AI tools in breast pathology practices. See our video with Dr Howard for more insights on AI in oncology! #bcsm #oncology www.onclive.com/view/dr-howa...

Deadline tomorrow! ASBMB Today is looking for first-person essays on teamwork and leadership in science. Share lessons from leading—or being part of—a research team. 250- or 500-word essays welcome. 📅 Due July 15 📧 [email protected] www.asbmb.org/asbmb-today/...

The HILL trial shows that the triple-combination therapy of FOLFOX-HAIC, lenvatinib, and durvalumab exhibits promising efficacy and manageable safety in unresectable #HepatocellularCarcinoma. #STTT #OpenAccess: doi.org/10.1038/s413... #ClinicalTrial #Cancer #Immunotherapy #Lenvatinib

Learn how aging influences cancer development and treatment efficacy. This review explores shared #molecularpathways and emerging therapeutic strategies that advance healthy aging and #cancerprevention and treatment. #OpenAccess in #STTT: doi.org/10.1038/s413...

Tumor-derived EVs often suppress immune responses, limiting #Cancer treatment. Researchers developed #Nanoproteolysis-targeting chimera (EVOTAC) that reprogram these vesicles toward immunogenic phenotypes to boost anti-tumor responses. #STTT #OpenAccess: doi.org/10.1038/s413...

New therapeutic strategies are needed to overcome treatment resistance in #MultipleMyeloma. Inhibiting COPII-dependent endoplasmic reticulum export disrupts proteostasis and metabolic resilience, suppressing tumor growth. #STTT #OpenAccess: doi.org/10.1038/s413...

#StressHormones prioritize cardiac energetics! This study identifies a two-strata energy flux system that prioritizes cardiac energetics during physiological demand coordinating metabolic regulation and #CardiovascularHomeostasis. #STTT #OpenAccess: doi.org/10.1038/s413...

More effective #Antivirals are needed against emerging viral threats. In this study, researchers developed novel brincidofovir and HPMPA derivatives with greater potency against #Orthopoxviruses and human #Adenoviruses. @fudan-university.bsky.social #OpenAccess in #STTT: doi.org/10.1038/s413...

What controls #LipidHomeostasis in alcohol-associated liver disease? This study identifies the AKAP12-PKA axis as a key regulator of hepatic lipid metabolism and a promising #TherapeuticTarget against #LiverInjury. #STTT #OpenAccess: doi.org/10.1038/s413...

👉 Calling ESMO #PatientAdvocate Members across Asia-Pacific (megaphone emoji). Apply for the ESMO Patient Engagement Summit 2026 at #ESMOAsia2026 (4–6 Dec, Singapore). Connect with experts, build advocacy skills, and shape patient-centred cancer care. #PatientAdvocacy 🔗 https://ow.ly/lEA150ZkCsJ

Submit an abstract by July 13 for the AACR Conference on Pancreatic Cancer (Sept 25-28; San Diego), chaired by Andrew J. Aguirre, Florencia McAllister, Kenneth P. Olive, Eileen O’Reilly, Diane M. Simeone, and Colin D. Weekes. buff.ly/pSzoa0m #AACRpan26 @kenolivelab.bsky.social

📣 #JobAlert The Faculty of Biology of @uni-freiburg.de invites applications for a Professorship (W3) for Bioinformatics and Molecular Genetics. ❗ Application Deadline: 15 August, 2026 🔗 kurzlinks.de/roi8 #Biology #Bioinformatics #MolecularGenetics

#Atherosclerosis and #VascularCalcification remain difficult to treat. This study shows that the tripeptide DT-109 reduces these pathologies in primates by targeting #OxidativeStress, supporting its translational potential. #STTT #OpenAccess: doi.org/10.1038/s413...

Chronic stress is a major driver of #AtrialFibrillation. This study links #ChronicMildStress to atrial fibrillation through S100A8/A9-driven neutrophil extracellular trap formation, revealing a #TherapeuticTarget. #STTT #OpenAccess: doi.org/10.1038/s413...

How does #WntSignaling influence health & disease? This review in #STTT explores canonical & non-canonical pathways, regulation and therapeutic advances targeting Wnt signaling across multiple disorders. #OpenAccess: doi.org/10.1038/s413... #Cancer #RegenerativeMedicine #LifeSciences

#Phototherapy is reshaping #Cancer treatment through advances in photodynamic, photothermal & #Photoimmunotherapy. This review details the mechanisms, delivery strategies, clinical progress & challenges limiting its translation. #BiomedicalResearch #STTT #OpenAccess: doi.org/10.1038/s413...

Excessive #Inflammation during #InfluenzaA infection causes severe tissue damage. This study identifies Ninjurin-1 as a driver of #PANoptotic cell lysis and inflammatory responses, revealing a potential #TherapeuticTarget. @tsinghuauniversity.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...

Achieving broad-spectrum protection against diverse #Influenza strains? A new #Nanobody-based #PROTAC shows promise by targeting and degrading viral proteins, thus providing broad-spectrum protection against diverse influenza viruses. #OpenAccess: doi.org/10.1038/s413...

How do tumors promote immune suppression? This study identifies proton-sensing GPR65 as a regulator of the immunosuppressive #TumorMicroenvironment, highlighting a promising target for #Cancer #Immunotherapy. @unimainz.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...

Submit an abstract by July 13 for the San Antonio Breast Cancer Symposium (December 8-11), presented by UT Health San Antonio in collaboration with the AACR. Learn more: buff.ly/98T3KHj #SABCS26

WEBINAR: Everything you wanted to know about pre-mRNA splicing but were afraid to ask 📆 July 15 | 12:15 p.m. ET @uwmadisonrna.bsky.social will give an overview of pre-mRNA splicing and the cellular machine responsible—the spliceosome! 💻 Free registration required: www.asbmb.org/meetings-eve...

Select people with advanced lung cancer may benefit from lung transplant, LGBTQ+ people are less likely to get some cancer screenings, and more from the Week in Cancer News in Cancer Today magazine. buff.ly/1QJPrAh

This study shows that #Hypoxia-induced microRNA-27b drives pathological cardiac endoreplication, providing mechanistic insights and highlighting it as a potential #TherapeuticTarget for #CardiacDiseases. @goetheuni.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...

How do #Glycosylation sites affect vaccine immune response? This review explores the mechanisms influencing #COVID19 vaccine #Immunogenicity, providing guidelines for designing effective & resilient vaccines for better protection. #STTT #OpenAccess: doi.org/10.1038/s413...

Immune suppression limits #Myeloma treatment. SSTNIV, a syndecan-1-targeting #PeptideChimera, reverses immune suppression by remodelling the immune microenvironment, offering a promising strategy to inhibit disease progression. @unmc.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...

Understanding disease cellular crosstalk is complex. This study presents #iS2C2, a cointelligent platform that integrates #ArtificialIntelligence with biological expertise to uncover mechanisms of disease-associated cellular crosstalk. #STTT #OpenAccess: doi.org/10.1038/s413...

This randomized, controlled phase 2a trial evaluated the acute effects of #TPN171H and demonstrated favorable hemodynamic improvements with an acceptable safety profile, supporting further clinical development. #STTT #OpenAccess: doi.org/10.1038/s413... #Therapeutics #HeartHealth

Durable responses in advanced #NSCLC remain challenging. This study shows that low-dose #Radiotherapy enhances PD-1 blockade by reprogramming neutrophils, improving antitumor immunity and survival in #LungCancer. #STTT #OpenAccess: doi.org/10.1038/s413...

This study identifies ADAMTS4 as a driver of #LiverFibrosis in metabolic dysfunction-associated steatotic liver disease (#MASLD), showing that targeting ADAMTS4 reduces myeloid cell recruitment, liver injury, and #Fibrogenesis. #OpenAccess in #STTT: doi.org/10.1038/s413...

This phase II SILENSES trial showed that sintilimab plus lenvatinib converted advanced unresectable #HepatocellularCarcinoma to resectable disease in over half of patients, enabling curative surgery and durable survival benefits. #STTT #OpenAccess: doi.org/10.1038/s413...