Researchers discovered that certain #ImmuneCells in early-life #skin are more reactive than in adults, which may explain why #eczema often begins in #childhood.  #AtopicDermatitis #DendriticCells #AllergicInflammation

New research shows a #KetogenicDiet reduced #HighBloodSugar in mice and enhanced their #AerobicCapacity. #Hyperglycemia #ExerciseBenefits

A newly developed #UniversalVaccine formula, delivered intranasally, protects against a wide range of #RespiratoryViruses, #bacteria, and even #allergens in preclinical studies. #MucosalVaccine #IntranasalVaccination #RespiratoryInfections

A new study in mice finds that an #UnhealthyDiet early in life causes lasting changes in the #brain and #FeedingBehavior, but interventions targeting the #GutMicrobiome can help restore #HealthyEatingHabits. #HealthyEating

Counties in the U.S. near operational #NuclearPowerPlants have higher #CancerMortality rates than those farther away, even after adjusting for socioeconomic, environmental, and health care factors. #CancerRisk

A large longitudinal study found that #CannabisUse in #adolescents is linked to a significantly higher risk of developing serious #PsychiatricDisorders by #YoungAdulthood. #Cannabis #MentalHealth #BipolarDisorder #Depression #Anxiety

Consuming #VirginOliveOil, as opposed to #RefinedOliveOil, improves #GutMicrobiome diversity and helps preserve #CognitiveFunction in #OlderAdults. #ExtraVirginOliveOil

A new study shows #RedBloodCells act as hidden #GlucoseSponges in #LowOxygen conditions, explaining why people living at #HighAltitude have lower #diabetes rates and pointing toward new treatments.  #Hypoxia #GlucoseSink #BloodGlucoseControl #GlucoseTolerance

Researchers improve the efficacy of #CARTCellTherapy in #SolidTumors by modifying #TCells to make them resistant to local inhibition within the #TumorMicroenvironment. #CancerTreatment

Two #GutBacteria working together contribute to #ChronicConstipation by destroying the #IntestinalMucus that is essential for keeping the #colon lubricated and the feces hydrated.  #GutHealth #GutMicrobiome #Constipation

Study finds that an #exercise-induced #liver protein strengthens the #BloodBrainBarrier, improving #memory and slowing #AgeRelatedDecline. #Aging #Exercise #PhysicalActivity #Exerkine #BrainHealth

#IntermittentFasting is unlikely to lead to greater #WeightLoss in #overweight or #obese adults than traditional #DietaryAdvice or doing nothing at all, according to a new #CochraneReview.

A #SystematicReview and #MetaAnalysis of available evidence finds that #AerobicExercises, such as running, swimming, and dancing, may be the most effective for relieving symptoms of #depression and #anxiety. #MentalHealth #PhysicalActivity #Exercise

A study tracking the web activity of more than 1,000 U.S. adults found that low-credibility #HealthInformation #websites are relatively rare and receive little overall traffic, but these sites are visited disproportionately by #OlderAdults. #MedicalMisinformation #HealthMisinformation

Increasing #OvernightFasting by three hours to align with #sleep patterns improved #CardiometabolicHealth in #MiddleAged and #OlderAdults at higher risk of #CardiometabolicDisease. #Fasting

Scientists have discovered a surprising new way the body can fight #InsulinResistance and #diabetes – by boosting a special type of “good” #ImmuneCell in #FatTissue. #Macrophages #Type2Diabetes

A large global study identified a group of #GutBacteria consistently abundant in healthy #GutMicrobiomes, highlighting their potential for #therapeutic use.  #HumanHealth #Probiotics

A new randomized controlled study found that #TimeRestrictedFeeding — a form of #IntermittentFasting—significantly reduced symptomatic disease activity and systemic #inflammation in #overweight or #obese adults with #CrohnsDisease #InflammatoryBowelDisease

A new study in mice hints at the potential to use tiny #RNANanoparticles to deliver #ChemotherapyDrugs and other therapies directly to #tumors, killing #CancerCells without generating an immune response or toxicity-related #SideEffects.  #RNATherapeutics #CancerTherapy

#GutBacteria influence whether the #AminoAcid #asparagine from the #diet promotes #TumorGrowth or activates #ImmuneCells against #cancer, highlighting the #GutMicrobiome 's key role in the body's response to cancer and #immunotherapies. #AnticancerImmunity

Researchers have deciphered the #MolecularSignature of so-called #SleepingNociceptors —a type of #PainSensing #neurons that normally remains quiet and does not respond to touch or pressure, but can become overactive and drive #ChronicPain.

International study redefines the #NeurologicalBasis of #ParkinsonsDisease and lays the groundwork for more effective, #PrecisionTreatments. #ParkinsonsTreatment

#Brain #estrogen levels, along with differences in #EstrogenReceptors between men and women, help explain why women are more likely to develop #PostTraumaticStressDisorder and face a higher risk of #Dementia later in life. #MemoryProblems #SexDifferences #BrainHealth

A novel #LiquidBiopsy method using a new metric, the #EpigeneticInstability Index, accurately distinguishes patients with early-stage lung and #BreastCancers from healthy individuals. #EarlyDetection #LungCancer

Researchers have identified #BloodBiomarkers for #ParkinsonsDisease in its earliest stages, before extensive #BrainDamage occurs.  #EarlyDetection

New research reveals why some #brain #neurons resist the toxic buildup of #TauProtein—a hallmark of #Alzheimers and related #dementias—potentially aiding the development of #NewTherapies.

Two Canadian #ClinicalTrials show that #FecalMicrobiotaTransplants can help patients respond better to #immunotherapy while also reducing the toxic #SideEffects of #CancerDrugs. 

#FecalMicrobiotaTransplantation can enhance the effectiveness of #immunotherapy in patients with advanced #metastatic #RenalCellCarcinoma. #KidneyCancer #ImmunotherapyResponse

A new study found that adults who stay up late and are active at #night are more likely to have poor #CardiovascularHealth scores than those with more typical #sleep -wake schedules. #Chronotype #SleepWakeCycle #CardiovascularDisease #CardiovascularRisk

Researchers have created a topical #CRISPR -based #GeneTherapy that could offer a lasting cure for a range of #SkinDisorders.  #CongenitalIchthyosis #Ichthyosis #GeneEditing

A two-day #CalorieReduced #OatBasedDiet significantly lowers serum #cholesterol levels in #MetabolicSyndrome patients, with effects lasting six weeks and linked to changes in #GutMicrobiome composition. #MicrobialMetabolites #LDLCholesterol

Severe #vitaminDdeficiency is associated with a higher rate of #hospitalization for #RespiratoryTractInfections such as #bronchitis and #pneumonia. #VitaminD #VitaminDSupplementation

#Chemotherapy alters #GutBacteria, increasing the #MicrobialMetabolite indole-3-propionic acid, which travels to the #BoneMarrow to reduce #immunosuppressive cells and limit #CancerMetastasis.

Prolonged exposure to #AirPollution may increase the risk of serious #NeurodegenerativeDiseases such as #ALS and appears to accelerate their pathological progression. #AmyotrophicLateralSclerosis #MotorNeuronDisease

#ShinglesVaccination not only protects against the painful illness but is also associated with reduced #inflammation, slower #EpigeneticAging, and slower overall #BiologicalAging in Americans aged 70 and older. #Aging #Shingles #ShinglesVaccine

Subtle variations in #KidneyFunction—even within the normal range—may help identify people at risk of developing #ChronicKidneyDisease. #EarlyDetection #KidneyDisease #KidneyDamage #KidneyDiseasePrevention

Symptoms of #depression are common among people with #asthma, but growing evidence suggests they may arise from #BiologicalMechanisms different from those underlying #MajorDepressiveDisorder. 

A #MicrobialMetabolite produced by #GutBacteria of the #Bifidobacteria type reduces the risk of #allergies and #asthma in #infants.

A #SystematicReview and #MetaAnalysis of 43 existing studies indicate that taking #paracetamol (#acetaminophen) during #pregnancy does not increase the risk of #autism, #AttentionDeficitHyperactivityDisorder (#ADHD), or #IntellectualDisability in #children. #DrugSafety #PrenatalExposure

An oral #compound was developed to lower #BloodTriglycerides by selectively inhibiting #LiverXReceptor in the #liver and #gut, offering a potential treatment for high triglyceride-related diseases. #Triglycerides #Hypertriglyceridemia #Dyslipidemia

#BeigeFat suppresses an enzyme that contributes to #HighBloodPressure, uncovering a new #MolecularPathway and identifying a potential target for future #PrecisionTherapies. #Hypertension #BloodPressureRegulation 

Researchers have discovered a #SmallMolecule produced naturally by #GutBacteria that doubled the response to #LungCancer #immunotherapy in mice and can now be made into a #drug for testing in humans. #LungCancerTreatment #CombinationTherapy #MicrobialMetabolite

Study finds that the mechanisms young mice use to fight #infection and the resulting #sepsis become disadvantageous in #OlderAge, suggesting that #AgeSpecificTreatments may be necessary in the ongoing #AntibioticResistance crisis. #Aging #ImmuneResponse  

Study finds enduring benefits of #VagusNerveStimulation for patients with #TreatmentResistantDepression. #Depression #MajorDepressiveDisorder #DepressionTreatment #MentalHealth

A recent study reports that a new #immunotherapy using autologous #TCellTherapy targeting multiple #TumorAntigens has shown promising safety and clinical effects in a first-in-human phase 1/2 #ClinicalTrial for #PancreaticCancer. #PancreaticCancerTreatment

A #simulation of an individual patient's #BrainCancer, kept up to date with readily available data, can identify whether #DietaryTreatments and #drugs are likely to work.  #BrainCancerTreatment #DigitalTwin #PredictiveModels #TreatmentOutcomes

A national, #RandomizedControlledTrial found that a short-term, #CalorieRestrictiveDiet significantly improved both physical symptoms and biological indicators of mild-to-moderate #CrohnsDisease. #InflammatoryBowelDisease #Fasting #FastingMimickingDiet

New research found that more than 90 percent of #AlzheimersDisease cases and nearly half of all #dementia cases are likely influenced by the #APOEgene.

A class of ultrasmall #SilicaNanoparticles stimulates the #ImmuneSystem against #melanoma, significantly enhancing the effectiveness of #CancerImmunotherapy. #MelanomaImmunotherapy

Stopping #GLP1 #WeightLossDrugs is followed by #WeightRegain and a reversal of the beneficial effects on #heart and #MetabolicHealth markers. #GLP1Drugs #HeartHealth