A new study suggests an intestinal disorder causing #malnutrition and stunted growth is passed between generations via #GutBacteria that trigger #inflammation and damage #NutrientAbsorption.  #GutHealth

A targeted approach to treating #InflammatoryBowelDisease (#IBD) uses #bacteriophages — #viruses that infect specific #bacteria—to disarm harmful microbes without disrupting the broader gut ecosystem. #GutHealth #CrohnsDisease #PhageTherapy

Researchers have found that adding the #ThyroidHormone to standard #chemotherapy may significantly improve treatment outcomes and prevent #TumorRecurrence in #medulloblastoma, a common malignant #BrainTumor in #children.

Changes in the #GutMicrobiome and #metabolism can predict #Type2DiabetesRisk years before its onset, enabling #EarlyDetection. #Type2Diabetes

Greater adherence to a #MediterraneanDiet was positively associated with #PsychologicalWellBeing among #OlderAdults and appeared to act as a protective factor against the emotional impact of the #COVID19Pandemic. #HealthyEating #MentalHealth

A new #PeptideVaccine targeting a common #GeneticMutation in high-grade #astrocytomas, a malignant #BrainTumor, has shown promising long-term safety and effectiveness in a clinical trial when combined with standard treatments.  #BrainCancer #CancerVaccine #Immunotherapy

A new #AI model called COMPASS uses #tumor #GeneExpression data to predict which patients will respond to #CancerImmunotherapy with #ImmuneCheckpointInhibitors. #ArtificialIntelligence

#PsychologicalStress accelerates #aging -like changes in blood-forming #StemCells by altering the #GutMicrobiota, linking it to increased risk of #CardiovascularDisease and #diabetes, especially with weakened #ImmuneResponse.

#Prenatal high #fructose exposure impairs #learning and #memory in adult rats by reducing #neurogenesis through lasting #EpigeneticChanges in #NeuralStemCells. #Pregnancy #MaternalNutrition #BrainHealth

Data from more than 91,000 participants in the UK Biobank who wore activity monitors for seven days revealed an association between prolonged #SedentaryBehavior and the risk of #CancerDeath. #CancerMortallity #CancerRisk

#StemTCells, a small subset of #TCells that express the protein LEF1, continuously generate new T cells to maintain #ImmuneResponses in #ChronicDiseases.

#EndothelialCells, derived from #StemCells and lining retinal #BloodVessels, restore retinal function in mouse models and form retinal tissue in vitro for future disease studies. #Retina #CellTherapy

Genetically engineered #TCells, delivered directly via catheter, have been shown to specifically target and control #bladder #tumors in mice, suggesting the potential of #CARTCellTherapy for treating #BladderCancer in humans. #BladderCancerTreatment #Immunotherapy

New research has shown that a #GenomeEditing technique can be used to alter a single gene in #human #EmbryonicCells, enabling the study of very early #HumanDevelopment in unparalleled detail. #HumanEmbryonicDevelopment

Researchers discovered that supplementing a specific #GutBacterium, which is depleted in #lupus patients, significantly reduced disease markers in animal models. #SystemicLupusErythematosus #AutoimmuneDisease #GutMicrobiome #Probiotics #ProbioticTreatment

A #MicrobialMetabolite produced in the #gut from compounds in #pomegranates, #walnuts, and #berries supports #GutHealth by protecting the #GutBarrier and could lead to new treatments for #InflammatoryBowelDisease (#IBD). #GutBacteria #GutMicrobiome

Animals fed a #LowProteinDiet based on #plants and #fish, supplemented with #methionine, showed improved #cardiometabolic markers; human data suggest similar benefits from reducing #AnimalProtein intake combined with #EssentialAminoAcid supplementation. #MetabolicHealth #Healthspan #LongevityDiet

Tiny #algae -based #MicroRobots guided by magnets could improve #BladderCancerTreatment by boosting delivery of #ChemotherapyDrugs into #tumors. #BladderCancer #Chemotherapy #DrugDelivery

New primate study reveals that #EarlyLife #adversity causes lasting, widespread changes in the #epigenome across multiple tissues in #adulthood.  #Aging #Epigenetics

A study conducted in mice showed that a common type of #microplastic may worsen #FattyLiverDisease and cause additional #LiverDamage under #HighFat dietary conditions. #HighFatDiet #LiverHealth

An experimental molecule, N-oleoyl-Leucine (OLE), reprograms #brain #ImmuneCells to reduce #BetaAmyloidPlaques and improve #CognitivePerformance in #Alzheimers animal models. #AlzheimersDisease #Microglia

#Prebiotic #XyloOligosaccharides (XOS) may improve #FattyLiverDisease by reducing harmful metabolic byproducts in the #gut, with the initial #GutMicrobiome composition influencing the benefits. #FattyLiver #MASLD #DietaryFiber

A new study demonstrates that a person with severe #paralysis caused by #AmyotrophicLateralSclerosis (ALS) can use a #BrainComputerInterface at home to communicate, work, and interact with the digital world. #ALS #AssistiveTechnology

Preclinical study shows that #prostate -targeted engineered amorphous #SilicaNanoparticles effectively kill aggressive #ProstateCancer cells and enhance #AntitumorImmunity, supporting further clinical investigation.

Research using #MiniBrains shows that #VitaminB3 may slow the progression of a rare #childhood #NeurodegenerativeDisease caused by mutations in the #DHDDS gene.

#BrainMRI shows lower plasma #VitaminC levels in #OlderAdults are linked to reduced #brain #GrayMatter and connectivity, suggesting vitamin C may support #BrainHealth.  #BrainVolume #BrainConnectivity

A #Phase3Trial showed that in vivo #CRISPR #GeneTherapy is effective and safe for #HereditaryAngioedema, marking a crucial step toward regulatory approval for this #GeneEditing treatment. #CRISPRTherapy

Study identifies the #Parkinsons #drug #pramipexole as a potential new therapy for #depression with marked #anhedonia, a condition characterized by reduced ability to feel joy, pleasure, or motivation. #MentalHealth #AnhedoniaTreatment #DepressionTreatment

A short-term #FastingMimickingDiet may reduce #inflammation markers linked to #GumDisease, highlighting the importance of #LifestyleChanges alongside plaque control in managing #OralHealth. #Periodontitis #CalorieRestriction #LowCalorieDiet

Limiting the #AminoAcid #methionine in the #diet was found to destabilize DNA, cause cancer cell death, and improve survival in animal models of #glioma, suggesting new treatment approaches for this deadly #BrainCancer. #MethionineRestrictedDiet #BrainCancerTherapy

#Fathers #health before #conception may leave a biological imprint on future #children through paternal #EpigeneticInheritance. #PaternalHealth #MensHealth

New report highlights potential reproductive benefits alongside #WeightLoss in #women with #PolyendocrineMetabolicOvarianSyndrome ( #PMOS ) treated with #semaglutide.  #WomensHealth #EndocrineDisorder #PMOSTreatment #PCOS

New research analyzing #BrainScans from over 900 people reveals subtle but widespread differences in #emotion, #reward, and #CognitiveControl #BrainNetworks in #BipolarDisorder, offering insights into illness severity and treatment.

New study reveals that people with #CeliacDisease have subtle but consistent differences in #ImmuneCellFunction, particularly in CD4 #HelperTCells, suggesting that #AutoimmuneRisk involves altered #ImmuneCell behavior. #AutoimmuneDisease

A newly developed compound slows #Alzheimers progression, protects nerve cells, and shows potential #AntiAging effects in mice. #AlzheimersDiseaseDrug #AlzheimersTreatment #PreclinicalStudy

Early-stage (phase 1/2) #ClinicalTrial shows that an #OralDrug combination for older #AcuteMyeloidLeukemia patients is an effective alternative to the standard intravenous treatment requiring frequent hospital visits. #OlderAdults #AMLTreatment #CombinationTherapy

Researchers used #CARTCellTherapy to lower harmful #antibodies in two highly sensitized patients, enabling #KidneyTransplants after years of waiting.

Combining #vaccination with #phage steering represents a promising approach for further exploration in eliminating #infectious reservoirs, particularly in #newborn #meningitis. #BacterialMeningitis #CombinationTherapy

Researchers unveil a #smartwatch prototype that uses the electrical properties of #BloodFlow to provide accurate #BloodPressure readings. #WearableDevice #BloodPressureMonitoring #CardiovascularHealth

Simultaneous administration of five #therapeutic #mRNAs effectively promoted #CardiacRepair and extended survival in mice with #HeartFailure. #RNATherapy #HeartFailureTreatment

A new type of #CancerImmunotherapy links #ImmuneCells to #tumor cells by targeting a tumor protein and an immune cell marker, activating the #ImmuneSystem to destroy advanced #SolidTumors. #Immunotherapy #CancerTreatment

In a #Phase3Trial for #metastatic #PancreaticCancer, the #RASInhibitor #daraxonrasib significantly improved overall and progression-free survival compared to #chemotherapy, with a manageable safety profile and no unexpected findings. #PancreaticCancerTreatment

#PhyticAcid, a #NaturalCompound present in whole grains, beans, lentils, nuts, and seeds, plays an important role in maintaining the integrity of the #IntestinalBarrier and preventing #LeakyGut. #GutHealth

More than ten years after #ColorectalAdenoma removal, the #GutMicrobiome partially resembles that of #ColorectalCancer patients and shows a stronger association with #diet and #lifestyle compared to individuals without #adenomas.

A small trial found that adding #paricalcitol, a #vitaminD analog, to #chemotherapy is safe, reduces #tumor #fibroblast activation, and improves both treatment response as well as survival in #metastatic #PancreaticCancer.

A new study suggests that a #SmallMolecule may play a significant role in the development of #NeurologicalDisorders that affect many patients after a #HeartAttack. #BraiInflammation #BrainHealth

Clinical trial results show that the new #CellTherapy significantly reduces the risk of death or #LiverTransplant in patients with advanced #LiverDisease compared to standard care. #LiverCirrhosis #MacrophageTherapy

Researchers discovered a #mitochondrial #checkpoint that functions as a #MetabolicSwitch, enabling #DendriticCells to effectively activate #TCells to fight #viruses and #tumors. #TCellActivation #TCellResponse #ImmuneResponse #Immunotherapy

Overproduction of the #DNARepair protein #exonuclease1 (#EXO1) in certain #cancers causes #DNADamage that mimics #BRCAmutations, potentially making these cancers responsive to the same #TargetedTreatments.

Nearly 1.2 billion people #worldwide now live with #MentalDisorders, nearly double since 1990, making these disorders the leading cause of global #disability, ahead of cardiovascular disease, cancer, and musculoskeletal conditions. #MentalHealth #GlobalPrevalence #GlobalBurden