Some fiery prefrontal cortical neurons projecting to the locus coeruleus that are labeled in the mouse brain #FluorescenceFriday 🧠🔬🔥 Image credit to @rehg-j.bsky.social and the @lieberinstitute.bsky.social Circuits Team

I'd like to thank 🙏🏽 @cynthiasc.bsky.social for her 3 years at @lieberinstitute.bsky.social working in my team analyzing data generated by @kr-maynard.bsky.social et al. Cynthia led our first foray into the world of multi-omics data (snRNA-seq + snATAC-seq) #multiome #snRNAseq #scATACseq

Huge congratulations and kudos to RA @rehg-j.bsky.social @jorge-miranda.bsky.social who led this study that is a continuation of ongoing collaboration between the Circuits group in our division with the @lieberinstitute.bsky.social Behavioral Pharmacology group led by Greg Carr! 🧠🧪

Really excited to share this new study - collaboration across several teams in our division @lieberinstitute.bsky.social, led by @lahuuki.bsky.social @kr-maynard.bsky.social @lcolladotor.bsky.social - congratulations to everyone! 🧠🔬👩‍🔬

Thank you to all of our collaborators at the @lieberinstitute.bsky.social for their excellent work on this project! 🧑‍🔬 @heenadivecha.bsky.social @svitlanabach.bsky.social @madelinevalentine.bsky.social @nick-eagles.bsky.social @berniejmulvey.bsky.social and UK collaborators @jamesrevans.bsky.social

Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025... Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”

For more #RStats videos from my @lieberinstitute.bsky.social team, subscribe to www.youtube.com/@lcolladotor. #DataViz

For #FluorescenceFriday - RNAscope marking subfields of the hippocampus in a section of postmortem human 🧠 tissue. Image credit to the Imaging Development team @lieberinstitute.bsky.social 🔬🧪👩‍🔬

Thanks so much - that means a lot to hear! I have a huge amount of gratitude for the amazing teams we have built here @lieberinstitute.bsky.social and the network of collaborators with such huge range of diverse expertise!

Pretty neat to see our paper - led by @kr-maynard.bsky.social @lcolladotor.bsky.social on the 2021 list of most cited neuroscience papers 🧠🔬🧪 www.thetransmitter.org/publishing/w...

This effort started back in the early Visium days with our colleagues at the @lieberinstitute.bsky.social including @martinowk.bsky.social @kr-maynard.bsky.social @lcolladotor.bsky.social and others. Wonderful to have a complete release version out now. Thanks to everyone who contributed! 🧬🧠🎉

For #FluorescenceFriday - one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪

Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠 I'm there too - get in touch!

Me lurking in people's folders on the server for #FluorescenceFriday. Image is so fresh off the scope that I don't even know what it is so I can't even tell you what the channels are - but, somebody (RA Jason Rehg) is doing something in the VTA and whatever it is, it looks super cool 🤩🧠🔬🧪

Hot take: ggplot2 is better than any plotting option available in Python-- but I discuss a couple options in Python at an R Stats Club session @libdrstats.bsky.social linked below. I personally use plotnine, since it's essentially a port of ggplot2 for Python. youtu.be/xK9UNcOfjnI

I just completed my first radio 📻 interview ^_^ You'll be able to listen to it next Friday or so at www.iheart.com/podcast/269-.... Thanks Clau from iHeartRadio Miami's "Estamos Contigo" podcast for reaching out! I'll be talking in Spanish about our recent #HabenulaLIBD 📜 bsky.app/profile/lcol...

Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41... #Calicumimaging #miniscopes #rCPT #PrL

Had the most rewarding time at the HTNA #cshlcourses It was fun science-ing all day/night for 2wks to learn modern viral, whole 🧠 imaging & barcode-based seq approaches to understand neuroanatomy/function. Inspired & energized as I think of all the ways these tools can be applied in my own work!🧪 1/

This study is part of an ongoing collaboration between mine and Greg Carr's group @lieberinstitute.bsky.social to develop translational screening platforms for identifying and validating interventions for deficits in sustained attention, a process disrupted across many neuropsychiatric disorders.

Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online www.nature.com/articles/s41...

Para más, checa los anuncios de @lieberinstitute.bsky.social 🔗 www.libd.org/tiny-brain-r... 🔗 www.libd.org/inside-the-h... además del comunicado de prensa de la Asociación Americana de Psiquiatría 🔗 www.psychiatry.org/News-room/Ne... ¡Y gracias a @lahuuki.bsky.social por el hilo 🧵 original!

Estos datos servirán para trabajo futuro sobre cambios moleculares que ocurren en #Habénula en enfermedades 🧠🧬 Mantén un 👀 abierto en @lieberinstitute.bsky.social para nuevos resultados de Hb de datos transcriptómicos con resolución espacial @10xgenomics.bsky.social speakerdeck.com/lahuuki/2025...

Acá va en español 🇲🇽 --- o --- "¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...

Biostats professor @lcolladotor.bsky.social, along with his colleagues from @lieberinstitute.bsky.social, have created the first detailed molecular map of the human habenula, and with it gained new insights into its role in schizophrenia. Read the original study: psychiatryonline.org/doi/10.1176/...

Excited to share that the second project from my time at @lieberinstitute.bsky.social with @lcolladotor.bsky.social is now published! This was such a rewarding collaboration to be part of. 💡🧠 Huge congrats to @lahuuki.bsky.social and all co-authors!

For more, check the @lieberinstitute.bsky.social announcements at 🔗 www.libd.org/tiny-brain-r... 🔗 www.libd.org/inside-the-h... As well as the American Psychiatry Association press release 🔗 www.psychiatry.org/News-room/Ne...

Thanks to @nataliematosin.bsky.social and Sophie Debs for highlighting our work in their editorial “Unlocking the Molecular Secrets of the Human Habenula” 🔗 doi.org/10.1176/appi...

This data provides a foundation for future work into molecular changes that occur in the #Habenula in disease 🧠🧬 Keep an eye on @lieberinstitute.bsky.social for future work on the Hb spatially resolved transcriptomics with @10xgenomics.bsky.social tech #Visium and #Xenium 👀 #HabenulaLIBD

Thank you to all of our collaborators at the @lieberinstitute.bsky.social for their dedication and hard work on this project! 🧑‍🔬 #HabenulaLIBD @freneegf.bsky.social @nick-eagles.bsky.social @lcolladotor.bsky.social @kr-maynard.bsky.social @martinowk.bsky.social

#OpenData and #OpenCode from our latest @lieberinstitute.bsky.social project Lots of #RStats and @bioconductor.bsky.social code inside of that repository! #OpenScience

Congrats to @lahuuki.bsky.social and many members of @kr-maynard.bsky.social and @lcolladotor.bsky.social teams in our division who contributed to this study! Really excited to see this paper now published with contribution of data resources for molecular profiles of human habenula cell types 🧠🔬🧪

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

We recently checked out tidySingleCellExperiment at the R Stats Club @libdrstats.bsky.social, an R package part of a broader effort to bring tidy coding to genomics. Pretty useful! youtu.be/ob_SQY4-YjQ?... #RStats

Huge effort across many teams at @lieberinstitute.bsky.social. Shout out to @kr-maynard.bsky.social and Stephanie Page for major contributions to supervision and project management and computational collaboration with @stephaniehicks.bsky.social at @jhubiostat.bsky.social

Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...

Hippocampus masquerading as a 🦇 for Halloween 🎃 #FluorescenceFriday Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪

For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪

"What Makes a Good Data Visualization?" 🤔 Check @christinezhang.bsky.social's 🤩 excellent 💯 guest lecture for 140.776 Statistical Computing at @johnshopkinssph.bsky.social 📽️: youtu.be/SeLucCb05Dk Slides: speakerdeck.com/lcolladotor/... #RStats @jhubiostat.bsky.social @lieberinstitute.bsky.social

We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience recruiting.paylocity.com/recruiting/j...

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social www.libd.org/careers/ Links to individual positions in the thread below.

Really proud of huge collaborative efforts from several teams in Translational Neuroscience Division @lieberinstitute.bsky.social w/ labs of @stephaniehicks.bsky.social and @alexisbattle.bsky.social to provide this resource on cell types and spatial organization in nucleus accumbens of human 🧠

so excited to share that our preprint characterizing the dorsal anterior cingulate cortex in post-mortem human brain from @lieberinstitute.bsky.social is out! we integrated matched SRT and snRNA-seq data to investigate agranularity and von Economo neurons

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠 www.nature.com/articles/s41...

Grateful to have started my dream postdoc with @kr-maynard.bsky.social this week 🤩 Thanks to @martinowk.bsky.social @lieberinstitute.bsky.social and everyone for such a warm welcome, and so happy to be part of the team! Excited for all the great science and memories to come in this next chapter 🧠🎉

Thanks to Heather Thomas and everyone on the @oneneurojhu.org team for coming over to @lieberinstitute.bsky.social to interview us and hear about research being conducted by our teams! 👩‍🔬🔬🧠🔵

OneNeuro's August #FotoFriday #FluorescenceFriday contest winner is "Cellular Subtype Composition of an Amphetamine-activated Ensemble in mPFC," by Suhaas Adiraju from @martinowk.bsky.social at the @lieberinstitute.bsky.social View the complete gallery here: www.oneneurojhu.org/art/

(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium

Hi everyone! Check my journal club talk on the latest review paper: Cell-type deconvolution methods for spatial transcriptomics 🧬 🎥 www.youtube.com/watch?v=xDjF... 🛝 speakerdeck.com/manishabarse @lieberinstitute.bsky.social #Bioinformatics #SpatialTranscriptomics #Cell-TypeDeconvolution

Welcome @heenadivecha.bsky.social to Bsky! ^_^ Heena is a great scientist who worked at @lieberinstitute.bsky.social before joining @jhu.edu as a PhD student, and who is now back doing her PhD with @kr-maynard.bsky.social at LIBD 🔁