I just completed my first radio 📻 interview ^_^ You'll be able to listen to it next Friday or so at www.iheart.com/podcast/269-.... Thanks Clau from iHeartRadio Miami's "Estamos Contigo" podcast for reaching out! I'll be talking in Spanish about our recent #HabenulaLIBD 📜 bsky.app/profile/lcol...

Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41... #Calicumimaging #miniscopes #rCPT #PrL

Had the most rewarding time at the HTNA #cshlcourses It was fun science-ing all day/night for 2wks to learn modern viral, whole 🧠 imaging & barcode-based seq approaches to understand neuroanatomy/function. Inspired & energized as I think of all the ways these tools can be applied in my own work!🧪 1/

This study is part of an ongoing collaboration between mine and Greg Carr's group @lieberinstitute.bsky.social to develop translational screening platforms for identifying and validating interventions for deficits in sustained attention, a process disrupted across many neuropsychiatric disorders.

Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online www.nature.com/articles/s41...

Para más, checa los anuncios de @lieberinstitute.bsky.social 🔗 www.libd.org/tiny-brain-r... 🔗 www.libd.org/inside-the-h... además del comunicado de prensa de la Asociación Americana de Psiquiatría 🔗 www.psychiatry.org/News-room/Ne... ¡Y gracias a @lahuuki.bsky.social por el hilo 🧵 original!

Estos datos servirán para trabajo futuro sobre cambios moleculares que ocurren en #Habénula en enfermedades 🧠🧬 Mantén un 👀 abierto en @lieberinstitute.bsky.social para nuevos resultados de Hb de datos transcriptómicos con resolución espacial @10xgenomics.bsky.social speakerdeck.com/lahuuki/2025...

Acá va en español 🇲🇽 --- o --- "¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...

Biostats professor @lcolladotor.bsky.social, along with his colleagues from @lieberinstitute.bsky.social, have created the first detailed molecular map of the human habenula, and with it gained new insights into its role in schizophrenia. Read the original study: psychiatryonline.org/doi/10.1176/...

Excited to share that the second project from my time at @lieberinstitute.bsky.social with @lcolladotor.bsky.social is now published! This was such a rewarding collaboration to be part of. 💡🧠 Huge congrats to @lahuuki.bsky.social and all co-authors!

For more, check the @lieberinstitute.bsky.social announcements at 🔗 www.libd.org/tiny-brain-r... 🔗 www.libd.org/inside-the-h... As well as the American Psychiatry Association press release 🔗 www.psychiatry.org/News-room/Ne...

Thanks to @nataliematosin.bsky.social and Sophie Debs for highlighting our work in their editorial “Unlocking the Molecular Secrets of the Human Habenula” 🔗 doi.org/10.1176/appi...

This data provides a foundation for future work into molecular changes that occur in the #Habenula in disease 🧠🧬 Keep an eye on @lieberinstitute.bsky.social for future work on the Hb spatially resolved transcriptomics with @10xgenomics.bsky.social tech #Visium and #Xenium 👀 #HabenulaLIBD

Thank you to all of our collaborators at the @lieberinstitute.bsky.social for their dedication and hard work on this project! 🧑‍🔬 #HabenulaLIBD @freneegf.bsky.social @nick-eagles.bsky.social @lcolladotor.bsky.social @kr-maynard.bsky.social @martinowk.bsky.social

#OpenData and #OpenCode from our latest @lieberinstitute.bsky.social project Lots of #RStats and @bioconductor.bsky.social code inside of that repository! #OpenScience

Congrats to @lahuuki.bsky.social and many members of @kr-maynard.bsky.social and @lcolladotor.bsky.social teams in our division who contributed to this study! Really excited to see this paper now published with contribution of data resources for molecular profiles of human habenula cell types 🧠🔬🧪

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

We recently checked out tidySingleCellExperiment at the R Stats Club @libdrstats.bsky.social, an R package part of a broader effort to bring tidy coding to genomics. Pretty useful! youtu.be/ob_SQY4-YjQ?... #RStats

Huge effort across many teams at @lieberinstitute.bsky.social. Shout out to @kr-maynard.bsky.social and Stephanie Page for major contributions to supervision and project management and computational collaboration with @stephaniehicks.bsky.social at @jhubiostat.bsky.social

Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...

Hippocampus masquerading as a 🦇 for Halloween 🎃 #FluorescenceFriday Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪

For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪

"What Makes a Good Data Visualization?" 🤔 Check @christinezhang.bsky.social's 🤩 excellent 💯 guest lecture for 140.776 Statistical Computing at @johnshopkinssph.bsky.social 📽️: youtu.be/SeLucCb05Dk Slides: speakerdeck.com/lcolladotor/... #RStats @jhubiostat.bsky.social @lieberinstitute.bsky.social

We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience recruiting.paylocity.com/recruiting/j...

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social www.libd.org/careers/ Links to individual positions in the thread below.

Really proud of huge collaborative efforts from several teams in Translational Neuroscience Division @lieberinstitute.bsky.social w/ labs of @stephaniehicks.bsky.social and @alexisbattle.bsky.social to provide this resource on cell types and spatial organization in nucleus accumbens of human 🧠

so excited to share that our preprint characterizing the dorsal anterior cingulate cortex in post-mortem human brain from @lieberinstitute.bsky.social is out! we integrated matched SRT and snRNA-seq data to investigate agranularity and von Economo neurons

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠 www.nature.com/articles/s41...

Grateful to have started my dream postdoc with @kr-maynard.bsky.social this week 🤩 Thanks to @martinowk.bsky.social @lieberinstitute.bsky.social and everyone for such a warm welcome, and so happy to be part of the team! Excited for all the great science and memories to come in this next chapter 🧠🎉

Thanks to Heather Thomas and everyone on the @oneneurojhu.org team for coming over to @lieberinstitute.bsky.social to interview us and hear about research being conducted by our teams! 👩‍🔬🔬🧠🔵

OneNeuro's August #FotoFriday #FluorescenceFriday contest winner is "Cellular Subtype Composition of an Amphetamine-activated Ensemble in mPFC," by Suhaas Adiraju from @martinowk.bsky.social at the @lieberinstitute.bsky.social View the complete gallery here: www.oneneurojhu.org/art/

(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium

Hi everyone! Check my journal club talk on the latest review paper: Cell-type deconvolution methods for spatial transcriptomics 🧬 🎥 www.youtube.com/watch?v=xDjF... 🛝 speakerdeck.com/manishabarse @lieberinstitute.bsky.social #Bioinformatics #SpatialTranscriptomics #Cell-TypeDeconvolution

Welcome @heenadivecha.bsky.social to Bsky! ^_^ Heena is a great scientist who worked at @lieberinstitute.bsky.social before joining @jhu.edu as a PhD student, and who is now back doing her PhD with @kr-maynard.bsky.social at LIBD 🔁

Biostats assistant professor @lcolladotor.bsky.social is also an investigator @lieberinstitute.bsky.social where he leads the R/Bioconductor-powered Team Data Science group. Learn more about his work in the video below: www.youtube.com/watch?v=Rz4L...

Phenomenal talk from @hyejungwon.bsky.social who is visiting us @lieberinstitute.bsky.social for the day. Groundbreaking work w/ important implications and roadmap for using rapidly emerging information on psychiatric genetics to prioritize variants and understand their impact on 🧠 function

Just covered the data.table and dtplyr packages at LIBD R Stats Club @libdrstats.bsky.social. Really useful to be able to write dplyr code and get data.table performance! #rstats youtu.be/D3u64PMlJSI

Great collaboration motivates methodological and biological innovation! Grateful for the opportunity to work together with @martinowk.bsky.social and @lieberinstitute.bsky.social, investigating the molecular pathology of neuropsychiatric disorder, coming soon! 😉

App: r-graph-gallery.com/color-palett... Special thanks to @emilhvitfeldt.bsky.social for the {paletteer} package and to the @libdrstats.bsky.social club for fostering these practical #bioinformatics tips!

🎨 Struggling to pick the perfect color palette for data visualizations? Check out walkthrough of interactive tools and the awesome {paletteer} package by @emilhvitfeldt.bsky.social ! 🔗 youtu.be/9tAeTjVD7ns Let’s make our plots both beautiful and accessible! #RStats @libdrstats.bsky.social

Hi everyone! Check my beginner-friendly #RStats talk at @lieberinstitute.bsky.social on reshaping, joining, binding, & set ops- all #tidyverse way! Shared simple demo to handle data better! 🎥 youtu.be/5L133h_1SNo 🛝 speakerdeck.com/manishabarse... @libdrstats.bsky.social #DataWrangling #DataScience

And response to the Matters Arising from the authors of the original paper here: www.nature.com/articles/s41...

Important 'Matters Arising' from @neurome.bsky.social and Zhaoxia Yu discussing false positives due to multiple comparisons in large-scale gene expression data. I applaud Eran and others who consistently raise these issues for discussion in the community. www.nature.com/articles/s41...

🚨 New paper published in @natmethods.nature.com! We introduce SpotSweeper, the first spatially-aware QC methods for spatial transcriptomics. 📰 Paper : nature.com/articles/s41... 💻 Code: github.com/MicTott/Spot... 📈 Website: mictott.github.io/SpotSweeper/ 🧵👇

Important methods development for spatial transcriptomics (ST) data from @mictott.bsky.social @boyiguo.bsky.social @stephaniehicks.bsky.social - congrats! Applying this method to our QC workflow has substantially improved many new ST datasets generated across diverse regions/tissues in the human 🧠

New career milestone: served on a @jhu.edu PhD thesis committee meeting for the first time 🙌🏽 Thanks @jef.works for inviting me! And thanks @mikeschatz.bsky.social @jihk.bsky.social for your guidance! Great to share this experience with Fred Tan as well ^_^ It’s exciting to talk about […]

Do a lot of PCA? Interested in streamlining data wrangling? In a couple recent LIBD R Stats Club @libdrstats.bsky.social sessions I talk about PCAtools, and dplyr for beginners. youtu.be/rClA0Ms-oOw youtu.be/XIbraIgPt0M #RStats

🔬 Diving into ATAC-seq workflows? You've likely heard about Seurat, Signac, MACS2, Cicero, and chromVAR—core components in many workflows. Here’s a quick overview I put together that showcases different approaches used across recent studies. youtu.be/R5P8mGMXuIg?... #SingleCell #Epigenomics #LIBD

Learning more about APOE differences in the cell types of the brain 🧠 I presented "APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease" from @zhaonaa.bsky.social at our team journal club, check it out! doi.org/10.1016/j.ne... ▶️ youtu.be/L4J9jFS-Pic