Sit back, relax, sip on a beverage of your choice, and listen to 45min of Nat Mat explaining what stress does to your brain, and why you need to stress less Raising the Bar - What stress does to the brain Thursday 7 May, 8:00PM Mountain Culture Beer Co, 158 Regent St, Redfern lnkd.in/gQVM9GyC

🧵 When I started working on #FKBP5 as a postdoc in Elisabeth's lab, I was surprised that there are actually four splice variants of the gene that produce two different #FKBP51 proteins with different functions - yet we know very little about them!

I am very excited to share this book! It has been so much to collaborate on the project. We hope you find it useful!

In an AJP editorial, @sophiedebs.bsky.social and @nataliematosin.bsky.social @sydney.edu.au discuss a study that unlocks the molecular secrets of the human habenula. bit.ly/3LyVicX

Fabulous job on this paper, check it out if you haven't yet.

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

New lab paper! @sophiedebs.bsky.social and @nataliematosin.bsky.social discuss a recent study from LIBD investigating the transcriptomic landscape of the human habenula in schizophrenia 🧠 Our editorial: psychiatryonline.org/doi/10.1176/... 📜 The original study: psychiatryonline.org/doi/10.1176/...

Thanks to BPA for receiving the work so well and all the positive feedback. The conference was a huge success, well done to Leigh and Alex and the LOC. Looking forward to the Australasian Neuroscience Alliance meeting in Sydney next year!

~dogfish

Home 💜

Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in: www.biorxiv.org/content/10.1...

Wonderful visits, highlighted the need for face-to-face interactions. Cant wait for all our upcoming collabs 🙌 thanks for carving time out to come see us @drcricru.bsky.social @nikosdaskalakis.bsky.social @rcbagot.bsky.social

Microdosing delight to combat stress; interesting concept, backed by neuroscience. Was a pleasure to comment on the very excellent work of @drrachelbarr.bsky.social ‬on how the experience of delight can tune down our stress response. @brainandmindcentre.bsky.social www.smh.com.au/lifestyle/he...

BIOLOGICAL STRESS

US children's health has worsened from 2007 to 2023 across various indicators, including mortality, chronic conditions, and mental health. ja.ma/4lZnRxG #MedSky #PedSky

This title! “What happens to children’s mental health when we treat their parent’s depression? We have no idea. An empty systematic review.” www.cambridge.org/core/journal...

Reminder that applications are due this week!

Looking for the next member of our team to support our ongoing projects. Check out the PD and if you think you're a fit, please apply!

This is important

A pleasure to spend the last week with @drcricru.bsky.social - to share her fascinating work on brain/placenta with my colleagues at @Sydney_Uni and introduce her to our beautiful city + home. So lucky to have had extended time to bounce ideas and ponder life with this brilliant mind✨

Check out our new paper led by the MINDS Lab original mass spec baddie @katrinazedmond.bsky.social 💃

🚨 NEW PAPER 🚨 Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...

Unbelievable to think about what this is doing at the health level and a focus of the #sydneyhorizonfellows

Thrilled that @rcbagot.bsky.social will be visiting us at The University of Sydney and delivering a Flagship seminar on August 11 on the mechanisms of resilience. Please join by registering here events.humanitix.com/soms-flagshi...

Yes - Biological Psychiatry Australia is now on Bluesky! Please follow us for #biologicalpsychiatry research news Watch this space! 👀

Biological Psychiatry Australia @biolpsychaust.bsky.social have joined Bluesky! If you are a #biologicalpsychiatry #molecularpsychiatry researcher, give them a follow for research and news in this exciting area of research #neuroskyence

I spent all day doing finances which was a bit miserable, so here’s a timeline cleanse 🩵✨

Psychiatric disorders share genetic roots, but the mechanisms are unclear. With exon-level brain data, we linked common & rare variants to 110 core genes in pathways such as cortisol & dopamine cascades, mainly in excitatory neurons, offering new therapeutic targets 🧠✨ www.nature.com/articles/s41...

The thing no one tells you about having small children is that if you try to wake up at an ungodly hour to work, they will just wake up at that time too.

When the conference organizers ask if you can send in your slides a week in advance

Thanks to Biological Psychiatry Australia for recognising our lab @mindslab.bsky.social and all their hard work. Who's coming to #BPA2025?

Sydney skyline 🩵

A little quiet on the interwebs of late; a combination of slowing down in life and speeding up at work. Now that the lab move is complete, it’s all systems go. Excited about what’s brewing in the science cauldron! We have a ton of papers under review right now, so watch this space.

If you’re wondering whether or not new neurons are generated in the adult human brain, this is your lucky day. Here’s my lab’s most recent paper, precisely on this topic. Kudos to PhD student Sophie Simard and to collaborators Corina Nagy and @nataliematosin.bsky.social. www.jpn.ca/content/49/5...

Another wonderful paper, great work Schmidt lab!

If you are in #MolecularPsychiatry research, and interested in accessing existing samples/establishing #collaboration to boost your research, check out the Consortium for Preclinical Psychiatric Research. A great and productive group to be a part of! figshare.com/articles/onl...

Don't miss the first SoMs Neuroscience Theme Meeting for 2025 - Tuesday 18 Feb with two fabulous speakers, Asheeta Prasad , and @nataliematosin.bsky.social ⬇️ @kevinkeay.bsky.social @sydneyuni.bsky.social

Microglial plasticity governed by state-specific enhancer landscapes www.biorxiv.org/content/10.1...

🔔 New preprint 🔔 We show our previously reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by @katrinazedmond.bsky.social and Dominic Kaul with collaborators Elisabeth Binder and @lieberinstitute.bsky.social

An enormous year for our lab moving to USyd and *A LOT* happened. Check out our 2024 wrap-up 💌👇 Happy holidays and Happy New Year. I'm offline for a long summer break, and I'll be back late January 2025. Thanks @mindslab.bsky.social for another year mindslaboratory.wordpress.com/2024/12/29/t...

New paper alert! We previously reported that early-life adversity is associated with an increase in perineuronal nets in human prefrontal cortex. This new study implicates microglia in this phenomenon. Special kudos to Drs Belliveau and Rahimian! www.sciencedirect.com/science/arti...

Best time of the year Hydrangeas on tap 😍💐

And that’s the end of the 2024 conference season. Had a wonderful time at #ACNP2024 presenting, hanging with collaborators, friends, mentors and colleagues new and old. Topped with being promoted to Associate Member of @acnporg.bsky.social. Peace out Arizona 🏜️🌵 and Happy Holidays everyone ✌🏽

Well ACNP is a tough cookie to crack so was very surprised to wake up to this news. I guess you'll all have to learn some more Aussie slang 🤩 Big thanks to the many many people who support and have endorsed our lab's work 🧠✨🔬 🦘 #ACNP2024 @acnporg.bsky.social

In a terrific session at #ACNP2024 @nataliematosin.bsky.social highlight astrocyte responses to #earlylifeadversity. 🧠🧪 #neurobiologyofstress @npp-journal.bsky.social

Lovely to meet Cate and share this incredible work lead by our grad student Dr Dominic Kaul

Really excited to be part of this session on Monday with fabulous collaborators #ACNP2024

Hey #ACNP2024…. I’m coming for you ✌🏽

On my way to #ACNP2024 ! Excited to chair a Monday morning panel on molecular dissection of #stress pathways in psychiatric disorders with esteemed colleagues from @ #globe Joel Kleinman, Corina Nagy @nataliematosin.bsky.social & Cristiana Cruceanu! @acnporg.bsky.social @npp-journal.bsky.social