Grateful for some absolutely spectacular weather ☀️ for our annual cross-research teams spring party!!

New method for identifying the fine transcriptomic types of thousands of neurons recorded in vivo!

New from the lab: BARseq3! Barcodes + high efficiency spatial transcriptomics and translatomics in the same cells, or just a nice spatial transcriptomics assay. All in a modular, expandable system to enable truly multimodal measurements. Check it out: www.biorxiv.org/content/10.6...

Happy to share our new review on Neural Mechanisms of Social Hierarchy across Species. We discussed different routes to achieve high social status across species, from fish to humans, and the neural circuits that support each of those strategies. www.nature.com/articles/s41...

Check out my first @libdrstats.bsky.social presentation on one strategy our team @lcolladotor.bsky.social at @lieberinstitute.bsky.social is taking to deal with doublets during quality control for single nucleus RNA-sequencing data: www.youtube.com/watch?v=SMA-...

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

Great work from Claire, Ravi, and the whole team– the initial lifelong continuous screen of behaving vertebrates provided a wealth of ideas on progression/staging of brain function across lifespan. Behavior is unmatched as a noninvasive quantitative readout of brain function (and, one that matters).

Today I received a note from a grad student who lives in Tehran. Her note gives you firsthand experience of what it’s like to live in a city that is being bombed, and what it’s like to be young and feel despair about your future. rezashadmehr.blogspot.com/2026/03/hope...

Super excited about these #FluorescentFriday images 🔬🧪 as part of project led by @drjennkim.bsky.social in @kr-maynard.bsky.social lab to understand the molecular anatomy of VTA-NAc circuitry in the developing human 🧠

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

#FluorescenceFriday to mark my first foray into human neuroanatomy @lieberinstitute.bsky.social 🧠 RNAscope of marker genes for the ventral tegmental area (VTA) and nucleus accumbens (Ac) in the developing human brain

FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)

Bad Bunny sends a message at the Super Bowl: "God Bless America" "The only thing more powerful than hate is love"

Honored to be appointed Chief Scientific Officer @lieberinstitute.bsky.social. LIBD is a uniquely collaborative place with extraordinary biological resources and a commitment to translation 🧠🔬🧪. Grateful to my colleagues and excited to help guide our next chapter! www.libd.org/keri-martino...

Happy new year from Ollie & Bella 🐾 May your 2026 be as cozy and warm as these two ❤️

“Basic neuroscience hasn’t produced new drugs.” 💊 Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab. I wrote a Perspective on why this matters. @thetransmitter.bsky.social www.thetransmitter.org/drug-develop...

Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention. 1/7 www.biorxiv.org/content/10.6...

Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025... Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”

Excited to share new preprint led by Sergio Salas on “unassigned RNAs” in imaging-based spatial transcriptomics. Across technologies, 30-40% of transcripts fall outside segmentation, & many show structured, biologically meaningful extrasomatic patterns. 📄 www.biorxiv.org/content/10.6...

Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online www.nature.com/articles/s41...

Scientists point to a long list of findings that emerged out of fundamental research, the type of studies the US government is cutting, and went on to change the world. Nature lists a few of their examples. 🧪

Had the most rewarding time at the HTNA #cshlcourses It was fun science-ing all day/night for 2wks to learn modern viral, whole 🧠 imaging & barcode-based seq approaches to understand neuroanatomy/function. Inspired & energized as I think of all the ways these tools can be applied in my own work!🧪 1/

Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus https://www.biorxiv.org/content/10.1101/2025.11.03.686433v1

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site #microscopy #ImageJ #FluorescenceFriday #microscopyMonday imagej.net/plugins/imag...

"What Makes a Good Data Visualization?" 🤔 Check @christinezhang.bsky.social's 🤩 excellent 💯 guest lecture for 140.776 Statistical Computing at @johnshopkinssph.bsky.social 📽️: youtu.be/SeLucCb05Dk Slides: speakerdeck.com/lcolladotor/... #RStats @jhubiostat.bsky.social @lieberinstitute.bsky.social

Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke. www.sciencedirect.com/science/arti...

Effective and empathetic scientific communication is so critical right now. We had an interactive workshop at the #2025ICDB led by @rebeccacalisi.bsky.social and Dr. Kevin Alicea-Torres and facilitated by @spiraldoc.bsky.social and myself- and we practiced this. Please check out our perspective!

All scientists can easily respond to this and you can choose to stay anonymous. I modified my comment from the FASEB response. We all know that international scientists are essential to US science and that these proposed rules are cruel to our colleagues. www.regulations.gov/comment/ICEB...

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social www.libd.org/careers/ Links to individual positions in the thread below.

As I was saying…

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Look at academia giving me a little hope

The Trump Administration has announced measures to gut longstanding pathways based on exceptional ability, national interest, & merit in favor of pay-to-play immigration. @urbanviewradio.bsky.social This sends a signal to the world’s top talent that the U.S. is closing its doors. bit.ly/4nz1XBE

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Yes, I am on the academic job market looking to start my own lab at the intersection of molecular, computational, and systems neuroscience! If you think my work may be interest to your department, please don't hesitate to reach out. Thank you, Keri!

I love how this feature uses graphics to explain the latest thinking on possible Alzheimer's causes and the many treatment targets. @sciam.bsky.social @jenchristiansen.com @estherlandau.bsky.social

Congratulations to @mictott.bsky.social, Rita Cervera Juanes and @svitlanabach.bsky.social and all co-authors! Really fun collaboration w/labs of @vincentcostaphd.bsky.social and @stephaniehicks.bsky.social to better understand cell type and spatial heterogeneity across amygdala in primate 🧠!

Super excited to share this work & accompanying data resources in collab with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social! Congrats to all coauthors and big shout out to @svitlana-bach.bsky.social @prashanthi-ravi.bsky.social for leading this NIDA-funded project.

Grateful to have started my dream postdoc with @kr-maynard.bsky.social this week 🤩 Thanks to @martinowk.bsky.social @lieberinstitute.bsky.social and everyone for such a warm welcome, and so happy to be part of the team! Excited for all the great science and memories to come in this next chapter 🧠🎉

Important 'Matters Arising' from @neurome.bsky.social and Zhaoxia Yu discussing false positives due to multiple comparisons in large-scale gene expression data. I applaud Eran and others who consistently raise these issues for discussion in the community. www.nature.com/articles/s41...

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...

Grateful to work with amazing lead authors Isaac Kauvar, Ethan Richman, & Tony Liu, and brilliant faculty of our HNC program: Carolyn Rodriguez (@crodriguezmdphd.bsky.social‬), Paul Nuyujukian, & Vivek Buch, and many others spanning hospital and laboratory. med.stanford.edu/news/all-new...

Proud of Harvard for pushing back, exercising some creativity, and, maybe, helping folks get some needed education. Harvard is making many of their online government courses FREE. I just signed up for "Citizen Politics in America". They even asked me my Gender. pll.harvard.edu/subject/gove...

Some of the graduating class of UBC Neuroscience PhDs at Grad 2025. Finally got to wear the floofy hat! Forever grateful for my time at UBC 💙💛 @bonniee-leee.bsky.social @dmcbrainhealth.bsky.social

The NIH move to restrict animal research is a bad one and not just about health - it's about national security. More here: medium.com/@eblissmorea...

🚨New paper from the Epp and Sargin Labs!🚨 We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis www.science.org/doi/10.1126/... Simplified highlights below: 🧵/15

Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share docs.google.com/document/d/1...

🧵DISMANTLING DEMOCRACY I've been keeping track of Trump actions - now up to 192. Here, I dig into 69 actions specifically targeted at undermining democracy, rule of law & suppressing dissent. It's been 12 weeks of assaults on democracy. based on christinapagel.substack.com/p/a-republic... 1/18

Long-standing training grants for underrepresented minorities have been canceled under Trump’s NIH. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/funding/excl...