📊YEAR IN CHARTS📉📈 I pulled together 14 charts to summarize the trends that shaped business and the economy in 2025 My 3rd time in a row doing a year in charts for DealBook, this edition is the most robust one yet in both charts & text! www.nytimes.com/2025/12/20/b... 🎁 link nyti.ms/3LdhNo3

Thanks for the mug @jhubiostat.bsky.social! And thanks for the apple 🍎 butter Kelsey from @lieberinstitute.bsky.social End of year gifts 🎁 are well appreciated ^_^ Thank you again!

2025 was an election “off-year”, but there were many consequential races. For those of us working elections it was hardly a year off! Some of the key takeaways, brought to you by Caroline Soler, Alex Lemonides & me. www.nytimes.com/interactive/... and 🎁 a link, for the holidays: nyti.ms/4s5533p

Cynthia @cynthiasc.bsky.social pasó de alumna de un curso de la CDSB a trabajar con uno de nuestros co-fundadores por 3 años en EEUU. Ahora Cynthia está de regreso en México 🇲🇽 y disponible para dar cursos, colaborar, proyectos como consultora, y mucho más lcolladotor.github.io/es/authors/c...

I'd like to thank 🙏🏽 @cynthiasc.bsky.social for her 3 years at @lieberinstitute.bsky.social working in my team analyzing data generated by @kr-maynard.bsky.social et al. Cynthia led our first foray into the world of multi-omics data (snRNA-seq + snATAC-seq) #multiome #snRNAseq #scATACseq

Really excited to share this new study - collaboration across several teams in our division @lieberinstitute.bsky.social, led by @lahuuki.bsky.social @kr-maynard.bsky.social @lcolladotor.bsky.social - congratulations to everyone! 🧠🔬👩‍🔬

When academic spam doesn’t know where you work (@lieberinstitute.bsky.social) or that the job as involves working with @kr-maynard.bsky.social and yourself hehehe 🤭

Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025... Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”

[2025-10-16] What Makes a Good Data Visualization? Here's a teaser video of @christinezhang.bsky.social's guest lecture for the "140.776 Statistical Computing" 💻 course that I instructed this year at @johnshopkinssph.bsky.social Watch Christine's full guest lecture for free at youtu.be/SeLucCb05Dk

Clever approach - and I'll vouch - we've tried it, and it works. Path to more rigorous experimental design for comparisons across individuals and biological sex within cohorts, and most importantly for me - saves us some $$$.

Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉 Check it out here: doi.org/10.1093/narg... #NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics

Pretty neat to see our paper - led by @kr-maynard.bsky.social @lcolladotor.bsky.social on the 2021 list of most cited neuroscience papers 🧠🔬🧪 www.thetransmitter.org/publishing/w...

We are excited to share our online book and preprint on “Orchestrating Spatial Transcriptomics Analysis with Bioconductor”!

NEW: New Jersey’s township data is (mostly) in, so @shanegoldmacher.bsky.social & I crunched the numbers on NJ’s blue shift/pendulum swing The same majority-Hispanic cities & towns that swung to Trump in 24 shifted back D, to Mikie Sherrill, in the governor’s race www.nytimes.com/2025/11/15/u...

Hot take: ggplot2 is better than any plotting option available in Python-- but I discuss a couple options in Python at an R Stats Club session @libdrstats.bsky.social linked below. I personally use plotnine, since it's essentially a port of ggplot2 for Python. youtu.be/xK9UNcOfjnI

Congratulations to our habenula team! We've learned a lot about working in this tiny brain region. Here we characterize the molecular signatures of human habenula cell types and transcriptomic changes associated with schizophrenia. Stay tuned 👀 for more exciting habenula findings in the near future.

Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41... #Calicumimaging #miniscopes #rCPT #PrL

I just completed my first radio 📻 interview ^_^ You'll be able to listen to it next Friday or so at www.iheart.com/podcast/269-.... Thanks Clau from iHeartRadio Miami's "Estamos Contigo" podcast for reaching out! I'll be talking in Spanish about our recent #HabenulaLIBD 📜 bsky.app/profile/lcol...

Acá va en español 🇲🇽 --- o --- "¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...

Biostats professor @lcolladotor.bsky.social, along with his colleagues from @lieberinstitute.bsky.social, have created the first detailed molecular map of the human habenula, and with it gained new insights into its role in schizophrenia. Read the original study: psychiatryonline.org/doi/10.1176/...

Excited to share that the second project from my time at @lieberinstitute.bsky.social with @lcolladotor.bsky.social is now published! This was such a rewarding collaboration to be part of. 💡🧠 Huge congrats to @lahuuki.bsky.social and all co-authors!

#OpenData and #OpenCode from our latest @lieberinstitute.bsky.social project Lots of #RStats and @bioconductor.bsky.social code inside of that repository! #OpenScience

Congrats to @lahuuki.bsky.social and many members of @kr-maynard.bsky.social and @lcolladotor.bsky.social teams in our division who contributed to this study! Really excited to see this paper now published with contribution of data resources for molecular profiles of human habenula cell types 🧠🔬🧪

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

Finally, we made 2 web tools to share to this unprecedently large human LC xscriptomic data. A 3rd (that visualizes high-res H&E and NM with and spatial gene xpr.) on the way (last URL). We hope these help the #bluespot #LC #catecholamines community! Tools at: research.libd.org/LFF_spatial_... (7/8)

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...

Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.

I'll be keynoting at R/Pharma a week from today! The conference is free and virtual. I'll be focused on the mundane use cases of LLMs for wrangling data with #rstats, and the content should feel applicable for folks outside of pharma—come through. :) Register: events.zoom.us/ev/Ai-geyS63...

We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience recruiting.paylocity.com/recruiting/j...

Thanks again Weiqiang Zhou & Margaret Taub for organizing the "Current Topics in Biostatistics" seminar series for 1st year @jhubiostat.bsky.social students While my notes (docs.google.com/document/d/1...) were similar, the questions and discussion lead me to talk about more about team organization

"What Makes a Good Data Visualization?" 🤔 Check @christinezhang.bsky.social's 🤩 excellent 💯 guest lecture for 140.776 Statistical Computing at @johnshopkinssph.bsky.social 📽️: youtu.be/SeLucCb05Dk Slides: speakerdeck.com/lcolladotor/... #RStats @jhubiostat.bsky.social @lieberinstitute.bsky.social

In this blog post, I use #RStats to explore publicly available ICE arrest data. #Dataviz shows recent trend where ICE are primarily targeting/locating people without criminal records in communities. Code along and take a look for yourself: jef.works/blog/2025/09... #CodeTutorial

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social www.libd.org/careers/ Links to individual positions in the thread below.

I loved the "Hmmmmmm" in the crowd when @jcheng5.bsky.social showed this data quality problem uncovered by the #positron Databot tool. No human caught this during the Tidy Tuesday for the data. I've been skeptical of AI for data analysis, but this is an extremely compelling use case. 🫣

Shiny app to search and filter posit::conf(2025) Bluesky posts with the #positconf2025 #positconf25 or #positconf hashtags. App: apps.machlis.com/shiny/positc... GitHub repo: github.com/smach/bluesk... #RStats #RShiny

@sara-altman.bsky.social and I just shared the second release of the Posit AI Newsletter! In this edition, a landmark settlement on LLM training data and copyright, the emergence of agentic browsers, and more. Read and subscribe on the Posit Blog: posit.co/blog/2025-09...

So stoked to share about the first release of the Posit AI Newsletter! @sara-altman.bsky.social and I have been working on a pilot of this newsletter internally for a few months now—an opinionated and pragmatic snapshot of AI news released every two weeks. First edition: posit.co/blog/2025-08...

(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium

This paper reviews the latest computational approaches for cell-type deconvolution in spatial transcriptomics, comparing tools and data integration. 🔗 doi.org/10.1038/s415... Thanks 🙌 @lgaspardboulinc.bsky.social, Luca Gortana, @thomas-walter.bsky.social, Emmanuel Barillot & Florence Cavalli

Hi everyone! Check my journal club talk on the latest review paper: Cell-type deconvolution methods for spatial transcriptomics 🧬 🎥 www.youtube.com/watch?v=xDjF... 🛝 speakerdeck.com/manishabarse @lieberinstitute.bsky.social #Bioinformatics #SpatialTranscriptomics #Cell-TypeDeconvolution

Ready to get the day started at @jhu.edu’s Schizophrenia Center Symposium day

We are hiring into 3 (THREE!) tenure track lines this year at Wake Forest — if you’re looking please reach out, I love chatting about our department! We are a vibrant group that love & embrace the teacher-scholar model 👩‍🏫

In this interview, I explain how university research, when funded by independent #NIH #NSF federal grants, brings oversight to biotech to fuel innovation while keeping science transparent, reliable, and in service of the public good: hub.jhu.edu/2025/07/30/j... #ResearchMatters

I visualize trends in #ICE #immigration arrests and encounters over time and across select US cities using public data from deportationdata.org/data/ice.html Here is the #RStats #ggplot code so you can visualize the #dataviz trends in your own city: gist.github.com/JEFworks/0c7... #codetutorial

Congress has decided to claw back previously approved funding for public media. This decision hurts people in communities across the country, but it has only strengthened our resolve to keep Americans informed and connected. (1/2)

In this blog post, I use #RStats to analyze ICE detention data. #Datavisualization shows record numbers of detainees without any criminal records. Further more/bigger ICE facilities are popping up far from the border. Code along and take a look for yourself: jef.works/blog/2025/07... #CodeTutorial

Phenomenal talk from @hyejungwon.bsky.social who is visiting us @lieberinstitute.bsky.social for the day. Groundbreaking work w/ important implications and roadmap for using rapidly emerging information on psychiatric genetics to prioritize variants and understand their impact on 🧠 function

1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders. www.cell.com/cell/abstrac...

Biostats assistant professor @lcolladotor.bsky.social is also an investigator @lieberinstitute.bsky.social where he leads the R/Bioconductor-powered Team Data Science group. Learn more about his work in the video below: www.youtube.com/watch?v=Rz4L...