How accurate is your sequencing data—really? Our updated Sequencing 101 post breaks down what accuracy really means and how SPRQ-Nx chemistry and AI-driven consensus models are raising the bar. Blog here: bit.ly/42SCmex #PacBio #HiFisequencing #SPRQNx

The feedback loop between AI and genomics is moving fast. Our latest blog looks at how AlphaEvolve refined DeepConsensus to push PacBio HiFi accuracy even further. With SPRQ-Nx chemistry and AI driven analysis, we’ve reduced the cost of a human genome to ~$345. Read here: bit.ly/4cIUNsa

Webinar: Filling the gaps in #RareDisease research with long-read sequencing See how HiFi sequencing is helping resolve undiagnosed cases by detecting complex genetic variation and integrating multiomic data from real-world cohorts. Register: bit.ly/4t31HgB#RareDisease #PacBio

New AAV tech note! 🧬 We compared a “heat-then-extract” workflow to the official #PacBio protocol to reduce partial snapback genomes in favor of full-length ones. See the data: bit.ly/4cJ43fV#PacBio Learn more at our #ASGCT2026 talk! 🗓️ Tues 5/12 | 10:45 AM 📍 Room 257AB

We are answering your top 5 HiFi questions. First up: What can #PacBio see that short reads miss? If you only have pieces of your data, you are missing the full picture. HiFi fills in the gaps that short reads leave behind. Watch the full breakdown: bit.ly/4cBxnVp #TheresHiFiForThat

The new economics of HiFi are here with #PacBio SPRQ-Nx. Sequence human genomes for $345, a ~30% savings per sample. Get industry-leading accuracy, phasing, and methylation for less. Stretch your budget while maintaining the same HiFi quality. Download our new App Brief: bit.ly/4sR3S71 #SPRQNx

Heading to APHL 2026 next week? 🦠 Visit PacBio at booth 422 to see how HiFi long-read sequencing helps public health labs resolve complete genomes, sharpen AMR insights, and strengthen pathogen surveillance. Learn more: bit.ly/42ALnJa #PacBio #PublicHealth #APHL #MicrobialGenomics

From cost and sample input to methylation and accuracy, we are answering the top 5 questions we get asked most about #PacBio HiFi long read sequencing. Watch the full video to see how HiFi stacks up against other methods and how to get started: bit.ly/4cBxnVp#PacBio #TheresHiFiForThat

We updated our SMRT Cell Sequencing 101 post to reflect how PacBio HiFi sequencing actually works today. From SPRQ-Nx chemistry to what you can do in a single run, it’s a more current look at sequencing performance. Read the full blog here: bit.ly/4uhjhi8 #PacBio #HiFisequencing #Seq101

Experience the best of #PacBioPRISM San Diego in under 60 seconds! 🎥 Check out the official highlights to see how our community is using HiFi sequencing to push the boundaries of biology. Watch the full highlights and stay tuned for our next global stop!

Last call to register for our gene editing webinar! Short reads and PCR bias can hide critical editing outcomes. Join us to see how amplification free #PacBio HiFi sequencing and PureTarget provide a complete view of #CRISPR edits. Register here: bit.ly/4mbDW4i

Happy National #DNADay from all of us at #PacBio! 💖 🧬 💖 Today we celebrate your game changing discoveries and the scientists pushing the boundaries of what is possible in genomics. We are proud to support the community with the accuracy and clarity of HiFi sequencing. Let's keep exploring!

That is a wrap on #PacBioPRISM San Diego! Our final day focused on microbiome breakthroughs, rare disease genomics, and more, showing how HiFi sequencing is transforming our understanding of complex biology. Thank you for joining us to push the boundaries of the field!

Day 1 of #PacBioPRISM San Diego concluded with a scenic harbor cruise! 🌊 It was a wonderful evening of networking and live music on the water. We are officially fueled up and ready for Day 2 sessions. Let’s keep the momentum going!

Day 1 of #PacBioPRISM San Diego was an incredible start!

From the Women in Life Science lunch to sessions on cancer and RNA diversity, the energy was unmatched.

It was also great seeing the community explore the new SPRQ-Nx chemistry and Vega system. We're ready for more!

Next up on our global tour: #PacBioPRISM San Diego! 🌴 Last night we kicked off with a networking reception on the bayfront to explore posters and the exhibit room. We are ready for 2 days of learning and 20+ talks led by inspiring experts. Stay tuned for highlights!

This Earth Day, we’re celebrating the science bringing our planet into focus. 🌎 See how PacBio HiFi sequencing and multiomics are helping researchers uncover a more complete picture of biodiversity, from chromatin to ecosystems. Read the blog here: bit.ly/4vLzqxy #PacBio #EarthDay #HiFisequencing

Happening now at #AACR26! Visit #PacBio Poster 5510 to see Zev Kronenberg present a new way to hunt for microsatellite instability in long-read data. See how the "Owl" tool is advancing bioinformatics workflows for MSI detection. 📍 Section 4, Board 15 ⏰ Until 5 PM

That is a wrap on our #AACR26 workshop. Thank you to everyone who joined us to learn how HiFi sequencing is advancing our ability to understand cancer biology while simplifying translational lab workflows. See you at #PacBio booth 3754!

Finally, we have the discovery of a resistance mechanism. Researchers used PacBio Kinnex long read RNA sequencing to detect an EGFR isoform with three kinase domains. This is what seeing cancer completely looks like.  #AACR26 #PacBio

Continuing with the importance of the complete picture. Short reads only give you a partial picture, but long read RNA sequencing lets you see the whole elephant by capturing somatic mutations, fusions, and splicing events from a single assay.  #AACR26 #PacBio

Moving on to key takeaways. The future of cancer research is here! Research from Ambry Genetics shows that combining clinical, tumor, and RNA data and then applying HiFi LRS is revealing the hidden variants that short reads simply cannot see.  #AACR26 #PacBio #HiFisequencing

Next up, a powerful discovery case. Standard testing missed it but HiFi long read WGS found it. PacBio HiFi revealed a balanced translocation that had gone undetected, changing the clinical report and the patient path forward.  #AACR26 #PacBio #HiFisequencing

First, we are looking at FFPE compatibility. Archival tumor samples are no longer a dead end. PacBio Ampli-Fi protocol and Kinnex concatenation now enable 40X WGS coverage from FFPE tissue, unlocking long read sequencing on one of the most challenging sample types. #AACR26 #PacBio

We are live at our #AACR26 workshop! Stay tuned as we share updates on how HiFi sequencing is enabling a better way to study and translate cancer genomics. We are diving into how to move beyond legacy methods to see the cancer genome and epigenome more completely. #PacBio

In 1 hour! 🚨 Don't miss our #AACR26 workshop in Theater E at 12:30 PM. Lunch will be provided for the first 50 guests! Discover how #PacBio HiFi sequencing consolidates complex workflows into a single assay to reveal the structural variants and methylation that legacy tests miss.

#PacBio welcomes Lucid Genomics as an official PacBio Compatible partner for tertiary analysis of HiFi sequencing. This collaboration expands access to solutions purpose-built to interpret long-read data and drive biological insights. Learn more here: bit.ly/4vPt1Sj #TertiaryAnalysis

Happening now at #AACR26! 🚨 Visit #PacBio Poster 3253 to see Camille Conner present a new long-read workflow for FFPE tumor samples. Streamline structural variant detection and phasing of somatic mutations. 📍 Section 22, Board 18 ⏰ Until 5 PM

Missing #PacBioPRISM this year? We will bring the highlights to you. Sign up to be notified when PRISM 2026 on-demand content is available, featuring insights from experts on advances in human, plant, microbial genomics, and more. 👉 Get notified: bit.ly/4tqglzF

Day 2 at #AACR26 is in full swing! Stop by booth #3754 to meet the #PacBio team and see how HiFi sequencing is advancing oncology research. Catch our poster session today at 2:00 PM in Section 22. We are sharing a new FFPE workflow at poster 3253 (Board 18). See you there! #CancerResearch

The innovation at #AACR26 is in full swing! See how #PacBio HiFi sequencing is accelerating cancer drug R&D by providing a unified view of structural variants and isoforms that short reads miss. Read the blog and apply for our SMRT Grant: bit.ly/4sFEAsk#AACR26#PacBio#CancerResearch

We have arrived in San Diego for #AACR26! 🌊🧬 The #PacBio team is gearing up for a great week. Make sure to visit us at booth #3754 starting Sunday to see a live demo of the Vega system and learn about our latest innovations. Full program here: bit.ly/3NnvTED#AACR26#PacBio#3754#CancerResearch

Want about 30% lower reagent costs on HiFi sequencing? Our new #SPRQNx chemistry on Revio system brings multi-use SMRT Cell capabilities to your #PacBio workflow with zero hardware upgrades. Watch our step-by-step video to see how easy it is to start saving: bit.ly/4dTrTGM

🎉We are now a @pacbio.bsky.social Certified Service Provider @sinaihealth.bsky.social for high-quality long-read sequencing! If short reads aren't enough, long reads can unlock the answers. Contact us for your projects: bit.ly/4mySM57

How do different long-read sequencing technologies actually stack up? Our latest Sequencing 101 blog update compares the leading platforms across accuracy, cost, and application fit to help you choose the right fit for your lab. See the #PacBio difference here: bit.ly/46cQMqR

PacBio and Covaris have launched a new joint workflow for high-accuracy HiFi sequencing from FFPE tumor samples. Unlock archived tissue with over 100M HiFi reads and 11k+ structural variants per sample. Get up to speed before #AACR26: bit.ly/4cf1RfW #PacBio #OncologyResearch #CancerGenomics

Day 2 at #PacBioPRISM is in full swing! Discussions focus on genomics across the lifespan and the shift from diagnosis to prevention. We’re also highlighting the move from product to partnership. Looking forward to continuing these conversations through the end of the day! #PacBio #HiFisequencing

The first day of #PacBioPRISM concluded with an unforgettable evening overlooking the skyline of Barcelona. ✨ Our reception was filled with networking, dancing, and great company. We are officially fueled up and ready for Day 2! Let’s keep the momentum going. #PacBio #HiFisequencing #Genomics

A huge thank you to our sponsors for helping bring #PacBioPRISM 2026 to life! We are grateful for your support in connecting the genomics community. Attending onsite? Be sure to visit the sponsor booths to explore new ways to enhance your workflows and discover latest insights! #PacBio

The energy at #PacBioPRISM is incredible! 🇪🇸 We started Day 1 with a powerful look at the 350M people globally with undiagnosed diseases, a reminder that fueled our clinical and SPRQ-Nx sessions throughout the day. So many great talks down, and we can't wait for Day 2 tomorrow!

Day 1 of #PacBioPRISM 2026 is officially underway! 🇪🇸 Hear from our CEO, Christian Henry, as we kick off an incredible week in Barcelona. We can’t wait to dive into the latest research and connect with the HiFi sequencing community. Follow along for updates throughout the week! #PacBio

What if one assay could capture it all? 🧬 Our updated pre-clinical playbook helps advance clinical workflows with confidence. Explore accurate, comprehensive long-read approaches for LDTs. Access here: bit.ly/4mpZ85b Visiting #AACR26? Stop by PacBio booth #3754 to learn more!

Excitement is building in Barcelona! 🇪🇸 #PacBioPRISM 2026 is officially here. We’re kicking things off with 200+ guests and 25+ expert-led talks on the way. We can't wait to see the latest in HiFi sequencing and discovery over the next few days. #PacBio

From DNA to discovery: what are the steps of HiFi sequencing? 🧬 This blog breaks down the 5-step PacBio workflow, covering everything from Nanobind sample prep to real-time data analysis on the Revio and Vega systems. See how it all comes together: bit.ly/4vDRhGW #PacBio #HiFisequencing #Genomics

Traditional cancer testing workflows can be slow, fragmented, and costly. 🧬 Discover how SPRQ-Nx chemistry enables assay consolidation, reducing laboratory costs and shortening the path to answers with a single HiFi genomic workflow. Read more: bit.ly/4t3MQ6x #PacBio #AACR26 #SPRQNx

One week until #PacBioPRISM 2026 kicks off in Barcelona! 🇪🇸 With over 25 technical talks and 200 experts in one place, we are ready to colour the future of genomics together. Follow along next week for updates and highlights. #PacBio #Genomics

Join us on June 27 for a PacBio 5K supporting iHope and Genetic Alliance. Many families wait years for a diagnosis, and your participation helps provide life-changing answers. Register to join us for a meaningful morning: bit.ly/4mh0yQV #SeqItForward5K #PacBio #RareDisease

Structural variants drive disease associations, but they are often hidden. In this webinar, Dr. Michael Schatz discusses using #PacBio HiFi WGS to resolve complex regions and improve SV detection across diverse populations. Watch the session: bit.ly/4uUclIz#PacBio #AllofUs #WGS #HiFisequencing

Is PCR bias clouding your gene editing analysis? Join our webinar to see how amplification-free HiFi sequencing captures complex on-target and off-target edits that short reads miss. See how Uppsala University is leading the way. Register: bit.ly/4mbDW4i #PacBio #GeneEditing #CRISPR

Ready to see cancer more completely? Join the PacBio workshop at #AACR26 to learn how HiFi sequencing consolidates disparate workflows into a single, highly accurate assay for cancer genomics and epigenomics. More details here: bit.ly/3NnvTED#AACR26 #PacBio #CancerResearch #AACR2026