Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online www.nature.com/articles/s41...

Congratulations to our habenula team! We've learned a lot about working in this tiny brain region. Here we characterize the molecular signatures of human habenula cell types and transcriptomic changes associated with schizophrenia. Stay tuned 👀 for more exciting habenula findings in the near future.

If you're heading to #SfN25 in a couple weeks, pop in early to the posters on Saturday afternoon and Sunday morning to see a bunch of cool unpublished work from the lab.

People who know me know I rarely shill for much, but my experience at UAB as a family member of a patient was amazing. Huge thanks to Neurosurgery and Drs. Kristen Riley, Brad Woodworth, and Harrison Walker (Neurology).

For #FluorescenceFriday - simple image, but structure of hippocampus is beautiful with additional fanfare. 🟢 is Fos - labeling cells that get activated in response to disinhibition of inhibitory neuron subpopulation in the prefrontal cortex. Image credit to JHU Neuroscience student Aaron Salisbury.

Don't miss this new 🔥 Hot Topic 🔥 from @rphillips3.bsky.social & Stephanie Page 👇

For postdocs interested in spatial transcriptomics, UAB just launched a Spatial PRIME postdoc program which training and increased funds for postdocs in this area. Check it out if interested

New Hot Topics piece from @rphillips3.bsky.social and Stephanie Page in @npp-journal.bsky.social describing emerging insights on roles of molecularly-defined cell types in the lateral septum, which serves as a hub for coordinating diverse social behaviors. www.nature.com/articles/s41...

Was awesome to be apart of this project. Congrats and kudos to @jtuscher.bsky.social for taking some interesting findings in rat sequencing data all the way to human astrocytes!

Yes, I am on the academic job market looking to start my own lab at the intersection of molecular, computational, and systems neuroscience! If you think my work may be interest to your department, please don't hesitate to reach out. Thank you, Keri!

A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (www.science.org/doi/10.1126/...). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions. Lots of updates from the preprint!

Excited to be co-chairing this @acnporg.bsky.social panel with chair @kr-maynard.bsky.social on opioid-responsive subpopulations in brain reward circuits. Special thanks to @rphillips3.bsky.social for helping to assemble the panel!

It was awesome to be a part of this project and continue probing molecular heterogeneity in the NAc! Check out Prashanti's thread below

Excited to share my main PhD work is finally out! 🥳 We built a phage-assisted evolution platform to evolve allosteric protein switches (POGO-PANCE) and introduce cumulative, targeted mutations/Indels (RAMPhaGE)! See how we evolved ultra-strong, light-switchable AraC variants 🌚🌞

For #FluorescenceFriday - image credit to JHU Neuro grad student Suhaas Adiraju - parvalbumin 🟢, somatostatin 🔴, vGlut1 (Cyan). 🟣 marks cells activated by amphetamine using the Fos-TRAP activity-dependent tagging system. 🔬🧪🧠

#FluorescenceFriday image from Olivia Drake in the lab. Red = Chst9+ neurons in the ventral striatum Cyan = DAPI, a DNA marker The red cells are full of the mu opioid receptor, the major target of opioids like morphine, fentanyl, and heroin.

Congrats @mictott.bsky.social !! Incredibly well-deserved

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠 www.nature.com/articles/s41...

Couldn’t agree more with Kenny. Super excited to be apart of the GRC-Amygdala community now.

This project started well over a decade ago (I actually did bench work here!) when we noted the presence of these divergent transcripts in the human BDNF locus. Project had a lot of stops and starts, but really excited to finally get to share it 🧠🧪👩‍🔬

Alright, so only people who create the starter pack can add folks. I am happy to add whoever, just message me or comment who to add. Thanks!!

Someone at the power hour brought up peak science twitter. I miss that too. Towards building/maintaining the GRC-Amygdala community, here is a starter pack with attendees. Please add folks who are attending!! go.bsky.app/13BbBW9

🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

Chesapeake Bay is at a turning point. Once severely polluted, the bay has seen major improvements in recent years. But President Trump's proposed budget would slash key programs.

Excited to announce that I'll start as a tenure-track assistant professor @uofuphs.bsky.social this fall. #BiostatsElevated The #GUOmics lab will focus on developing biologically informed machine learning methods to decode spatial and population-scale omics data. Look forward to exciting colabs!

For #FluorescenceFriday - really pretty image from fresh off the scope experiments to identify basolateral amygdala - lateral septum projection neurons 🟢 that are recruited in response to social cues 🔴 in 🐁🧠. Image credit to postdoc @rphillips3.bsky.social and summer RA Natalia Gonzalez Perez 🔬🧪👩‍🔬

🚨 New paper published in @natmethods.nature.com! We introduce SpotSweeper, the first spatially-aware QC methods for spatial transcriptomics. 📰 Paper : nature.com/articles/s41... 💻 Code: github.com/MicTott/Spot... 📈 Website: mictott.github.io/SpotSweeper/ 🧵👇

Important methods development for spatial transcriptomics (ST) data from @mictott.bsky.social @boyiguo.bsky.social @stephaniehicks.bsky.social - congrats! Applying this method to our QC workflow has substantially improved many new ST datasets generated across diverse regions/tissues in the human 🧠

Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understand the role of lateral septal Nts neurons in opioid withdrawal. Curious about the septum and addiction? Give it a read👇 www.cell.com/neuron/fullt...

Hi! Check my journal club talk: smart ML method to deconvolute pooled snRNA-seq using sex-specific expression🧬 Thanks @daylab.bsky.social & @rphillips3.bsky.social for this approach🙌 🎥 youtu.be/zpeCFwYfV3o 🛝 speakerdeck.com/manishabarse #snRNAseq #ML #Bioinformatics @lieberinstitute.bsky.social

New paper out in @genomeresearch.bsky.social on using contrastive self-supervised learning for spatial domain detection with multi-omics data! Huge congratulations to Jianing Yao and coauthors Jinglun Yu, Brian Caffo Stephanie Page & @martinowk.bsky.social! 🧬 🖥️ 🧪 doi.org/10.1101/gr.2...

New review from Kasey Brida on transcriptional & molecular mechanisms in drug-induced plasticity. Here we focused on mechanisms that determine which neurons are activated by drugs, and dynamic transcriptional cascades that facilitate plasticity in these cells. www.sciencedirect.com/science/arti...

I will never tire of looking at these clusters of DRD1🔴/RXFP1🟡/OPRM1🟣 cells - here showing RNAscope in nucleus accumbens of human 🧠. Patterning of them is so neat!

Not every day that you get to watch a phenomenal student present a stunning PhD defense - this is really one of the best parts of the job! Congrats to lab superstar Dr. Kasey Brida on her successful defense! We will miss you in the lab, but also look forward to all of your future accomplishments!

Excited to see this NIDA supported work from lab PhD student Kasey Brida officially published! Kasey identified a marker of neurons that are responsive to the psychostimulant drug cocaine, and discovered that this marker is essential for cocaine reward. www.science.org/doi/10.1126/...

"Funding from the NIH was contributed to 354 of 356 drugs (99.4%) approved from 2010 to 2019 totaling $187 billion" Reference: jamanetwork.com/journals/jam...

Thanks Fieldhouse & Mertens (2024) for help with my rally sign. #standupforscience2025

Investing in science is investing in the future. We’re driving discoveries that will transform our approach to brain health and these breakthroughs rely on continued support. #StandUpfForScience2025

These studies in human brain tissue from donors with Alzheimer's disease are designed to identify potential molecular targets that can be further studied with the goal of rescuing or preventing death of neurons in this region

The 80-year-old partnership between the federal government and research institutions has made the United States the leader in scientific innovation. But a proposed funding cut threatens the arrangement.

Our paper providing transcriptomic profiles of lateral septum (LS) cell types in human 🧠 is now online: www.cell.com/iscience/ful... All data and code are publicly available online (links in the paper) and we provide an interactive web-based app to explore the data: libd.shinyapps.io/LS_snRNAseq/

Using #FluorescenceFriday to highlight a specialized population of neurons in the lateral septum that may comprise a hormone-sensitive memory engram to suppress conditioned fear responses when females are in the high hormone phase of the reproductive cycle. Interested? Come see my talk at #ACNP2024!

Our new preprint using sex-biased genes for accurate deconvolution of sample identity in single cell transcriptomics is out! This work (led by PhD student Guy Twa and @rphillips3.bsky.social) may be useful for labs that incorporate both sexes in single cell RNA-seq. www.biorxiv.org/content/10.1...

Hi! With the neuroscience influx to bluesky, I thought I'd introduce myself. I'm a postdoc with @martinowk.bsky.social using cross-species approaches to study cell types and circuitry important for social behaviors that are often dysregulated in neuropsychiatric disorders.

Honored to be one of the contributing authors to this textbook! A topic near and dear to my heart...

I'm enthused to share this work with all of you! This #HabenulaLIBD 🧠 analysis we started with Josh & Erik, continued w/ Ege, Bukola, Renee is now out 🙌🏽 It's a pleasure to share co-corresponding author w/ @lahuuki.bsky.social & Kristen 1st one of many for Louise! ⏫ twitter.com/lahuuki/stat...

Make sure your PhD advisor appreciates art like mine did. Alternate title for this piece was "too hot to handle" (alternate title by @zipperlym.bsky.social )