Oof

'This review explores the current state of CAR-T cell therapy for solid tumors, highlighting challenges including the pronounced heterogeneity of tumor antigens and the immunosuppressive tumor microenvironment.' #Immunology #Immunotherapy

Happy to work together with my PhD supervisor Dr. Xi-Long Zheng on this review 😁 Glutaminase 1 in Vascular Disease: Linking Metabolic Reprogramming to Atherosclerosis Progression and Stability #JCardiovascTranslRes 2026 link.springer.com/article/10.1... Image credit Nano Banana

is there no news about the OMB apportionment to NIH issue after the budged was passed Feb 3, and that 30-day thing ended on March 5? this is all i've found, www.rdworldonline.com/nih-funding-... but it doesn't seem to have any real info on what's happening (including legal challenges)

Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age. perdy cool doi.org/10.1038/s435...

‘Data Dump’ would be an excellent name for a journal on gut microbiome

today is the 1-year anniversary of when I sent my R01 off to NIH. happy birthday little grant. 🎉 maybe one day we'll actually get to start work

P16+ Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated Recruitment of Cytotoxic Lymphocytes. Senescent fibroblasts drive T cell infiltration of the heart in MI doi.org/10.1161/CIRC...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice Really cool stuff from @bbparis1984.bsky.social lab doi.org/10.1038/s435...

I do now

Turns out a lot of ICs have NOT funded any new R01's yet in FY2026: FIC NCCIH NCI NCIPC NHLBI NIAAA NIAMS NIBIB NIEHS NIGMS NIMHD these IC's have: NEI NHGRI NIA NIAID NICHD NIDA NIDCD NIDCR NIDDK NIMH NINDS NINR

The impact is already hitting science agencies hard. The NIH—the world's largest public biomedical research funder—has had to rely on leftover stopgap funds. New grant awards have slowed to a trickle — exacerbating the effects of a record-long shutdown in October. (h/t @jeremymberg.bsky.social)

Yep, it lags a little. But still quite impressive considering that each "pixel" is a 150 MPixel multires image. Overall the total number of 'adressable' pixels in this 2D image are 225x225x150 Mpix = 7.6 Tera pixels. #ImageJ #Fiji #BigDataViewer

Is Panzanella salad, a sandwich?

"Here, we present SPAtial Cell Exploration (SPACE), a spatial CRISPR screening platform that integrates whole-transcriptome profiling (~18,000 genes), multiplexed protein detection (~68 markers), and CRISPR perturbation mapping at subcellular resolution" www.biorxiv.org/content/10.1...

There’s a lot of blank white space on the back of a lab coat. Lots of room for a giant thermofisher or sigma sponsorship logo just saying

@biorxivpreprint.bsky.social Optimal transport fate mapping resolves T cell differentiation dynamics across tissues www.biorxiv.org/content/10.6... @natstann.bsky.social

Thoughts and prayers for ESI’s followed closely by condolences

Hot Topic sounds like a podcast where a PI explains your own paper to you

Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease. Interesting stuff on human aging and disease from Tony Wyss-Coray's group doi.org/10.64898/202...

www.science.org/content/arti... Cool time to start a science career. As a grad student in the early 2010’s I thought I was lucky because I didn’t have to worry about funding at the time and things would be better when I was trying to start my lab

old me was really smart to leave gummy worms in current me's desk drawer

@biorxivpreprint.bsky.social A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling www.biorxiv.org/content/10.6... @mayoclinic.org @columbiauniversity.bsky.social

Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling really cool stuff on CD8 t cells and myocarditis doi.org/10.1084/jem....

NHLBI has not funded a single new R01 in FY2026 which began almost 5 months ago

Canadian bacon is just ham

Do you want to slide down the ice tube at 1000 mph on your back? On your stomach? In a missile? Alone or with a group?

Game! Wow. Canada played excellent but USA goaltending…yeesh!

Speed skaters should make it look harder during the race. It looks so easy for them but they have to be dying

ggpubfigs has a Python equivalent for matplotlib and seaborn :D Create scientific figures with colorblind-friendly color palettes with ease bsky.app/profile/jlst...

I used Claude Opus 4.5/4.6 (and a bit of Codex GPT-5.3) to port edgeR to Python. See edgePython github.com/pachterlab/e... This allowed me to develop a single-cell DE method that extends NEBULA with edgeR Empirical Bayes. All in one week. Details in doi.org/10.64898/202...

and here I am as a "junior" faculty at 37

Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics wow. that's cool. Trikine sounds like something from MCU doi.org/10.1126/scie...

Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability Pretty slick paper in European Heart Journal on spatial transcriptomics in athero in human people academic.oup.com/eurheartj/ad...

Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice NICE! v. cool paper doi.org/10.1038/s415...

Since I doubt I'll ever publish in Nature, I now aspire to publish in Nurture. only $150 APC is icing on the cake

okay Oura, cardiovascular aging? don't temp me with a good time. tugging at my heart strings.

Mike admits to nepotism!!!!! It’s all right here 👇

CCTV footage appears to show DHS agents posing as people having car trouble in order to lure a target out of his house before arresting them. The target comes out and starts helping them before 3 vehicles surround the scene. The car "experiencing" trouble then drives off with them.

Website verifies you’re human by faceID and you have to make a funny face

Senolytic CAR T cell NKG2DL-targeting Irradiated or Aged🐭 ⏫Adipocyte size ⏫Bone volume ⏫Myofiber size ⏫Physical activity Rhesus/Cynomolgus macaques 19~22 y/o A single dose of 1 M hNKG2D-CAR T cells 2-mo later⏬Senescence in Fat, Muscle, Liver, Kidney #ScienceTM 2023 www.science.org/doi/10.1126/...

IL-4-STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing. Ooooh cool to see this published! doi.org/10.1038/s415...

The CD8 immgenT framework as a universal reference of mouse CD8αβ T cell differentiation states. Interesting stuff on CD8 T cells doi.org/10.64898/202...

Curious why curling has women and men competing separately

Meningeal blood vessel blockage enhances anti-glioblastoma immunity. interesting paper for people who like T cells and BAMs in the brain doi.org/10.1016/j.ce...

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex. interesting preprint on aging spatial transcriptomic prefrontal cortex in HUMANs doi.org/10.64898/202...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis. T cell clones! very cool doi.org/10.1038/s415...

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice pretty slick methods here. nice doi.org/10.64898/202...

I'd like to see what YOU do in an elevated Y-maze