Pretty cool update from GlycoScape: Sugar-specific visualisation, based on the sugar type. Should help for hypothesis generation since you can plot each sugar type and compare.

Loool 😭

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

the elevator in my building is broken. only goes down. refuses to go up. its really getting me down

nice

"One stark fact: All of the Valkyries players combined make less than the lowest paid member of the Warriors, who have the same owners and play in the same building."

Four different papers, including one in Nature. The images appear to have been provided by a CDMO (Neurodigitech, LLC) to different teams in the US. Researchers have been adding these beautified and recycled images into their papers like they're filling up a sticker book.

Such a thoughtful, honest description of a really important question. Great thread & beautiful data. Most of the same cells seem to be present in mouse, zfish, and people but not a huge overlap in gene programs. Really interesting

Age-dependent changes in gene expression and regulation often unexpectedly (to us at least) represented homeostatic changes that potentially counteract the effects of inflammation and other deleterious aging-regulated processes. Reversing the age-dependent changes may prove counterproductive./34

Call me old fashioned but I don’t see how an AI chatbot trained on Aubrey de Grey’s old lab notebooks is going to “solve aging”. Weird move to name it after himself and give it a beard and stuff. If you don’t know about Aubrey, give him a google. Interesting character

Not sure Green Bay is a real place

It gives me great pleasure to present the latest from our lab, outlining a curious cellular and molecular pathway that limits thymic regeneration after acute insult. www.nature.com/articles/s41...

is this appropriate to include in a grant application? "The earliest research on atherosclerosis used larger mammals such as rabbits(120), chickens(121), dogs(122), and rhesus monkeys(123). In this historical sense, murine models could be considered appropriate NAMs to these larger animals."

Both of these were great. The evolution from cod to salt was really cool. Cod and fish were salted allowing Vikings and Basques to sail all over. Salary and “worth your salt” came about because people were paid in salt or brine. Yaw. Cool. Nice.

When do NAMs become OAMs?

Is this the new math?

Gift article. "A decade ago, Chinese Academy of Science was the only Chinese institution to figure in the top 10. Now eight of the 10 leaders are in China. If this does not constitute a Sputnik moment, it is hard to imagine what would." And we are smashing our Sputnik.

Why is Jonas Vingegaard still riding a yellow bike? Cervelo didn’t paint one red for him?

Excellent title. Bravo 👏 Actin up: Mrtfa regulates actomyosin and apical constriction

Didn’t post when I finished this one. Hesitated to read it but concluded that it’s better to be educated than ignorant. He was a slave owning confederate general and ‘grand wizard’ in the KKK. I think this biography was too kind to him but was interesting nonetheless

This was obviously very well written (Pulitzer Prize) and super interesting about the whole time period of 1900s-1970s. Hoover was an odd guy. I like reading these different biographies of overlapping periods with very distinctive points-of-view

6/ Beyond known links, our approach points to potentially underdiagnosed comorbidities with strong molecular evidence and therapeutic implications. We made it all explorable here 👉 disease-perception.bsc.es/rgenexcom/

This was so good. Expands on the few paragraphs taught about Douglass during Black history month. Also super interesting juxtaposition to compare with Mark Twain’s fame in a similar period in American history

Biggest new tech at the Vuelta: nose strips

The 2026 House bill with NIH budget preserved but elimination of ARPA-H democrats-appropriations.house.gov/sites/evo-su...

A great list of open-source textbooks curated by UMN. Click browse subjects for more. open.umn.edu/opentextbooks/

The music at the Michigan game has been pretty good. White stripes, Eminem, Crazy Train, Nirvana

This is a really cool graphic despite all the annoying on field ads placed by NBC

Don’t even get me started on my lysosomal limitations

So far so good

Calling out sick on Tuesday. I’m suffering from mitochondrial challenges

Can both teams lose? 🤞

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

Wow math meets mitochondria. Super cool

Stereo-seq V2 facilitates single-cell-resolution spatial RNA mapping in FFPE samples through random primer capture, uncovering ncRNAs, host-pathogen transcriptome profiling, and spatial immune repertoires in situ @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Rejected!

Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:

Wtf are the “mitochondrial challenges” referenced here?

'Notably, CD56+CD20+ NK cells are enriched in multiple inflammatory conditions, including multiple sclerosis, autoimmune hepatitis, hepatitis B infection, hepatocellular carcinoma, and lung cancer. Treatment with rituximab depletes this population, suggesting potential therapeutic implications.'

This was not only about JFK but about the whole period before he became president. Really interesting snapshot in an interesting time. I prefer this Kennedy to our current Kennedy

5 days in and our manuscript hasn’t been rejected yet! Good sign!? Wishful thinking?

This is why I love science

Blood, sweat, and beers: investigating mosquito biting preferences amidst noise and intoxication in a cross-sectional cohort study at a large music festival https://www.biorxiv.org/content/10.1101/2025.08.21.671470v1

Popping in to remind that my amazing wife has a new novel that you should check out! It’s about women, bike rides, friendships, ghosts of the past, elder care, service dogs, and switchblades. The book has 4.9/5 stars on Amazon and is getting great reviews elsewhere. bookshop.org/p/books/debr...

lol, these are new ??

WASHINGTON (AP) — Trump administration says grants for Hispanic-serving colleges are unconstitutional and it won't defend them in court.

This is so frustrating. In 2018 I remember thinking how this paper would transform my work since we were already looking at mitophagy. I have cited this paper in 3 of my papers between 2018-2020 and probably every grant application. This guy won a 2021 breakthrough prize in part because of this work

This was great! Tim Harford has a great podcast and this was a great long form book of vignettes.

🧪 New study: Learning about economic impact of NIH funding motivates action to oppose funding cuts. Evidence from two preregistered, randomized experiments with >5,000 U.S. adults. Similar change for liberals and conservatives. Preprint from @asinclair.bsky.social et al: osf.io/preprints/ps...

Wpost video: NIH cuts delayed his cancer treatment. This is his message. @carolynyjohnson.bsky.social wapo.st/3UB5e75