Combining biosensor imaging data with an animated plot of the quantified intensity, based on a blog I wrote earlier: thenode.biologists.com/crafting-plo... In this version I used a dark theme

Integrated Single-Cell Transcriptomic Atlas of Human #PulmonaryHypertension 10 iPAH + 20 SSc-PAH + 4 chronic thromboembolic PH + 30 healthy Ctrl 5 Smooth muscle cell states Contractile VCAN-/APOE-hi FLNA-/XIST-hi ATF3-/SOCS3-hi Cox4I2-/TMSB4X-hi #ATVB 2026 www.ahajournals.org/doi/10.1161/...

Allosteric Biosensors Unravel GTPase-Effector Feedback by Klaus Hahn and team: www.biorxiv.org/content/10.6...

TBF, it's DO-7, one of the most used clones, sold by many vendors, and it's one of the 51 images on that page. I validated that antibody for myself many times. Vendors are commonly bad with pictures for the websites, reusing them between vendors for the same antibody etc.

#MetaplasticBreastCancer #CaseReport 52 y/o 5.9 cm left breast mass TN, AE1/3+, CK5/6+, p63+, MDM2+, CDK4+, PD-L1+ cT3N0M0 stage IIb Sternal+Lung metastasis No progression in 30 mo since KEYNOTE-355/Pembrolizumab 🥸Transient lesion growth by 1 mo #AmJCaseRep 2026 amjcaserep.com/abstract/ind...

RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed by multiplexed optogenetics and biosensor imaging by Klaus M. Hahn and team: www.biorxiv.org/content/10.6...

Hao's Preprint Reading List May 18 2026 Curvature sensing Developmental Senescence & Hyaloid Vessel Collagen fibril network in 🫁Fibrosis vs COPD Copper & Phosphatidylcholine in MASH Hydraulic fracturing of media in Aortic Dissection Sox17-Runx1 iPAH docs.google.com/document/d/e...

Green genetically encoded IP3 biosensor for hierarchical analysis of its signaling network by Tetsuya Kitaguchi and team: www.biorxiv.org/content/10.6...

Hi All - had my stepmoms memorial this weekend and thought I would post it, she was an amazing scientist but also we had the ASO string quartet play and it’s worth it just for the music if you like that m.youtube.com/watch?v=aSYx...

Exogenous PCSK9 can be internalized by Smooth Muscle Cell, likely a major resource for arterial wall in vivo LRP1-mediated Compete with oxLDL Mathilde Varret lab #Atherosclerosis 2026 www.atherosclerosis-journal.com/article/S002...

Regulon prediction CollecTRI Collection of Transcription Regulation Interactions public databases + text mining + manual curation (ExTRI, Pavlidis, NTNU Curated, DoRothEA A, etc) Integrated into 1⃣OmniPath 2⃣DoRothEA 3⃣decoupler #NucAcidRes 2023 academic.oup.com/nar/article/...

FAT1 FibroAdipogenic Progenitor Muscle Regeneration #SciArt 1/2 Spatiotemporal maps of the FAP lineage, fibro (Tenascin C)-fatty (Perilipin-1) expansion, myofiber necrosis-regeneration in Cardiotoxin-/Glycerol-injured 🐭triceps brachii🤩 @fhelmbacher.bsky.social 2026 www.biorxiv.org/content/10.6...

#MetaplasticBreastCancer #CaseReport Immunotherapy-refractory 47 y/o Rapid growth 40 mm cT2N0M0 stage IIA➡️80 mm cT4bN1M0 stage IIIB in 2-wk Keynote-522 regimen: pembrolizumab +paclitaxel +carboplatin No recurrence in 18 mo post-mastectomy #NagoyaJMedSci 2026 pmc.ncbi.nlm.nih.gov/articles/PMC...

Thank you! I'm glad you say this, I thought this was a very informative way of looking at the dynamics of muscle regeneration. Since we do this in a big muscle, where not everything is damaged by the lesion, it is possible to capture the dynamics by looking at the outside to inside progression.

Happy #FluorescenceFriday. I feel so lucky to get to work with these weird and curious primary macrophages from 🐸. They exhibit myriad different morphologies and behaviours, including spinning endlessly and stationary, kinda like progenitor cells under compression from 🐟. Also actomyosin is strong!

The 2027 EMBO practical course on #devbio is now open for registration. You'll get work with a lot of different model organisms, from fly to frog and everything in between, plus amazing imaging too. And the city is beautiful, so what I've heard 😌!

FAT1 FibroAdipogenic Progenitor Muscle Regeneration #SciArt 1/2 Spatiotemporal maps of the FAP lineage, fibro (Tenascin C)-fatty (Perilipin-1) expansion, myofiber necrosis-regeneration in Cardiotoxin-/Glycerol-injured 🐭triceps brachii🤩 @fhelmbacher.bsky.social 2026 www.biorxiv.org/content/10.6...

Excited to share our latest work in @ScienceAdvances! 🔬 We’ve developed "dynaMIET"—a new spectroscopy technique that finally allows us to simultaneously measure 3D membrane dynamics in live cells with nanometer precision. www.science.org/doi/10.1126/...

⭐️ A transgenic hydra labeling the endoderm and ectoderm of two column ends regenerating.🔬📸 Credit: Raisa Bailon-Zambrano from the University of Colorado Anschutz Medical Campus taken during the 2021 MBL Embryology Course #FluorescenceFriday #devbio #Embryology 🪸

Pro-inflammatory cytokine-driven molecular signaling in skeletal muscle during cancer cachexia portlandpress.com/biochemsoctr...

S100A4 labels subpopulations of medial Smooth Muscle Cell & adventitial Fibroblast in🐭Aorta 2.5-fold⬆️upon AngII infusion S100A4-Cre;Agtr1 (AngII type 1 receptor) KO Ldlr-/-🐭+AngII 👉⏬Ascending aortic area 👉↔️BP↔️aortic rupture @alandaugherty.bsky.social #PLOSONE 2026 journals.plos.org/plosone/arti...

This is a fascinating approach to treating vision disorders. Photosynthetic structures have been transplanted into mammalian corneal cells to treat dry eye, a common and painful condition. 🧪 #Science #Biology #Chemistry #Medicine 1- www.science.org/content/arti... 2- www.cell.com/cell/fulltex...

So, as translation control is getting popular, please note the newly unified nomenclatures: Translons: a single term for translated regions www.nature.com/articles/s41... Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status www.nature.com/articles/s41...

#FluorescentFriday for my seductive Mimulus 👄 #plantjoy #microcopy #confocal #mimuluspropaganda #mimulus 🔬🌱🌸

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

#Neutrophil #Atherosclerosis CCR2+ Neutrophil ⬆️in👤🐭Atherosclerotic arteries ⬆️NETosis Unique Aortic Neutrophil immunophenotype (vs BM, Blood) CCL2 blockade⏫plaque stability in Apoe-/-🐭⏫Smooth muscle cell content ↔️Lesion, Mφ, collagen, necrotic core #ATVB 2026 www.ahajournals.org/doi/10.1161/...

happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...

Loeys-Dietz syndrome 4 TGFB2 #CaseReport Early-onset (6 y/o M) aortic root aneurysm (Z score +14) +Ventricular Septal Defect #EHJCaseRep 2026 academic.oup.com/ehjcr/articl...

🧵1/10 Astronomers recently revealed a giant cosmic structure that had been hiding behind the stars and dust of our own Milky Way. 🔭 🧪 ⚛️ Press release: www.sarao.ac.za/news/vela-th... #cosmology #universe #MilkyWay

#DBfeature 🐸 TMBIM4 affects left-right patterning via pluripotency exit during gastrulation in X. tropicalis, and its loss replicates the phenotypes of human congenital heart disease patients by Nicholas Diab, Mustafa Khokha et al www.sciencedirect.com/science/arti...

✨ 2026 SDB Art Show 🎨 SDB will host the show at the 85th Annual Meeting in Las Vegas 🎰 Deadline: June 1st ‼️ Open to meeting attendees: 2D & 3D in "Research Images as Art" or "Art Inspired by Research" 🎨 More information: www.sdbonline.org/2026mtg_art_...

Hyaluronan-Collagen balance dictates regenerative vs non-regenerative fate of adult🐭digit regeneration🤠 Soft matrix confers a pro-regenerative, HA-building (HAPLN1+) Blastema Fibroblast state Force mapping of wounded digits (stiffness fluidity) #Science 2026 www.science.org/doi/10.1126/...

A CandiChrome toolkit for multicolor labeling of Candida cells by Richard J Bennett and team: www.biorxiv.org/content/10.6...

Indeed, #methodsmatter www.nature.com/articles/s41...

🚨 One Week Left for the #SDB2026 Early Registration Deadline! 🚨 Register by May 20th for the Society for Developmental Biology 2026 Annual Meeting in Las Vegas 🎰 First 250 registrants get a FREE t-shirt 👕Don’t miss it! 🔗 www.sdbonline.org/2026mtg_regi... #DevBio

Urolithin A (gut microbiota metabolite) as a Senomorphic agent🤠 Little effect on Senescence But alleviating #SASP Senescence-associated secretion of pro-inflammatory cytokines (IL-6/-8/-1α, CCL2/5), likely via ⬇️cGAS-STING cascade #AgingCell 2025 onlinelibrary.wiley.com/doi/10.1111/...

Heading up to @ahascience.bsky.social #VascularDiscovery2026 in Bellevue WA 🏔️ Excited to catch up with old ATVB friends, make new ones & learn the latest in vascular biology research Will be presenting a poster from our lab on our latest work on COL8A1 mechanobiology in ECs 🧫

🚨 New preprint on bioRxiv! Pericyte loss triggers hypoperfusion, BBB dysfunction, endothelial VCAM-1/type I IFN activation, venular-like transitions & delayed white matter injury linked to human SVD signatures. Congrats Dr. Dorota Stefancova & team! www.biorxiv.org/content/10.6...

#DBfeature 🧑‍🎓 The Neural Tube CURE trains students in developmental biology methodology while offering a research course designed to increase opportunities for undergraduate research experience By Anneke Dixie Kakebeen, Joshua Fandel, Lee Niswander tinyurl.com/y2va2xpy

PINCH1, a FA protein & transcriptional co-factor, in mural cell differentiation & wrapping Pdgfrb-Cre;PINCH1f/f;PINCH2−/−🐭 👉Neonatal aortic/cerebral/carotid arterial dilation ⏫Wall thickness ⏫SMC proliferation🤓 👉🫀🧠vascular dysmorphogenesis #Angiogenesis 2026 link.springer.com/article/10.1...

Klumpe, S., Senti, K. A., Beck, F...., Briggs, J. A. G., Brennecke, J., Beck, M., Plitzko, J. M. (2025). In-cell structure a nd snapshots of copia retrotransposons in intact tissue by cryo-ET. Cell, 188(8):2094-2110. www.cell.com/cell/fulltex...

In🐭 #AbdominalAorticAneurysm Apoe-/-🐭♂️+AngII Mitochondrial dysfunction is more pronounced in suprarenal, where aneurysms manifest, than in infrarenal aorta Metformin oral 100 mg/kg/d, begin at D7 rescues Aortic Aneurysm, Not Mito dysfunctions by D28 #BiomedMDPI 2026 www.mdpi.com/2227-9059/14...

Now Dr. Amber Ide is presenting on Wnt regulation of Endothelial-to-hematopoietic transition in zebrafish🐟 🥰 SDB DevBioConnect DB Author Webinar @devbiol.bsky.social @socdevbio.bsky.social

Amazing talk by @dianavoss.bsky.social on 3D chromatin organization on neural-cardiomuscular lineage specification😍 SDB DevBioConnect DB Author Webinar @devbiol.bsky.social @socdevbio.bsky.social

@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk

Great to see how this research into mechanisms of neutrophil-assisted breast cancer metastasis has developed! Updates summarised in a postlight: doi.org/10.1242/prel... @prelights.bsky.social

quite a dense reading : infoscience.epfl.ch/entities/pub...

#DBfeature #DBeditorial Bridging developmental biology and social justice to reclaim trust in science and society by Nicole Theodosiou, Michael Barresi @spiraldoc.bsky.social www.sciencedirect.com/science/arti...

Corneal Endothelial Morphogenesis E6-E16🐣 #SciArt "Persistent dominance of hexagonal topology" Beautiful 2D nuclei Voronoi tessellation!🤩 +Molecular dynamics of N-cadherin F-actin Microtubule @rogerslabucd.bsky.social @sarathomasy.bsky.social www.biorxiv.org/content/10.6...