#DBfeature #ICYMI Loss of CMTR1 leads to gastrulation failure and disrupted anterior-posterior patterning, with unique gene expression profiles between XX and XY embryos By Janelle Welton, Kimberly Tremblay, Jesse Mager tinyurl.com/4ruh8b5k

PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension: doi.org/10.1172/jci....

Protein Arginine Methyltransferase 5 as a negative epigenetic regulator of SRF/Myocardin-mediated contractile phenotype of Smooth Muscle Cell PRMT5 ⏫H3R8me2 H3R4me2 SMC Prmt5 KO🐭; Lenti-shPRMT5; EPZ015666 (PRMT5i)▶️ ⏬Neointima in injured carotid #CardiovascRes 2023 academic.oup.com/cardiovascre...

Late in the office finishing up ahead of the long weekend, figured I'd find a #FluorescenceFriday to post before heading out... stumbled on this folder on our server that I hadn't yet snooped. I don't know exactly what the viral labels are, but its pretty beautiful 🔬🧠 😍🎆

Not many people know this but 🐸 embryos make an amazing system to study immune cells. If 🐟 embryos become less transparent as they grow, 🐸 embryos do the reverse, becoming progressively transparent. Their immune cells are very similar to 🐟 and 🚶‍♂️. Here are some 🐸 macrophages (🔴): #FluorescenceFriday

Profiling >10,000 islets & 16M cells across clinical stages of type 1 diabetes reveal early shifts in cell state, rising β-cell immunogenicity, & remodelling of the islet immune neighbourhood @natmetabolism.nature.com @bb-lab.bsky.social www.nature.com/articles/s42... www.nature.com/articles/s42...

Early cell-autonomous and niche-mediated epithelial response to influenza infection in primary alveolar organoids @insight.jci.org @cincyresearch.bsky.social @drwillzacharias.bsky.social insight.jci.org/articles/vie...

To celebrate, if you have fewer followers than I do and have something to promote -a post, a drawing, an art portfolio, a paper, a job ad, yourself, anything-, I will share it for everyone to see 🧪

Take a look at our LLM analysis of the evolution of preprints into peer-reviewed forms😎 biorxiv.org/content/10.6... Thanks a million to @rrust.bsky.social for this inspiring project😆 No surprise ~90% preprints that pass peer reviews had minimal-to-minor revisions of their scientific claims🤠

#DBfeature #LatestResearch Single-cell RNA-seq uncovers cellular diversity and dynamic gene regulatory networks along the progenitor-to-chondrocyte trajectory of late synovial joint development By Ji-Hye Yea, Qin Bian, Patrick Cahan, et al. tinyurl.com/3cwut5ft

Never 3D printed anything in my life but I think I should do it. Anyone ever followed through to see if these conferences are real?

Still two weeks left to apply for the special "From Postdoc to PI" symposium at the Heidelberg meeting in September! If you're a postdoc and are in the job market, take this opportunity to tell everyone who you are 🐟🧪 There will be a prize an all!

3D reconstruction reveals highly conserved vascular network architecture despite phylogenetic diversity spanning >300M years of evolution. Moer here: www.biorxiv.org/content/10.6...

Are you a recent Ph.D. graduate? Apply for the Science & SciLifeLab Prize for Young Scientists. The $30,000 grand prize will be awarded for outstanding research in cell and molecular biology, genomics, ecology, or molecular medicine. Apply by 15 July: https://scim.ag/4lUpKMN

Wow - this is worth a few minutes of your time today: focalplane.biologists.com/2026/06/30/l... Living cells grown on micropatterns to match the architecture of the musée d’Orsay An amazing art/science fusion from the indomitable @manuelthery.bsky.social and colleague in @focalplane.bsky.social

A High-Affinity Nanobody Recognizing mNeonGreen Enables Versatile Biochemical, Cellular, and in vivo Applications. by Steffen Frey and team: www.biorxiv.org/content/10.6...

Nidogen-2, a basement membrane component, directly binds to & activates Jag1 & Notch3 in Smooth Muscle Cell➡️⏫Contractile phenotype Nid2 KO🐭➡️⏫Neointima in wire-injured carotid artery Nidogen-2 ⬇️in SMC +PDGFBB ⬆️in SMC =TGFβ #Circulation 2021 www.ahajournals.org/doi/10.1161/...

1/9 What if the particles that make up you, your coffee 🧪⚛️, and entire galaxies🔭 followed rules written with “strange” numbers that don’t follow the normal rules of multiplication (remember the commutative & associative properties you learned in school)? Sounds crazy, but it might be pure #math.

#DBfeature #ICYMI Review: Critical roles of the primitive endoderm in in fetal cell fate specification and patterning By Marcelio Shammami, Alyssa Virola-Iarussi, Ian McCrary, Amy Ralston tinyurl.com/dy5js2f7

🤝 Media Partnership with ELRIG at Drug Discovery 2026 We are excited to announce our continued media partnership with ELRIG. Register now: elrig.org/portfolio/dr... #ELRIGDD26 #ELRIG #biotech #lifeScience #discovery

Don't laugh, just read! "Behavioral and clinical evidence distinguish two major forms of human laughter: spontaneous, emotionally driven vocalizations and volitional expressions used in social communication." 🧪 #Science #Biology #Neuroscience The neural basis of laughter www.cell.com/trends/neuro...

🔬 Innovation happens at the intersection of engineering and biology • Dr Kate McDole shares how advanced imaging reveals previously hidden dynamics in early mouse development. • Dr Jan Roden shares insights into the engineering and software that make such visualisation possible. 1/2

In patients with Spontaneous cervical artery dissection (n=5), Capillary enlargement are observed in 40~56% capillary loops at finger tips (Nailfold capillaroscopy) #CaseReport #Angiogenesis 2026 link.springer.com/article/10.1...

#DBfeature #LatestResearch Camk2g1 regulates Notch signaling and histone methylation to specify hematopoietic stem cells By Camden Kurtz, Sanyam Patel, Haerin Kim, Sarah Rothschild tinyurl.com/bdp9u37v

Considering that NS is twice as prevalent as MFS you can safely conclude that the dissections risk in NS is incredibly low

#DBfeature #ICYMI Review: Controllable targeted protein degradation as a promising tool for discovery of novel cellular and developmental mechanisms By De-Li Shi, Xuan Zhao, Chengtian Zhao, Ming Shao tinyurl.com/yc26fzy6

☕Mizrak et al. use single-molecule tracking to dissect mechanisms of protein targeting to lipid droplets. They show that nanodomain-based confinement drives selective protein accumulation on lipid droplets. www.nature.com/articles/s41...

Frequency of Thoracic Aortic Dilation in Noonan Syndrome #RASopathy N=37 0.6~32 y/o 14 PTPN11 variant carriers (out of 16 known variants) Aortic diameter Z > 2 10 Aortic annulus 8 Aortic Root 2 Ascending aorta #AortaEd #AmJCardiol 2014 www.sciencedirect.com/science/arti...

Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬 #3DImaging

Early clinical outcomes and molecular smooth muscle cell phenotyping using a prophylactic aortic arch replacement strategy in Loeys-Dietz syndrome Pathology 4D flow MRI Single-cell RNAseq Photos of freshly repaired ascending aortas!🤩 #AortaEd #JTCVS 2023 www.jtcvs.org/article/S002...

Smooth Muscle Cell #YAP protects against in (from ascending to suprarenal) Aortic Aneurysm/Dissection in 🐭+Angiotensin II SMC Yap1 KO🐭+AngII Aortic SMC⏬Proliferation ⏫Apoptosis YAP mediates Cyclic Stretch➡️SMC proliferation & elastin/collagen #AortaEd #ATVB 2023 www.ahajournals.org/doi/10.1161/...

I am so excited to get to share this paper that extends our work on understanding how circuitry between locus coeruleus and prefrontal cortex control attention. Just huge congrats to @rehg-j.bsky.social and @jorge-miranda.bsky.social - I am so proud of both of you 💙💙!!!

#DBfeature Loss of potassium channel Kcnj2 alters electrical activity in palate mesenchyme cells, which affects a network of calcium-induced transcription factors and causes cleft palate in mice. By Yunus Ozekin, Rebecca O'Rourke, Emily Anne Bates tinyurl.com/4c9w8saz

Don't use slop. Someone's trying to make money out of you and your colleagues and your friends. Do yourself a favor and read 100% human-crated content in @prelights.bsky.social Upload preprints. Read preprints. Cite preprints. Fuck AI 🧪

Ooooo, this is cool 😎 Pre-print highlights & insights by content experts brought to us by @biologists.bsky.social?! Yes, please! 🙌 Delving through the DevBio picks now 👀 🧪 prelights.biologists.com/prelists/pre...

A 3D Microfluidic Smooth Muscle Cell Calcification Model Immortalized SMC + 4d calcifying medium Fibrin + VP-co-GMA copolymer Hydrogel Fetuin A-mRuby as a dye for calcium mineral particle Calcification can spread throughout the gel😍 #FEBSOpenBio 2026 febs.onlinelibrary.wiley.com/doi/10.1002/...

#OTD in 1903, Marie Skłodowska Curie defended her PhD thesis. She, after thousands of crystallizations, finally had isolated 1 decigram of almost pure radium chloride & determined radium’s atomic weight as 225. The findings were presented in her PhD thesis. 🧪 ⚛️ #WomenInStem #Science #HistSci 1/3

The committee expressed the opinion that the findings represented the greatest scientific contribution ever made in a doctoral thesis. Later, in this same year, she was awarded a Nobel Prize in Physics. Reference➡️ www.nobelprize.org/prizes/theme... 2/3

Sinusoidal endothelial cells control liver inflammation & fibrosis A very enjoyable piece on pathogenic liver #Angiocrine (CCL2 CXCL1) & transcriptional programs (GATA4 ZEB2 RUNX3 NOTCH) A novel BRD4/PML phase separation superenhancer trigger #JCI 2026 www.jci.org/articles/vie...

About perception in the lower #animals. Discover how turtles find their way to that speck of land in the midst of the great Atlantic Ocean. 🧪 #Science #Biology #Ecology Migrating sea turtles only sort of know where they’re going 1- www.science.org/content/arti... 2- www.nature.com/articles/007...

Double preprint! 👇 Check out our latest studies on timing, heterogeneity and collective behaviour (with a fun tiny bonus on evolution!) 1. www.biorxiv.org/content/10.6... 2. arxiv.org/abs/2605.13234

Don't worry about not keeping up with AI. Nobody is. Identify and solve a problem! Even last year's AI is underutilized! For scientists, discover something new. Or create a tool that helps others.

Found an interesting preprint that I missed on the QED 1% page. It's from February 2026 (not updated since), and apparently just having legible figures is not part of the quality assessment of QED www.biorxiv.org/content/10.6...

🚨We are recruiting a Postdoc🚨 We are seeking a highly motivated Postdoctoral Researcher for our newly funded Horizon Europe Mission Cancer Melanoma Project! 🎯Apply, if you are interested in extracellular matrix-cancer cell interactions, tissue mechanics, advanced fluorescence imaging in 2D and 3D!

Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis: Current Biology www.cell.com/current-biol...

#FGF9 #LeydigCell In rats with dimethane sulfonate-induced Leydig cell depletion FGF9 ⏫Leydig cell prolifer/maturation ⏫Testosterone production +Evidence from 3D cultured seminiferous tubule FGF9 ⏫Leydig markers Scarb1 Stard1 Cyp11a1 Cyp17a1 #Reproduction 2026 academic.oup.com/reproduction...

Tateishi, K., Nishida, T., Inoue, K., & Tsukita, S. (2017). Three-dimensional organization of layered apical cytoskeletal networks associated with mouse airway tissue development. Scientific reports. #EpithelialMechanics doi.org/10.1038/srep...

In case you missed the big news ⬇️

FBN2 & Spinal CSF leak😎 From Lancet Neurol, Dr. Cassie Parks & Dr. Harry Dietz groups www.sciencedirect.com/science/arti... Thanks for the paper selection by Dr. Mark Lindsay @markelindsay.bsky.social