Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types #PNAS 2025 www.pnas.org/doi/10.1073/...

What a privilege to be in the audience for the #AHA25 Nobel Laureate address by @ardemp.bskyverified.social Inspiring story describing his Piezo journey, complete with sage advice & encouragement for researchers, as well as demonstration of his dermatological commitment to his discovery (video) 💪🏼

A non biologic PCSK9 inhibitor could be a game changer! www.nytimes.com/2025/11/08/h...

Works for grants too

Interesting organoid work on an often overlooked lineage emerging from the Lateral Plate Mesoderm: ventral dermis! #devbio #evodevo #MesodermIsStillCool 🧬🎈⚾

Lipid quality control #Ferroptosis "Lipid Droplet-localized FSP1/ferroptosis suppressor protein 1 reduces CoQ10 to generate local antioxidants that prevent neutral lipid peroxidation" Any role of FSP1 in #Atherosclerosis!?😆 @olzmannlab.bsky.social #NatCellBio 2025 www.nature.com/articles/s41...

Multimodal non-invasive imaging of mouse #LimbIschemia #LaserSpeckleImaging #NearInfrared2ZoneImaging #DuplexUltrasound Flow + Muscle elastography #OpticalCoherenceTomographyAngiography +Some human data #T2D #BioengTranslMed 2025 aiche.onlinelibrary.wiley.com/doi/10.1002/...

"Second Skin" A flexible PDMS window enables up to 3-week intravital imaging of mouse tissue dynamics of mammary gland, tumor & even skeletal muscle! Direct visualization of satellite cell division in injured muscle Enjoyable re-reading!😄 #ScienceAdvances 2021 www.science.org/doi/10.1126/...

#astrocytes #endothelium #cerebrovascular 😱🤩🤩

New in @natureportfolio.nature.com on microglial regulation in Alzheimer’s disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!

#DBfeature Developmental life history transitions can be shaped by structural inequities: Insights from the sociology of race by Sarah McMenamin, Latrica Best sciencedirect.com/science/arti...

Great opportunity for musculoskeletal researchers!! Help us grow more inclusive research across regenerative medicine, prosthetics, epidemiology, preclinical research, clinical trials & global health 🦴🏃‍♂️🌎 Grow your profile, networks & have real impact! Apply now 👇 #Dsxhe #datascience #FortisNet

#MetaplasticBreastCancer Neoadjuvant chemo-immunotherapy response predicts long-term survival KEYNOTE-522 N=32 stage I-III high stromal tumor-infiltrating lymphocytes corr. pCR pCR (n=7)➡️no recurrence 2/3 of residual disease➡️recurrence in 14 mo #NPJBreastCancer2025 www.nature.com/articles/s41...

Good morning from #AHA25! First up for your #sportscardio itinerary: “Competitive Sports Participation for Athletes with Heart Disease” Join us @ 12:30pm CT in Rm 275 for discussions on the new guidelines, SDM, PPE, CMY, ORCCA registry, and more Submit your ?’s via the AHA conference app 📱

Hao's Preprint Reading List November 7 2025 EndMT Thermogenesis Brown Adipose Tissue hiPSC-derived Lymphatic Endothelial Cell MERFISH+ 3D Spatial Transcriptomics Atherogenic stress & Neurovascular functions Smooth muscle lineage in Medial Arterial Calcification docs.google.com/document/d/e...

#SmoothMuscleCell Epitranscriptomics METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability) 135 METTL3 target genes by RNAseq+MeRIPseq in rat SMC SMC Mettl3 KO🐭➡️ ⏬carotid #IntimalHyperplasia➡️ ⏫by AAV9-SM22a-SGK1 #ATVB 2025 @ahascience.bsky.social www.ahajournals.org/doi/10.1161/...

📅 Save the Date! The 4th Canadian Zebrafish Research Conference will take place on Friday, May 15, 2026, at CHU Sainte-Justine, Montreal (just before the Canadian Neuroscience Conference!) Multiple travel awards available with 2 Postdoctoral Rising Stars Awards! #izfs

Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s. Makes me also wonder how many could be druggable targets.

The next Ethel Browne Harvey Postdoc Seminar will be Friday, November 14 at 3 pm Eastern Time with Olya Yarychkivska from @rockefeller.edu and Anthony Galenza from Stanford University. Register today and join us. bit.ly/4gvaHqd #SDBPostdocSeminar #Celegans #drosophila

#ThoughtfulThursday Why does my AVATAR outside the lab have MORE GREY HAIR than real-life me? 😳 Is it: ✅ The avatar actually wrote ALL th3 grants? ✅ It’s aging in DOG YEARS from reviewer feedback? ✅ Or is it secretly running experiments at 3 AM? What’s your theory?👇 #ScienceLife #LabHumor

Latest Powerpoint update refuses to display images on my old slides. Perfect opportunity to remake a better historical MPS slide! (It might not look like much but there's a lot of fiddling to extract good quality images from papers, remove labels, change colors to unify, put proper scale bars etc.)

#DBfeature 🐣🐠 Cereblon E3 ligase complex genes are expressed in tissues sensitive to thalidomide in chicken and zebrafish embryos but are unchanged following thalidomide exposure By LR Fraga, J Reeves, C Mahony, L Erskine, N Vargesson tinyurl.com/2fx6pbay #SpecialIssue in Avian Model Systems

❣️New in @JExpMed Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en ! Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin. rupress.org/jem/article/...

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

Bioengineering of the implantable vascularized pancreatic islet constructs for insulin delivery suitable for clinical upscaling Amniogel (human amniotic membrane-derived) Blood outgrowth endothelial cell Isolate islet s.c. graft in diabetic NSG🐭 bioRxiv 2025 www.biorxiv.org/content/10.1...

Not a bad place to work on a paper #libraries

New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬 An amazing set of resources for all scientists working on the brain! 🧠 Immersive feature: www.nature.com/immersive/d4... 🧠 Perspective: www.nature.com/articles/s41...

NRIP2+ #SmoothMuscleCell (likely mediating metabolic resilience by Leptin signaling) #AorticDissection Leptin antagonist R128Q or AAV9-SM22a-NRIP2 ⏬🐭AD #AorticRupture (BAPN) ⏫contractile SMC ⏫SMC mitochondrial ultrastructure & OXPHOS #AdvSci 2025 advanced.onlinelibrary.wiley.com/doi/10.1002/...

#DBfeature 🐦🦴 Micro-CT 3D structures provide new criteria which can be used to identify medullary bone and female individuals in the avian fossil record. By Crane AH, Baldry CJ, Rankin KE, Clarkin CE, Williams KA, Gostling NJ. tinyurl.com/pw5s23js #SpecialIssue on Avian model systems

We have observed a beautifully strange phenomenon of phase separation by human monocytes placed on soft matrix, which do it for survival. We model it by incorporating the Cahn–Hilliard equation with a Turing mechanism of local activation/global inhibition More here: www.nature.com/articles/s41...

The ongoing enthusiasm for studying and addressing #Sarcopenia associated with metabolic disorders #weightloss www.nature.com/articles/s41...

Here the authors propose T cell-derived sCD52 as a therapeutic target to mitigate #obesity-associated #MASLD and glucose intolerance www.sciencedirect.com/science/arti...

Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease🤠 Redox, Nitric Oxide, NOX Organotypic functions in 🫀, 🧠, kidney, bone marrow, adipose Endothelium-mediated cross-organ communications @brantisakson.bsky.social #ComprPhysiol 2025 onlinelibrary.wiley.com/doi/10.1002/...

HL60 cells take on so many fun shapes as they migrate! This #InsightFromImaging data features cells prepared by Leanna and imaged on the @aicjanelia.bsky.social LLSM by @cmhobson.bsky.social

A few more days to submit your abstract!

Bioengineers, Dr. Hans Clevers @hansclevers.bsky.social will give us a keynote lecture Tomorrow, November 5th, 2025, in London, Ontario🍁!!😆 Register this exciting event👇 Organoids: Transforming Disease Modelling into Personalized Medicine westernorganoids.ca/cancor-ccro

Bioengineers, Dr. Hans Clevers @hansclevers.bsky.social will give us a keynote lecture Tomorrow, November 5th, 2025, in London, Ontario🍁!!😆 Register this exciting event👇 Organoids: Transforming Disease Modelling into Personalized Medicine westernorganoids.ca/cancor-ccro

#VascularCalcification #SmoothMuscleCell m6A Epitranscriptomics High Pi ⏬METTL3 in SMCs METTL3-YTHDF2 destabilizes RUNX2 mRNA & ⏬ SMC Osteogenesis S-Adenosylhomocysteine METTL3/14i aggravates aortic calcification in CKD 🐭 (adenine + hi Pi diet) #CommsBio 2025 www.nature.com/articles/s42...

Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response www.mdpi.com/1422-0067/26...

The brain neurovascular epigenome and its association with dementia @cp-neuron.bsky.social Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes. These findings link vascular risk and Alzheimer’s mechanisms.

Interesting new work @natureportfolio.nature.com showing that a small molecule identified through in silico transcriptome matching (thiorphan) enhances corticospinal regeneration after spinal cord injury. Combined with neural stem cell grafts, it improved forelimb recovery and axonal growth.

Chipman, P. H., Lee, U., Orr, B. O., Fetter, R. D., Davis, G. W. (2025). A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses. Neuron, www.cell.com/neuron/fullt...

Come! We're hosting a fantastic list of speakers and hands-on workshops #ims2026

🚨 Join us tomorrow for two really exciting talks on the emergence of the fractal bronchial tree and tortoise/ crocodile head scale patterning!🚨 @rorylcooper.bsky.social @maltemederacke.bsky.social

Interesting new work modeling human cholinergic circuitry! Researchers generated nbM organoids from hPSCs and fused them with cortical organoids to form functional nbM–cortical assembloids. This provides a platform to study deficits seen in Down syndrome. @cp-cellstemcell.bsky.social

In new study from Ryken, Bezanilla et al., analysis of PIIB-type calcium pump localization and function elucidates one of the molecular mechanisms that maintains the strength of the calcium gradient during polarized growth. rupress.org/jcb/article/... #PlantBiology #Cytoskeleton #Trafficking

An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.

That GLOW we see is light from the universe at 380,000 years old. This thread is the poem cosmology was missing (READ IT). Repost + silent applause. 🔭 🧪 #cosmology #BigBang #Astrophysics #SciencePoetry