All data in this work are beautiful – look at this 3-day timelapse of in vivo myelination along a zebrafish axon! www.nature.com/articles/s41...

#DBfeature 🪰🐁🧠 Evolutionary conservation of midline repulsive signaling by Robo family receptors in flies and mice. By Allison Loy, Trent Daiber, Timothy Evans tinyurl.com/mudtsbnj

CADASIL 3D Vessel-on-Chip models the effects of NOTCH3 R182C on Vasculopathy AIM Biotech with primary or hiPSC-derived Smooth Muscle Cells ⏫SMC arborization surrounding endothelial tubes ⏫SMC NOTCH3-ECD, PDGFRβ, Contractile proteins, Ca2+ activity #StemCellRep 2026 www.cell.com/stem-cell-re...

😂

This is a very interesting result. At infinite sample size the true effect might not be 0, but these results at least nudge us away from remnant cholesterol and TGs playing a particularly big causal role in atherosclerosis risk. The results certainly fit with the current LDL-c-centric paradigm.

LDL-cholesterol is in the causal chain for atherosclerosis. It looks like there is residual risk that LDL-c doesn't explain, and other lipid entities are appealing candidates. Enter olezarsen, which degrades APOC3 mRNA and reduces ApoC-III levels. This lowers TG & remnant cholesterol.

Didn't have time to comment during the conference, but these are really interesting null results for a triglyceride-lowering therapy. www.ahajournals.org/doi/10.1161/...

RRAS2 #AbdominalAorticAneurysm Ang II▶️⏬MEG3▶️⏬RRAS2 in aortic Smooth Muscle Cell CLIP-seq RNA-binding protein of MEG3 + MEG3 IP-MS + CatRAPID predicted RRAS2 interactome▶️ ELAVL1▶️ ⏫RRAS2 mRNA stability SMC Rras2 KO🐭 +AngII or elastase ⏫AAA #NatComm 2025 www.nature.com/articles/s41...

Don’t miss next @evborg.bsky.social workshop!

Beware the SPY488-FastAct rollercoaster! We teamed up with CSR Biotech and their incredible MI-SIM microscope to drive you through the intricate actin network of live COS7 cells stained with SPY488-FastAct. Find out more about SPY488-FastAct: spirochrome.com/product/spy4...

Striking microtubule-actin compartmentalization. A cell so big must organize things I guess!

Here's a hint...

Can you guess why the microtubules are organized so differently at the bottom and top in this gigantic COS cell? (a game for you @manuelthery.bsky.social)

A powerful example of protein abundance regulation. The degradation rate of p53 determines its abundance. p53 is special, but regulation by protein degradation is not a special case. It's common: doi.org/10.1101/2025...

#DBfeature🪰👁️ Roles played by Enhancer of split transcription factors in Drosophila R7 photoreceptor specification "RTK & Notch signaling pathways jointly specify the R7 fate" by Ronald Arias, Yannis Mavromatakis, Andrew Tomlinson www.sciencedirect.com/science/arti...

My colleague Prof. Wu and our group have developed iCLAP to address the common problem of difficult detection of low-abundance antigens with immunostaining. Read about it here: www.nature.com/articles/s41...

@mads100tist.bsky.social continues his takeover in this insightful webinar 🤩 Please do attend, if interested (which you are)!

Taming Autoimmunity: Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Promote Regulatory T Cell Crosstalk to Reverse Diabetes: Molecular Therapy www.cell.com/molecular-th...

Some good SMLM preprints and papers out in the last couple of days! First is @wmarkbates.bsky.social's COMET drift correction approach 1/5

There are no medications for reducing rupture risk of brain arteriovenous malformations Park et al. find a role for microglia & macrophages in the destabilization of bAVMs, reporting that minocycline treatment in mice limited intracerebral hemorrhages: doi.org/10.1172/jci....

COBRA: Cell-type-specific Orthogonal Batch effect Removal Algorithm in single cell RNA-sequencing data Gene-wise Linear model No dimensionality reduction Compatible with direct downstream Faster vs Harmony vs Seurat limma ComBat scMerge fastMNN Harmony bioRxiv 2025 www.biorxiv.org/content/10.6...

New paper from Stefano Piccolo and colleagues. "3D morphogenetic blueprint for metastatic outgrowth in breast cancer" We contributed the 3D reconstructions using CODA. More here: www.sciencedirect.com/science/arti...

#VascularAging Smooth muscle cell estrogen receptor α promotes arterial stiffness in the absence of estradiol😎 Evidence from 1⃣Ovariectomy ♀️🐭 2⃣Acta2-CreERT2+ SMC KO of ERα ♂️♀️🐭 SMC ERα KO ⏬arterial stiffness (PWV), not fibrosis, in aged (18-mo)♂️♀️🐭😮 bioRxiv 2026 www.biorxiv.org/content/10.6...

Be there or be a square animal cap! 🧪 #DevBio

The next the Ethel Browne Harvey Postdoc Seminar will be held Friday, April 10 at 3 pm Eastern Time with Joaquín Navajas Acedo @mads100tist.bsky.social @biozentrum.unibas.ch and Yiqun Wang @ucsandiego.bsky.social. Register today and join us. bit.ly/42xUhYh #SDBPostdocSeminar

New paper from Kiemen and Wirtz groups. Using a new workflow, we map the 3D spatial distribution of immune cells in the vicinity of precancerous lesions. These maps reveals localized immune remodeling during early pancreatic cancer progression. More here: www.cell.com/cell-press-b...

The wonderful chocolate slime mould (Stemonitis splendens), taken by Nelson Milano. Microorganisms come in a vast array of colors and shapes that often call to mind sci-fi creatures. Such impressive biodiversity! 🧪 #Science #SciComm #NaturePhotography #Biology www.nature.com/immersive/d4...

Day 1 of the ALIGN-FMD Network meeting at Imperial College London

FGF8-expressing embryonic body Organizer fusion induced rostral-caudal arealization of elongated hPSC-derived cortical assembloids (15-mm long😎) Modeling FGFR3-related temporal lobe dysgenesis #NatMeth 2024 www.nature.com/articles/s41...

#DBfeature Previously unrecognized gene dosage effects suggest that maintaining appropriate levels of Mkx may be critical for tendon homeostasis. By Lin Liu, Tomoki Chiba, Takahide Matsushima, Maiko Inotsume, Tomomi Kato, Yuichi Hiraoka, Hiroshi Asahara tinyurl.com/paazm7wy

#MetaplasticBreastCancer #CaseReport N=7 MpBC with heterogeneous mesenchymal & matrix components c-MYC amplification (ISH) in 6/7 cases #AnnDiagnPathol 2026 www.sciencedirect.com/science/arti...

Happy #FluorescenceFriday! This is a confocal 🔬 series of a developing 🐭 spinal cord showing nuclei, actin, and cellular membrane stains colored in 🌈 Microscopy by postdoc @christinaadaly.bsky.social 👩‍🔬 🧪

#Cilia are beautiful! That's it, that's the tweet. Oh, and Happy #FluorescenceFriday 🔬

In the spirit 👻 of Freaky Friday 🎃, here is a beautiful yet eery video of zebrafish retina development showing horizontal cells (🔵) finding their way out of the crowded amacrine (🟠) layer to settle beneath the photoreceptors. Happy #Halloween! 🎥: PhD student Rae Wong from the @nordenlab.bsky.social

New insights into brain imaging by @annadevor.bsky.social just dropped 🧠✨ This study shows that neuromodulators, especially norepinephrine, actively reshape how neural activity translates into blood flow signals across the cortex. A powerful step toward more accurate brain mapping! #cerebrovascular

3d-OT Spatial Multi-omics Alignment Spatiotemporal reconstruction of🐭embryonic heart (+blood vessels) brain lung liver muscle (E11.5~16.5) Geometry-aware, soft correspondence optimal transport-based Chamfer Distance as a performance metric #NatMeth 2026 www.nature.com/articles/s41...

#DBfeature 🦋 Calreticulin is required for cuticle deposition and trabeculae formation inside butterfly wing scale cells by Ru Hong, Cédric Finet, Antónia Monteiro www.sciencedirect.com/science/arti...

The vasorelaxant & BP-lowering effects of Perivascular adipose tissue (by NOX4-H2O2 axis) on♀️rat mesenteric resistance arteries are abrogated by ovariectomy & restored by estrogen A role of adipose NOX4 in #VascularAging?😁 @tiagojcosta.bsky.social #JHypertens 2026 journals.lww.com/jhypertensio...

The Cooper lab is hiring a postdoc with a strong background in mouse genetics and molecular biology to advance.our gene drive work. Must be extremely organized, engineering-minded, and outcomes-oriented. Spread the word and have interested candidates email me directly.

Amazing opportunity to work with Kim, who is the most creative scientist and an amazing mentor

Help Skype a Scientist fund science communication projects across the USA! givebutter.com/Science_IRL2...

RE-read this important paper on small GTPases (Rac/Rho) in Smooth Muscle Cell responses to Matrix Stiffness Distinct Roles of YAP & TAZ in Mechanotransduction (to SMC priliferation)😎 PAGE gel matrix 0.1-50 kPa Richard Assoian lab #CellRep 2021 www.cell.com/cell-reports...

Integrated LC-MS/MS Metabolomics 1️⃣Angiotensin II-treated Smooth Muscle Cells 2️⃣Apoe-/-🐭Aorta +Angiotensin II Common metabolites ⏫5-HETE ⏫L-carnitine ⏫lysophosphatidylcholine (0:0/20:4) ⏬salicylamide #Biomed_MDPI 2026 www.mdpi.com/2227-9059/14...

Want to make your images/videos more inclusive? Avoid Red-Blind LUTs! 🫷 While single-color red images are accessible, multi-color LUTs with red can be confusing for a small proportion of the population with Protanopia. I'll give a quick example from a paper I covered in journal club. 1/2

Pancreas-Brain axis Alzheimer's disease Amylin not only forms amyloids in pancreas but also co-aggregates with Aβ in👤AD🧠vasculature Amylin vasculopathy in rats+👤Amylin▶️ ⏬Cerebral blood flow ⏫Pial arterial tone ⏬🧠microvascular P-gp LRP1➡️⏬Aβ efflux #CommsBio 2023 www.nature.com/articles/s42...

🔬Our team @urochestersmd.bsky.social is building a 📹camera to image through layers of the living eye👁️. By changing focus, we reject out-of-focus light to image 3 layers of retinal vessels @cvsuor.bsky.social @uofrbme.bsky.social @urneuroscience.bsky.social iovs.arvojournals.org/article.aspx...

#FluorescenceFriday This microscopic🔬 object is a specialized immune cell (microglia) that resides in your retina👁️ and is responsible for damage control and refinement of neural circuits. GFP labeled @urneuroscience.bsky.social @urochestersmd.bsky.social @flaumeye.bsky.social @uofrbme.bsky.social

Expanded iOn switch toolkit enables flexible clonal labeling and dynamic imaging in model and non-model animals by Takuma Kumamoto and team: www.nature.com/articles/s42...