#Pericyte Preprint #BloodLabyrinthBarrier Single-cell Transcriptomic feature of Adult🐭Cochlear Stria Vascularis CD31+NG2+ Pericyte Progenitor-like leader cells🤠 observed at the tip of vascular sprouts in 3D strial explant #Rq 2026 www.researchsquare.com/article/rs-8...

Interesting paper using genomic language models to assist with discovery. But not immediately obvious from a statistical standpoint that this should do much beyond a standard GWAS (barring close-proximity epistasis)—or that the gene-level analysis (stage 3) would beat MAGMA (not compared).

Whole-body Single-cell Spatial transcriptomic atlas of adult Danionella ~1 cm long scRNAseq MERFISH (500-gene) HCR Endothelial cell podxl+ (Fig S8) Vascular vs Visceral mural cell (Fig S10) Peter Reddien lab bioRxiv 2026 www.biorxiv.org/content/10.6...

🤯

Ever wondered what a scientific editor actually does? I recently shared my perspective on this in a written interview for the Academic Life Substack: 👇 shorturl.at/vqGxU #CareersOutsideAcademia #ScientificEditing #AdvancedScience

As always preprint formated using the #RxivMaker engine created together with @henriqueslab.bsky.social github.com/HenriquesLab...

#DBfeature 🪱 Wnt/β-catenin signaling promotes posterior axial regeneration in non-regenerative tissue of the annelid C. teleta, enabling the prospect of increasing regeneration ability in regeneration-deficient tissues By Lauren Kunselman, Elaine Seaver tinyurl.com/2bxpecek

#DBfeature 🐠 Development of the zebrafish anterior lateral line system is influenced by underlying cranial neural crest By Vishruth Venkataraman, Noel McGrory, Theresa Christiansen, Joaquin Navajas Acedo, Michael Coates, Victoria Prince tinyurl.com/22z6fsbh

#Pericyte Preprint #BloodLabyrinthBarrier Single-cell Transcriptomic feature of Adult🐭Cochlear Stria Vascularis CD31+NG2+ Pericyte Progenitor-like leader cells🤠 observed at the tip of vascular sprouts in 3D strial explant #Rq 2026 www.researchsquare.com/article/rs-8...

We used CAS13 and CAS7/11 in here, full protocol is available and just drop a line if you need the plasmids or help with it. Current version is running even smoother with synthetic guides… Also an opto-version will be available soon… stay tuned 🐸 link.springer.com/article/10.1...

Hey Frog-Folk, I saw that @eliasbarrigalab.bsky.social recently used Crispr-Cas13 for mRNA depletion. Anyone else used this in a published paper yet? @goodfrognosis.bsky.social @xenbase.bsky.social @mblscience.bsky.social @frogwranglers.bsky.social @socdevbio.bsky.social

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

Pial cell junctions with ZO-1 (green) and beta-catenin (magenta) with a few pial blood vessels at the edges (adult mouse) - the sample prep for this is tough but worth it to see these lovely cell connections. #microscopymonday

🚨 SAVE-THE-DATE 🚨 SEEON ANGIOSCIENCE! Fantastic, long-running meeting on Development & Maintenance of the Vasculature. 🗓️ Sept 2026 🌍 Bavaria, Germany Registration open! Join us! vwfb.de/start/regist...

Demystifying Oral Epithelial Dysplasia: a histological guide Enhanced interpretation of WHO 28 features Normal oral mucosa variants Core architectural & cytologic abnormalities #Pathology 2024 www.pathologyjournal.rcpa.edu.au/article/S003...

this is extremely cool: www.nature.com/articles/s41...

Whole-body Single-cell Spatial transcriptomic atlas of adult Danionella ~1 cm long scRNAseq MERFISH (500-gene) HCR Endothelial cell podxl+ (Fig S8) Vascular vs Visceral mural cell (Fig S10) Peter Reddien lab bioRxiv 2026 www.biorxiv.org/content/10.6...

#MetaplasticBreastCancer n=44🇬🇷 YAP/TAZ immunoreactivity in MpBC Not corr. CTGF CCND1 Not corr. Histological/Molecular subtype Not corr. Disease-free survival Marginal corr. Overall survival Chemo➡️⏫survival Recurrence➡️⏬ survival HR>100😨 #CurrIssuesMolBiol 2025 www.mdpi.com/1467-3045/47...

VERY excited that @harmitmalik.bsky.social will be giving the UNC Biology seminar tomorrow, and is featured in one of Bob Goldstein's gig posters. I missed him the last time he cams through (I was away giving a talk) and thus have never heard him speak

New preprint alert! We developed an automated framework to optimize tracking pipelines for bacteria, along with a nice integration of tools for bacteria imaging, in the recently released TrackMate 8 (Fiji plugin). www.biorxiv.org/content/10.6... 👇🧵

A menagerie of COS cells for #MicroscopyMonday 🧪

Microcephaly-lymphedema-chorioretinopathy syndrome (MLC) is an autosomal dominant condition. This issue’s cover: Ogmen et al. report on clinical features and disease mechanisms in MLC involving KIF11 pathogenic variants. doi.org/10.1172/jci....

#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. < 1 month till Deadline: March 5 @socdevbio.bsky.social www.sdbonline.org/gethired

EVBO Paper of the Month! Congratulations to the authors on this fantastic contribution! Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin by Aline Bauer and colleagues. rupress.org/jem/article/... More information: evbo.org/index.php/pa...

Job alert: eur04.safelinks.protection.outlook.com?url=https%3A...

Hao's Preprint Reading List February 9 2026 A nematic framework for sprouting angiogenesis Cell compliance & tissue rupture Cancer drives atherosclerotic plaque vulnerability Sheep model of PAH Whole-body single-cell spatial atlas of Danionella🐟 docs.google.com/document/d/e...

🤝 ICYMI: ELRIG x Zeeks - Art for Geeks | Media Partnership 2.0 We’re delighted to continue our partnership with ELRIG as media partners for Cell & Gene Therapy 2026, taking place in Cambridge. 👉 Register here: elrig.org/portfolio/ce... #ELRIG #SciComm #Conference #MarCom

So grateful to @epimechfc.bsky.social for citing our work! It’s a classic from the lab, forever thanks to @colomlab.bsky.social

Post-stretch (3 d) response of 👤fetal Airway Smooth Muscle Cell Mechanical Stretch mimicking continuous pos airway pressure▶️cyclic 5% 0.67 Hz + static 5%/10% vs control▶️cyclic 5% 0.67 Hz ⏫Proliferation ⏫IL-6 ↔️Collagen/Fn deposits Piezo-indie #AJPLung 2025 journals.physiology.org/doi/full/10....

Latest preprint from the lab - what does S1P do to neutrophils ? Click the link to find out… www.biorxiv.org/content/10.6...

I just started a cell biology and biophysics group at EPFL, Switzerland that will investigate how cells endure mechanical stress and release large cytoplasts. Get in touch if you’d like to join! See more at celldynamicslab.com

📄 Finally, the success of the probe comes in part from its availability. The University of Geneva licensed the probe to @spirochrome.com @lreymond.bsky.social which made it available around the world, along with new versions like Halo-Flippers 🔗 bsky.app/profile/epim...

📄 A major effort is carried out by the community to benchmark Flipper-TR alongside other membrane probes. This elegant paper from @sciezgin.bsky.social quantified the FLIM response of several probes in parallel 🔗 bsky.app/profile/epim...

📄 Methods: A practical FLIM analysis-focused guide: acquisition, fitting strategies, phasors, and interpretation. It clearly explains how lifetime reflects lipid packing, and where over-interpretation of “tension” can go wrong. 🔗 bsky.app/profile/epim...

📄 Tension gradients during migration. Using Flipper-TR FLIM, we showed that membrane tension gradients exist in all adherent cells and are actively maintained by actin and adhesion, not passively equilibrating. @rouxlab.bsky.social and Aumeier lab 🔗 bsky.app/profile/epim...

📄 In cells, osmotic shocks shift Flipper-TR lifetime consistently with increased or decreased membrane tension, provided composition is controlled. This paper also compared quantitatively tether force and F-TR lifetime measurements @chloeroffay.bsky.social 🔗 bsky.app/profile/epim...

💡 By tuning lipid composition and applied tension in GUVs, Flipper-TR lifetime could be quantitatively related to membrane mechanical state, establishing the physical basis for cellular measurements made later.

How does Flipper-TR work? Flipper-TR inserts in the lipid bilayer. Its mechanosensitive core rotates, sensing the lipid packing. The electron-rich head group confers the plasma membrane specificity... but other versions exist for alternative targeting! 🔗 bsky.app/profile/epim...

First, why Flipper-TR? It comes from swimming fins, also called swimming flippers, because of their shape! coined by the first author of the original paper, Marta Dal Molin, at @matilegroup.bsky.social. TR stands for ‘tension reporter’. Here’s a bit of history: www.unige.ch/campus/numer...

Fibroblast TGFβ signaling in systolic & diastolic🫀functions Protective▶️Lean 🐭 Pathogenic▶️Diabetic db/db🐭 Evidence from Fibroblast Tgfbr2 or Smad3 KO🐭 Speckle-tracking echo 👉Peak systolic/diastolic longitudinal endocardial/epicardial strain #CardiovascRes 2024 academic.oup.com/cardiovascre...

Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells. Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!

For both #RareDisease month and #MarfanSyndrome awareness month, I thought I'd share this article I wrote for the @ahajournals.bsky.social about being a patient-scientist working on developing genetic therapies for my condition and related conditions.

In spatial omic, using standard 2D sections undersamples 3D tumors and tissues, always. We asked how many slides or cores of a TMA are needed to capture the variations in tissue composition in a single 3D tumor? A lot! Download here: www.sciencedirect.com/science/arti...

FGF9:c.382-1264C>T a intronic SNP with Hu Sheep🐑 body weight (1070 male, 80~180 days of age) PIC 0.35 Heterozygosity 0.45 HWE p=0.89 Located near open chromatin region & H3K27ac+ locus Act in pituitary gland? How does it affect FGF9 level? #Animals 2025 www.mdpi.com/2076-2615/15...

'CD8+ T cells from patients with homozygous familial hypercholesterolemia, who harbor inactivating LDLR mutations, exhibited reduced proliferation and ICAM-1 expression upon activation.' #Immunology #Metabolism www.cell.com/iscience/ful...

I am looking forward to visiting the Dept of Chemical Engineering at the University of Washington. My seminar on CODA and new CAR T cells for solid tumors will be this Tuesday, 4 – 5 p.m in the PAA www.cheme.washington.edu/calendar?tru...

Dynamic actin waves in a zebrafish embryo. Credit to @aaandmoore.bsky.social & Dvir Gur. #ZebrafishZunday 🧪

An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.

Not something you see in textbooks very often: tripolar mitosis.

Generation of publication-ready(!😈🧐) statistical plots + schematics using AI 🎃 PaperBanada🍌 vs NanoBanada-Pro dwzhu-pku.github.io/PaperBanana/ arxiv.org/abs/2601.23265