Hi All - had my stepmoms memorial this weekend and thought I would post it, she was an amazing scientist but also we had the ASO string quartet play and it’s worth it just for the music if you like that m.youtube.com/watch?v=aSYx...

Exogenous PCSK9 can be internalized by Smooth Muscle Cell, likely a major resource for arterial wall in vivo LRP1-mediated Compete with oxLDL Mathilde Varret lab #Atherosclerosis 2026 www.atherosclerosis-journal.com/article/S002...

Regulon prediction CollecTRI Collection of Transcription Regulation Interactions public databases + text mining + manual curation (ExTRI, Pavlidis, NTNU Curated, DoRothEA A, etc) Integrated into 1⃣OmniPath 2⃣DoRothEA 3⃣decoupler #NucAcidRes 2023 academic.oup.com/nar/article/...

FAT1 FibroAdipogenic Progenitor Muscle Regeneration #SciArt 1/2 Spatiotemporal maps of the FAP lineage, fibro (Tenascin C)-fatty (Perilipin-1) expansion, myofiber necrosis-regeneration in Cardiotoxin-/Glycerol-injured 🐭triceps brachii🤩 @fhelmbacher.bsky.social 2026 www.biorxiv.org/content/10.6...

#MetaplasticBreastCancer #CaseReport Immunotherapy-refractory 47 y/o Rapid growth 40 mm cT2N0M0 stage IIA➡️80 mm cT4bN1M0 stage IIIB in 2-wk Keynote-522 regimen: pembrolizumab +paclitaxel +carboplatin No recurrence in 18 mo post-mastectomy #NagoyaJMedSci 2026 pmc.ncbi.nlm.nih.gov/articles/PMC...

Thank you! I'm glad you say this, I thought this was a very informative way of looking at the dynamics of muscle regeneration. Since we do this in a big muscle, where not everything is damaged by the lesion, it is possible to capture the dynamics by looking at the outside to inside progression.

Happy #FluorescenceFriday. I feel so lucky to get to work with these weird and curious primary macrophages from 🐸. They exhibit myriad different morphologies and behaviours, including spinning endlessly and stationary, kinda like progenitor cells under compression from 🐟. Also actomyosin is strong!

The 2027 EMBO practical course on #devbio is now open for registration. You'll get work with a lot of different model organisms, from fly to frog and everything in between, plus amazing imaging too. And the city is beautiful, so what I've heard 😌!

FAT1 FibroAdipogenic Progenitor Muscle Regeneration #SciArt 1/2 Spatiotemporal maps of the FAP lineage, fibro (Tenascin C)-fatty (Perilipin-1) expansion, myofiber necrosis-regeneration in Cardiotoxin-/Glycerol-injured 🐭triceps brachii🤩 @fhelmbacher.bsky.social 2026 www.biorxiv.org/content/10.6...

Excited to share our latest work in @ScienceAdvances! 🔬 We’ve developed "dynaMIET"—a new spectroscopy technique that finally allows us to simultaneously measure 3D membrane dynamics in live cells with nanometer precision. www.science.org/doi/10.1126/...

⭐️ A transgenic hydra labeling the endoderm and ectoderm of two column ends regenerating.🔬📸 Credit: Raisa Bailon-Zambrano from the University of Colorado Anschutz Medical Campus taken during the 2021 MBL Embryology Course #FluorescenceFriday #devbio #Embryology 🪸

Pro-inflammatory cytokine-driven molecular signaling in skeletal muscle during cancer cachexia portlandpress.com/biochemsoctr...

S100A4 labels subpopulations of medial Smooth Muscle Cell & adventitial Fibroblast in🐭Aorta 2.5-fold⬆️upon AngII infusion S100A4-Cre;Agtr1 (AngII type 1 receptor) KO Ldlr-/-🐭+AngII 👉⏬Ascending aortic area 👉↔️BP↔️aortic rupture @alandaugherty.bsky.social #PLOSONE 2026 journals.plos.org/plosone/arti...

This is a fascinating approach to treating vision disorders. Photosynthetic structures have been transplanted into mammalian corneal cells to treat dry eye, a common and painful condition. 🧪 #Science #Biology #Chemistry #Medicine 1- www.science.org/content/arti... 2- www.cell.com/cell/fulltex...

So, as translation control is getting popular, please note the newly unified nomenclatures: Translons: a single term for translated regions www.nature.com/articles/s41... Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status www.nature.com/articles/s41...

#FluorescentFriday for my seductive Mimulus 👄 #plantjoy #microcopy #confocal #mimuluspropaganda #mimulus 🔬🌱🌸

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

#Neutrophil #Atherosclerosis CCR2+ Neutrophil ⬆️in👤🐭Atherosclerotic arteries ⬆️NETosis Unique Aortic Neutrophil immunophenotype (vs BM, Blood) CCL2 blockade⏫plaque stability in Apoe-/-🐭⏫Smooth muscle cell content ↔️Lesion, Mφ, collagen, necrotic core #ATVB 2026 www.ahajournals.org/doi/10.1161/...

happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...

Loeys-Dietz syndrome 4 TGFB2 #CaseReport Early-onset (6 y/o M) aortic root aneurysm (Z score +14) +Ventricular Septal Defect #EHJCaseRep 2026 academic.oup.com/ehjcr/articl...

🧵1/10 Astronomers recently revealed a giant cosmic structure that had been hiding behind the stars and dust of our own Milky Way. 🔭 🧪 ⚛️ Press release: www.sarao.ac.za/news/vela-th... #cosmology #universe #MilkyWay

#DBfeature 🐸 TMBIM4 affects left-right patterning via pluripotency exit during gastrulation in X. tropicalis, and its loss replicates the phenotypes of human congenital heart disease patients by Nicholas Diab, Mustafa Khokha et al www.sciencedirect.com/science/arti...

✨ 2026 SDB Art Show 🎨 SDB will host the show at the 85th Annual Meeting in Las Vegas 🎰 Deadline: June 1st ‼️ Open to meeting attendees: 2D & 3D in "Research Images as Art" or "Art Inspired by Research" 🎨 More information: www.sdbonline.org/2026mtg_art_...

Hyaluronan-Collagen balance dictates regenerative vs non-regenerative fate of adult🐭digit regeneration🤠 Soft matrix confers a pro-regenerative, HA-building (HAPLN1+) Blastema Fibroblast state Force mapping of wounded digits (stiffness fluidity) #Science 2026 www.science.org/doi/10.1126/...

A CandiChrome toolkit for multicolor labeling of Candida cells by Richard J Bennett and team: www.biorxiv.org/content/10.6...

Indeed, #methodsmatter www.nature.com/articles/s41...

🚨 One Week Left for the #SDB2026 Early Registration Deadline! 🚨 Register by May 20th for the Society for Developmental Biology 2026 Annual Meeting in Las Vegas 🎰 First 250 registrants get a FREE t-shirt 👕Don’t miss it! 🔗 www.sdbonline.org/2026mtg_regi... #DevBio

Urolithin A (gut microbiota metabolite) as a Senomorphic agent🤠 Little effect on Senescence But alleviating #SASP Senescence-associated secretion of pro-inflammatory cytokines (IL-6/-8/-1α, CCL2/5), likely via ⬇️cGAS-STING cascade #AgingCell 2025 onlinelibrary.wiley.com/doi/10.1111/...

Heading up to @ahascience.bsky.social #VascularDiscovery2026 in Bellevue WA 🏔️ Excited to catch up with old ATVB friends, make new ones & learn the latest in vascular biology research Will be presenting a poster from our lab on our latest work on COL8A1 mechanobiology in ECs 🧫

🚨 New preprint on bioRxiv! Pericyte loss triggers hypoperfusion, BBB dysfunction, endothelial VCAM-1/type I IFN activation, venular-like transitions & delayed white matter injury linked to human SVD signatures. Congrats Dr. Dorota Stefancova & team! www.biorxiv.org/content/10.6...

#DBfeature 🧑‍🎓 The Neural Tube CURE trains students in developmental biology methodology while offering a research course designed to increase opportunities for undergraduate research experience By Anneke Dixie Kakebeen, Joshua Fandel, Lee Niswander tinyurl.com/y2va2xpy

PINCH1, a FA protein & transcriptional co-factor, in mural cell differentiation & wrapping Pdgfrb-Cre;PINCH1f/f;PINCH2−/−🐭 👉Neonatal aortic/cerebral/carotid arterial dilation ⏫Wall thickness ⏫SMC proliferation🤓 👉🫀🧠vascular dysmorphogenesis #Angiogenesis 2026 link.springer.com/article/10.1...

Klumpe, S., Senti, K. A., Beck, F...., Briggs, J. A. G., Brennecke, J., Beck, M., Plitzko, J. M. (2025). In-cell structure a nd snapshots of copia retrotransposons in intact tissue by cryo-ET. Cell, 188(8):2094-2110. www.cell.com/cell/fulltex...

In🐭 #AbdominalAorticAneurysm Apoe-/-🐭♂️+AngII Mitochondrial dysfunction is more pronounced in suprarenal, where aneurysms manifest, than in infrarenal aorta Metformin oral 100 mg/kg/d, begin at D7 rescues Aortic Aneurysm, Not Mito dysfunctions by D28 #BiomedMDPI 2026 www.mdpi.com/2227-9059/14...

Now Dr. Amber Ide is presenting on Wnt regulation of Endothelial-to-hematopoietic transition in zebrafish🐟 🥰 SDB DevBioConnect DB Author Webinar @devbiol.bsky.social @socdevbio.bsky.social

Amazing talk by @dianavoss.bsky.social on 3D chromatin organization on neural-cardiomuscular lineage specification😍 SDB DevBioConnect DB Author Webinar @devbiol.bsky.social @socdevbio.bsky.social

@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk

Great to see how this research into mechanisms of neutrophil-assisted breast cancer metastasis has developed! Updates summarised in a postlight: doi.org/10.1242/prel... @prelights.bsky.social

quite a dense reading : infoscience.epfl.ch/entities/pub...

#DBfeature #DBeditorial Bridging developmental biology and social justice to reclaim trust in science and society by Nicole Theodosiou, Michael Barresi @spiraldoc.bsky.social www.sciencedirect.com/science/arti...

Corneal Endothelial Morphogenesis E6-E16🐣 #SciArt "Persistent dominance of hexagonal topology" Beautiful 2D nuclei Voronoi tessellation!🤩 +Molecular dynamics of N-cadherin F-actin Microtubule @rogerslabucd.bsky.social @sarathomasy.bsky.social www.biorxiv.org/content/10.6...

Mind-blowing cell action alert! Watching vesicle cargo lanes light up like a @FedEx highway in real-time under the #microscope. Who knew that a home-brewed phosphatidic acid imaging probe would look so stunning in fibroblasts? Too late for #FluorescenceFriday but just in time for #MicroscopyMonday

Endothelialization of Implanted Bioprosthetic Heart Valves in Patients with Aeson Total Artificial Heart (N=7) Tricuspid, Mitral, Pulmonary >> Aortic valve (Shear?🧐) 14~270 days VE-cad+ Endothelial Cells form a monolayer over leukocyte pools🤓 #Angiogenesis 2026 link.springer.com/article/10.1...

Bring your family, friends and pupils to join us for a fun day of science! @compscitsui.bsky.social @alomshaha.bsky.social

Again, I shared this paper. This article is great! There's a video in it of microglia walking, I keep watching it. I wish I had written it, it's super! 👌🏻 When a single brain capillary endothelial cell dies, neighboring ECs stretch to fill the gap(no proliferation, no glial support

Astrangia poculata is an ideal model for coral development. Astrangia can be collected and induced to spawn in the laboratory, producing an abundance of embryos for experimentation. 📸 Credit: Leslie Babonis and Jake Warner, MBL Whitman Fellow #ModelMonday #DevBio #Cnidarians 🪸

#NAVBO InFocus - Contributions of Sex-specific Signaling Across Vascular Diseases Presentations will include: Sponsored by the NAVBO Online Program Committee Register 👉https://members.navbo.org/ap/Events/Register/nvFOVxkTECNCZ

Happy Monday everyone!!! Happy to share this book chapter by my awesome partner Made Nieves-Cintron and #MnMLab members on "Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome" Highly relevant topic these days!!! link.springer.com/chapter/10.1...

#DBfeature Long-term mitochondria-endoplasmic reticulum complexes in the oocytes and early embryos of a matrotrophic pseudoscorpion Chelifer cancroides By Izabela Jędrzejowska, Karol Małota, Arnold Garbiec tinyurl.com/45etdr9c